UniProtKB - Q69014 (POLG_SVM93)
Genome polyprotein
ORF1
Functioni
NTPase presumably plays a role in replication. Despite having similarities with helicases, does not seem to display any helicase activity (By similarity).
By similarityViral genome-linked protein is covalently linked to the 5'-end of the positive-strand, negative-strand genomic RNAs and subgenomic RNA. Acts as a genome-linked replication primer. May recruit ribosome to viral RNA thereby promoting viral proteins translation (By similarity).
By similarityProtease-polymerase processes the polyprotein: Pro-Pol is first released by autocleavage, then all other proteins are cleaved.
By similarityProtease-polymerase is an RNA-directed RNA polymerase which replicates genomic and antigenomic viral RNA by recognizing specific signals. Catalyzes the covalent attachment VPg with viral RNAs (By similarity).
By similarityCapsid protein self assembles to form an icosahedral capsid with a T=3 symmetry, about 38 nm in diameter, and consisting of 180 capsid proteins. The capsid encapsulate the genomic RNA and VP2 proteins. Attaches virion to target cells, inducing endocytosis of the viral particle. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm (By similarity).
By similarityMiscellaneous
Caution
Catalytic activityi
- Endopeptidase with a preference for cleavage when the P1 position is occupied by Glu-|-Xaa and the P1' position is occupied by Gly-|-Yaa.PROSITE-ProRule annotation EC:3.4.22.66
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 1012 | For 3CLpro activityPROSITE-ProRule annotation | 1 | |
Active sitei | 1033 | For 3CLpro activityPROSITE-ProRule annotation | 1 | |
Active sitei | 1097 | For 3CLpro activityPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 408 – 415 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- cysteine-type endopeptidase activity Source: InterPro
- nucleoside-triphosphatase activity Source: RHEA
- RNA binding Source: InterPro
- RNA-directed 5'-3' RNA polymerase activity Source: UniProtKB-KW
- RNA helicase activity Source: InterPro
GO - Biological processi
- DNA replication Source: UniProtKB-KW
- RNA-protein covalent cross-linking Source: UniProtKB-KW
- transcription, DNA-templated Source: InterPro
- viral RNA genome replication Source: InterPro
Keywordsi
Molecular function | Hydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymerase, Thiol protease, Transferase |
Biological process | DNA replication, Viral RNA replication |
Ligand | ATP-binding, Nucleotide-binding |
Protein family/group databases
MEROPSi | C24.003 |
Names & Taxonomyi
Protein namesi | Recommended name: Genome polyproteinCleaved into the following 6 chains: Alternative name(s): p35 Alternative name(s): VPg p14 Alternative name(s): VP1 p60 |
Gene namesi | ORF Names:ORF1 |
Organismi | Sapporo virus (strain Human/United Kingdom/Manchester/1993) (Hu/SV/Man/1993/UK) |
Taxonomic identifieri | 82659 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Pisuviricota › Pisoniviricetes › Picornavirales › Caliciviridae › Sapovirus › |
Virus hosti | Homo sapiens (Human) [TaxID: 9606] |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000341624 | ‹1 – 2208 | Genome polyproteinAdd BLAST | ›2208 | |
ChainiPRO_0000036921 | 1 – 252 | Protein p28By similarityAdd BLAST | 252 | |
ChainiPRO_0000036922 | 253 – 593 | NTPaseBy similarityAdd BLAST | 341 | |
ChainiPRO_0000036923 | 594 – 867 | Protein p32By similarityAdd BLAST | 274 | |
ChainiPRO_0000036924 | 868 – 981 | Viral genome-linked proteinBy similarityAdd BLAST | 114 | |
ChainiPRO_0000036926 | 982 – 1649 | Protease-polymerase p70By similarityAdd BLAST | 668 | |
ChainiPRO_0000036927 | 1650 – 2208 | Capsid proteinBy similarityAdd BLAST | 559 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 893 | O-(5'-phospho-RNA)-tyrosineBy similarity | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 252 – 253 | Cleavage; by Pro-PolBy similarity | 2 | |
Sitei | 593 – 594 | Cleavage; by Pro-PolBy similarity | 2 | |
Sitei | 867 – 868 | Cleavage; by Pro-PolBy similarity | 2 | |
Sitei | 981 – 982 | Cleavage; by Pro-PolBy similarity | 2 | |
Sitei | 1649 – 1650 | Cleavage; by Pro-PolBy similarity | 2 |
Keywords - PTMi
Covalent protein-RNA linkage, PhosphoproteinProteomic databases
PRIDEi | Q69014 |
Structurei
Secondary structure
3D structure databases
SMRi | Q69014 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q69014 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 382 – 536 | SF3 helicasePROSITE-ProRule annotationAdd BLAST | 155 | |
Domaini | 982 – 1130 | Peptidase C24PROSITE-ProRule annotationAdd BLAST | 149 | |
Domaini | 1370 – 1495 | RdRp catalyticPROSITE-ProRule annotationAdd BLAST | 126 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1650 – 1674 | DisorderedSequence analysisAdd BLAST | 25 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1653 – 1674 | Polar residuesSequence analysisAdd BLAST | 22 |
Domaini
Family and domain databases
CDDi | cd00205, rhv_like, 1 hit |
Gene3Di | 2.60.120.20, 1 hit 3.30.70.270, 2 hits 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR004005, Calicivirus_coat IPR043502, DNA/RNA_pol_sf IPR004004, Helic/Pol/Pept_Calicivir-typ IPR000605, Helicase_SF3_ssDNA/RNA_vir IPR014759, Helicase_SF3_ssRNA_vir IPR001665, Norovirus_pept_C37 IPR027417, P-loop_NTPase IPR000317, Peptidase_C24 IPR009003, Peptidase_S1_PA IPR043128, Rev_trsase/Diguanyl_cyclase IPR033703, Rhv-like IPR001205, RNA-dir_pol_C IPR007094, RNA-dir_pol_PSvirus IPR029053, Viral_coat |
Pfami | View protein in Pfam PF00915, Calici_coat, 1 hit PF03510, Peptidase_C24, 1 hit PF05416, Peptidase_C37, 1 hit PF00680, RdRP_1, 1 hit PF00910, RNA_helicase, 1 hit |
PRINTSi | PR00916, 2CENDOPTASE PR00918, CALICVIRUSNS |
SUPFAMi | SSF50494, SSF50494, 1 hit SSF52540, SSF52540, 1 hit SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS51894, CV_3CL_PRO, 1 hit PS50507, RDRP_SSRNA_POS, 1 hit PS51218, SF3_HELICASE_2, 1 hit |
s (3)i Sequence
Sequence statusi: Fragment.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative promoter usage and alternative initiation. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MFGTKAPDSV QEGTLFRELF GVDQTEQFPL SLADLARLQG ELVDATRTPG
60 70 80 90 100
HALRQKYTMT TIQDLINKIT KVVPVQATLN EMHARRQFER ERADLFHELP
110 120 130 140 150
LVDEDAVAQP KTYFYTMWRQ VVKKGKAYFC PLVKTSAWRT KISAITEPIK
160 170 180 190 200
DFLIAFWQAV QQEMGVNPQY LQLAWLQKLK PTTLTIILQQ HKHTVSGWLA
210 220 230 240 250
TMTALVEVYS NLFDDLRKSS VTIVSSIGAF FDICKDFVSQ VVELVKTTFT
260 270 280 290 300
AQGPTDLGWA AVLAGAAMIL LKMSGCPGVI GMWTKVLKIC GGITTITAAA
310 320 330 340 350
RGVRWLKDLY EEAEGRRLPK MYMARGAALI ELAASREVTG VDELKGLLDC
360 370 380 390 400
FTILIEEGTE LIHKFGTSPL AGLVRTYVSE LETQANNIRS TIKLDTPRRV
410 420 430 440 450
PVVIILTGAP GIGKTRLAQY IGQRFGKTSN FSVAVDHHDG YTGNTVCIWD
460 470 480 490 500
EFDVDSKGAF VETMIGIANT APFPLNCDRV ENKGRVFTSD YVICTSNYPT
510 520 530 540 550
SVIPDNPRAA AFYRRVLTVD VSAPDLEEWK KRNPGKRPTP DLYQDDFSHL
560 570 580 590 600
KLMLRPYLGY NPDGDTLEGP RVAPTQISIA GLITLMERRF KEQAGPLQNL
610 620 630 640 650
WLQVPKTLVE QSTNMVKAFM YANRAVCDVI PNPATRDITE TALSKVFVCG
660 670 680 690 700
TAPPPEFVGK HIVITGIEVG DASIANSLLS MFTTTTRLSA AAQREYMYRV
710 720 730 740 750
WSPLIHIQDR SMNTQNLPYI NRVIPVTSHW DFLRGLRHHL GFTSIPGMWK
760 770 780 790 800
AFQGWRTSQG IVDFVAHHMA DVTFPSNPEC TIFRTPDADV VFYTFGSYVC
810 820 830 840 850
FATPARVPYV GTPPTTIHSN TPRCMTWGET LALLCEVVAE FVLHFGPVIL
860 870 880 890 900
SAANIAYLMT RGSRTEEAKG KTKHGRGMRH GHRAGVSLSD DEYDEWRDLM
910 920 930 940 950
RDWRRDMSVN DFLMLRERSA LGMDDEDVAR YRAWLEIRAM RMAGGAYTHA
960 970 980 990 1000
TIIGRGGVRD EIIRTSPRRA PTRPQQHYEE EGPTAIVEFT QGGDHIGYGV
1010 1020 1030 1040 1050
HIGNGNVITV THVASTSDEV NGSAFKITRT VGETTWVQGP FSQLPHMQIG
1060 1070 1080 1090 1100
SGSPVYFTTR LHPVFTISEG TFETPNITVN GFHVRIMNGY PTKKGDCGLP
1110 1120 1130 1140 1150
YFNSNRQLVA LHAGTDTQGE TKVAQRVVKE VTTQDEFQWK GLPVVKSGLD
1160 1170 1180 1190 1200
VGGMPTGTRY HRSPAWPEEQ PGETHAPAPF GSGDKRYTFS QTEMLVNGLK
1210 1220 1230 1240 1250
PYTEPTAGVP PQLLSRAVTH VRSYIETIIG THRSPVLTYH QACELLERTT
1260 1270 1280 1290 1300
SCGPFVQGLK GDYWDEEQQQ YTGVLANHLE QAWDKANKGI APRNAYKLAL
1310 1320 1330 1340 1350
KDELRPIEKN KAGKRRLLWG CDAATTLIAT AAFKAVATRL QVVTPMTPVA
1360 1370 1380 1390 1400
VGINMDSVQM QVMNDSLKGG VLYCLDYSKW DSTQNPAVTA ASLAILERFA
1410 1420 1430 1440 1450
EPHPIVSCAI EALSSPAEGY VNDIKFVTRG GLPSGMPFTS VVNSINHMIY
1460 1470 1480 1490 1500
VAAAILQAYE SHNVPYTGNV FQVETIHTYG DDCMYSVCPA TASIFHTVLA
1510 1520 1530 1540 1550
NLTSYGLKPT AADKSDAIKP TNTPVFLKRT FTQTPHGIRA LLDITSITRQ
1560 1570 1580 1590 1600
FYWLKANRTS DPSSPPAFDR QARSAQLENA LAYASQHGPV MFDTVRQIAI
1610 1620 1630 1640 1650
KTAQGEGLVL VNTNYDQALA TYNAWFIGGT VPDPVGHTEG THKIVFEMEG
1660 1670 1680 1690 1700
NGSNPEPKQS NNPMVVDPPG TTGPTTSHVV VANPEQPNGA AQRLELAVAT
1710 1720 1730 1740 1750
GAIQSNVPEA IRNCFAVFRT FAWNDRMPTG TFLGSISLHP NINPYTSHLS
1760 1770 1780 1790 1800
GMWAGWGGSF EVRLSISGSG VFAGRIIASV IPPGVDPSSI RDPGVLPHAF
1810 1820 1830 1840 1850
VDARITEPVS FMIPDVRAVD YHRMDGAEPT CSLGFWVYQP LLNPFSTTAV
1860 1870 1880 1890 1900
STCWVSVETK PGGDFDFCLL RPPGQQMENG VSPEGLLPRR LGYSRGNRVG
1910 1920 1930 1940 1950
GLVVGMILVA EHKQVNRHFN SNSVTFGWST APVNPMAAEI VTNQAHSTSR
1960 1970 1980 1990 2000
HAWLSIGAQN KGPLFPGIPN HFPDSCASTV VGAMDTSLGG RPSTGVCGPA
2010 2020 2030 2040 2050
ISFQNNGDVY ENDTPSVMFA TYDPLTSGTG VALTNSINPA SLALVRISNN
2060 2070 2080 2090 2100
DFDTSGFAND KNVVVQMSWE MYTGTNQIRG QVTPMSGTNY TFTSTGANTL
2110 2120 2130 2140 2150
VLWQERMLSY DGHQAILYSS QLERTAEYFQ NDIVNIPENS MAVFNVETNS
2160 2170 2180 2190 2200
ASFQIGIRPD GYMVTGGSIG VNVPLEPETR FQYVGILPLS AALSGPSGNM
GRARRVFQ
The sequence of this isoform differs from the canonical sequence as follows:
1-1647: Missing.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_034384 | 1 – 1647 | Missing in isoform Subgenomic capsid protein. CuratedAdd BLAST | 1647 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X86560 Genomic RNA Translation: CAA60262.1 |
Keywords - Coding sequence diversityi
Alternative initiation, Alternative promoter usageSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X86560 Genomic RNA Translation: CAA60262.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2CKW | X-ray | 2.30 | A | 1135-1649 | [»] | |
2UUT | X-ray | 2.40 | A | 1135-1649 | [»] | |
2UUW | X-ray | 2.76 | A | 1135-1649 | [»] | |
2WK4 | X-ray | 2.98 | A/B | 1135-1649 | [»] | |
SMRi | Q69014 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein family/group databases
MEROPSi | C24.003 |
Proteomic databases
PRIDEi | Q69014 |
Miscellaneous databases
EvolutionaryTracei | Q69014 |
Family and domain databases
CDDi | cd00205, rhv_like, 1 hit |
Gene3Di | 2.60.120.20, 1 hit 3.30.70.270, 2 hits 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR004005, Calicivirus_coat IPR043502, DNA/RNA_pol_sf IPR004004, Helic/Pol/Pept_Calicivir-typ IPR000605, Helicase_SF3_ssDNA/RNA_vir IPR014759, Helicase_SF3_ssRNA_vir IPR001665, Norovirus_pept_C37 IPR027417, P-loop_NTPase IPR000317, Peptidase_C24 IPR009003, Peptidase_S1_PA IPR043128, Rev_trsase/Diguanyl_cyclase IPR033703, Rhv-like IPR001205, RNA-dir_pol_C IPR007094, RNA-dir_pol_PSvirus IPR029053, Viral_coat |
Pfami | View protein in Pfam PF00915, Calici_coat, 1 hit PF03510, Peptidase_C24, 1 hit PF05416, Peptidase_C37, 1 hit PF00680, RdRP_1, 1 hit PF00910, RNA_helicase, 1 hit |
PRINTSi | PR00916, 2CENDOPTASE PR00918, CALICVIRUSNS |
SUPFAMi | SSF50494, SSF50494, 1 hit SSF52540, SSF52540, 1 hit SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS51894, CV_3CL_PRO, 1 hit PS50507, RDRP_SSRNA_POS, 1 hit PS51218, SF3_HELICASE_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | POLG_SVM93 | |
Accessioni | Q69014Primary (citable) accession number: Q69014 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | September 29, 2021 | |
This is version 133 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structureDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references