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Entry version 142 (29 Sep 2021)
Sequence version 1 (11 Oct 2004)
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Protein

Plakophilin-4

Gene

Pkp4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cadherin binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-6805567, Keratinization
R-MMU-6809371, Formation of the cornified envelope
R-MMU-9696264, RND3 GTPase cycle
R-MMU-9696270, RND2 GTPase cycle
R-MMU-9696273, RND1 GTPase cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Plakophilin-4
Alternative name(s):
Armadillo-related protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pkp4
Synonyms:Armrp
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:109281, Pkp4

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000026991

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000642901 – 1190Plakophilin-4Add BLAST1190

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei75PhosphoserineBy similarity1
Modified residuei84PhosphothreonineCombined sources1
Modified residuei106PhosphoserineBy similarity1
Modified residuei132PhosphoserineCombined sources1
Modified residuei136PhosphoserineCombined sources1
Modified residuei139PhosphoserineCombined sources1
Modified residuei220PhosphoserineCombined sources1
Modified residuei230PhosphoserineCombined sources1
Modified residuei235PhosphoserineBy similarity1
Modified residuei253Omega-N-methylarginineCombined sources1
Modified residuei269Omega-N-methylarginineCombined sources1
Modified residuei272PhosphoserineBy similarity1
Modified residuei280PhosphoserineCombined sources1
Modified residuei313PhosphoserineCombined sources1
Modified residuei326PhosphoserineCombined sources1
Modified residuei336PhosphoserineCombined sources1
Modified residuei371PhosphotyrosineCombined sources1
Modified residuei391PhosphoserineBy similarity1
Modified residuei402PhosphoserineCombined sources1
Modified residuei405PhosphoserineCombined sources1
Modified residuei411PhosphothreonineCombined sources1
Modified residuei414PhosphotyrosineBy similarity1
Modified residuei421PhosphoserineCombined sources1
Modified residuei426PhosphoserineCombined sources1
Modified residuei437PhosphoserineCombined sources1
Modified residuei477PhosphotyrosineCombined sources1
Modified residuei509PhosphoserineCombined sources1
Modified residuei511PhosphoserineCombined sources1
Modified residuei514PhosphoserineCombined sources1
Modified residuei775PhosphoserineCombined sources1
Modified residuei1012PhosphothreonineCombined sources1
Modified residuei1016PhosphothreonineCombined sources1
Modified residuei1044PhosphoserineCombined sources1
Modified residuei1090PhosphoserineCombined sources1
Modified residuei1099PhosphoserineCombined sources1
Modified residuei1133PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q68FH0

PeptideAtlas

More...
PeptideAtlasi
Q68FH0

PRoteomics IDEntifications database

More...
PRIDEi
Q68FH0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
289517 [Q68FH0-1]
289518 [Q68FH0-2]
289519 [Q68FH0-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q68FH0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q68FH0

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q68FH0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000026991, Expressed in ciliary body and 313 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q68FH0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q68FH0, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via the C-terminus) with FRMPD2 (via the PDZ 2 domain).

Interacts with PDZD2.

Interacts with RHOA; the interaction is detected at the midbody.

Interacts with ECT2; the interaction is detected at the midbody (By similarity).

Interacts with CCDC85B (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
230696, 13 interactors

Protein interaction database and analysis system

More...
IntActi
Q68FH0, 3 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000099815

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q68FH0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q68FH0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati517 – 556ARM 1Add BLAST40
Repeati559 – 598ARM 2Add BLAST40
Repeati603 – 643ARM 3Add BLAST41
Repeati861 – 900ARM 4Add BLAST40

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 32DisorderedSequence analysisAdd BLAST32
Regioni73 – 347DisorderedSequence analysisAdd BLAST275
Regioni772 – 809DisorderedSequence analysisAdd BLAST38

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili36 – 63Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi10 – 32Polar residuesSequence analysisAdd BLAST23
Compositional biasi75 – 91Polar residuesSequence analysisAdd BLAST17
Compositional biasi106 – 279Polar residuesSequence analysisAdd BLAST174
Compositional biasi285 – 347Polar residuesSequence analysisAdd BLAST63
Compositional biasi772 – 786Basic and acidic residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the beta-catenin family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1048, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155773

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007897_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q68FH0

Identification of Orthologs from Complete Genome Data

More...
OMAi
SAGNWKX

Database of Orthologous Groups

More...
OrthoDBi
233858at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q68FH0

TreeFam database of animal gene trees

More...
TreeFami
TF321877

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR000225, Armadillo
IPR028443, Plakophilin-4
IPR028435, Plakophilin/d_Catenin

The PANTHER Classification System

More...
PANTHERi
PTHR10372, PTHR10372, 1 hit
PTHR10372:SF8, PTHR10372:SF8, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00514, Arm, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00185, ARM, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50176, ARM_REPEAT, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q68FH0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPAPEQGSLV EEGQPQTHQE AVSTGPGMEP ETTATTILAS VKEQELQFQR
60 70 80 90 100
LTRELEVERQ IVASQLERCR LGAESPSIAS TSSTEKSFPW RSTDVPNPGV
110 120 130 140 150
SKPRVSDTIH PNNYLIRTEP EQGTLYSPEQ TSLHESEGSL GNSRSSTQMN
160 170 180 190 200
SYSDSGYQEA GSFHNSQTVN KADSRQHPFT GSTSNHVVRT SRAEGQTLVQ
210 220 230 240 250
PSVANRAMRR VSSVPSRAQS PSYVTSTGVS PSRGSLRTSL GSGFGSPSVT
260 270 280 290 300
DSRPLNPSAY SSSTLPAQRA ASPYSQRPAS PTAVRRVGSV TSRQTSNPNG
310 320 330 340 350
PVPQYQTTTR VGSPLTLTDA QTRVASPSQG QVGSSSPKRS GMTAVPQHLG
360 370 380 390 400
PSLQRTVHDM DQFGQQQYDI YERMVPPRPD SLTGLRSSYA SQHSQLGQEL
410 420 430 440 450
RSAVSPDLHI TPIYEGRTYY SPVYRSPNHG TVELQGSQTA LYRTGSVGIG
460 470 480 490 500
NLQRTSSQRS TLTYQRNNYA LNTAATYAEP YRPVQYRVQE CSYNRLQHTG
510 520 530 540 550
PADDGATRSP SIDSIQKDPR EFAWRDPELP EVIHMLQHQF PSVQANAAAY
560 570 580 590 600
LQHLCFGDNK VKMEVYRLGG IKHLVDLLDH RVLEVQKNAC GALRNLVFGK
610 620 630 640 650
STDENKIAMK NVGGIPALLR LLRKSIDAEV RELVTGVLWN LSSCDAVKMT
660 670 680 690 700
IIRDALSTLT NTVIVPHSGW NNSSFDDDHK IKFQTSLVLR NTTGCLRNLS
710 720 730 740 750
SAGEEARKQM RSCEGLVDSL LYVIHTCVNT SDYDSKTVEN CVCTLRNLSY
760 770 780 790 800
RLELEVPQAR LLGLNELDDL LGKESPSKDS EPSCWGKKKK KKKRTPQEDQ
810 820 830 840 850
WDGVGPIPGL SKSPKGVEML WHPSVVKPYL TLLAESSNPA TLEGSAGSLQ
860 870 880 890 900
NLSAGNWKFA AYIRAAVRKE KGLPILVELL RMDNDRVVSS VATALRNMAL
910 920 930 940 950
DVRNKELIGK YAMRDLVNRL PGGNGPSILS DETVAAICCA LHEVTSKNME
960 970 980 990 1000
NAKALADSGG IEKLVNITKG RGDRSSLKVV KAAAQVLNTL WQYRDLRSIY
1010 1020 1030 1040 1050
KKDGWNQNHF ITPVSTLERD RFKSHPSLST TNQQMSPIIQ SVGSTSSSPA
1060 1070 1080 1090 1100
LLGIREPRSE YDRTQPPMQY YNSQGDTTHK GLYPGSSKPS PIYISSYSSP
1110 1120 1130 1140 1150
AREQNRRLQH QQLYYQDDST RKTLDAYRLY LQSPRSYEDP YCDDRVHFPA
1160 1170 1180 1190
STDYSTQYGL KSTTNYVDFY STKRPSYRAE QYPGSPDSWV
Length:1,190
Mass (Da):131,551
Last modified:October 11, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDB6548B5EBE72CFE
GO
Isoform 2 (identifier: Q68FH0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1042-1084: Missing.

Show »
Length:1,147
Mass (Da):126,783
Checksum:iDEC21F1C1F960B7A
GO
Isoform 3 (identifier: Q68FH0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-341: Missing.
     637-637: V → G
     638-1190: Missing.

Show »
Length:296
Mass (Da):33,263
Checksum:iD0630AA63A0911E8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AS45A2AS45_MOUSE
Plakophilin-4
Pkp4
1,163Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AS44A2AS44_MOUSE
Plakophilin-4
Pkp4
803Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AS47A2AS47_MOUSE
Plakophilin-4
Pkp4
849Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GXG7V9GXG7_MOUSE
Plakophilin-4
Pkp4
215Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GWY7V9GWY7_MOUSE
Plakophilin-4
Pkp4
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC37187 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti328S → F in AAH78638 (PubMed:15489334).Curated1
Sequence conflicti877V → A in BAC36708 (PubMed:16141072).Curated1
Sequence conflicti1118D → G in BAC36708 (PubMed:16141072).Curated1
Sequence conflicti1161K → R in BAB32313 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0123741 – 341Missing in isoform 3. 1 PublicationAdd BLAST341
Alternative sequenceiVSP_012375637V → G in isoform 3. 1 Publication1
Alternative sequenceiVSP_012376638 – 1190Missing in isoform 3. 1 PublicationAdd BLAST553
Alternative sequenceiVSP_0123771042 – 1084Missing in isoform 2. 1 PublicationAdd BLAST43

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL845536 Genomic DNA No translation available.
BC078638 mRNA Translation: AAH78638.1
BC079848 mRNA Translation: AAH79848.1
BC082578 mRNA Translation: AAH82578.1
AK021168 mRNA Translation: BAB32313.1
AK077250 mRNA Translation: BAC36708.1
AK078240 mRNA Translation: BAC37187.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS16052.1 [Q68FH0-1]
CCDS50588.1 [Q68FH0-2]

NCBI Reference Sequences

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RefSeqi
NP_080637.1, NM_026361.2 [Q68FH0-1]
NP_780673.2, NM_175464.2 [Q68FH0-2]
XP_006499234.1, XM_006499171.3 [Q68FH0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000102754; ENSMUSP00000099815; ENSMUSG00000026991 [Q68FH0-1]
ENSMUST00000168631; ENSMUSP00000129836; ENSMUSG00000026991 [Q68FH0-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
227937

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:227937

UCSC genome browser

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UCSCi
uc008jtb.1, mouse [Q68FH0-1]
uc008jtd.1, mouse [Q68FH0-2]
uc008jtg.1, mouse [Q68FH0-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL845536 Genomic DNA No translation available.
BC078638 mRNA Translation: AAH78638.1
BC079848 mRNA Translation: AAH79848.1
BC082578 mRNA Translation: AAH82578.1
AK021168 mRNA Translation: BAB32313.1
AK077250 mRNA Translation: BAC36708.1
AK078240 mRNA Translation: BAC37187.1 Different initiation.
CCDSiCCDS16052.1 [Q68FH0-1]
CCDS50588.1 [Q68FH0-2]
RefSeqiNP_080637.1, NM_026361.2 [Q68FH0-1]
NP_780673.2, NM_175464.2 [Q68FH0-2]
XP_006499234.1, XM_006499171.3 [Q68FH0-1]

3D structure databases

SMRiQ68FH0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi230696, 13 interactors
IntActiQ68FH0, 3 interactors
STRINGi10090.ENSMUSP00000099815

PTM databases

iPTMnetiQ68FH0
PhosphoSitePlusiQ68FH0
SwissPalmiQ68FH0

Proteomic databases

PaxDbiQ68FH0
PeptideAtlasiQ68FH0
PRIDEiQ68FH0
ProteomicsDBi289517 [Q68FH0-1]
289518 [Q68FH0-2]
289519 [Q68FH0-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
33712, 172 antibodies

The DNASU plasmid repository

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DNASUi
227937

Genome annotation databases

EnsembliENSMUST00000102754; ENSMUSP00000099815; ENSMUSG00000026991 [Q68FH0-1]
ENSMUST00000168631; ENSMUSP00000129836; ENSMUSG00000026991 [Q68FH0-2]
GeneIDi227937
KEGGimmu:227937
UCSCiuc008jtb.1, mouse [Q68FH0-1]
uc008jtd.1, mouse [Q68FH0-2]
uc008jtg.1, mouse [Q68FH0-3]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
8502
MGIiMGI:109281, Pkp4
VEuPathDBiHostDB:ENSMUSG00000026991

Phylogenomic databases

eggNOGiKOG1048, Eukaryota
GeneTreeiENSGT00940000155773
HOGENOMiCLU_007897_0_0_1
InParanoidiQ68FH0
OMAiSAGNWKX
OrthoDBi233858at2759
PhylomeDBiQ68FH0
TreeFamiTF321877

Enzyme and pathway databases

ReactomeiR-MMU-6805567, Keratinization
R-MMU-6809371, Formation of the cornified envelope
R-MMU-9696264, RND3 GTPase cycle
R-MMU-9696270, RND2 GTPase cycle
R-MMU-9696273, RND1 GTPase cycle

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
227937, 3 hits in 61 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Pkp4, mouse

Protein Ontology

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PROi
PR:Q68FH0
RNActiQ68FH0, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000026991, Expressed in ciliary body and 313 other tissues
ExpressionAtlasiQ68FH0, baseline and differential
GenevisibleiQ68FH0, MM

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR000225, Armadillo
IPR028443, Plakophilin-4
IPR028435, Plakophilin/d_Catenin
PANTHERiPTHR10372, PTHR10372, 1 hit
PTHR10372:SF8, PTHR10372:SF8, 1 hit
PfamiView protein in Pfam
PF00514, Arm, 3 hits
SMARTiView protein in SMART
SM00185, ARM, 7 hits
SUPFAMiSSF48371, SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50176, ARM_REPEAT, 3 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPKP4_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q68FH0
Secondary accession number(s): A2AS46
, Q640N0, Q68G56, Q8BK47, Q8BVH1, Q9CRE3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: October 11, 2004
Last modified: September 29, 2021
This is version 142 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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