UniProtKB - Q68G74 (LHX8_HUMAN)
Protein
LIM/homeobox protein Lhx8
Gene
LHX8
Organism
Homo sapiens (Human)
Status
Functioni
Transcription factor involved in differentiation of certain neurons and mesenchymal cells.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 225 – 284 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- female gonad development Source: Ensembl
- forebrain neuron development Source: GO_Central
- learning or memory Source: Ensembl
- neuron differentiation Source: GO_Central
- odontogenesis of dentin-containing tooth Source: Ensembl
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q68G74 |
Names & Taxonomyi
Protein namesi | Recommended name: LIM/homeobox protein Lhx8Short name: LIM homeobox protein 8 |
Gene namesi | Name:LHX8 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28838, LHX8 |
MIMi | 604425, gene |
neXtProti | NX_Q68G74 |
VEuPathDBi | HostDB:ENSG00000162624.14 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- female germ cell nucleus Source: Ensembl
- nuclear chromatin Source: NTNU_SB
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 431707 |
OpenTargetsi | ENSG00000162624 |
PharmGKBi | PA142671553 |
Miscellaneous databases
Pharosi | Q68G74, Tbio |
Genetic variation databases
BioMutai | LHX8 |
DMDMi | 296434566 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000295810 | 1 – 356 | LIM/homeobox protein Lhx8Add BLAST | 356 |
Proteomic databases
MassIVEi | Q68G74 |
PaxDbi | Q68G74 |
PeptideAtlasi | Q68G74 |
PRIDEi | Q68G74 |
ProteomicsDBi | 20303 66139 [Q68G74-1] |
PTM databases
iPTMneti | Q68G74 |
PhosphoSitePlusi | Q68G74 |
Expressioni
Gene expression databases
Bgeei | ENSG00000162624, Expressed in secondary oocyte and 62 other tissues |
Genevisiblei | Q68G74, HS |
Organism-specific databases
HPAi | ENSG00000162624, Tissue enhanced (brain, lymphoid tissue, salivary gland, tongue) |
Interactioni
Binary interactionsi
Hide detailsQ68G74
Protein-protein interaction databases
BioGRIDi | 136112, 28 interactors |
IntActi | Q68G74, 43 interactors |
MINTi | Q68G74 |
STRINGi | 9606.ENSP00000294638 |
Miscellaneous databases
RNActi | Q68G74, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 73 – 133 | LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST | 61 | |
Domaini | 134 – 196 | LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST | 63 |
Keywords - Domaini
Homeobox, LIM domain, RepeatPhylogenomic databases
eggNOGi | KOG0490, Eukaryota |
GeneTreei | ENSGT00940000156200 |
HOGENOMi | CLU_027802_1_0_1 |
InParanoidi | Q68G74 |
OMAi | LLVMCED |
OrthoDBi | 1161127at2759 |
PhylomeDBi | Q68G74 |
TreeFami | TF315442 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR001781, Znf_LIM |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit PF00412, LIM, 2 hits |
SMARTi | View protein in SMART SM00389, HOX, 1 hit SM00132, LIM, 2 hits |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit PS00478, LIM_DOMAIN_1, 2 hits PS50023, LIM_DOMAIN_2, 2 hits |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q68G74-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MQILSRCQGL MSEECGRTTA LAAGRTRKGA GEEGLVSPEG AGDEDSCSSS
60 70 80 90 100
APLSPSSSPR SMASGSGCPP GKCVCNSCGL EIVDKYLLKV NDLCWHVRCL
110 120 130 140 150
SCSVCRTSLG RHTSCYIKDK DIFCKLDYFR RYGTRCSRCG RHIHSTDWVR
160 170 180 190 200
RAKGNVYHLA CFACFSCKRQ LSTGEEFALV EEKVLCRVHY DCMLDNLKRE
210 220 230 240 250
VENGNGISVE GALLTEQDVN HPKPAKRART SFTADQLQVM QAQFAQDNNP
260 270 280 290 300
DAQTLQKLAE RTGLSRRVIQ VWFQNCRARH KKHVSPNHSS STPVTAVPPS
310 320 330 340 350
RLSPPMLEEM AYSAYVPQDG TMLTALHSYM DAHSPTTLGL QPLLPHSMTQ
LPISHT
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 297 | V → A in AAH40321 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_047378 | 1 – 10 | Missing in isoform 2. Curated | 10 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC099786 Genomic DNA No translation available. BC040321 mRNA Translation: AAH40321.1 |
CCDSi | CCDS30756.1 [Q68G74-1] CCDS58008.1 [Q68G74-2] |
RefSeqi | NP_001001933.1, NM_001001933.1 [Q68G74-1] NP_001243043.1, NM_001256114.1 [Q68G74-2] |
Genome annotation databases
Ensembli | ENST00000294638; ENSP00000294638; ENSG00000162624 [Q68G74-1] ENST00000356261; ENSP00000348597; ENSG00000162624 [Q68G74-2] |
GeneIDi | 431707 |
KEGGi | hsa:431707 |
UCSCi | uc001dgo.3, human [Q68G74-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC099786 Genomic DNA No translation available. BC040321 mRNA Translation: AAH40321.1 |
CCDSi | CCDS30756.1 [Q68G74-1] CCDS58008.1 [Q68G74-2] |
RefSeqi | NP_001001933.1, NM_001001933.1 [Q68G74-1] NP_001243043.1, NM_001256114.1 [Q68G74-2] |
3D structure databases
SMRi | Q68G74 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 136112, 28 interactors |
IntActi | Q68G74, 43 interactors |
MINTi | Q68G74 |
STRINGi | 9606.ENSP00000294638 |
PTM databases
iPTMneti | Q68G74 |
PhosphoSitePlusi | Q68G74 |
Genetic variation databases
BioMutai | LHX8 |
DMDMi | 296434566 |
Proteomic databases
MassIVEi | Q68G74 |
PaxDbi | Q68G74 |
PeptideAtlasi | Q68G74 |
PRIDEi | Q68G74 |
ProteomicsDBi | 20303 66139 [Q68G74-1] |
Protocols and materials databases
Antibodypediai | 33466, 206 antibodies |
DNASUi | 431707 |
Genome annotation databases
Ensembli | ENST00000294638; ENSP00000294638; ENSG00000162624 [Q68G74-1] ENST00000356261; ENSP00000348597; ENSG00000162624 [Q68G74-2] |
GeneIDi | 431707 |
KEGGi | hsa:431707 |
UCSCi | uc001dgo.3, human [Q68G74-1] |
Organism-specific databases
CTDi | 431707 |
DisGeNETi | 431707 |
GeneCardsi | LHX8 |
HGNCi | HGNC:28838, LHX8 |
HPAi | ENSG00000162624, Tissue enhanced (brain, lymphoid tissue, salivary gland, tongue) |
MIMi | 604425, gene |
neXtProti | NX_Q68G74 |
OpenTargetsi | ENSG00000162624 |
PharmGKBi | PA142671553 |
VEuPathDBi | HostDB:ENSG00000162624.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0490, Eukaryota |
GeneTreei | ENSGT00940000156200 |
HOGENOMi | CLU_027802_1_0_1 |
InParanoidi | Q68G74 |
OMAi | LLVMCED |
OrthoDBi | 1161127at2759 |
PhylomeDBi | Q68G74 |
TreeFami | TF315442 |
Enzyme and pathway databases
PathwayCommonsi | Q68G74 |
Miscellaneous databases
BioGRID-ORCSi | 431707, 3 hits in 896 CRISPR screens |
ChiTaRSi | LHX8, human |
GenomeRNAii | 431707 |
Pharosi | Q68G74, Tbio |
PROi | PR:Q68G74 |
RNActi | Q68G74, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000162624, Expressed in secondary oocyte and 62 other tissues |
Genevisiblei | Q68G74, HS |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR001781, Znf_LIM |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit PF00412, LIM, 2 hits |
SMARTi | View protein in SMART SM00389, HOX, 1 hit SM00132, LIM, 2 hits |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit PS00478, LIM_DOMAIN_1, 2 hits PS50023, LIM_DOMAIN_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LHX8_HUMAN | |
Accessioni | Q68G74Primary (citable) accession number: Q68G74 Secondary accession number(s): E9PGE3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 24, 2007 |
Last sequence update: | May 18, 2010 | |
Last modified: | February 10, 2021 | |
This is version 148 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot