Hematopoietic cell-specific LYN substrate 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• actin filament binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• protein-containing complex binding Source: RGD
• protein kinase binding Source: RGD
• RNA polymerase II transcription factor binding Source: RGD
• SH3 domain binding Source: RGD

GO - Biological processⁱ

• actin filament polymerization Source: InterPro
• cellular response to cytokine stimulus Source: RGD
• erythrocyte differentiation Source: UniProtKB
• negative regulation of leukocyte apoptotic process Source: RGD
• negative regulation of transcription by RNA polymerase II Source: RGD
• positive regulation of cell population proliferation Source: UniProtKB
• positive regulation of DNA-binding transcription factor activity Source: RGD
• positive regulation of granulocyte differentiation Source: RGD
• positive regulation of macrophage differentiation Source: RGD
• positive regulation of peptidyl-serine phosphorylation Source: RGD
• positive regulation of peptidyl-tyrosine phosphorylation Source: RGD
• positive regulation of phosphatidylinositol 3-kinase signaling Source: RGD
• positive regulation of protein import into nucleus Source: RGD
• positive regulation of protein kinase B signaling Source: RGD
• positive regulation of transcription by RNA polymerase II Source: RGD
• positive regulation of tyrosine phosphorylation of STAT protein Source: UniProtKB
• regulation of actin filament polymerization Source: RGD
• response to hormone Source: UniProtKB

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• actin filament binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• protein kinase binding Source: RGD
• RNA polymerase II transcription factor binding Source: RGD
• SH3 domain binding Source: RGD

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MWKSVVGHNV SVSVETQGDD WDTDPDFVND ISEKEQRWGA KTIEGSGRTE 
        60         70         80         90        100
HINIHQLRNK VSEEHDILKK RELESGPKAS HGYGGRFGVE RDRMDKSAVG 
       110        120        130        140        150
HEYVAEVEKH SSQTDAAKGF GGKYGVERDR ADKSAVGFDY KGEVEKHASQ 
       160        170        180        190        200
KDYSHGFGGR YGVEKDKRDK AALGYDYKGE TEKHESQRDY AKGFGGQYGI 
       210        220        230        240        250
QKDRVDKSAV GFNEMEAPTT AYKKTTPIEA ASSGARGLKA KFESMAEEKR 
       260        270        280        290        300
KREEEEKAQQ MARQQQERKA MVKMSREAQQ PSVPVDEPAA PAPLPKKISS 
       310        320        330        340        350
EVWPPAESHL PPQSEPVGGR REYPVPSLPT RQPPPQNPLE DNEEPPALPP 
       360        370        380        390        400
RTPEGLQVVE EPVYEAAPEP EPEPEPDYED VGELDRPDEE AEGDYEDVLE 
       410        420        430        440        450
PEDTPSLSYQ AGHSAGAGGA GISAVALYDY QGEGSDELSF DPDDVITDIE 
       460        470 
MVDEGWWRGR CHGHFGLFPA NYVKLL                           

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ