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Protein

Spectrin beta chain

Gene

Sptbn2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin cappingUniRule annotation, Actin-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-MMU-2132295 MHC class II antigen presentation
R-MMU-375165 NCAM signaling for neurite out-growth
R-MMU-445095 Interaction between L1 and Ankyrins
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-6807878 COPI-mediated anterograde transport

Names & Taxonomyi

Protein namesi
Recommended name:
Spectrin beta chainUniRule annotation
Gene namesi
Name:Sptbn2Imported
Synonyms:Spnb3Imported
ORF Names:mCG_8401Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1313261 Sptbn2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, CytoskeletonUniRule annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000067889 Expressed in 218 organ(s), highest expression level in CA1 field of hippocampus

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ68FG2, 14 interactors
Q68FG2, 14 interactors
STRINGi10090.ENSMUSP00000008991

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 161Calponin-homology (CH)InterPro annotationAdd BLAST105
Domaini176 – 281Calponin-homology (CH)InterPro annotationAdd BLAST106
Domaini2218 – 2328PHInterPro annotationAdd BLAST111

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili116 – 136Sequence analysisAdd BLAST21
Coiled coili715 – 742Sequence analysisAdd BLAST28
Coiled coili994 – 1021Sequence analysisAdd BLAST28
Coiled coili1100 – 1127Sequence analysisAdd BLAST28
Coiled coili1246 – 1266Sequence analysisAdd BLAST21
Coiled coili1425 – 1452Sequence analysisAdd BLAST28
Coiled coili1849 – 1869Sequence analysisAdd BLAST21
Coiled coili1981 – 2001Sequence analysisAdd BLAST21
Coiled coili2072 – 2095Sequence analysisAdd BLAST24

Sequence similaritiesi

Belongs to the spectrin family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation

Phylogenomic databases

eggNOGiKOG0035 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00760000118813
HOVERGENiHBG057912
KOiK06115
OMAiKQLNHRW
OrthoDBiEOG091G003V
TreeFamiTF313446

Family and domain databases

CDDicd00014 CH, 2 hits
Gene3Di1.10.418.10, 2 hits
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR011993 PH-like_dom_sf
IPR001605 PH_dom-spectrin-type
IPR001849 PH_domain
IPR018159 Spectrin/alpha-actinin
IPR016343 Spectrin_bsu
IPR002017 Spectrin_repeat
PfamiView protein in Pfam
PF00307 CH, 2 hits
PF00435 Spectrin, 17 hits
PIRSFiPIRSF002297 Spectrin_beta_subunit, 1 hit
PRINTSiPR00683 SPECTRINPH
SMARTiView protein in SMART
SM00033 CH, 2 hits
SM00233 PH, 1 hit
SM00150 SPEC, 17 hits
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS50003 PH_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q68FG2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSTLSPTDF DSLEIQGQYS DINNRWDLPD SDWDNDSSSA RLFERSRIKA
60 70 80 90 100
LADEREAVQK KTFTKWVNSH LARVTCRVGD LYSDLRDGRN LLRLLEVLSG
110 120 130 140 150
ETLPKPTKGR MRIHCLENVD KALQFLKEQK VHLENMGSHD IVDGNHRLTL
160 170 180 190 200
GLVWTIILRF QIQDISVETE DNKEKKSAKD ALLLWCQMKT AGYPNVNVHN
210 220 230 240 250
FTTSWRDGLA FNAIVHKHRP DLLDFESLKK CNAHYNLQNA FNLAEKELGL
260 270 280 290 300
TKLLDPEDVN VDQPDEKSII TYVATYYHYF SKMKALAVEG KRIGKVLDHA
310 320 330 340 350
MEAEHLVEKY ESLASELLQW IEQTIVTLND RQLANSLSGV QNQLQSFNSY
360 370 380 390 400
RTVEKPPKFT EKGNLEVLLF TIQSKLRANN QKVYTPREGR LISDINKAWE
410 420 430 440 450
RLEKAEHERE LALRTELIRQ EKLEQLAARF DRKAAMRETW LSENQRLVSQ
460 470 480 490 500
DNFGLELAAV EAAVRKHEAI ETDIVAYSGR VQAVDAVAAE LAAEHYHDIK
510 520 530 540 550
RIAARQNNVA RLWDFLRQMV AARRERLLLN LELQKVFQDL LYLMDWMAEM
560 570 580 590 600
KGRLQSQDLG KHLAGVEDLL QLHELVEADI AVQAERVRAV SASALRFCDP
610 620 630 640 650
GKEYRPCDPQ LVSERVATLE QSYEALCELA ATRRARLEES RRLWRFLWEV
660 670 680 690 700
GEAEAWVREQ QHLLASADTG RDLTGVLRLL NKHAALRGEM SGRLGPLKLT
710 720 730 740 750
LEQGQQLVAE GHPGANQAST RAAELQAQWE RLEALAEERA QQLAQAASLY
760 770 780 790 800
QFQADANDME AWLVDALRLV SSPEVGHDEF STQALARQHR ALEEEIRAHR
810 820 830 840 850
PTLDALREQA AALPPALSHT PEVQGRVPTL EQHYEELQAR AGERARALEA
860 870 880 890 900
ALAFYTMLSE AGACGLWVEE KEQWLNGLAL PERLEDLEVV QQRFETLEPE
910 920 930 940 950
MNALAARVTA VNDIAEQLLK ASPPGKDRII GTQEQLNQRW QQFRSLADGK
960 970 980 990 1000
KAALTSALSI QNYHLECTET QAWMREKTKV IESTQGLGND LAGVLALQRK
1010 1020 1030 1040 1050
LAGTERDLEA ISARVGELTQ EANALAAGHP AQAPAINTRL GEVQAGWEDL
1060 1070 1080 1090 1100
RATMRRREES LGEARRLQDF LRSLDDFQAW LGRTQTAVAS EEGPATLPEA
1110 1120 1130 1140 1150
EALLAQHAAL RGEVERAQSE YSRLRTLGEE VTRDQADPQC LFLRQRLEAL
1160 1170 1180 1190 1200
GTGWEELGRM WESRQGRLAQ AHGFQGFLRD ARQAEGVLSS QEYVLSHTEM
1210 1220 1230 1240 1250
PGTLQAADAA IKKLEDFMST MDANGERIRG LLEAGRQLVS KGNIHAEKIQ
1260 1270 1280 1290 1300
EKADSIEKRH RKNQEAVQQL LGRLRDNREQ QHFLQDCQEL RLWIDEKMLT
1310 1320 1330 1340 1350
AQDVSYDEAR NLHTKWQKHQ AFMAELAANK DWLDKVDKEG RELTLEKPEL
1360 1370 1380 1390 1400
KVVVSEKLED LHRRWDELET TTQAKARSLF DANRAELFAQ SCSALESWLE
1410 1420 1430 1440 1450
SLQAQLHSDD YGKDLTSVNI LLKKQQMLER EMAVREKEVE AIQAQAQALA
1460 1470 1480 1490 1500
QEDQSAGEVE RTSRAVEEKF RALCQPMKER CRRLHASREQ HQFHRDVEDE
1510 1520 1530 1540 1550
ILWVTERLPM ASSLEHGKDL PSVQLLMKKN QTLQKEIQGH EPRIADLKER
1560 1570 1580 1590 1600
QRTLGTAAAG PELAELQEMW KRLSHELELR GKRLEEALRA QQFYRDAAEA
1610 1620 1630 1640 1650
EAWMGEQELH MMGQEKAKDE LSAQAEVKKH QVLEQALADY AQTIKQLAAS
1660 1670 1680 1690 1700
SQDMIDHEHP ESTRLTIRQA QVDKLYASLK ELAGERRERL QEHLRLCQLR
1710 1720 1730 1740 1750
RELDDLEQWI QEREVVAASH ELGQDYEHVT MLRDKFREFS KDTSTIGQER
1760 1770 1780 1790 1800
VDSANALANG LIAGGHAARA TVAEWKDSLN EAWADLLELL DTRGQVLAAA
1810 1820 1830 1840 1850
YELQRFLHGA RQALARVQHK QQQLPDGTGR DLNAAEALQR RHCAYEHDIQ
1860 1870 1880 1890 1900
ALSTQVQQVQ DDGQRLQKAY AGDKAEEIGR HMQAVAEAWA QLQGSSAARR
1910 1920 1930 1940 1950
QLLLDTTDKF RFFKAVRELM LWMDGINLQM DAQERPRDVS SADLVIKNQQ
1960 1970 1980 1990 2000
GIKAEIEARA DRFSSCIDMG QELLARSHYA AEEISEKLSQ LQSRRQETAD
2010 2020 2030 2040 2050
KWQEKMDWLQ LVLEVLVFGR DAGMAEAWLC SQEPLVRSAE LGCTVDEVES
2060 2070 2080 2090 2100
LIKRHEAFQK SAVAWEERFS ALEKLTALEE RENERKRKRE EEERRKQPPT
2110 2120 2130 2140 2150
SEPMASQPEG SLVDGQRVPD TAWDGTQSKL PPSTQAPSVN GVCTDTDSSQ
2160 2170 2180 2190 2200
PLLEQQRLEQ SNVPEGPGSG TGDESSGPRG ERQTLPRGPA PSPMPQSRSS
2210 2220 2230 2240 2250
EAAHGATLPT RGPELSAQEQ MEGMLCRKQE MEAFNKKAAN RSWQNVYCVL
2260 2270 2280 2290 2300
RRGSLGFYKD ARAASAGVPY HGEVPVSLAR AQGSVAFDYR KRKHVFKLGL
2310 2320 2330 2340 2350
QDGKEYLFQA KDEAEMSSWL RVVNAAIATA SSAPGESEEP VVPSASRGLT
2360 2370 2380
RAMTMPPVSQ PEGSIVLRSK DGREREREKR FSFFKKNK
Length:2,388
Mass (Da):270,923
Last modified:October 11, 2004 - v1
Checksum:i19DA7460B75576D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC147618 Genomic DNA No translation available.
BC079860 mRNA Translation: AAH79860.1
CH466612 Genomic DNA Translation: EDL33059.1
RefSeqiNP_067262.1, NM_021287.1
XP_006531767.1, XM_006531704.3
XP_006531768.1, XM_006531705.3
UniGeneiMm.329668
Mm.387591

Genome annotation databases

EnsembliENSMUST00000008991; ENSMUSP00000008991; ENSMUSG00000067889
GeneIDi20743
KEGGimmu:20743
UCSCiuc008gan.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC147618 Genomic DNA No translation available.
BC079860 mRNA Translation: AAH79860.1
CH466612 Genomic DNA Translation: EDL33059.1
RefSeqiNP_067262.1, NM_021287.1
XP_006531767.1, XM_006531704.3
XP_006531768.1, XM_006531705.3
UniGeneiMm.329668
Mm.387591

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ68FG2, 14 interactors
Q68FG2, 14 interactors
STRINGi10090.ENSMUSP00000008991

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000008991; ENSMUSP00000008991; ENSMUSG00000067889
GeneIDi20743
KEGGimmu:20743
UCSCiuc008gan.1 mouse

Organism-specific databases

CTDi6712
MGIiMGI:1313261 Sptbn2

Phylogenomic databases

eggNOGiKOG0035 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00760000118813
HOVERGENiHBG057912
KOiK06115
OMAiKQLNHRW
OrthoDBiEOG091G003V
TreeFamiTF313446

Enzyme and pathway databases

ReactomeiR-MMU-2132295 MHC class II antigen presentation
R-MMU-375165 NCAM signaling for neurite out-growth
R-MMU-445095 Interaction between L1 and Ankyrins
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-6807878 COPI-mediated anterograde transport

Miscellaneous databases

ChiTaRSiSptbn2 mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000067889 Expressed in 218 organ(s), highest expression level in CA1 field of hippocampus

Family and domain databases

CDDicd00014 CH, 2 hits
Gene3Di1.10.418.10, 2 hits
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR011993 PH-like_dom_sf
IPR001605 PH_dom-spectrin-type
IPR001849 PH_domain
IPR018159 Spectrin/alpha-actinin
IPR016343 Spectrin_bsu
IPR002017 Spectrin_repeat
PfamiView protein in Pfam
PF00307 CH, 2 hits
PF00435 Spectrin, 17 hits
PIRSFiPIRSF002297 Spectrin_beta_subunit, 1 hit
PRINTSiPR00683 SPECTRINPH
SMARTiView protein in SMART
SM00033 CH, 2 hits
SM00233 PH, 1 hit
SM00150 SPEC, 17 hits
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS50003 PH_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ68FG2_MOUSE
AccessioniPrimary (citable) accession number: Q68FG2
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2004
Last sequence update: October 11, 2004
Last modified: November 7, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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