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UniProtKB - Q68FF9 (S5A1_MOUSE)
Protein
3-oxo-5-alpha-steroid 4-dehydrogenase 1
Gene
Srd5a1
Organism
Mus musculus (Mouse)
Status
Functioni
Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
By similarityCatalytic activityi
- EC:1.3.1.22By similarityThis reaction proceeds in the backwardBy similarity direction.
- EC:1.3.1.22By similarityThis reaction proceeds in the backwardBy similarity direction.
- EC:1.3.1.22By similarityThis reaction proceeds in the backwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
GO - Molecular functioni
- 3-oxo-5-alpha-steroid 4-dehydrogenase activity Source: MGI
- amide binding Source: MGI
- cholestenone 5-alpha-reductase activity Source: UniProtKB-EC
- NADPH binding Source: MGI
- oxidoreductase activity Source: GO_Central
- progesterone 5-alpha-reductase activity Source: RHEA
GO - Biological processi
- androgen biosynthetic process Source: MGI
- androgen catabolic process Source: MGI
- androgen metabolic process Source: MGI
- cell differentiation Source: UniProtKB-KW
- progesterone metabolic process Source: MGI
- response to xenobiotic stimulus Source: MGI
- sex differentiation Source: UniProtKB-KW
- steroid biosynthetic process Source: MGI
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Differentiation, Lipid metabolism, Sexual differentiation |
Ligand | NADP |
Enzyme and pathway databases
Reactomei | R-MMU-193048, Androgen biosynthesis |
Names & Taxonomyi
Protein namesi | Recommended name: 3-oxo-5-alpha-steroid 4-dehydrogenase 1Curated (EC:1.3.1.22By similarity)Alternative name(s): SR type 1 Steroid 5-alpha-reductase 1 Short name: S5AR 1 |
Gene namesi | Name:Srd5a1Imported |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:98400, Srd5a1 |
Subcellular locationi
Endoplasmic reticulum
- Microsome membrane By similarity; Multi-pass membrane protein By similarity
- Endoplasmic reticulum membrane Curated; Multi-pass membrane protein Curated
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Other locations
- cell body fiber Source: MGI
- cytoplasm Source: MGI
- integral component of membrane Source: UniProtKB-KW
- intracellular membrane-bounded organelle Source: MGI
- myelin sheath Source: MGI
- neuronal cell body Source: MGI
- perinuclear region of cytoplasm Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 6 – 26 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 82 – 102 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 107 – 127 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 142 – 162 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 205 – 225 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, MicrosomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000317711 | 1 – 255 | 3-oxo-5-alpha-steroid 4-dehydrogenase 1Add BLAST | 255 |
Proteomic databases
jPOSTi | Q68FF9 |
MaxQBi | Q68FF9 |
PaxDbi | Q68FF9 |
PRIDEi | Q68FF9 |
ProteomicsDBi | 260801 |
PTM databases
iPTMneti | Q68FF9 |
PhosphoSitePlusi | Q68FF9 |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000089097 |
Miscellaneous databases
RNActi | Q68FF9, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the steroid 5-alpha reductase family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1638, Eukaryota |
InParanoidi | Q68FF9 |
OrthoDBi | 1574389at2759 |
PhylomeDBi | Q68FF9 |
TreeFami | TF314668 |
Family and domain databases
InterProi | View protein in InterPro IPR016636, 3-oxo-5-alpha-steroid_4-DH IPR001104, 3-oxo-5_a-steroid_4-DH_C IPR039357, SRD5A/TECR |
PANTHERi | PTHR10556, PTHR10556, 1 hit |
Pfami | View protein in Pfam PF02544, Steroid_dh, 1 hit |
PIRSFi | PIRSF015596, 5_alpha-SR2, 1 hit |
PROSITEi | View protein in PROSITE PS50244, S5A_REDUCTASE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q68FF9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MELDELCLLD ALVYLEGFLA FVAFVGLQMV GSSYGRYSSQ WSGRRVPARP
60 70 80 90 100
AWFLQELPSM AWPLYECIRP AAARLGNLPN RVLLAMFLIH YVQRTLVFPV
110 120 130 140 150
LIRGGKPTLL FTFVLAFLFC TLNGYLQSRY LSQFAVYAED WVTHPCFLTG
160 170 180 190 200
FALWLVGMVI NIHSDHILRN LRKPGETGYK IPRGGLFEYV SSANYFGELV
210 220 230 240 250
EWCGFALASW SLQGVVFALF TLCALFTRAR QHHQWYLEKF EDYPKTRKIL
IPFLL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0R4J136 | A0A0R4J136_MOUSE | 3-oxo-5-alpha-steroid 4-dehydrogena... | Srd5a1 | 255 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 7 | C → R in AAH79863 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 142 | V → I in AAH94503 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 176 | E → D in AAH94503 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC079863 mRNA Translation: AAH79863.1 BC094503 mRNA Translation: AAH94503.1 |
CCDSi | CCDS26624.1 |
RefSeqi | NP_780492.2, NM_175283.3 |
Genome annotation databases
GeneIDi | 78925 |
KEGGi | mmu:78925 |
UCSCi | uc007rck.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC079863 mRNA Translation: AAH79863.1 BC094503 mRNA Translation: AAH94503.1 |
CCDSi | CCDS26624.1 |
RefSeqi | NP_780492.2, NM_175283.3 |
3D structure databases
AlphaFoldDBi | Q68FF9 |
SMRi | Q68FF9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000089097 |
PTM databases
iPTMneti | Q68FF9 |
PhosphoSitePlusi | Q68FF9 |
Proteomic databases
jPOSTi | Q68FF9 |
MaxQBi | Q68FF9 |
PaxDbi | Q68FF9 |
PRIDEi | Q68FF9 |
ProteomicsDBi | 260801 |
Protocols and materials databases
DNASUi | 78925 |
Genome annotation databases
GeneIDi | 78925 |
KEGGi | mmu:78925 |
UCSCi | uc007rck.1, mouse |
Organism-specific databases
CTDi | 6715 |
MGIi | MGI:98400, Srd5a1 |
Phylogenomic databases
eggNOGi | KOG1638, Eukaryota |
InParanoidi | Q68FF9 |
OrthoDBi | 1574389at2759 |
PhylomeDBi | Q68FF9 |
TreeFami | TF314668 |
Enzyme and pathway databases
Reactomei | R-MMU-193048, Androgen biosynthesis |
Miscellaneous databases
BioGRID-ORCSi | 78925, 0 hits in 75 CRISPR screens |
ChiTaRSi | Srd5a1, mouse |
PROi | PR:Q68FF9 |
RNActi | Q68FF9, protein |
SOURCEi | Search... |
Family and domain databases
InterProi | View protein in InterPro IPR016636, 3-oxo-5-alpha-steroid_4-DH IPR001104, 3-oxo-5_a-steroid_4-DH_C IPR039357, SRD5A/TECR |
PANTHERi | PTHR10556, PTHR10556, 1 hit |
Pfami | View protein in Pfam PF02544, Steroid_dh, 1 hit |
PIRSFi | PIRSF015596, 5_alpha-SR2, 1 hit |
PROSITEi | View protein in PROSITE PS50244, S5A_REDUCTASE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | S5A1_MOUSE | |
Accessioni | Q68FF9Primary (citable) accession number: Q68FF9 Secondary accession number(s): Q505K7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | February 5, 2008 | |
Last modified: | May 25, 2022 | |
This is version 112 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families