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Protein

Fc receptor-like protein 5

Gene

Fcrl5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

It is uncertain whether Met-1 or Met-14 is the initiator.Curated

GO - Biological processi

Keywordsi

Molecular functionReceptor

Names & Taxonomyi

Protein namesi
Recommended name:
Fc receptor-like protein 5
Short name:
FcR-like protein 5
Short name:
FcRL5
Alternative name(s):
BXMAS1-like protein 2
Short name:
mBXMH2
Fc receptor homolog 3
Short name:
FcRH3
Short name:
moFcRH3
CD_antigen: CD307e
Gene namesi
Name:Fcrl5
Synonyms:Fcrh3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:3053558 Fcrl5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 496ExtracellularSequence analysisAdd BLAST470
Transmembranei497 – 517HelicalSequence analysisAdd BLAST21
Topological domaini518 – 596CytoplasmicSequence analysisAdd BLAST79

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000033164127 – 596Fc receptor-like protein 5Add BLAST570

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi55 ↔ 99PROSITE-ProRule annotation
Disulfide bondi137 ↔ 181PROSITE-ProRule annotation
Disulfide bondi228 ↔ 277PROSITE-ProRule annotation
Glycosylationi324N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi325 ↔ 373PROSITE-ProRule annotation
Disulfide bondi419 ↔ 466PROSITE-ProRule annotation
Glycosylationi436N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Phosphorylated on cytoplasmic tyrosines; required for interaction with protein tyrosine phosphatases and protein tyrosine kinases.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ68SN8
PRIDEiQ68SN8

PTM databases

PhosphoSitePlusiQ68SN8

Expressioni

Tissue specificityi

Preferentially expressed in marginal zone B cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000048031 Expressed in 17 organ(s), highest expression level in spleen
ExpressionAtlasiQ68SN8 baseline and differential

Interactioni

Subunit structurei

Interacts with PTPN6, PTPN11, SYK and ZAP70.By similarity

Protein-protein interaction databases

DIPiDIP-60955N
IntActiQ68SN8, 1 interactor
STRINGi10090.ENSMUSP00000050151

Structurei

3D structure databases

ProteinModelPortaliQ68SN8
SMRiQ68SN8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 115Ig-like C2-type 1Add BLAST82
Domaini106 – 199Ig-like C2-type 2Add BLAST94
Domaini207 – 294Ig-like C2-type 3Add BLAST88
Domaini296 – 384Ig-like C2-type 4Add BLAST89
Domaini398 – 483Ig-like C2-type 5Add BLAST86

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH5T Eukaryota
ENOG410YF57 LUCA
GeneTreeiENSGT00760000119130
HOGENOMiHOG000036945
HOVERGENiHBG074073
InParanoidiQ68SN8
KOiK06727
OMAiTVFQGER

Family and domain databases

Gene3Di2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF13895 Ig_2, 3 hits
SMARTiView protein in SMART
SM00409 IG, 5 hits
SM00408 IGc2, 4 hits
SUPFAMiSSF48726 SSF48726, 5 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 5 hits

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q68SN8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGSFSPCVV FTQMWLTLLV VTPVNGQHEA AQQSVVSLQP PWTTFFRGEV
60 70 80 90 100
VTLTCYRFGF SVPQKTKWYQ KRKTVKQTPG ALVIKAHTLK VHESGEYWCQ
110 120 130 140 150
ADSLLPSMHV NVEFSEDFLV LQAPPAVFEG DSVVLRCYAK KGIEAETLTF
160 170 180 190 200
YKDGKALTLH PQSSEFYIHR ANLKDNGQYK CTSKKKWSFG SLYTSNTVVV
210 220 230 240 250
QVQELFPRPV LRARPSHPID GSPVTLTCQT QLSAQKSDAR LQFCFFRNLQ
260 270 280 290 300
LLGSGCSRSS EFHIPAIWTE ESKRYQCKAE TVNSQVSKQS TAFIIPVQRA
310 320 330 340 350
SARFQTHIIP ASKLVFEGQL LLLNCSVKGV PGPLKFSWYK KDMLNKETKI
360 370 380 390 400
LKSSNAEFKI SQVNISDAGE YYCEANNSRR SFVSRAFPIT IKVPVSQPVL
410 420 430 440 450
TLSTGKTQAL EGDLMTLHCQ SQRGSPCILY EFFYENVSLG NSSILSGGGA
460 470 480 490 500
YFNFSMSTER SGNYYCTADN GLGAQCSEAI RISIFDMTKN RSVPMAAGIT
510 520 530 540 550
VGLLIMAVGV FLFYCWFSRK AGGKPTSDDS RNPSDSEPQE PTYYNVPACI
560 570 580 590
ELQPVYSNEP EENVIYTEVR RTQPRQKHAD QESESPRSRC QMAEKK
Length:596
Mass (Da):66,779
Last modified:July 27, 2011 - v3
Checksum:i3EF9C7E4728461B4
GO
Isoform 2 (identifier: Q68SN8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     29-116: Missing.

Note: No experimental confirmation available.
Show »
Length:508
Mass (Da):56,709
Checksum:i9E86672E7DDC03ED
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QJU0J3QJU0_MOUSE
Fc receptor-like protein 5
Fcrl5
596Annotation score:

Sequence cautioni

The sequence AAO20873 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti161 – 163PQS → HQ in AAS91578 (PubMed:15302849).Curated3
Sequence conflicti161 – 163PQS → HQ in AAO20873 (Ref. 2) Curated3
Sequence conflicti166F → L in BAC40954 (PubMed:16141072).Curated1
Sequence conflicti167Y → S in AAS91578 (PubMed:15302849).Curated1
Sequence conflicti167Y → S in AAO20873 (Ref. 2) Curated1
Sequence conflicti170R → H in BAC40954 (PubMed:16141072).Curated1
Sequence conflicti199V → R in AAS91578 (PubMed:15302849).Curated1
Sequence conflicti199V → R in AAO20873 (Ref. 2) Curated1
Sequence conflicti273K → R in AAS91578 (PubMed:15302849).Curated1
Sequence conflicti273K → R in AAO20873 (Ref. 2) Curated1
Sequence conflicti287S → R in AAS91578 (PubMed:15302849).Curated1
Sequence conflicti287S → R in AAO20873 (Ref. 2) Curated1
Sequence conflicti287S → R in BAC40954 (PubMed:16141072).Curated1
Sequence conflicti346K → E in AAS91578 (PubMed:15302849).Curated1
Sequence conflicti346K → E in AAO20873 (Ref. 2) Curated1
Sequence conflicti372Y → H in AAS91578 (PubMed:15302849).Curated1
Sequence conflicti372Y → H in AAO20873 (Ref. 2) Curated1
Sequence conflicti373C → R in BAC40954 (PubMed:16141072).Curated1
Sequence conflicti376N → T in AAS91578 (PubMed:15302849).Curated1
Sequence conflicti376N → T in AAO20873 (Ref. 2) Curated1
Sequence conflicti376N → T in BAC40954 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03330929 – 116Missing in isoform 2. 1 PublicationAdd BLAST88

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY506558 mRNA Translation: AAS91578.1
AY158090 mRNA Translation: AAO20873.1 Different initiation.
AK089756 mRNA Translation: BAC40954.1
AC163618 Genomic DNA No translation available.
CCDSiCCDS50943.1 [Q68SN8-1]
CCDS50944.1 [Q68SN8-2]
RefSeqiNP_001106709.1, NM_001113238.1 [Q68SN8-2]
NP_899045.3, NM_183222.3 [Q68SN8-1]
UniGeneiMm.331122

Genome annotation databases

EnsembliENSMUST00000049926; ENSMUSP00000050151; ENSMUSG00000048031 [Q68SN8-1]
ENSMUST00000166297; ENSMUSP00000131176; ENSMUSG00000048031 [Q68SN8-2]
ENSMUST00000193229; ENSMUSP00000141311; ENSMUSG00000048031 [Q68SN8-2]
ENSMUST00000194102; ENSMUSP00000142210; ENSMUSG00000048031 [Q68SN8-1]
GeneIDi329693
KEGGimmu:329693
UCSCiuc008psf.1 mouse [Q68SN8-2]
uc012crg.1 mouse [Q68SN8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY506558 mRNA Translation: AAS91578.1
AY158090 mRNA Translation: AAO20873.1 Different initiation.
AK089756 mRNA Translation: BAC40954.1
AC163618 Genomic DNA No translation available.
CCDSiCCDS50943.1 [Q68SN8-1]
CCDS50944.1 [Q68SN8-2]
RefSeqiNP_001106709.1, NM_001113238.1 [Q68SN8-2]
NP_899045.3, NM_183222.3 [Q68SN8-1]
UniGeneiMm.331122

3D structure databases

ProteinModelPortaliQ68SN8
SMRiQ68SN8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60955N
IntActiQ68SN8, 1 interactor
STRINGi10090.ENSMUSP00000050151

PTM databases

PhosphoSitePlusiQ68SN8

Proteomic databases

PaxDbiQ68SN8
PRIDEiQ68SN8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049926; ENSMUSP00000050151; ENSMUSG00000048031 [Q68SN8-1]
ENSMUST00000166297; ENSMUSP00000131176; ENSMUSG00000048031 [Q68SN8-2]
ENSMUST00000193229; ENSMUSP00000141311; ENSMUSG00000048031 [Q68SN8-2]
ENSMUST00000194102; ENSMUSP00000142210; ENSMUSG00000048031 [Q68SN8-1]
GeneIDi329693
KEGGimmu:329693
UCSCiuc008psf.1 mouse [Q68SN8-2]
uc012crg.1 mouse [Q68SN8-1]

Organism-specific databases

CTDi83416
MGIiMGI:3053558 Fcrl5

Phylogenomic databases

eggNOGiENOG410IH5T Eukaryota
ENOG410YF57 LUCA
GeneTreeiENSGT00760000119130
HOGENOMiHOG000036945
HOVERGENiHBG074073
InParanoidiQ68SN8
KOiK06727
OMAiTVFQGER

Miscellaneous databases

PROiPR:Q68SN8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000048031 Expressed in 17 organ(s), highest expression level in spleen
ExpressionAtlasiQ68SN8 baseline and differential

Family and domain databases

Gene3Di2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF13895 Ig_2, 3 hits
SMARTiView protein in SMART
SM00409 IG, 5 hits
SM00408 IGc2, 4 hits
SUPFAMiSSF48726 SSF48726, 5 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiFCRL5_MOUSE
AccessioniPrimary (citable) accession number: Q68SN8
Secondary accession number(s): E9QLI5, Q80WN2, Q8BJA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 106 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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