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Protein

Syntaxin-18

Gene

Stx18

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-18
Gene namesi
Name:Stx18
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi1310058 Stx18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 308CytoplasmicSequence analysisAdd BLAST308
Transmembranei309 – 329Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini330 – 334VesicularSequence analysis5

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002102341 – 334Syntaxin-18Add BLAST334

Proteomic databases

PaxDbiQ68FW4

Expressioni

Gene expression databases

BgeeiENSRNOG00000006139 Expressed in 10 organ(s), highest expression level in testis
GenevisibleiQ68FW4 RN

Interactioni

Subunit structurei

Component of a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L, and SEC22B. RINT1/TIP20L and ZW10 are associated with the complex through interaction with BNIP1/SEC20L. Interacts directly with USE1L and BNIP1/SEC20L (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

CORUMiQ68FW4
IntActiQ68FW4, 1 interactor
STRINGi10116.ENSRNOP00000008410

Structurei

3D structure databases

ProteinModelPortaliQ68FW4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini242 – 304t-SNARE coiled-coil homologyAdd BLAST63

Sequence similaritiesi

Belongs to the syntaxin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3894 Eukaryota
ENOG410XSGT LUCA
GeneTreeiENSGT00390000014853
HOGENOMiHOG000007595
HOVERGENiHBG054890
InParanoidiQ68FW4
KOiK08492
OMAiLQHRKDY
OrthoDBiEOG091G0FVR
PhylomeDBiQ68FW4
TreeFamiTF105868

Family and domain databases

InterProiView protein in InterPro
IPR019529 Syntaxin-18_N
IPR006012 Syntaxin/epimorphin_CS
PfamiView protein in Pfam
PF10496 Syntaxin-18_N, 1 hit
PROSITEiView protein in PROSITE
PS00914 SYNTAXIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q68FW4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVDITLLFR ASVKTVKTRN KALGVAVGGG ADGSRDELFR RSPRPKGDFS
60 70 80 90 100
SRAREVISHI GKLRDFLLEH RKEYINAYSH TMSEYGRMTD TERDQIDQDA
110 120 130 140 150
QIFMRTCKDA IQQLRTEAHK EIHSQQVKEH RTAVLDFVED YLKRVCKLYS
160 170 180 190 200
EQRAIRVKRV VDKKRLSKLE PEPHTKRKEP ASEKSSHNAS QDSEEKPAAE
210 220 230 240 250
DLPEKPLAES QPELGTWGDG KGEDELSPEE IQMFEQENQR LIGEMNSLFD
260 270 280 290 300
EVRQIEGKVV EISRLQEIFT EKVLQQETEI DSIHQLVVGA TENIKEGNED
310 320 330
IREAIKNNAG FRVWILFFLV MCSFSLLFLD WYDS
Length:334
Mass (Da):38,512
Last modified:October 11, 2004 - v1
Checksum:i98CB261E598BFF84
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079183 mRNA Translation: AAH79183.1
RefSeqiNP_001012151.1, NM_001012151.1
UniGeneiRn.53006

Genome annotation databases

EnsembliENSRNOT00000008410; ENSRNOP00000008410; ENSRNOG00000006139
GeneIDi360953
KEGGirno:360953

Similar proteinsi

Entry informationi

Entry nameiSTX18_RAT
AccessioniPrimary (citable) accession number: Q68FW4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: October 11, 2004
Last modified: September 12, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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