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Entry version 116 (08 May 2019)
Sequence version 3 (27 Jul 2011)
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Protein

A disintegrin and metalloproteinase with thrombospondin motifs 7

Gene

Adamts7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Metalloprotease that may play a role in the degradation of COMP.1 Publication

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi194Zinc; in inhibited formBy similarity1
Metal bindingi372Zinc; catalyticBy similarity1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei373PROSITE-ProRule annotation1
Metal bindingi376Zinc; catalyticBy similarity1
Metal bindingi382Zinc; catalyticBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-5173214 O-glycosylation of TSR domain-containing proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
A disintegrin and metalloproteinase with thrombospondin motifs 7 (EC:3.4.24.-)
Short name:
ADAM-TS 7
Short name:
ADAM-TS7
Short name:
ADAMTS-7
Alternative name(s):
COMPase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Adamts7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1347346 Adamts7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000034823421 – 2201 PublicationAdd BLAST200
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000348235221 – 1657A disintegrin and metalloproteinase with thrombospondin motifs 7Add BLAST1437

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi84N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi302 ↔ 356By similarity
Disulfide bondi331 ↔ 338By similarity
Disulfide bondi350 ↔ 432By similarity
Disulfide bondi389 ↔ 416By similarity
Disulfide bondi459 ↔ 482By similarity
Disulfide bondi470 ↔ 488By similarity
Disulfide bondi477 ↔ 507By similarity
Disulfide bondi501 ↔ 512By similarity
Disulfide bondi535 ↔ 572By similarity
Disulfide bondi539 ↔ 577By similarity
Disulfide bondi550 ↔ 562By similarity
Glycosylationi622N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

May be cleaved by a furin endopeptidase (By similarity). The precursor is sequentially processed.By similarity1 Publication
N-glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X2-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs. N- and C-glycosylations can also facilitate secretion (By similarity). O-glycosylated proteoglycan. Contains chondroitin sulfate.By similarity1 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Proteoglycan, Zymogen

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q68SA9

PRoteomics IDEntifications database

More...
PRIDEi
Q68SA9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q68SA9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q68SA9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000032363 Expressed in 117 organ(s), highest expression level in gonadal ridge

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q68SA9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q68SA9 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with COMP.By similarity

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q68SA9, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000108682

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q68SA9

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini226 – 437Peptidase M12BPROSITE-ProRule annotationAdd BLAST212
Domaini447 – 522DisintegrinAdd BLAST76
Domaini523 – 578TSP type-1 1PROSITE-ProRule annotationAdd BLAST56
Domaini804 – 863TSP type-1 2PROSITE-ProRule annotationAdd BLAST60
Domaini864 – 923TSP type-1 3PROSITE-ProRule annotationAdd BLAST60
Domaini925 – 978TSP type-1 4PROSITE-ProRule annotationAdd BLAST54
Domaini1366 – 1414TSP type-1 5PROSITE-ProRule annotationAdd BLAST49
Domaini1417 – 1477TSP type-1 6PROSITE-ProRule annotationAdd BLAST61
Domaini1479 – 1522TSP type-1 7PROSITE-ProRule annotationAdd BLAST44
Domaini1524 – 1584TSP type-1 8PROSITE-ProRule annotationAdd BLAST61
Domaini1587 – 1627PLACPROSITE-ProRule annotationAdd BLAST41

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni683 – 794SpacerAdd BLAST112

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi192 – 199Cysteine switchBy similarity8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi580 – 682Cys-richAdd BLAST103
Compositional biasi1078 – 1364Pro-richAdd BLAST287

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.By similarity
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme (By similarity).By similarity

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3538 Eukaryota
ENOG410XPKZ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159819

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000015092

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q68SA9

KEGG Orthology (KO)

More...
KOi
K08622

Database of Orthologous Groups

More...
OrthoDBi
125522at2759

TreeFam database of animal gene trees

More...
TreeFami
TF313537

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.100.10, 8 hits
3.40.390.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041645 ADAM_CR_2
IPR006586 ADAM_Cys-rich
IPR010294 ADAM_spacer1
IPR013273 ADAMTS/ADAMTS-like
IPR024079 MetalloPept_cat_dom_sf
IPR001590 Peptidase_M12B
IPR002870 Peptidase_M12B_N
IPR010909 PLAC
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17771 ADAM_CR_2, 1 hit
PF05986 ADAM_spacer1, 1 hit
PF01562 Pep_M12B_propep, 1 hit
PF01421 Reprolysin, 1 hit
PF00090 TSP_1, 8 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01857 ADAMTSFAMILY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00608 ACR, 1 hit
SM00209 TSP1, 8 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF82895 SSF82895, 8 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50215 ADAM_MEPRO, 1 hit
PS50900 PLAC, 1 hit
PS50092 TSP1, 6 hits
PS00142 ZINC_PROTEASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q68SA9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MHRGPSLLLI LCALASRVLG PASGLVTEGR AGLDIVHPVR VDAGGSFLSY
60 70 80 90 100
ELWPRVLRKR DVSTTQASSA FYQLQYQGRE LLFNLTTNPY LMAPGFVSEI
110 120 130 140 150
RRHSTLGHAH IQTSVPTCHL LGDVQDPELE GGFAAISACD GLRGVFQLSN
160 170 180 190 200
EDYFIEPLDG VSAQPGHAQP HVVYKHQGSR KQAQQGDSRP SGTCGMQVPP
210 220 230 240 250
DLEQQREHWE QQQQKRRQQR SVSKEKWVET LVVADSKMVE YHGQPQVESY
260 270 280 290 300
VLTIMNMVAG LFHDPSIGNP IHISIVRLII LEDEEKDLKI THHAEETLKN
310 320 330 340 350
FCRWQKNINI KGDDHPQHHD TAILLTRKDL CASMNQPCET LGLSHVSGLC
360 370 380 390 400
HPQLSCSVSE DTGMPLAFTV AHELGHSFGI QHDGTGNDCE SIGKRPFIMS
410 420 430 440 450
PQLLYDRGIP LTWSRCSREY ITRFLDRGWG LCLDDRPSKD VIALPSVLPG
460 470 480 490 500
VLYDVNHQCR LQYGSHSAYC EDMDDVCHTL WCSVGTTCHS KLDAAVDGTS
510 520 530 540 550
CGKNKWCLKG ECVPEGFQPE AVDGGWSGWS AWSDCSRSCG VGVRSSERQC
560 570 580 590 600
TQPVPKNRGK YCVGERKRSQ LCNLPACPPD RPSFRHTQCS QFDGMLYKGK
610 620 630 640 650
LHKWVPVPND DNPCELHCRP SNSSNTEKLR DAVVDGTPCY QSRISRDICL
660 670 680 690 700
NGICKNVGCD FVIDSGAEED RCGVCRGDGS TCQTVSRTFK ETEGQGYVDI
710 720 730 740 750
GLIPAGAREI LIEEVAEAAN FLALRSEDPD KYFLNGGWTI QWNGDYRVAG
760 770 780 790 800
TTFTYARKGN WENLTSPGPT SEPVWIQLLF QEKNPGVHYQ YTIQRDSHDQ
810 820 830 840 850
VRPPEFSWHY GPWSKCTVTC GTGVQRQSLY CMERQAGVVA EEYCNTLNRP
860 870 880 890 900
DERQRKCSEE PCPPRWWAGE WQPCSRSCGP EGLSRRAVFC IRSMGLDEQR
910 920 930 940 950
ALELSACEHL PRPLAETPCN RHVICPSTWG VGNWSQCSVT CGAGIRQRSV
960 970 980 990 1000
LCINNTDVPC DEAERPITET FCFLQPCQYP MYIVDTGASG SGSSSPELFN
1010 1020 1030 1040 1050
EVDFIPNQLA PRPSPASSPK PVSISNAIDE EELDPPGPVF VDDFYYDYNF
1060 1070 1080 1090 1100
INFHEDLSYG SFEEPHPDLV DNGGWTAPPH IRPTESPSDT PVPTAGALGA
1110 1120 1130 1140 1150
EAEDIQGSWS PSPLLSEASY SPPGLEQTSI NPLANFLTEE DTPMGAPELG
1160 1170 1180 1190 1200
FPSLPWPPAS VDDMMTPVGP GNPDELLVKE DEQSPPSTPW SDRNKLSTDG
1210 1220 1230 1240 1250
NPLGHTSPAL PQSPIPTQPS PPSISPTQAS PSPDVVEVST GWNAAWDPVL
1260 1270 1280 1290 1300
EADLKPGHGE LPSTVEVASP PLLPMATVPG IWGRDSPLEP GTPTFSSPEL
1310 1320 1330 1340 1350
SSQHLKTLTM PGTLLLTVPT DLRSPGPSGQ PQTPNLEGTQ SPGLLPTPAR
1360 1370 1380 1390 1400
ETQTNSSKDP EVQPLQPSLE EDGDPADPLP ARNASWQVGN WSQCSTTCGL
1410 1420 1430 1440 1450
GAIWRLVSCS SGNDEDCTLA SRPQPARHCH LRPCAAWRTG NWSKCSRNCG
1460 1470 1480 1490 1500
GGSSTRDVQC VDTRDLRPLR PFHCQPGPTK PPNRQLCGTQ PCLPWYTSSW
1510 1520 1530 1540 1550
RECSEACGGG EQQRLVTCPE PGLCEESLRP NNSRPCNTHP CTQWVVGPWG
1560 1570 1580 1590 1600
QCSAPCGGGV QRRLVRCVNT QTGLAEEDSD LCSHEAWPES SRPCATEDCE
1610 1620 1630 1640 1650
LVEPPRCERD RLSFNFCETL RLLGRCQLPT IRAQCCRSCP PLSRGVPSRG

HQRVARR
Length:1,657
Mass (Da):182,313
Last modified:July 27, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2B05A3B6567617FD
GO
Isoform 2 (identifier: Q68SA9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     936-977: Missing.

Show »
Length:1,615
Mass (Da):177,712
Checksum:i0F7E9D2D303C12E2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6UD05F6UD05_MOUSE
A disintegrin and metalloproteinase...
Adamts7
1,556Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PX36E9PX36_MOUSE
A disintegrin and metalloproteinase...
Adamts7
1,633Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RI90D6RI90_MOUSE
A disintegrin and metalloproteinase...
Adamts7
506Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti600K → N in AAT36307 (PubMed:15192113).Curated1
Sequence conflicti1124G → V in AAT36307 (PubMed:15192113).Curated1
Sequence conflicti1124G → V in AAI41174 (PubMed:15489334).Curated1
Sequence conflicti1244A → V in AAT36307 (PubMed:15192113).Curated1
Sequence conflicti1244A → V in AAI41174 (PubMed:15489334).Curated1
Sequence conflicti1312 – 1333GTLLL…GQPQT → VAGPMV in AAT36307 (PubMed:15192113).CuratedAdd BLAST22

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_035113936 – 977Missing in isoform 2. 1 PublicationAdd BLAST42

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY551090 mRNA Translation: AAT36307.1
AC140392 Genomic DNA No translation available.
AC151735 Genomic DNA No translation available.
BC141173 mRNA Translation: AAI41174.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS40724.1 [Q68SA9-2]
CCDS85708.1 [Q68SA9-1]

NCBI Reference Sequences

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RefSeqi
NP_001313280.1, NM_001326351.1 [Q68SA9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000113059; ENSMUSP00000108682; ENSMUSG00000032363 [Q68SA9-1]
ENSMUST00000113060; ENSMUSP00000108683; ENSMUSG00000032363 [Q68SA9-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
108153

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:108153

UCSC genome browser

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UCSCi
uc009raa.1 mouse [Q68SA9-1]
uc009rab.1 mouse [Q68SA9-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY551090 mRNA Translation: AAT36307.1
AC140392 Genomic DNA No translation available.
AC151735 Genomic DNA No translation available.
BC141173 mRNA Translation: AAI41174.1
CCDSiCCDS40724.1 [Q68SA9-2]
CCDS85708.1 [Q68SA9-1]
RefSeqiNP_001313280.1, NM_001326351.1 [Q68SA9-1]

3D structure databases

SMRiQ68SA9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ68SA9, 1 interactor
STRINGi10090.ENSMUSP00000108682

PTM databases

iPTMnetiQ68SA9
PhosphoSitePlusiQ68SA9

Proteomic databases

PaxDbiQ68SA9
PRIDEiQ68SA9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000113059; ENSMUSP00000108682; ENSMUSG00000032363 [Q68SA9-1]
ENSMUST00000113060; ENSMUSP00000108683; ENSMUSG00000032363 [Q68SA9-2]
GeneIDi108153
KEGGimmu:108153
UCSCiuc009raa.1 mouse [Q68SA9-1]
uc009rab.1 mouse [Q68SA9-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
11173
MGIiMGI:1347346 Adamts7

Phylogenomic databases

eggNOGiKOG3538 Eukaryota
ENOG410XPKZ LUCA
GeneTreeiENSGT00940000159819
HOGENOMiHOG000015092
InParanoidiQ68SA9
KOiK08622
OrthoDBi125522at2759
TreeFamiTF313537

Enzyme and pathway databases

ReactomeiR-MMU-5173214 O-glycosylation of TSR domain-containing proteins

Miscellaneous databases

Protein Ontology

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PROi
PR:Q68SA9

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000032363 Expressed in 117 organ(s), highest expression level in gonadal ridge
ExpressionAtlasiQ68SA9 baseline and differential
GenevisibleiQ68SA9 MM

Family and domain databases

Gene3Di2.20.100.10, 8 hits
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR041645 ADAM_CR_2
IPR006586 ADAM_Cys-rich
IPR010294 ADAM_spacer1
IPR013273 ADAMTS/ADAMTS-like
IPR024079 MetalloPept_cat_dom_sf
IPR001590 Peptidase_M12B
IPR002870 Peptidase_M12B_N
IPR010909 PLAC
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PfamiView protein in Pfam
PF17771 ADAM_CR_2, 1 hit
PF05986 ADAM_spacer1, 1 hit
PF01562 Pep_M12B_propep, 1 hit
PF01421 Reprolysin, 1 hit
PF00090 TSP_1, 8 hits
PRINTSiPR01857 ADAMTSFAMILY
SMARTiView protein in SMART
SM00608 ACR, 1 hit
SM00209 TSP1, 8 hits
SUPFAMiSSF82895 SSF82895, 8 hits
PROSITEiView protein in PROSITE
PS50215 ADAM_MEPRO, 1 hit
PS50900 PLAC, 1 hit
PS50092 TSP1, 6 hits
PS00142 ZINC_PROTEASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATS7_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q68SA9
Secondary accession number(s): B2RUI8, E9QMY0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: July 27, 2011
Last modified: May 8, 2019
This is version 116 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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