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Protein

Autophagy-related protein 9A

Gene

Atg9a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H (By similarity). Required for carbonyl cyanide m-chlorophenylhydrazone (CCCP)-induced ATG8 family proteins lipidation, a key autophagy step.By similarity1 Publication

Miscellaneous

Isoform displayed in this entry matches to human isoform 3.

GO - Biological processi

Keywordsi

Biological processAutophagy, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Autophagy-related protein 9A
Alternative name(s):
APG9-like 1
Gene namesi
Name:Atg9a
Synonyms:Apg9l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2138446 Atg9a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei73 – 93HelicalSequence analysisAdd BLAST21
Transmembranei132 – 152HelicalSequence analysisAdd BLAST21
Transmembranei290 – 310HelicalSequence analysisAdd BLAST21
Transmembranei372 – 392HelicalSequence analysisAdd BLAST21
Transmembranei401 – 421HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001198212 – 551Autophagy-related protein 9AAdd BLAST550

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei14PhosphoserineBy similarity1
Modified residuei16PhosphoserineCombined sources1
Modified residuei18PhosphoserineCombined sources1
Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei524PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ68FE2
PaxDbiQ68FE2
PeptideAtlasiQ68FE2
PRIDEiQ68FE2

PTM databases

iPTMnetiQ68FE2
PhosphoSitePlusiQ68FE2
SwissPalmiQ68FE2

Expressioni

Gene expression databases

CleanExiMM_ATG9A

Interactioni

Subunit structurei

Interacts with SUPT20H.By similarity

Protein-protein interaction databases

IntActiQ68FE2, 1 interactor
MINTiQ68FE2
STRINGi10090.ENSMUSP00000047449

Family & Domainsi

Sequence similaritiesi

Belongs to the ATG9 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2173 Eukaryota
ENOG410XQBE LUCA
InParanoidiQ68FE2
KOiK17907

Family and domain databases

InterProiView protein in InterPro
IPR007241 Autophagy-rel_prot_9
PANTHERiPTHR13038 PTHR13038, 1 hit
PfamiView protein in Pfam
PF04109 APG9, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q68FE2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQFDTEYQR LEASYSDSPP GEEDLLVHVA EGSKSPWHHI ENLDLFFSRV
60 70 80 90 100
YNLHQKNGFT CMLIGEMFEL MQFLFVVAFT TFLVSCVDYD ILFANKMVNH
110 120 130 140 150
SLHPTEPVKV TLPDAFLPAQ VCSARIQENG SLITILVIAG VFWIHRLIKF
160 170 180 190 200
IYNICCYWEI HSFYLHALRI PMSALPYCTW QEVQARIVQT QKEHQICIHK
210 220 230 240 250
RELTELDIYH RILRFQNYMV ALVNKSLLPL RFRLPGLGEV VFFTRGLKYN
260 270 280 290 300
FELILFWGPG SLFLNEWSLK AEYKRGGQRL ELAQRLSNRI LWIGIANFLL
310 320 330 340 350
CPLILIWQIL YAFFSYAEVL KREPGALGAR CWSLYGRCYL RHFNELEHEL
360 370 380 390 400
QSRLNRGYKP ASKYMNCFLS PLLTLLAKNG AFFAGSILAV LIALTIYDED
410 420 430 440 450
VLAVEHVLTT VTLLGVTVTV CRSFIPDQHM VFCPEQLLRV ILAHIHYMPD
460 470 480 490 500
HWQGVHLGGV AESHRHTPHS HLLPPPSGPG DHRLLPQLYG RGRGCGRHLL
510 520 530 540 550
LCSDGRSPAW PSSVAVWRAD RGLSVPASRG REDRVVAHAL CHHQSRLAAP

S
Length:551
Mass (Da):63,138
Last modified:October 11, 2004 - v1
Checksum:iBDCDBA33E0D10C26
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3ZAQ4Q3ZAQ4_MOUSE
Autophagy-related protein 9
Atg9a Apg9l1, Atg9
839Annotation score:
A0A087WP33A0A087WP33_MOUSE
Autophagy-related protein 9
Atg9a
847Annotation score:
A0A087WPL8A0A087WPL8_MOUSE
Autophagy-related protein 9
Atg9a
278Annotation score:
A0A087WQ26A0A087WQ26_MOUSE
Autophagy-related protein 9A
Atg9a
176Annotation score:
A0A087WRG3A0A087WRG3_MOUSE
Autophagy-related protein 9A
Atg9a
47Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079884 mRNA Translation: AAH79884.1
RefSeqiNP_001003917.2, NM_001003917.4
NP_001275541.1, NM_001288612.1
UniGeneiMm.238266
Mm.491221

Genome annotation databases

GeneIDi245860
KEGGimmu:245860

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079884 mRNA Translation: AAH79884.1
RefSeqiNP_001003917.2, NM_001003917.4
NP_001275541.1, NM_001288612.1
UniGeneiMm.238266
Mm.491221

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ68FE2, 1 interactor
MINTiQ68FE2
STRINGi10090.ENSMUSP00000047449

PTM databases

iPTMnetiQ68FE2
PhosphoSitePlusiQ68FE2
SwissPalmiQ68FE2

Proteomic databases

MaxQBiQ68FE2
PaxDbiQ68FE2
PeptideAtlasiQ68FE2
PRIDEiQ68FE2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi245860
KEGGimmu:245860

Organism-specific databases

CTDi79065
MGIiMGI:2138446 Atg9a

Phylogenomic databases

eggNOGiKOG2173 Eukaryota
ENOG410XQBE LUCA
InParanoidiQ68FE2
KOiK17907

Miscellaneous databases

ChiTaRSiAtg9a mouse
PROiPR:Q68FE2
SOURCEiSearch...

Gene expression databases

CleanExiMM_ATG9A

Family and domain databases

InterProiView protein in InterPro
IPR007241 Autophagy-rel_prot_9
PANTHERiPTHR13038 PTHR13038, 1 hit
PfamiView protein in Pfam
PF04109 APG9, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiATG9A_MOUSE
AccessioniPrimary (citable) accession number: Q68FE2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: October 11, 2004
Last modified: November 7, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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