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UniProtKB - Q68FE8 (Z280D_MOUSE)
Protein
Zinc finger protein 280D
Gene
Znf280d
Organism
Mus musculus (Mouse)
Status
Functioni
May function as a transcription factor.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 333 – 355 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 370 – 393 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 400 – 424 | C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 430 – 453 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 459 – 481 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 280DAlternative name(s): Suppressor of hairy wing homolog 4 |
Gene namesi | Name:Znf280d Synonyms:Suhw4, Zfp280d |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2384583, Zfp280d |
VEuPathDBi | HostDB:ENSMUSG00000038535 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000227978 | 1 – 974 | Zinc finger protein 280DAdd BLAST | 974 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 44 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 46 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 86 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 99 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 138 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 201 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 222 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 245 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 287 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 304 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 557 | PhosphoserineBy similarity | 1 | |
Cross-linki | 752 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 904 | PhosphoserineCombined sources | 1 | |
Modified residuei | 907 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q68FE8 |
jPOSTi | Q68FE8 |
MaxQBi | Q68FE8 |
PaxDbi | Q68FE8 |
PeptideAtlasi | Q68FE8 |
PRIDEi | Q68FE8 |
ProteomicsDBi | 302096 [Q68FE8-2] 302097 [Q68FE8-3] |
PTM databases
iPTMneti | Q68FE8 |
PhosphoSitePlusi | Q68FE8 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000038535, Expressed in undifferentiated genital tubercle and 295 other tissues |
ExpressionAtlasi | Q68FE8, baseline and differential |
Genevisiblei | Q68FE8, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 231667, 4 interactors |
STRINGi | 10090.ENSMUSP00000096175 |
Miscellaneous databases
RNActi | Q68FE8, protein |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 188 – 216 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 507 – 624 | DisorderedSequence analysisAdd BLAST | 118 | |
Regioni | 751 – 797 | DisorderedSequence analysisAdd BLAST | 47 | |
Regioni | 815 – 974 | DisorderedSequence analysisAdd BLAST | 160 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 532 – 624 | Polar residuesSequence analysisAdd BLAST | 93 | |
Compositional biasi | 818 – 833 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 836 – 856 | Basic and acidic residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 857 – 885 | Polar residuesSequence analysisAdd BLAST | 29 | |
Compositional biasi | 935 – 956 | Polar residuesSequence analysisAdd BLAST | 22 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 333 – 355 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 370 – 393 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 400 – 424 | C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 430 – 453 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 459 – 481 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000158889 |
HOGENOMi | CLU_010097_1_0_1 |
InParanoidi | Q68FE8 |
OMAi | CDANAFE |
OrthoDBi | 105829at2759 |
PhylomeDBi | Q68FE8 |
TreeFami | TF331707 |
Family and domain databases
InterProi | View protein in InterPro IPR025243, DUF4195 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF13836, DUF4195, 1 hit |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 9 hits |
SUPFAMi | SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 5 hits PS50157, ZINC_FINGER_C2H2_2, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q68FE8-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVTTYIKSDL QLDGRQFFQP KDNLKMAELF MECEEEELEP WQKKVKEVEE
60 70 80 90 100
DDDDEPIFVA EIASSKPAIS NILNRVNPSS HSRGIKNGIL NRGFTASFKP
110 120 130 140 150
TSQRCLNSAS NPVAALPVNF HPESRSSDSS VIVQPFSKPG YVTNSPRVLS
160 170 180 190 200
NNSSELLFDL TQDTGLSHYQ GGPTLSIAGL NETSFLSKRP SGSDISSVNP
210 220 230 240 250
KKPKPSENTS GIDASSVISS EKSPSVISLQ VVPSQGANCS SSQSKNGTTF
260 270 280 290 300
PRACPKCDIH FNLLDPLKNH MTYCCPDMIN NFLGLTKADN LNSANEAKTL
310 320 330 340 350
ESEKGKLIML VNDFYYGKHE GDVLEEQKTH TTFKCFSCLK VLKNNIRFMN
360 370 380 390 400
HMKHHLELEK QSSESWEKHT TCQHCYRQFP TPFQLQCHIE STHTPHEFST
410 420 430 440 450
ICKICELSFE TEQILLQHMK DNHKPGEMPY ICQVCNYRSS LFSEVESHFR
460 470 480 490 500
TSHENTKNLL CPFCLKVIKI ATPYMHHYMK HQKKGIHRCT KCRLQFLTCK
510 520 530 540 550
EKMDHKTQHH RTFVKPKQLE GLPPGTKVTI RASVGPLQSG SSVTPSISPS
560 570 580 590 600
TSTLQLSPPE PDNVTAKNHV KLTTSTPNTT ISDPSKANET KSNGSKSKNK
610 620 630 640 650
SKVSNMQKKQ STLSSSNKKS KVNTALRNLR LRRGVHECIE CSSEVKDFAN
660 670 680 690 700
HFPTYVHCSF CRYNTSCSKA YVNHMMSFHS NRPSKRYCIF KKHSENLRGI
710 720 730 740 750
SLVCLNCDFL TDVSGLDNMA THLSQHETHS CRVLVEQVSV CIPTSERLSE
760 770 780 790 800
IKTEAPTKGQ EPVSKETARH SRAEGEPGAS HSGSKQDKVP SSEEGTGCDA
810 820 830 840 850
SVCEAAAATH CEKDVTVSDT ENVSSSKNIL SHDPDVGTDT MEKEEKTHHA
860 870 880 890 900
CQEMELKVDQ SSESTNPTEA ELSSETRQGL QLTSGDVGID QFLRQGDEPK
910 920 930 940 950
SVNSDASDPG SVRLEPLTPS EVLEYEATEI LHDGDDPSAN TSDTVSDQTG
960 970
GSPGGSNPCR AETAVDLADG EERS
Computationally mapped potential isoform sequencesi
There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketV9GWW1 | V9GWW1_MOUSE | Zinc finger protein 280D | Zfp280d | 949 | Annotation score: | ||
V9GXP2 | V9GXP2_MOUSE | Zinc finger protein 280D | Zfp280d | 799 | Annotation score: | ||
V9GXC9 | V9GXC9_MOUSE | Zinc finger protein 280D | Zfp280d | 529 | Annotation score: | ||
V9GX97 | V9GX97_MOUSE | Zinc finger protein 280D | Zfp280d | 180 | Annotation score: | ||
Q8R2V6 | Q8R2V6_MOUSE | Suhw4 protein | Zfp280d Suhw4 | 218 | Annotation score: | ||
V9GWV5 | V9GWV5_MOUSE | Zinc finger protein 280D | Zfp280d | 148 | Annotation score: | ||
V9GWZ2 | V9GWZ2_MOUSE | Zinc finger protein 280D | Zfp280d | 103 | Annotation score: | ||
V9GWT3 | V9GWT3_MOUSE | Zinc finger protein 280D | Zfp280d | 92 | Annotation score: | ||
V9GX57 | V9GX57_MOUSE | Zinc finger protein 280D | Zfp280d | 172 | Annotation score: | ||
V9GXF6 | V9GXF6_MOUSE | Zinc finger protein 280D | Zfp280d | 136 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_017629 | 1 – 270 | Missing in isoform 3. 1 PublicationAdd BLAST | 270 | |
Alternative sequenceiVSP_017630 | 751 – 787 | IKTEA…GSKQD → CRSSPEISKHVQGVPGQCPL RWTQVLPVLSFPGMRMN in isoform 2. 1 PublicationAdd BLAST | 37 | |
Alternative sequenceiVSP_017631 | 784 | S → R in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_017632 | 785 – 974 | Missing in isoform 3. 1 PublicationAdd BLAST | 190 | |
Alternative sequenceiVSP_017633 | 788 – 974 | Missing in isoform 2. 1 PublicationAdd BLAST | 187 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK045173 mRNA Translation: BAC32247.1 AK172652 mRNA Translation: BAE43113.1 BC079878 mRNA Translation: AAH79878.1 |
CCDSi | CCDS40683.1 [Q68FE8-1] |
RefSeqi | NP_001298034.1, NM_001311105.1 NP_666336.3, NM_146224.5 [Q68FE8-1] XP_006511183.1, XM_006511120.2 [Q68FE8-2] |
Genome annotation databases
Ensembli | ENSMUST00000098576; ENSMUSP00000096175; ENSMUSG00000038535 [Q68FE8-1] ENSMUST00000184517; ENSMUSP00000138970; ENSMUSG00000038535 [Q68FE8-2] |
GeneIDi | 235469 |
KEGGi | mmu:235469 |
UCSCi | uc009qpo.1, mouse [Q68FE8-2] uc009qpp.1, mouse [Q68FE8-3] uc009qpq.1, mouse [Q68FE8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK045173 mRNA Translation: BAC32247.1 AK172652 mRNA Translation: BAE43113.1 BC079878 mRNA Translation: AAH79878.1 |
CCDSi | CCDS40683.1 [Q68FE8-1] |
RefSeqi | NP_001298034.1, NM_001311105.1 NP_666336.3, NM_146224.5 [Q68FE8-1] XP_006511183.1, XM_006511120.2 [Q68FE8-2] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 231667, 4 interactors |
STRINGi | 10090.ENSMUSP00000096175 |
PTM databases
iPTMneti | Q68FE8 |
PhosphoSitePlusi | Q68FE8 |
Proteomic databases
EPDi | Q68FE8 |
jPOSTi | Q68FE8 |
MaxQBi | Q68FE8 |
PaxDbi | Q68FE8 |
PeptideAtlasi | Q68FE8 |
PRIDEi | Q68FE8 |
ProteomicsDBi | 302096 [Q68FE8-2] 302097 [Q68FE8-3] |
Protocols and materials databases
DNASUi | 235469 |
Genome annotation databases
Ensembli | ENSMUST00000098576; ENSMUSP00000096175; ENSMUSG00000038535 [Q68FE8-1] ENSMUST00000184517; ENSMUSP00000138970; ENSMUSG00000038535 [Q68FE8-2] |
GeneIDi | 235469 |
KEGGi | mmu:235469 |
UCSCi | uc009qpo.1, mouse [Q68FE8-2] uc009qpp.1, mouse [Q68FE8-3] uc009qpq.1, mouse [Q68FE8-1] |
Organism-specific databases
CTDi | 235469 |
MGIi | MGI:2384583, Zfp280d |
VEuPathDBi | HostDB:ENSMUSG00000038535 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000158889 |
HOGENOMi | CLU_010097_1_0_1 |
InParanoidi | Q68FE8 |
OMAi | CDANAFE |
OrthoDBi | 105829at2759 |
PhylomeDBi | Q68FE8 |
TreeFami | TF331707 |
Miscellaneous databases
BioGRID-ORCSi | 235469, 1 hit in 63 CRISPR screens |
ChiTaRSi | Zfp280d, mouse |
PROi | PR:Q68FE8 |
RNActi | Q68FE8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000038535, Expressed in undifferentiated genital tubercle and 295 other tissues |
ExpressionAtlasi | Q68FE8, baseline and differential |
Genevisiblei | Q68FE8, MM |
Family and domain databases
InterProi | View protein in InterPro IPR025243, DUF4195 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF13836, DUF4195, 1 hit |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 9 hits |
SUPFAMi | SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 5 hits PS50157, ZINC_FINGER_C2H2_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Z280D_MOUSE | |
Accessioni | Q68FE8Primary (citable) accession number: Q68FE8 Secondary accession number(s): Q3T9B1, Q8BI82 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 21, 2006 |
Last sequence update: | October 11, 2004 | |
Last modified: | February 23, 2022 | |
This is version 131 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot