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Protein

Nucleoporin NUP35

Gene

Nup35

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-RNO-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-RNO-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-RNO-191859 snRNP Assembly
R-RNO-3108214 SUMOylation of DNA damage response and repair proteins
R-RNO-3301854 Nuclear Pore Complex (NPC) Disassembly
R-RNO-3371453 Regulation of HSF1-mediated heat shock response
R-RNO-4551638 SUMOylation of chromatin organization proteins
R-RNO-4615885 SUMOylation of DNA replication proteins
R-RNO-5578749 Transcriptional regulation by small RNAs

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoporin NUP35Imported
Alternative name(s):
35 kDa nucleoporin
Nuclear pore complex protein Nup53
Nucleoporin NUP53By similarity
Gene namesi
Name:Nup35
Synonyms:Nup53
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1303069 Nup35

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002342961 – 325Nucleoporin NUP35Add BLAST325

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei53PhosphoserineBy similarity1
Modified residuei55PhosphoserineBy similarity1
Modified residuei66PhosphoserineBy similarity1
Modified residuei73PhosphoserineCombined sources1
Modified residuei99PhosphoserineBy similarity1
Modified residuei100PhosphoserineBy similarity1
Modified residuei106PhosphothreonineBy similarity1
Modified residuei121PhosphoserineBy similarity1
Modified residuei128PhosphothreonineBy similarity1
Modified residuei137PhosphoserineBy similarity1
Modified residuei251PhosphoserineBy similarity1
Modified residuei258PhosphoserineBy similarity1
Modified residuei264PhosphothreonineCombined sources1
Modified residuei272PhosphothreonineBy similarity1
Modified residuei274PhosphothreonineBy similarity1
Modified residuei278PhosphoserineBy similarity1
Modified residuei279PhosphothreonineBy similarity1
Modified residuei283PhosphoserineBy similarity1
Modified residuei307PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ68FY1
PRIDEiQ68FY1

PTM databases

iPTMnetiQ68FY1
PhosphoSitePlusiQ68FY1

Expressioni

Gene expression databases

BgeeiENSRNOG00000009290
GenevisibleiQ68FY1 RN

Interactioni

Subunit structurei

Interacts with TMEM48/NDC1 (By similarity). Forms a complex with NUP93, NUP155, NUP205 and lamin B. The interaction with NUP93 is direct (By similarity).By similarity

Protein-protein interaction databases

CORUMiQ68FY1
STRINGi10116.ENSRNOP00000012628

Structurei

3D structure databases

ProteinModelPortaliQ68FY1
SMRiQ68FY1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini169 – 249RRM Nup35-typePROSITE-ProRule annotationAdd BLAST81

Sequence similaritiesi

Belongs to the Nup35 family.Curated

Phylogenomic databases

eggNOGiKOG4285 Eukaryota
ENOG4111ARE LUCA
GeneTreeiENSGT00390000005923
HOGENOMiHOG000231921
HOVERGENiHBG060396
InParanoidiQ68FY1
KOiK14313
OMAiAPQNGNW
OrthoDBiEOG091G0DAQ
PhylomeDBiQ68FY1
TreeFamiTF325369

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR017389 Nucleoporin_NUP53
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR007846 RRM_NUP35_dom
PfamiView protein in Pfam
PF05172 Nup35_RRM, 1 hit
PIRSFiPIRSF038119 Nucleoporin_NUP53, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS51472 RRM_NUP35, 1 hit

Sequencei

Sequence statusi: Complete.

Q68FY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAFAVDPQA PTLGSEPMML GSPTSPKPGA NAQFLPGFLM GDLPAPVTPQ
60 70 80 90 100
PRSISGPSVG VMEMRSPLLA GGSPPQPVVP AHKDKSGAPP VRSIYDDISS
110 120 130 140 150
PGLGSTPLPS RRQANISVLQ SPLVGVTTPV TGQSMFSPAN IGQPRKTTLS
160 170 180 190 200
PAQLDPFYTQ GDSLTSEDHL DDTWVTVFGF PQASASYILL QFAQYGNILK
210 220 230 240 250
HVMSNTGNWM HIRYQSKLQA RKALSKDGRI FGESIMIGVK PCIDKNVMEN
260 270 280 290 300
SDRGVLSSPS LAFTPPIRTL GTPTQPGSTP RVSTMRPLAT AYKASTSDYQ
310 320
VISDRQTPKK DESLVSRAME YMFGW
Length:325
Mass (Da):34,802
Last modified:October 11, 2004 - v1
Checksum:i5EC3D9E5FE80B9FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078914 mRNA Translation: AAH78914.1
RefSeqiNP_001004229.1, NM_001004229.1
UniGeneiRn.203627

Genome annotation databases

EnsembliENSRNOT00000012628; ENSRNOP00000012628; ENSRNOG00000009290
GeneIDi295692
KEGGirno:295692
UCSCiRGD:1303069 rat

Similar proteinsi

Entry informationi

Entry nameiNUP35_RAT
AccessioniPrimary (citable) accession number: Q68FY1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: October 11, 2004
Last modified: May 23, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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