UniProtKB - Q68FY0 (QCR1_RAT)
Cytochrome b-c1 complex subunit 1, mitochondrial
Uqcrc1
Functioni
GO - Molecular functioni
- metal ion binding Source: InterPro
- protein-containing complex binding Source: RGD
- ubiquitin protein ligase binding Source: RGD
GO - Biological processi
- mitochondrial electron transport, ubiquinol to cytochrome c Source: RGD
- response to activity Source: RGD
- response to alkaloid Source: RGD
Keywordsi
Biological process | Electron transport, Respiratory chain, Transport |
Enzyme and pathway databases
Reactomei | R-RNO-611105, Respiratory electron transport |
Protein family/group databases
MEROPSi | M16.975 |
Names & Taxonomyi
Protein namesi | Recommended name: Cytochrome b-c1 complex subunit 1, mitochondrialAlternative name(s): Complex III subunit 1 Core protein I Ubiquinol-cytochrome-c reductase complex core protein 1 |
Gene namesi | Name:Uqcrc1 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1303314, Uqcrc1 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity; Matrix side By similarity
Cytosol
- cytosol Source: Ensembl
Mitochondrion
- mitochondrial respiratory chain complex III Source: RGD
- mitochondrion Source: RGD
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 34 | MitochondrionBy similarityAdd BLAST | 34 | |
ChainiPRO_0000271398 | 35 – 480 | Cytochrome b-c1 complex subunit 1, mitochondrialAdd BLAST | 446 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 111 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 138 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 163 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 163 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 212 | PhosphoserineCombined sources | 1 | |
Modified residuei | 214 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
jPOSTi | Q68FY0 |
PaxDbi | Q68FY0 |
PRIDEi | Q68FY0 |
2D gel databases
World-2DPAGEi | 0004:Q68FY0 |
PTM databases
CarbonylDBi | Q68FY0 |
iPTMneti | Q68FY0 |
PhosphoSitePlusi | Q68FY0 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000032134, Expressed in heart and 21 other tissues |
Genevisiblei | Q68FY0, RN |
Interactioni
Subunit structurei
Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1 (By similarity). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI1III2IV1 and megacomplex MCI2III2IV2) (By similarity).
Interacts with BRAWNIN (By similarity).
By similarityGO - Molecular functioni
- ubiquitin protein ligase binding Source: RGD
Protein-protein interaction databases
BioGRIDi | 256797, 1 interactor |
CORUMi | Q68FY0 |
IntActi | Q68FY0, 1 interactor |
STRINGi | 10116.ENSRNOP00000044696 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG0960, Eukaryota |
GeneTreei | ENSGT00940000158931 |
HOGENOMi | CLU_009902_4_0_1 |
InParanoidi | Q68FY0 |
OMAi | GPGWSNP |
OrthoDBi | 638125at2759 |
PhylomeDBi | Q68FY0 |
TreeFami | TF105032 |
Family and domain databases
InterProi | View protein in InterPro IPR011249, Metalloenz_LuxS/M16 IPR011765, Pept_M16_N IPR007863, Peptidase_M16_C |
Pfami | View protein in Pfam PF00675, Peptidase_M16, 1 hit PF05193, Peptidase_M16_C, 1 hit |
SUPFAMi | SSF63411, SSF63411, 2 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MAASAVCRAA CSGTQALLRT CRSPALLRLP ALRGTATFVQ ALQSVPETQV
60 70 80 90 100
SVLDNGLRVA SEQSSHPTCT VGVWIDVGSR YETEKNNGAG YFLEHLAFKG
110 120 130 140 150
TKNRPGNALE KEVESIGAHL NAYSTREHTA YLIKALSKDL PKVVELLADI
160 170 180 190 200
VQNISLEDSQ IEKERDVILR EMQENDASMQ NVVFDYLHAT AFQGTPLAQA
210 220 230 240 250
VEGPSENVRR LSRTDLTDYL SRHYKAPRMV LAAAGGVKHQ QLLDLAQDHF
260 270 280 290 300
SSVSQVYEED AVPSITPCRF TGSEIRHRDD ALPLAHVAIA VEGPGWANPD
310 320 330 340 350
NVALQVANAI IGHYDCTYGG GVHLSSPLAS VAVANKLCQS FQTFNISYSE
360 370 380 390 400
TGLLGAHFVC DAMSIDDMIF FLQGQWMRLC TSATESEVTR GKNILRNALI
410 420 430 440 450
SHLDGTTPVC EDIGRSLLTY GRRIPLAEWE SRIEEVDAQM VREVCSKYFY
460 470 480
DQCPAVAGYG PIEQLSDYNR IRSGMFWLRF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC078923 mRNA Translation: AAH78923.1 |
RefSeqi | NP_001004250.1, NM_001004250.2 |
Genome annotation databases
Ensembli | ENSRNOT00000042114; ENSRNOP00000044696; ENSRNOG00000032134 |
GeneIDi | 301011 |
KEGGi | rno:301011 |
UCSCi | RGD:1303314, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC078923 mRNA Translation: AAH78923.1 |
RefSeqi | NP_001004250.1, NM_001004250.2 |
3D structure databases
SMRi | Q68FY0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 256797, 1 interactor |
CORUMi | Q68FY0 |
IntActi | Q68FY0, 1 interactor |
STRINGi | 10116.ENSRNOP00000044696 |
Protein family/group databases
MEROPSi | M16.975 |
PTM databases
CarbonylDBi | Q68FY0 |
iPTMneti | Q68FY0 |
PhosphoSitePlusi | Q68FY0 |
2D gel databases
World-2DPAGEi | 0004:Q68FY0 |
Proteomic databases
jPOSTi | Q68FY0 |
PaxDbi | Q68FY0 |
PRIDEi | Q68FY0 |
Genome annotation databases
Ensembli | ENSRNOT00000042114; ENSRNOP00000044696; ENSRNOG00000032134 |
GeneIDi | 301011 |
KEGGi | rno:301011 |
UCSCi | RGD:1303314, rat |
Organism-specific databases
CTDi | 7384 |
RGDi | 1303314, Uqcrc1 |
Phylogenomic databases
eggNOGi | KOG0960, Eukaryota |
GeneTreei | ENSGT00940000158931 |
HOGENOMi | CLU_009902_4_0_1 |
InParanoidi | Q68FY0 |
OMAi | GPGWSNP |
OrthoDBi | 638125at2759 |
PhylomeDBi | Q68FY0 |
TreeFami | TF105032 |
Enzyme and pathway databases
Reactomei | R-RNO-611105, Respiratory electron transport |
Miscellaneous databases
PROi | PR:Q68FY0 |
Gene expression databases
Bgeei | ENSRNOG00000032134, Expressed in heart and 21 other tissues |
Genevisiblei | Q68FY0, RN |
Family and domain databases
InterProi | View protein in InterPro IPR011249, Metalloenz_LuxS/M16 IPR011765, Pept_M16_N IPR007863, Peptidase_M16_C |
Pfami | View protein in Pfam PF00675, Peptidase_M16, 1 hit PF05193, Peptidase_M16_C, 1 hit |
SUPFAMi | SSF63411, SSF63411, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | QCR1_RAT | |
Accessioni | Q68FY0Primary (citable) accession number: Q68FY0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 9, 2007 |
Last sequence update: | October 11, 2004 | |
Last modified: | December 2, 2020 | |
This is version 119 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Peptidase families
Classification of peptidase families and list of entries