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Protein
Submitted name:

Inward rectifier potassium channel 16

Gene

Kcnj16

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei161Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Voltage-gated channelUniRule annotationSAAS annotation
Biological processIon transport, Potassium transportUniRule annotationSAAS annotation, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-RNO-1296041 Activation of G protein gated Potassium channels
R-RNO-1296067 Potassium transport channels
R-RNO-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Names & Taxonomyi

Protein namesi
Submitted name:
Inward rectifier potassium channel 16Imported
Submitted name:
Potassium inwardly-rectifying channel, subfamily J, member 16Imported
Submitted name:
RCG34188, isoform CRA_aImported
Gene namesi
Name:Kcnj16Imported
ORF Names:rCG_34188Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi61824 Kcnj16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei74 – 96HelicalSequence analysisAdd BLAST23
Transmembranei145 – 170HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiQ68G21

Expressioni

Gene expression databases

BgeeiENSRNOG00000004713 Expressed in 7 organ(s), highest expression level in adult mammalian kidney

Family & Domainsi

Sequence similaritiesi

Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3827 Eukaryota
ENOG410XQ62 LUCA
GeneTreeiENSGT00920000149056
HOVERGENiHBG006178
KOiK05009
OMAiSIFWLIA
OrthoDBiEOG091G08HC
TreeFamiTF313676

Family and domain databases

Gene3Di2.60.40.1400, 2 hits
InterProiView protein in InterPro
IPR014756 Ig_E-set
IPR016449 K_chnl_inward-rec_Kir
IPR008061 K_chnl_inward-rec_Kir5
IPR013518 K_chnl_inward-rec_Kir_cyto
PANTHERiPTHR11767 PTHR11767, 1 hit
PTHR11767:SF24 PTHR11767:SF24, 1 hit
PfamiView protein in Pfam
PF01007 IRK, 1 hit
PIRSFiPIRSF005465 GIRK_kir, 1 hit
PRINTSiPR01678 KIR5CHANNEL
PR01320 KIRCHANNEL
SUPFAMiSSF81296 SSF81296, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q68G21-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSYYGSSYRI VNVDSKYPGY PPEHAIAEKR RARRRLLHKD GSCNVYFKHI
60 70 80 90 100
FGEWGSYMVD IFTTLVDTKW RHMFVIFSLS YILSWLIFGS IFWLIALHHG
110 120 130 140 150
DLLSDPDITP CVDNVHSFTA AFLFSLETQT TIGYGYRCVT EECSVAVLTV
160 170 180 190 200
ILQSILSCII NTFIIGAALA KMATARKRAQ TIRFSYFALI GMRDGKLCLM
210 220 230 240 250
WRIGDFRPNH VVEGTVRAQL LRYSEDSEGR MTMAFKDLKL VNDQIILVTP
260 270 280 290 300
VTIVHEIDHE SPLYALDRKA VAKDNFEILV TFIYTGDSTG TSHQSRSSYV
310 320 330 340 350
PREILWGHRF HDVLEVKRKY YKVNCLQFEG SVEVYAPFCS AKQLDWKDQQ
360 370 380 390 400
LNNLEKTSPA RGSCTSDTNT RRRSFSAVAM VSSCENPEET SLSPQDECKE
410
VPYQKALLTL NRISMESQM
Length:419
Mass (Da):47,950
Last modified:October 11, 2004 - v1
Checksum:iCBEB903205527BCD
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P52191KCJ16_RAT
Inward rectifier potassium channel ...
Kcnj16
419Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07030684 Genomic DNA No translation available.
BC078776 mRNA Translation: AAH78776.1
CH473948 Genomic DNA Translation: EDM06495.1
CH473948 Genomic DNA Translation: EDM06496.1
CH473948 Genomic DNA Translation: EDM06497.1
CH473948 Genomic DNA Translation: EDM06498.1
RefSeqiNP_445766.2, NM_053314.2
XP_006247630.1, XM_006247568.2
XP_006247631.1, XM_006247569.2
XP_006247632.1, XM_006247570.2
UniGeneiRn.1989

Genome annotation databases

EnsembliENSRNOT00000006238; ENSRNOP00000006238; ENSRNOG00000004713
GeneIDi29719
KEGGirno:29719

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07030684 Genomic DNA No translation available.
BC078776 mRNA Translation: AAH78776.1
CH473948 Genomic DNA Translation: EDM06495.1
CH473948 Genomic DNA Translation: EDM06496.1
CH473948 Genomic DNA Translation: EDM06497.1
CH473948 Genomic DNA Translation: EDM06498.1
RefSeqiNP_445766.2, NM_053314.2
XP_006247630.1, XM_006247568.2
XP_006247631.1, XM_006247569.2
XP_006247632.1, XM_006247570.2
UniGeneiRn.1989

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ68G21

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000006238; ENSRNOP00000006238; ENSRNOG00000004713
GeneIDi29719
KEGGirno:29719

Organism-specific databases

CTDi3773
RGDi61824 Kcnj16

Phylogenomic databases

eggNOGiKOG3827 Eukaryota
ENOG410XQ62 LUCA
GeneTreeiENSGT00920000149056
HOVERGENiHBG006178
KOiK05009
OMAiSIFWLIA
OrthoDBiEOG091G08HC
TreeFamiTF313676

Enzyme and pathway databases

ReactomeiR-RNO-1296041 Activation of G protein gated Potassium channels
R-RNO-1296067 Potassium transport channels
R-RNO-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Gene expression databases

BgeeiENSRNOG00000004713 Expressed in 7 organ(s), highest expression level in adult mammalian kidney

Family and domain databases

Gene3Di2.60.40.1400, 2 hits
InterProiView protein in InterPro
IPR014756 Ig_E-set
IPR016449 K_chnl_inward-rec_Kir
IPR008061 K_chnl_inward-rec_Kir5
IPR013518 K_chnl_inward-rec_Kir_cyto
PANTHERiPTHR11767 PTHR11767, 1 hit
PTHR11767:SF24 PTHR11767:SF24, 1 hit
PfamiView protein in Pfam
PF01007 IRK, 1 hit
PIRSFiPIRSF005465 GIRK_kir, 1 hit
PRINTSiPR01678 KIR5CHANNEL
PR01320 KIRCHANNEL
SUPFAMiSSF81296 SSF81296, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ68G21_RAT
AccessioniPrimary (citable) accession number: Q68G21
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2004
Last sequence update: October 11, 2004
Last modified: September 12, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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