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Protein

Plakophilin-4

Gene

Pkp4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques (By similarity).By similarity

GO - Molecular functioni

  • cadherin binding Source: GO_Central

GO - Biological processi

  • cell-cell adhesion Source: GO_Central
  • cell-cell junction assembly Source: UniProtKB
  • positive regulation of cytokinesis Source: UniProtKB
  • positive regulation of GTPase activity Source: UniProtKB

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-MMU-6805567 Keratinization
R-MMU-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Plakophilin-4
Alternative name(s):
Armadillo-related protein
Gene namesi
Name:Pkp4
Synonyms:Armrp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:109281 Pkp4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000642901 – 1190Plakophilin-4Add BLAST1190

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei75PhosphoserineBy similarity1
Modified residuei84PhosphothreonineCombined sources1
Modified residuei106PhosphoserineBy similarity1
Modified residuei132PhosphoserineCombined sources1
Modified residuei136PhosphoserineCombined sources1
Modified residuei139PhosphoserineCombined sources1
Modified residuei220PhosphoserineCombined sources1
Modified residuei230PhosphoserineCombined sources1
Modified residuei235PhosphoserineBy similarity1
Modified residuei253Omega-N-methylarginineCombined sources1
Modified residuei269Omega-N-methylarginineCombined sources1
Modified residuei272PhosphoserineBy similarity1
Modified residuei280PhosphoserineCombined sources1
Modified residuei313PhosphoserineCombined sources1
Modified residuei326PhosphoserineCombined sources1
Modified residuei336PhosphoserineCombined sources1
Modified residuei371PhosphotyrosineCombined sources1
Modified residuei391PhosphoserineBy similarity1
Modified residuei402PhosphoserineCombined sources1
Modified residuei405PhosphoserineCombined sources1
Modified residuei411PhosphothreonineCombined sources1
Modified residuei414PhosphotyrosineBy similarity1
Modified residuei421PhosphoserineCombined sources1
Modified residuei426PhosphoserineCombined sources1
Modified residuei437PhosphoserineCombined sources1
Modified residuei477PhosphotyrosineCombined sources1
Modified residuei509PhosphoserineCombined sources1
Modified residuei511PhosphoserineCombined sources1
Modified residuei514PhosphoserineCombined sources1
Modified residuei775PhosphoserineCombined sources1
Modified residuei1012PhosphothreonineCombined sources1
Modified residuei1016PhosphothreonineCombined sources1
Modified residuei1044PhosphoserineCombined sources1
Modified residuei1090PhosphoserineCombined sources1
Modified residuei1099PhosphoserineCombined sources1
Modified residuei1133PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ68FH0
PeptideAtlasiQ68FH0
PRIDEiQ68FH0

PTM databases

iPTMnetiQ68FH0
PhosphoSitePlusiQ68FH0
SwissPalmiQ68FH0

Expressioni

Gene expression databases

BgeeiENSMUSG00000026991 Expressed in 289 organ(s), highest expression level in ciliary body
CleanExiMM_PKP4
ExpressionAtlasiQ68FH0 baseline and differential
GenevisibleiQ68FH0 MM

Interactioni

Subunit structurei

Interacts (via the C-terminus) with FRMPD2 (via the PDZ 2 domain). Interacts with PDZD2. Interacts with RHOA; the interaction is detected at the midbody. Interacts with ECT2; the interaction is detected at the midbody (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi230696, 6 interactors
IntActiQ68FH0, 3 interactors
STRINGi10090.ENSMUSP00000099815

Structurei

3D structure databases

ProteinModelPortaliQ68FH0
SMRiQ68FH0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati517 – 556ARM 1Add BLAST40
Repeati559 – 598ARM 2Add BLAST40
Repeati603 – 643ARM 3Add BLAST41
Repeati861 – 900ARM 4Add BLAST40

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili36 – 63Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi787 – 793Poly-Lys7

Sequence similaritiesi

Belongs to the beta-catenin family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG1048 Eukaryota
ENOG410Y21Q LUCA
GeneTreeiENSGT00760000119167
HOVERGENiHBG004284
InParanoidiQ68FH0
OrthoDBiEOG091G00SB
PhylomeDBiQ68FH0
TreeFamiTF321877

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR028443 Plakophilin-4
IPR028435 Plakophilin/d_Catenin
PANTHERiPTHR10372 PTHR10372, 1 hit
PTHR10372:SF8 PTHR10372:SF8, 1 hit
PfamiView protein in Pfam
PF00514 Arm, 3 hits
SMARTiView protein in SMART
SM00185 ARM, 7 hits
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50176 ARM_REPEAT, 3 hits

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q68FH0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPAPEQGSLV EEGQPQTHQE AVSTGPGMEP ETTATTILAS VKEQELQFQR
60 70 80 90 100
LTRELEVERQ IVASQLERCR LGAESPSIAS TSSTEKSFPW RSTDVPNPGV
110 120 130 140 150
SKPRVSDTIH PNNYLIRTEP EQGTLYSPEQ TSLHESEGSL GNSRSSTQMN
160 170 180 190 200
SYSDSGYQEA GSFHNSQTVN KADSRQHPFT GSTSNHVVRT SRAEGQTLVQ
210 220 230 240 250
PSVANRAMRR VSSVPSRAQS PSYVTSTGVS PSRGSLRTSL GSGFGSPSVT
260 270 280 290 300
DSRPLNPSAY SSSTLPAQRA ASPYSQRPAS PTAVRRVGSV TSRQTSNPNG
310 320 330 340 350
PVPQYQTTTR VGSPLTLTDA QTRVASPSQG QVGSSSPKRS GMTAVPQHLG
360 370 380 390 400
PSLQRTVHDM DQFGQQQYDI YERMVPPRPD SLTGLRSSYA SQHSQLGQEL
410 420 430 440 450
RSAVSPDLHI TPIYEGRTYY SPVYRSPNHG TVELQGSQTA LYRTGSVGIG
460 470 480 490 500
NLQRTSSQRS TLTYQRNNYA LNTAATYAEP YRPVQYRVQE CSYNRLQHTG
510 520 530 540 550
PADDGATRSP SIDSIQKDPR EFAWRDPELP EVIHMLQHQF PSVQANAAAY
560 570 580 590 600
LQHLCFGDNK VKMEVYRLGG IKHLVDLLDH RVLEVQKNAC GALRNLVFGK
610 620 630 640 650
STDENKIAMK NVGGIPALLR LLRKSIDAEV RELVTGVLWN LSSCDAVKMT
660 670 680 690 700
IIRDALSTLT NTVIVPHSGW NNSSFDDDHK IKFQTSLVLR NTTGCLRNLS
710 720 730 740 750
SAGEEARKQM RSCEGLVDSL LYVIHTCVNT SDYDSKTVEN CVCTLRNLSY
760 770 780 790 800
RLELEVPQAR LLGLNELDDL LGKESPSKDS EPSCWGKKKK KKKRTPQEDQ
810 820 830 840 850
WDGVGPIPGL SKSPKGVEML WHPSVVKPYL TLLAESSNPA TLEGSAGSLQ
860 870 880 890 900
NLSAGNWKFA AYIRAAVRKE KGLPILVELL RMDNDRVVSS VATALRNMAL
910 920 930 940 950
DVRNKELIGK YAMRDLVNRL PGGNGPSILS DETVAAICCA LHEVTSKNME
960 970 980 990 1000
NAKALADSGG IEKLVNITKG RGDRSSLKVV KAAAQVLNTL WQYRDLRSIY
1010 1020 1030 1040 1050
KKDGWNQNHF ITPVSTLERD RFKSHPSLST TNQQMSPIIQ SVGSTSSSPA
1060 1070 1080 1090 1100
LLGIREPRSE YDRTQPPMQY YNSQGDTTHK GLYPGSSKPS PIYISSYSSP
1110 1120 1130 1140 1150
AREQNRRLQH QQLYYQDDST RKTLDAYRLY LQSPRSYEDP YCDDRVHFPA
1160 1170 1180 1190
STDYSTQYGL KSTTNYVDFY STKRPSYRAE QYPGSPDSWV
Length:1,190
Mass (Da):131,551
Last modified:October 11, 2004 - v1
Checksum:iDB6548B5EBE72CFE
GO
Isoform 2 (identifier: Q68FH0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1042-1084: Missing.

Show »
Length:1,147
Mass (Da):126,783
Checksum:iDEC21F1C1F960B7A
GO
Isoform 3 (identifier: Q68FH0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-341: Missing.
     637-637: V → G
     638-1190: Missing.

Show »
Length:296
Mass (Da):33,263
Checksum:iD0630AA63A0911E8
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AS45A2AS45_MOUSE
Plakophilin-4
Pkp4
1,163Annotation score:
A2AS44A2AS44_MOUSE
Plakophilin-4
Pkp4
803Annotation score:
A2AS47A2AS47_MOUSE
Plakophilin-4
Pkp4
849Annotation score:
V9GXG7V9GXG7_MOUSE
Plakophilin-4
Pkp4
215Annotation score:
V9GWY7V9GWY7_MOUSE
Plakophilin-4
Pkp4
46Annotation score:

Sequence cautioni

The sequence BAC37187 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti328S → F in AAH78638 (PubMed:15489334).Curated1
Sequence conflicti877V → A in BAC36708 (PubMed:16141072).Curated1
Sequence conflicti1118D → G in BAC36708 (PubMed:16141072).Curated1
Sequence conflicti1161K → R in BAB32313 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0123741 – 341Missing in isoform 3. 1 PublicationAdd BLAST341
Alternative sequenceiVSP_012375637V → G in isoform 3. 1 Publication1
Alternative sequenceiVSP_012376638 – 1190Missing in isoform 3. 1 PublicationAdd BLAST553
Alternative sequenceiVSP_0123771042 – 1084Missing in isoform 2. 1 PublicationAdd BLAST43

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL845536 Genomic DNA No translation available.
BC078638 mRNA Translation: AAH78638.1
BC079848 mRNA Translation: AAH79848.1
BC082578 mRNA Translation: AAH82578.1
AK021168 mRNA Translation: BAB32313.1
AK077250 mRNA Translation: BAC36708.1
AK078240 mRNA Translation: BAC37187.1 Different initiation.
CCDSiCCDS16052.1 [Q68FH0-1]
CCDS50588.1 [Q68FH0-2]
RefSeqiNP_080637.1, NM_026361.2 [Q68FH0-1]
NP_780673.2, NM_175464.2 [Q68FH0-2]
XP_006499234.1, XM_006499171.3 [Q68FH0-1]
UniGeneiMm.260938

Genome annotation databases

EnsembliENSMUST00000102754; ENSMUSP00000099815; ENSMUSG00000026991 [Q68FH0-1]
ENSMUST00000168631; ENSMUSP00000129836; ENSMUSG00000026991 [Q68FH0-2]
GeneIDi227937
KEGGimmu:227937
UCSCiuc008jtb.1 mouse [Q68FH0-1]
uc008jtd.1 mouse [Q68FH0-2]
uc008jtg.1 mouse [Q68FH0-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL845536 Genomic DNA No translation available.
BC078638 mRNA Translation: AAH78638.1
BC079848 mRNA Translation: AAH79848.1
BC082578 mRNA Translation: AAH82578.1
AK021168 mRNA Translation: BAB32313.1
AK077250 mRNA Translation: BAC36708.1
AK078240 mRNA Translation: BAC37187.1 Different initiation.
CCDSiCCDS16052.1 [Q68FH0-1]
CCDS50588.1 [Q68FH0-2]
RefSeqiNP_080637.1, NM_026361.2 [Q68FH0-1]
NP_780673.2, NM_175464.2 [Q68FH0-2]
XP_006499234.1, XM_006499171.3 [Q68FH0-1]
UniGeneiMm.260938

3D structure databases

ProteinModelPortaliQ68FH0
SMRiQ68FH0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230696, 6 interactors
IntActiQ68FH0, 3 interactors
STRINGi10090.ENSMUSP00000099815

PTM databases

iPTMnetiQ68FH0
PhosphoSitePlusiQ68FH0
SwissPalmiQ68FH0

Proteomic databases

PaxDbiQ68FH0
PeptideAtlasiQ68FH0
PRIDEiQ68FH0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102754; ENSMUSP00000099815; ENSMUSG00000026991 [Q68FH0-1]
ENSMUST00000168631; ENSMUSP00000129836; ENSMUSG00000026991 [Q68FH0-2]
GeneIDi227937
KEGGimmu:227937
UCSCiuc008jtb.1 mouse [Q68FH0-1]
uc008jtd.1 mouse [Q68FH0-2]
uc008jtg.1 mouse [Q68FH0-3]

Organism-specific databases

CTDi8502
MGIiMGI:109281 Pkp4

Phylogenomic databases

eggNOGiKOG1048 Eukaryota
ENOG410Y21Q LUCA
GeneTreeiENSGT00760000119167
HOVERGENiHBG004284
InParanoidiQ68FH0
OrthoDBiEOG091G00SB
PhylomeDBiQ68FH0
TreeFamiTF321877

Enzyme and pathway databases

ReactomeiR-MMU-6805567 Keratinization
R-MMU-6809371 Formation of the cornified envelope

Miscellaneous databases

ChiTaRSiPkp4 mouse
PROiPR:Q68FH0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026991 Expressed in 289 organ(s), highest expression level in ciliary body
CleanExiMM_PKP4
ExpressionAtlasiQ68FH0 baseline and differential
GenevisibleiQ68FH0 MM

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR028443 Plakophilin-4
IPR028435 Plakophilin/d_Catenin
PANTHERiPTHR10372 PTHR10372, 1 hit
PTHR10372:SF8 PTHR10372:SF8, 1 hit
PfamiView protein in Pfam
PF00514 Arm, 3 hits
SMARTiView protein in SMART
SM00185 ARM, 7 hits
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50176 ARM_REPEAT, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPKP4_MOUSE
AccessioniPrimary (citable) accession number: Q68FH0
Secondary accession number(s): A2AS46
, Q640N0, Q68G56, Q8BK47, Q8BVH1, Q9CRE3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: October 11, 2004
Last modified: November 7, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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