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Protein

Teashirt homolog 2

Gene

Tshz2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential).Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri216 – 240C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri276 – 300C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri381 – 405C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST25
DNA bindingi837 – 907HomeoboxAdd BLAST71
Zinc fingeri922 – 944C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri990 – 1013C2H2-type 5PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Teashirt homolog 2
Alternative name(s):
SDCCAG33-like protein
Zinc finger protein 218
Gene namesi
Name:Tshz2
Synonyms:Kiaa4248, Sdccag33l, Tsh2, Zfp218, Znf218
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2153084 Tshz2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000470651 – 1030Teashirt homolog 2Add BLAST1030

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki189Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki307Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki316Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki418Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki462Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki480Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki497Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki601Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki652Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki796Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki816Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki962Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei976PhosphoserineCombined sources1

Post-translational modificationi

Sumoylated.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ68FE9
PaxDbiQ68FE9
PRIDEiQ68FE9

PTM databases

iPTMnetiQ68FE9
PhosphoSitePlusiQ68FE9

Expressioni

Developmental stagei

Expressed in mesenchymal cells in proximal ureters at 14 dpc, preceding the smooth muscle precursor cells differentiation and the expression of contractile proteins from 15 dpc.1 Publication

Gene expression databases

BgeeiENSMUSG00000047907 Expressed in 231 organ(s), highest expression level in olfactory epithelium
CleanExiMM_TSHZ2
ExpressionAtlasiQ68FE9 baseline and differential
GenevisibleiQ68FE9 MM

Interactioni

Subunit structurei

Interacts (via homeobox domain) with APBB1 (via PID domain 1).1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104785

Structurei

3D structure databases

ProteinModelPortaliQ68FE9
SMRiQ68FE9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili11 – 42Sequence analysisAdd BLAST32

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri216 – 240C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri276 – 300C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri381 – 405C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST25
Zinc fingeri922 – 944C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri990 – 1013C2H2-type 5PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Coiled coil, Homeobox, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IJ7P Eukaryota
ENOG4110HP7 LUCA
GeneTreeiENSGT00390000014977
HOGENOMiHOG000231480
HOVERGENiHBG079626
InParanoidiQ68FE9
KOiK09236
OMAiYQLRKTG
OrthoDBiEOG091G01GX
PhylomeDBiQ68FE9
TreeFamiTF328447

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR001356 Homeobox_dom
IPR027008 Teashirt_fam
IPR027010 Tshz2
IPR013087 Znf_C2H2_type
PANTHERiPTHR12487 PTHR12487, 1 hit
PTHR12487:SF3 PTHR12487:SF3, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00355 ZnF_C2H2, 5 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q68FE9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRRKQQAPK RAAGYAQEEV LKEEEEIKEE EEEEEDSGSV AQHQSSNDTG
60 70 80 90 100
TDEELETGPE QKGYFSCQNS PGSHLSNQDA ENESLLSDAS DQVSDVKSVC
110 120 130 140 150
GRDVSDKKAN THPKLPSEPH NCMDKMTAVY ANILSDSYWS GLGLGFKLSN
160 170 180 190 200
SERRNCDTRN SSGKNDFDWH QDALSKSLQQ NLPSRSVSKP SLFSSVQLYR
210 220 230 240 250
QSSKLCGSVF TGASRFRCRQ CSAAYDTLVE LTVHMNETGH YQDDNRKKDK
260 270 280 290 300
LRPTSYSKPR KRAFQDMDKE DAQKVLKCMF CGDSFDSLQD LSVHMIKTKH
310 320 330 340 350
YQKVPLKEPV PTISSKMVTP AKKRVFDVNR PCSPDSTTGS LADSFSSQKS
360 370 380 390 400
ANLQLPSNSR YGYQNGASYT WQFEACKSQI LKCMECGSSH DTLQQLTTHM
410 420 430 440 450
MVTGHFLKVT SSASKKGKQL VLDPLAVEKM QSLSETPNSE SLAPKPSSNS
460 470 480 490 500
PSECTASTTE LKKESKKEKG EGIEDEQGVK SEDYEDSLQK PLDPTIKYQY
510 520 530 540 550
LREEDLEDGS KGGGDILKSL ENTVTTAINK AQNGAPSWSA YPSIHAAYQL
560 570 580 590 600
SEGTKPPMAM GSQILQIRPN LANKLRPIAP KWKGMPLGPV PTSLALYTQV
610 620 630 640 650
KKETEDKDEV VKQCGKESPH EEATSFSQPE GESFSKIEPP SESRKAEPCP
660 670 680 690 700
LKEEEKPQKE KPEPLEPVSS LTNGCAPANH TPALPSINPL SALQSVLNNH
710 720 730 740 750
LGKATEPLRS PSCSSPNSST SPVFHKSSLH VVDKPVISPT STRPAASVAR
760 770 780 790 800
HYLFENTDQP IDLTKSKSKR AESSQAQSCT SPPQKHALCD IADMVKVLPK
810 820 830 840 850
ATTPKPAASS RVPPMKLEID VRRFEDVSSE VSTLHKRKGR QSNWNPQHLL
860 870 880 890 900
ILQAQFASSL FQTSEGKYLL SDLGPQERMQ ISKFTGLSMT TISHWLANVK
910 920 930 940 950
YQLRKTGGTK FLKNMDKGHP IFYCSDCASQ FRTPSTYISH LESHLGFQMK
960 970 980 990 1000
DMTRMAADQQ SKVEQEISRV SSAQRSPETI AGEEDTDSKF KCKLCRRTFV
1010 1020 1030
SKHAVKLHLS KTHSKSPEHH SQFVADVDEE
Length:1,030
Mass (Da):114,223
Last modified:October 11, 2004 - v1
Checksum:i1F8075095AE4D60E
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8K350Q8K350_MOUSE
Teashirt homolog 2
Tshz2 Sdccag33l, Zfp218
208Annotation score:
A0A087WS38A0A087WS38_MOUSE
Teashirt homolog 2
Tshz2
522Annotation score:
A0A0A0MQI3A0A0A0MQI3_MOUSE
Teashirt homolog 2
Tshz2
561Annotation score:

Sequence cautioni

The sequence AAF64095 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAD90333 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti159 – 227Missing in AAH79550 (PubMed:15489334).CuratedAdd BLAST69
Sequence conflicti607K → R in AAF64095 (PubMed:10704881).Curated1
Sequence conflicti1012T → A in AAF64095 (PubMed:10704881).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079877 mRNA Translation: AAH79877.1
BC079550 mRNA Translation: AAH79550.1
AK220569 mRNA Translation: BAD90333.1 Different initiation.
AF207880 Genomic DNA Translation: AAF64095.1 Different initiation.
CCDSiCCDS50805.1
RefSeqiNP_536703.2, NM_080455.2
XP_011237817.1, XM_011239515.2
XP_017173455.1, XM_017317966.1
UniGeneiMm.315789
Mm.468546
Mm.482636

Genome annotation databases

EnsembliENSMUST00000109157; ENSMUSP00000104785; ENSMUSG00000047907
ENSMUST00000109159; ENSMUSP00000104787; ENSMUSG00000047907
GeneIDi228911
KEGGimmu:228911
UCSCiuc008obo.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079877 mRNA Translation: AAH79877.1
BC079550 mRNA Translation: AAH79550.1
AK220569 mRNA Translation: BAD90333.1 Different initiation.
AF207880 Genomic DNA Translation: AAF64095.1 Different initiation.
CCDSiCCDS50805.1
RefSeqiNP_536703.2, NM_080455.2
XP_011237817.1, XM_011239515.2
XP_017173455.1, XM_017317966.1
UniGeneiMm.315789
Mm.468546
Mm.482636

3D structure databases

ProteinModelPortaliQ68FE9
SMRiQ68FE9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104785

PTM databases

iPTMnetiQ68FE9
PhosphoSitePlusiQ68FE9

Proteomic databases

MaxQBiQ68FE9
PaxDbiQ68FE9
PRIDEiQ68FE9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000109157; ENSMUSP00000104785; ENSMUSG00000047907
ENSMUST00000109159; ENSMUSP00000104787; ENSMUSG00000047907
GeneIDi228911
KEGGimmu:228911
UCSCiuc008obo.2 mouse

Organism-specific databases

CTDi128553
MGIiMGI:2153084 Tshz2
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IJ7P Eukaryota
ENOG4110HP7 LUCA
GeneTreeiENSGT00390000014977
HOGENOMiHOG000231480
HOVERGENiHBG079626
InParanoidiQ68FE9
KOiK09236
OMAiYQLRKTG
OrthoDBiEOG091G01GX
PhylomeDBiQ68FE9
TreeFamiTF328447

Miscellaneous databases

ChiTaRSiTshz2 mouse
PROiPR:Q68FE9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000047907 Expressed in 231 organ(s), highest expression level in olfactory epithelium
CleanExiMM_TSHZ2
ExpressionAtlasiQ68FE9 baseline and differential
GenevisibleiQ68FE9 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR001356 Homeobox_dom
IPR027008 Teashirt_fam
IPR027010 Tshz2
IPR013087 Znf_C2H2_type
PANTHERiPTHR12487 PTHR12487, 1 hit
PTHR12487:SF3 PTHR12487:SF3, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00355 ZnF_C2H2, 5 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTSH2_MOUSE
AccessioniPrimary (citable) accession number: Q68FE9
Secondary accession number(s): Q5DTF1, Q6AXH5, Q9JL71
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: October 11, 2004
Last modified: September 12, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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