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Protein

3-oxo-5-alpha-steroid 4-dehydrogenase 1

Gene

Srd5a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology (By similarity).By similarity

Catalytic activityi

A 3-oxo-5-alpha-steroid + NADP+ = a 3-oxo-Delta4-steroid + NADPH.

GO - Molecular functioni

  • 3-oxo-5-alpha-steroid 4-dehydrogenase activity Source: MGI
  • amide binding Source: MGI
  • cholestenone 5-alpha-reductase activity Source: UniProtKB-EC
  • NADPH binding Source: MGI
  • oxidoreductase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processDifferentiation, Sexual differentiation
LigandNADP

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (EC:1.3.1.22)
Alternative name(s):
SR type 1
Steroid 5-alpha-reductase 1
Short name:
S5AR 1
Gene namesi
Name:Srd5a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:98400 Srd5a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 26HelicalSequence analysisAdd BLAST21
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Transmembranei107 – 127HelicalSequence analysisAdd BLAST21
Transmembranei142 – 162HelicalSequence analysisAdd BLAST21
Transmembranei205 – 225HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003177111 – 2553-oxo-5-alpha-steroid 4-dehydrogenase 1Add BLAST255

Proteomic databases

MaxQBiQ68FF9
PaxDbiQ68FF9
PRIDEiQ68FF9

PTM databases

iPTMnetiQ68FF9
PhosphoSitePlusiQ68FF9

Expressioni

Gene expression databases

CleanExiMM_SRD5A1

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000089097

Structurei

3D structure databases

ProteinModelPortaliQ68FF9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the steroid 5-alpha reductase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1638 Eukaryota
ENOG410XS6P LUCA
HOGENOMiHOG000050133
HOVERGENiHBG003402
InParanoidiQ68FF9
KOiK12343
PhylomeDBiQ68FF9
TreeFamiTF314668

Family and domain databases

InterProiView protein in InterPro
IPR016636 3-oxo-5-alpha-steroid_4-DH
IPR001104 3-oxo-5_a-steroid_4-DH_C
IPR039357 SRD5A/TECR
PANTHERiPTHR10556 PTHR10556, 1 hit
PfamiView protein in Pfam
PF02544 Steroid_dh, 1 hit
PIRSFiPIRSF015596 5_alpha-SR2, 1 hit
PROSITEiView protein in PROSITE
PS50244 S5A_REDUCTASE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q68FF9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELDELCLLD ALVYLEGFLA FVAFVGLQMV GSSYGRYSSQ WSGRRVPARP
60 70 80 90 100
AWFLQELPSM AWPLYECIRP AAARLGNLPN RVLLAMFLIH YVQRTLVFPV
110 120 130 140 150
LIRGGKPTLL FTFVLAFLFC TLNGYLQSRY LSQFAVYAED WVTHPCFLTG
160 170 180 190 200
FALWLVGMVI NIHSDHILRN LRKPGETGYK IPRGGLFEYV SSANYFGELV
210 220 230 240 250
EWCGFALASW SLQGVVFALF TLCALFTRAR QHHQWYLEKF EDYPKTRKIL

IPFLL
Length:255
Mass (Da):29,344
Last modified:February 5, 2008 - v2
Checksum:i80A5624B25D46D1A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J136A0A0R4J136_MOUSE
3-oxo-5-alpha-steroid 4-dehydrogena...
Srd5a1
255Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7C → R in AAH79863 (PubMed:15489334).Curated1
Sequence conflicti142V → I in AAH94503 (PubMed:15489334).Curated1
Sequence conflicti176E → D in AAH94503 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079863 mRNA Translation: AAH79863.1
BC094503 mRNA Translation: AAH94503.1
CCDSiCCDS26624.1
RefSeqiNP_780492.2, NM_175283.3
UniGeneiMm.451912
Mm.483181

Genome annotation databases

GeneIDi78925
KEGGimmu:78925
UCSCiuc007rck.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079863 mRNA Translation: AAH79863.1
BC094503 mRNA Translation: AAH94503.1
CCDSiCCDS26624.1
RefSeqiNP_780492.2, NM_175283.3
UniGeneiMm.451912
Mm.483181

3D structure databases

ProteinModelPortaliQ68FF9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000089097

PTM databases

iPTMnetiQ68FF9
PhosphoSitePlusiQ68FF9

Proteomic databases

MaxQBiQ68FF9
PaxDbiQ68FF9
PRIDEiQ68FF9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi78925
KEGGimmu:78925
UCSCiuc007rck.1 mouse

Organism-specific databases

CTDi6715
MGIiMGI:98400 Srd5a1

Phylogenomic databases

eggNOGiKOG1638 Eukaryota
ENOG410XS6P LUCA
HOGENOMiHOG000050133
HOVERGENiHBG003402
InParanoidiQ68FF9
KOiK12343
PhylomeDBiQ68FF9
TreeFamiTF314668

Miscellaneous databases

ChiTaRSiSrd5a1 mouse
PROiPR:Q68FF9
SOURCEiSearch...

Gene expression databases

CleanExiMM_SRD5A1

Family and domain databases

InterProiView protein in InterPro
IPR016636 3-oxo-5-alpha-steroid_4-DH
IPR001104 3-oxo-5_a-steroid_4-DH_C
IPR039357 SRD5A/TECR
PANTHERiPTHR10556 PTHR10556, 1 hit
PfamiView protein in Pfam
PF02544 Steroid_dh, 1 hit
PIRSFiPIRSF015596 5_alpha-SR2, 1 hit
PROSITEiView protein in PROSITE
PS50244 S5A_REDUCTASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS5A1_MOUSE
AccessioniPrimary (citable) accession number: Q68FF9
Secondary accession number(s): Q505K7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: November 7, 2018
This is version 98 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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