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UniProtKB - Q68G74 (LHX8_HUMAN)

Entry version 150 (02 Jun 2021)
Sequence version 2 (18 May 2010)
Previous versions | rss
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Protein

LIM/homeobox protein Lhx8

Gene

LHX8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor involved in differentiation of certain neurons and mesenchymal cells.

By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi225 – 284HomeoboxPROSITE-ProRule annotationAdd BLAST60

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q68G74

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
LIM/homeobox protein Lhx8
Short name:
LIM homeobox protein 8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LHX8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:28838, LHX8

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604425, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q68G74

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000162624.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		431707

Open Targets

More...OpenTargetsi		ENSG00000162624

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142671553

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q68G74, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		LHX8

Domain mapping of disease mutations (DMDM)

More...DMDMi		296434566

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002958101 – 356LIM/homeobox protein Lhx8Add BLAST356

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q68G74

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q68G74

PRoteomics IDEntifications database

More...PRIDEi		Q68G74

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		20303
66139 [Q68G74-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q68G74

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q68G74

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000162624, Expressed in secondary oocyte and 62 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q68G74, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000162624, Tissue enhanced (brain, lymphoid tissue, salivary gland, tongue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q68G74
With#Exp.IntAct
ABI2 - isoform 2 [Q9NYB9-2]3EBI-8474075,EBI-11096309
ATF2 [P15336]3EBI-8474075,EBI-1170906
ATF6B [Q96QL7]3EBI-8474075,EBI-12015400
AXIN1 [A0A0S2Z4M1]3EBI-8474075,EBI-16429430
BANP - isoform 2 [Q8N9N5-2]3EBI-8474075,EBI-11524452
CCHCR1 - isoform 3 [Q8TD31-3]3EBI-8474075,EBI-10175300
CCT5 [P48643]3EBI-8474075,EBI-355710
CSNK2A1 [P68400]3EBI-8474075,EBI-347804
DMWD [G5E9A7]3EBI-8474075,EBI-10976677
EFS - isoform Efs2 [O43281-2]3EBI-8474075,EBI-11525448
FGFR3 [P22607]3EBI-8474075,EBI-348399
FIGLA [Q6QHK4]8EBI-8474075,EBI-11976617
FOSL2 [P15408]3EBI-8474075,EBI-3893419
FOXN1 [O15353]3EBI-8474075,EBI-11319000
GINS4 [Q9BRT9]3EBI-8474075,EBI-747500
GLE1 [Q53GS7]3EBI-8474075,EBI-1955541
GRIN2C [Q14957]3EBI-8474075,EBI-8285963
GRN [P28799]3EBI-8474075,EBI-747754
HTT [P42858]12EBI-8474075,EBI-466029
KIF1B - isoform 2 [O60333-2]3EBI-8474075,EBI-10975473
KLF3 [P57682]3EBI-8474075,EBI-8472267
KRT85 [P78386]3EBI-8474075,EBI-1049371
LDB1 [Q86U70]3EBI-8474075,EBI-677177
LDB1 - isoform 3 [Q86U70-2]6EBI-8474075,EBI-11979761
LDB2 [O43679]5EBI-8474075,EBI-2865580
NEDD9 - isoform 2 [Q14511-2]3EBI-8474075,EBI-11746523
NUTM1 [Q86Y26]3EBI-8474075,EBI-10178410
PEX1 [O43933]3EBI-8474075,EBI-988601
PRPF31 [Q8WWY3]3EBI-8474075,EBI-1567797
RNF11 [Q9Y3C5]3EBI-8474075,EBI-396669
SCYL3 [Q8IZE3]3EBI-8474075,EBI-1380680
SIK1B [A0A0B4J2F2]3EBI-8474075,EBI-22345187
SPRED1 [Q7Z699]3EBI-8474075,EBI-5235340
TBC1D1 [Q86TI0]3EBI-8474075,EBI-1644036
TBC1D22B [Q9NU19]3EBI-8474075,EBI-8787464
TSC1 [Q86WV8]3EBI-8474075,EBI-12806590
UBQLN1 [Q9UMX0]3EBI-8474075,EBI-741480
WFS1 [O76024]3EBI-8474075,EBI-720609
ZBTB24 [O43167]3EBI-8474075,EBI-744471

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		136112, 28 interactors

Protein interaction database and analysis system

More...IntActi		Q68G74, 43 interactors

Molecular INTeraction database

More...MINTi		Q68G74

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000294638

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q68G74, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q68G74

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini73 – 133LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST61
Domaini134 – 196LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST63

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni23 – 63DisorderedSequence analysisAdd BLAST41

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi43 – 63Polar residuesSequence analysisAdd BLAST21

Keywords - Domaini

Homeobox, LIM domain, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0490, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156200

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_027802_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q68G74

Identification of Orthologs from Complete Genome Data

More...OMAi		LLVMCED

Database of Orthologous Groups

More...OrthoDBi		1161127at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q68G74

TreeFam database of animal gene trees

More...TreeFami		TF315442

Family and domain databases

Conserved Domains Database

More...CDDi		cd00086, homeodomain, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR009057, Homeobox-like_sf
IPR017970, Homeobox_CS
IPR001356, Homeobox_dom
IPR001781, Znf_LIM

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00046, Homeodomain, 1 hit
PF00412, LIM, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00389, HOX, 1 hit
SM00132, LIM, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46689, SSF46689, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00027, HOMEOBOX_1, 1 hit
PS50071, HOMEOBOX_2, 1 hit
PS00478, LIM_DOMAIN_1, 2 hits
PS50023, LIM_DOMAIN_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q68G74-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQILSRCQGL MSEECGRTTA LAAGRTRKGA GEEGLVSPEG AGDEDSCSSS 
        60         70         80         90        100
APLSPSSSPR SMASGSGCPP GKCVCNSCGL EIVDKYLLKV NDLCWHVRCL 
       110        120        130        140        150
SCSVCRTSLG RHTSCYIKDK DIFCKLDYFR RYGTRCSRCG RHIHSTDWVR 
       160        170        180        190        200
RAKGNVYHLA CFACFSCKRQ LSTGEEFALV EEKVLCRVHY DCMLDNLKRE 
       210        220        230        240        250
VENGNGISVE GALLTEQDVN HPKPAKRART SFTADQLQVM QAQFAQDNNP 
       260        270        280        290        300
DAQTLQKLAE RTGLSRRVIQ VWFQNCRARH KKHVSPNHSS STPVTAVPPS 
       310        320        330        340        350
RLSPPMLEEM AYSAYVPQDG TMLTALHSYM DAHSPTTLGL QPLLPHSMTQ 

LPISHT
Length:356
Mass (Da):39,301
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9BA025D3ECADCD56
GO
Isoform 2 (identifier: Q68G74-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: Missing.

Show »
Length:346
Mass (Da):38,170
Checksum:i989F0E991481A24F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti297V → A in AAH40321 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0473781 – 10Missing in isoform 2. Curated10

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC099786 Genomic DNA No translation available.
BC040321 mRNA Translation: AAH40321.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS30756.1 [Q68G74-1]
CCDS58008.1 [Q68G74-2]

NCBI Reference Sequences

More...RefSeqi		NP_001001933.1, NM_001001933.1 [Q68G74-1]
NP_001243043.1, NM_001256114.1 [Q68G74-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000294638; ENSP00000294638; ENSG00000162624 [Q68G74-1]
ENST00000356261; ENSP00000348597; ENSG00000162624 [Q68G74-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		431707

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:431707

UCSC genome browser

More...UCSCi		uc001dgo.3, human [Q68G74-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC099786 Genomic DNA No translation available.
BC040321 mRNA Translation: AAH40321.1
CCDSiCCDS30756.1 [Q68G74-1]
CCDS58008.1 [Q68G74-2]
RefSeqiNP_001001933.1, NM_001001933.1 [Q68G74-1]
NP_001243043.1, NM_001256114.1 [Q68G74-2]

3D structure databases

SMRiQ68G74
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi136112, 28 interactors
IntActiQ68G74, 43 interactors
MINTiQ68G74
STRINGi9606.ENSP00000294638

PTM databases

iPTMnetiQ68G74
PhosphoSitePlusiQ68G74

Genetic variation databases

BioMutaiLHX8
DMDMi296434566

Proteomic databases

MassIVEiQ68G74
PaxDbiQ68G74
PRIDEiQ68G74
ProteomicsDBi20303
66139 [Q68G74-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		33466, 209 antibodies

The DNASU plasmid repository

More...DNASUi		431707

Genome annotation databases

EnsembliENST00000294638; ENSP00000294638; ENSG00000162624 [Q68G74-1]
ENST00000356261; ENSP00000348597; ENSG00000162624 [Q68G74-2]
GeneIDi431707
KEGGihsa:431707
UCSCiuc001dgo.3, human [Q68G74-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		431707
DisGeNETi431707

GeneCards: human genes, protein and diseases

More...GeneCardsi		LHX8
HGNCiHGNC:28838, LHX8
HPAiENSG00000162624, Tissue enhanced (brain, lymphoid tissue, salivary gland, tongue)
MIMi604425, gene
neXtProtiNX_Q68G74
OpenTargetsiENSG00000162624
PharmGKBiPA142671553
VEuPathDBiHostDB:ENSG00000162624.14

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0490, Eukaryota
GeneTreeiENSGT00940000156200
HOGENOMiCLU_027802_1_0_1
InParanoidiQ68G74
OMAiLLVMCED
OrthoDBi1161127at2759
PhylomeDBiQ68G74
TreeFamiTF315442

Enzyme and pathway databases

PathwayCommonsiQ68G74

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		431707, 4 hits in 1007 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		LHX8, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		431707
PharosiQ68G74, Tbio

Protein Ontology

More...PROi		PR:Q68G74
RNActiQ68G74, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000162624, Expressed in secondary oocyte and 62 other tissues
GenevisibleiQ68G74, HS

Family and domain databases

CDDicd00086, homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057, Homeobox-like_sf
IPR017970, Homeobox_CS
IPR001356, Homeobox_dom
IPR001781, Znf_LIM
PfamiView protein in Pfam
PF00046, Homeodomain, 1 hit
PF00412, LIM, 2 hits
SMARTiView protein in SMART
SM00389, HOX, 1 hit
SM00132, LIM, 2 hits
SUPFAMiSSF46689, SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027, HOMEOBOX_1, 1 hit
PS50071, HOMEOBOX_2, 1 hit
PS00478, LIM_DOMAIN_1, 2 hits
PS50023, LIM_DOMAIN_2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLHX8_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q68G74
Secondary accession number(s): E9PGE3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: May 18, 2010
Last modified: June 2, 2021
This is version 150 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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