Gelsolin

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• actin binding Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Involvement of gelsolin in cadmium-induced disruption of the mesangial cell cytoskeleton."
    Apostolova M.D., Christova T., Templeton D.M.
    Toxicol Sci 89:465-474(2006) [PubMed] [Europe PMC] [Abstract]
• actin filament binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• calcium ion binding Source: RGD
• myosin II binding Source: RGD
• phosphatidylinositol 3-kinase catalytic subunit binding Source: RGD
• phosphatidylinositol-4,5-bisphosphate binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• actin cytoskeleton organization Source: RGD
• actin filament capping Source: RGD
• actin filament depolymerization Source: RGD
• actin filament polymerization Source: UniProtKB
• actin filament reorganization Source: RGD
• actin filament severing Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Gelsolin--evidence for a role in turnover of junction-related actin filaments in Sertoli cells."
    Guttman J.A., Janmey P., Vogl A.W.
    J Cell Sci 115:499-505(2002) [PubMed] [Europe PMC] [Abstract]
• actin nucleation Source: InterPro
• actin polymerization or depolymerization Source: RGDInferred from direct assayⁱ
  • "Involvement of gelsolin in cadmium-induced disruption of the mesangial cell cytoskeleton."
    Apostolova M.D., Christova T., Templeton D.M.
    Toxicol Sci 89:465-474(2006) [PubMed] [Europe PMC] [Abstract]
• aging Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Aging-associated increase of gelsolin for apoptosis resistance."
    Ahn J.S., Jang I.S., Kim D.I., Cho K.A., Park Y.H., Kim K., Kwak C.S., Chul Park S.
    Biochem Biophys Res Commun 312:1335-1341(2003) [PubMed] [Europe PMC] [Abstract]
• amyloid fibril formation Source: RGD
• apoptotic process Source: RGDInferred from direct assayⁱ
  • "Evidence for apoptosis after intercerebral hemorrhage in rat striatum."
    Matsushita K., Meng W., Wang X., Asahi M., Asahi K., Moskowitz M.A., Lo E.H.
    J Cereb Blood Flow Metab 20:396-404(2000) [PubMed] [Europe PMC] [Abstract]
• barbed-end actin filament capping Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cardiac muscle cell contraction Source: RGD
• cell projection assembly Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cellular response to cadmium ion Source: RGDInferred from direct assayⁱ
  • "Involvement of gelsolin in cadmium-induced disruption of the mesangial cell cytoskeleton."
    Apostolova M.D., Christova T., Templeton D.M.
    Toxicol Sci 89:465-474(2006) [PubMed] [Europe PMC] [Abstract]
• cellular response to interferon-gamma Source: RGD
• central nervous system development Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cilium assembly Source: UniProtKB
• hepatocyte apoptotic process Source: RGD
• negative regulation of viral entry into host cell Source: RGD
• oligodendrocyte development Source: RGDInferred from expression patternⁱ
  • "High gelsolin content of developing oligodendrocytes."
    Lena J.Y., Legrand C., Faivre-Sarrailh C., Sarlieve L.L., Ferraz C., Rabie A.
    Int J Dev Neurosci 12:375-386(1994) [PubMed] [Europe PMC] [Abstract]
• phagocytosis, engulfment Source: RGD
• phosphatidylinositol-mediated signaling Source: RGDInferred from mutant phenotypeⁱ
  • "Gelsolin--evidence for a role in turnover of junction-related actin filaments in Sertoli cells."
    Guttman J.A., Janmey P., Vogl A.W.
    J Cell Sci 115:499-505(2002) [PubMed] [Europe PMC] [Abstract]
• positive regulation of actin nucleation Source: RGD
• positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source: RGD
• positive regulation of gene expression Source: RGD
• positive regulation of keratinocyte apoptotic process Source: RGD
• positive regulation of protein processing in phagocytic vesicle Source: RGD
• protein destabilization Source: RGD
• regulation of cell adhesion Source: RGDInferred from mutant phenotypeⁱ
  • "Gelsolin--evidence for a role in turnover of junction-related actin filaments in Sertoli cells."
    Guttman J.A., Janmey P., Vogl A.W.
    J Cell Sci 115:499-505(2002) [PubMed] [Europe PMC] [Abstract]
• regulation of establishment of T cell polarity Source: RGD
• regulation of plasma membrane raft polarization Source: RGD
• regulation of podosome assembly Source: RGD
• regulation of receptor clustering Source: RGD
• relaxation of cardiac muscle Source: RGD
• renal protein absorption Source: RGD
• response to ethanol Source: RGDInferred from expression patternⁱ
  • "Effect of prenatal exposure to ethanol on hepatic elongation factor-2 and proteome in 21 d old rats: protective effect of folic acid."
    Garcia-Rodriguez S., Arguelles S., Llopis R., Murillo M.L., Machado A., Carreras O., Ayala A.
    Free Radic Biol Med 35:428-437(2003) [PubMed] [Europe PMC] [Abstract]
• response to folic acid Source: RGDInferred from expression patternⁱ
  • "Effect of prenatal exposure to ethanol on hepatic elongation factor-2 and proteome in 21 d old rats: protective effect of folic acid."
    Garcia-Rodriguez S., Arguelles S., Llopis R., Murillo M.L., Machado A., Carreras O., Ayala A.
    Free Radic Biol Med 35:428-437(2003) [PubMed] [Europe PMC] [Abstract]
• response to muscle stretch Source: RGD
• sequestering of actin monomers Source: RGD
• striated muscle atrophy Source: RGD
• tissue regeneration Source: RGDInferred from expression patternⁱ
  • "Gelsolin gene expression is upregulated in damaged rat and human livers within non-parenchymal cells and not in hepatocytes."
    Neubauer K., Baruch Y., Lindhorst A., Saile B., Ramadori G.
    Histochem Cell Biol 120:265-275(2003) [PubMed] [Europe PMC] [Abstract]
• vesicle-mediated transport Source: RGD
• wound healing Source: RGDInferred from expression patternⁱ
  • "Modulation of gelsolin content in rat aortic smooth muscle cells during development, experimental intimal thickening and culture. An immunohistochemical and biochemical study."
    Chaponnier C., Kocher O., Gabbiani G.
    Eur J Biochem 190:559-565(1990) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• actin binding Source: RGDInferred from direct assayⁱ
  • "Involvement of gelsolin in cadmium-induced disruption of the mesangial cell cytoskeleton."
    Apostolova M.D., Christova T., Templeton D.M.
    Toxicol Sci 89:465-474(2006) [PubMed] [Europe PMC] [Abstract]
• actin filament binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• myosin II binding Source: RGD
• phosphatidylinositol 3-kinase catalytic subunit binding Source: RGD

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

        10         20         30         40         50
MAPYCSSLRS ALLVLALCAL SPSHAATASR GRAQERAPQS RVSETRPSTM 
        60         70         80         90        100
VVEHPEFLKA GKEPGLQIWR VEKFDLVPVP PNLYGDFFTG DAYVILKTVQ 
       110        120        130        140        150
LRNGNLQYDL HYWLGNECSQ DESGAAAIFT VQLDDYLNGR AVQHREVQGF 
       160        170        180        190        200
ESSTFQGYFK SGLKYKKGGV ASGFKHVVPN EVVVQRLFQV KGRRVVRATE 
       210        220        230        240        250
VPVSWDSFNN GDCFILDLGN NIYQWCGSGS NKFERLKATQ VSKGIRDNER 
       260        270        280        290        300
SGRAQVHVSE EGSEPEAMLQ VLGPKPDLPQ GTEDTAKEDA ANRRLAKLYK 
       310        320        330        340        350
VSNSGGSMSV SLVADENPFA QSALRSEDCF ILDHGRDGKI FVWKGKQANM 
       360        370        380        390        400
DERKAALKTA SDFISKMQYP RQTQVSVLPE GGETPLFKQF FKNWRDPDQT 
       410        420        430        440        450
DGPGLSYLSS HIANVERVPF DAATLHTSTA MAAQHGMDDD GTGQKQIWRI 
       460        470        480        490        500
EGSNKVLVDP ATYGQFYGGD SYIILYNYRH GGRQGQIIYN WQGAQSTQDE 
       510        520        530        540        550
VAASAILTAQ LDEELGGTPV QSRVVQGKEP AHLMSLFGGK PMIIYKGGTS 
       560        570        580        590        600
RDGGQTTPAS TRLFQVRASS SGATRAVEVM PKAGALNSND AFVLKTPSAA 
       610        620        630        640        650
YLWVGTGASD AEKTGALELL KVLRAQHVQV EEGSEPDGFW EALGGKTAYR 
       660        670        680        690        700
TSPRLKDKKM DAHPPRLFAC SNRIGRFVIE EVPGELMQED LATDDVMLLD 
       710        720        730        740        750
TWDQVFVWVG KDSQEEEKTE ALTSAKRYIE TDPANRDRRT PITVVRQGFE 
       760        770        780
PPSFVGWFLG WDDDYWSVDP LDRALAELAA                       

        10         20         30         40         50
MVVEHPEFLK AGKEPGLQIW RVEKFDLVPV PPNLYGDFFT GDAYVILKTV 
        60         70         80         90        100
QLRNGNLQYD LHYWLGNECS QDESGAAAIF TVQLDDYLNG RAVQHREVQG 
       110        120        130        140        150
FESSTFQGYF KSGLKYKKGG VASGFKHVVP NEVVVQRLFQ VKGRRVVRAT 
       160        170        180        190        200
EVPVSWDSFN NGDCFILDLG NNIYQWCGSG SNKFERLKAT QVSKGIRDNE 
       210        220        230        240        250
RSGRAQVHVS EEGSEPEAML QVLGPKPDLP QGTEDTAKED AANRRLAKLY 
       260        270        280        290        300
KVSNSGGSMS VSLVADENPF AQSALRSEDC FILDHGRDGK IFVWKGKQAN 
       310        320        330        340        350
MDERKAALKT ASDFISKMQY PRQTQVSVLP EGGETPLFKQ FFKNWRDPDQ 
       360        370        380        390        400
TDGPGLSYLS SHIANVERVP FDAATLHTST AMAAQHGMDD DGTGQKQIWR 
       410        420        430        440        450
IEGSNKVLVD PATYGQFYGG DSYIILYNYR HGGRQGQIIY NWQGAQSTQD 
       460        470        480        490        500
EVAASAILTA QLDEELGGTP VQSRVVQGKE PAHLMSLFGG KPMIIYKGGT 
       510        520        530        540        550
SRDGGQTTPA STRLFQVRAS SSGATRAVEV MPKAGALNSN DAFVLKTPSA 
       560        570        580        590        600
AYLWVGTGAS DAEKTGALEL LKVLRAQHVQ VEEGSEPDGF WEALGGKTAY 
       610        620        630        640        650
RTSPRLKDKK MDAHPPRLFA CSNRIGRFVI EEVPGELMQE DLATDDVMLL 
       660        670        680        690        700
DTWDQVFVWV GKDSQEEEKT EALTSAKRYI ETDPANRDRR TPITVVRQGF 
       710        720        730 
EPPSFVGWFL GWDDDYWSVD PLDRALAELA A                     

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families