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Entry version 117 (07 Apr 2021)
Sequence version 1 (11 Oct 2004)
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Protein

Folliculin-interacting protein 1

Gene

Fnip1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binding partner of the GTPase-activating protein FLCN: involved in the cellular response to amino acid availability by regulating the mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 (PubMed:23582324). In low-amino acid conditions, component of the lysosomal folliculin complex (LFC) on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, thereby inactivating mTORC1 and promoting nuclear translocation of TFEB and TFE3 (By similarity). Upon amino acid restimulation, disassembly of the LFC complex liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent cytoplasmic retention of TFEB and TFE3 (By similarity). Required to promote FLCN recruitment to lysosomes and interaction with Rag GTPases (By similarity). Together with FLCN, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (By similarity). In addition to its role in mTORC1 signaling, also acts as a co-chaperone of HSP90AA1/Hsp90: following gradual phosphorylation by CK2, inhibits the ATPase activity of HSP90AA1/Hsp90, leading to activate both kinase and non-kinase client proteins of HSP90AA1/Hsp90 (By similarity). Acts as a scaffold to load client protein FLCN onto HSP90AA1/Hsp90 (By similarity). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (By similarity). Required for B-cell development (PubMed:22709692, PubMed:27303042).By similarity3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-9639288, Amino acids regulate mTORC1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Folliculin-interacting protein 11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Fnip11 PublicationImported
Synonyms:Kiaa19611 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2444668, Fnip1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice develop normally but display defects in B-cell development independent of mTOR activity (PubMed:22709692, PubMed:27303042). B-cell development defects result from rapid caspase-induced pre-B cell death (PubMed:22709692). Heterozygous mice show caused a loss of marginal zone B-cells (PubMed:27303042). Mice also develop cardiomyopathy characterized by left ventricular hypertrophy and elevated AMPK activity (PubMed:25775561, PubMed:27303042). Mice do not show strong susceptibility to kidney neoplasia (PubMed:22709692, PubMed:25775561). They however display slightly enlarged kidney size and slightly increased renal cyst formation, characterized by decreased AMPK activation, increased mTOR activation and metabolic hyperactivation (PubMed:29897930). Mice lacking both Fnip1 and Fnip2 show enlarged polycystic kidneys (PubMed:25775561).4 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003084851 – 1165Folliculin-interacting protein 1Add BLAST1165

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei220PhosphoserineBy similarity1
Modified residuei294PhosphothreonineBy similarity1
Modified residuei296PhosphoserineBy similarity1
Modified residuei593PhosphoserineCombined sources1
Modified residuei594PhosphoserineCombined sources1
Modified residuei760PhosphoserineCombined sources1
Modified residuei763PhosphoserineCombined sources1
Modified residuei907PhosphoserineCombined sources1
Modified residuei937Phosphoserine; alternateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi937O-linked (GlcNAc) serine; alternateBy similarity1
Modified residuei938PhosphoserineBy similarity1
Modified residuei940PhosphoserineCombined sources1
Modified residuei945PhosphoserineBy similarity1
Modified residuei947PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1118Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sequential phosphorylation by CK2 promotes its gradual interaction with HSP90AA1/Hsp90. Priming phosphorylation at Ser-937 is followed by relay phosphorylation at Ser-938, Ser-940, Ser-945 and Ser-947, promoting its gradual interaction with HSP90AA1/Hsp90. This leads to incremental inhibition of HSP90AA1/Hsp90 ATPase activity and gradual activation of both kinase and non-kinase clients. Dephosphorylated by protein phosphatase 5 (PP5), promoting glycosylation by OGT. Phosphorylated by AMPK.By similarity
GlcNAcylation at Ser-937 by OGT following dephosphorylation by protein phosphatase 5 (PP5) promotes ubiquitination and degradation by the proteasome.By similarity
Ubiquitinated through 'Lys-11' linkage of ubiquitin moieties at Lys-1118 following glycosylation by OGT, leading to its degradation by the proteasome.By similarity

Keywords - PTMi

Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q68FD7

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q68FD7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q68FD7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q68FD7

PeptideAtlas

More...
PeptideAtlasi
Q68FD7

PRoteomics IDEntifications database

More...
PRIDEi
Q68FD7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
271782

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q68FD7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q68FD7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000035992, Expressed in quadriceps femoris and 257 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q68FD7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q68FD7, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer and homomultimer. Heterodimer and heteromultimer with FNIP2.

Interacts with FLCN (via C-terminus) (By similarity).

Component of the lysosomal folliculin complex (LFC), composed of FLCN, FNIP1 (or FNIP2), RRAGA/RagA or RRAGB/RagB GDP-bound, RRAGC/RagC or RRAGD/RagD GTP-bound, and Ragulator (By similarity).

Interacts with HSPCA and with the PRKAA1, PRKAB1 and PRKAG1 subunits of 5'-AMP-activated protein kinase (AMPK). Phosphorylated FLCN and AMPK are preferentially bound.

Interacts with HSP70, STIP1, PTGES3, CDC37, BRAF, GCR and CDK4.

Interacts with HSP90AA1; the interaction inhibits HSP90AA1 ATPase activity (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
229777, 7 interactors

Protein interaction database and analysis system

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IntActi
Q68FD7, 1 interactor

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000049026

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q68FD7, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini37 – 478uDENN FNIP1/2-typePROSITE-ProRule annotationAdd BLAST442
Domaini486 – 1091cDENN FNIP1/2-typePROSITE-ProRule annotationAdd BLAST606
Domaini1101 – 1156dDENN FNIP1/2-typePROSITE-ProRule annotationAdd BLAST56

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni928 – 1165Interaction with HSP90AA1By similarityAdd BLAST238

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi96 – 99Poly-Ser4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FNIP family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3693, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00390000009391

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_003447_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q68FD7

Identification of Orthologs from Complete Genome Data

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OMAi
EHAYINH

Database of Orthologous Groups

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OrthoDBi
303571at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q68FD7

TreeFam database of animal gene trees

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TreeFami
TF324090

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037545, DENN_FNIP1/2
IPR028086, FNIP_C_dom
IPR026156, FNIP_fam
IPR028085, FNIP_mid_dom
IPR028084, FNIP_N_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14638, FNIP_C, 1 hit
PF14637, FNIP_M, 1 hit
PF14636, FNIP_N, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR02073, FOLLICULNIP1

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51836, DENN_FNIP12, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q68FD7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPTLFQKLF SKRSGLGAPG RDARDPDCAF SWPLPEFDPS QIRLIVYQDC
60 70 80 90 100
ERRGRNVLFD SSVKRKNEDT SVSKLCNDAQ VKVFGKCCQL KPGGDSSSSL
110 120 130 140 150
DSSITLSSDG KDQCPKYQGS RCSSDANMLG EMMFGSVAMS YKGSTLKIHQ
160 170 180 190 200
IRSPPQLMLS KVFTARTGSS ICGSLNTLQD SLEFINQDSN TLKADSSTVS
210 220 230 240 250
NGLLGNIGLS QFCSPRRAFS EQGPLRLIRS ASFFAVHSNP MDMPGRELNE
260 270 280 290 300
DRDSGIARSA SLSSLFITPF PSPNSSLTRS CASSYQRRWR RSQTTSLENG
310 320 330 340 350
VFPRWSVEES FNLSDESCGP NPGIVRKKKI AIGVIFSLSK DEDENNKFNE
360 370 380 390 400
FFFSHFPLFE SHMNKLKSAI EQAMKMSRRS ADASQRSLAY NRILDALTEF
410 420 430 440 450
RTTICNLYTM PRIGEPVWLT MMSGTPEKNQ LCHRFMKEFT FLMENASKNQ
460 470 480 490 500
FLPALITAVL TNHLAWVPTV MPNGQPPIKI FLEKHSSQSV GMLAKTHPYN
510 520 530 540 550
PLWAQLGDLY GAIGSPVRLA RTVVVGKRQD LVQRLLYFLT YFIRCSELQE
560 570 580 590 600
THLLENGEDE AIVMPGTVIT TTLEKGEIEE SEYVLITMHR NKSSLLFKES
610 620 630 640 650
EETRTPNCNC KYCSHPVLGQ NTENVSQPER EDTQDNSKEL LGISDECQKI
660 670 680 690 700
SPPDCQEENA VDVQQYRDKL RTCLDTKLET VVCTGSAPAD KCVLSETCLE
710 720 730 740 750
PREESWQNKE LLDSDNHTGT AMRPTGIVVE KKPPDKNVPS AFSCEVTQTK
760 770 780 790 800
VTFLIGDSMS PDSDTELRSQ AVVDQINRHH SEPLKEDRGV ADKHQESKIT
810 820 830 840 850
KDQSEDSDTQ NIVSGESCEL PCWSHSDPES MSLFDEYFND DSIETRTIDD
860 870 880 890 900
VPVKTSTDSK EYCCMLEYPK RLYTKTNKQK SELCKCIETV HQDSCNACFP
910 920 930 940 950
QQDQRNSLSI LVPHGDKESS DKKNAVGTEW DIPRNESSDS ALGDSESEDT
960 970 980 990 1000
GPDIRRQAGG YCGGDQEDWT EEDEIPFPGS KLIEVSAVQP NIANFGRSLL
1010 1020 1030 1040 1050
GGYCSSYVPD FVLQGIGNDE RLRQCLVSDL SHAVQHPVLD EPIAEAVCII
1060 1070 1080 1090 1100
ADMDKWTVQV ASSQRRVTDN KLGKEVLVSS LVSNLLHSTL QLYKHNLSPN
1110 1120 1130 1140 1150
FCVMHLEDRL QELYFKSKML SEYLRGQMRV HVKELGVVLG IESSDLPLLA
1160
AVASTHSPYV AQILL
Length:1,165
Mass (Da):130,126
Last modified:October 11, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA03A39AC2FB53D29
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6RJ64F6RJ64_MOUSE
Folliculin-interacting protein 1
Fnip1
631Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC33163 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC65856 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK122574 mRNA Translation: BAC65856.1 Different initiation.
AL596127 Genomic DNA No translation available.
BC079892 mRNA Translation: AAH79892.1
AK047814 mRNA Translation: BAC33163.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS24698.1

NCBI Reference Sequences

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RefSeqi
NP_776114.2, NM_173753.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000046835; ENSMUSP00000049026; ENSMUSG00000035992

Database of genes from NCBI RefSeq genomes

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GeneIDi
216742

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:216742

UCSC genome browser

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UCSCi
uc007ixx.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122574 mRNA Translation: BAC65856.1 Different initiation.
AL596127 Genomic DNA No translation available.
BC079892 mRNA Translation: AAH79892.1
AK047814 mRNA Translation: BAC33163.1 Different initiation.
CCDSiCCDS24698.1
RefSeqiNP_776114.2, NM_173753.4

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
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Protein-protein interaction databases

BioGRIDi229777, 7 interactors
IntActiQ68FD7, 1 interactor
STRINGi10090.ENSMUSP00000049026

PTM databases

iPTMnetiQ68FD7
PhosphoSitePlusiQ68FD7

Proteomic databases

EPDiQ68FD7
jPOSTiQ68FD7
MaxQBiQ68FD7
PaxDbiQ68FD7
PeptideAtlasiQ68FD7
PRIDEiQ68FD7
ProteomicsDBi271782

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
25902, 140 antibodies

Genome annotation databases

EnsembliENSMUST00000046835; ENSMUSP00000049026; ENSMUSG00000035992
GeneIDi216742
KEGGimmu:216742
UCSCiuc007ixx.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
96459
MGIiMGI:2444668, Fnip1

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
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Phylogenomic databases

eggNOGiKOG3693, Eukaryota
GeneTreeiENSGT00390000009391
HOGENOMiCLU_003447_0_0_1
InParanoidiQ68FD7
OMAiEHAYINH
OrthoDBi303571at2759
PhylomeDBiQ68FD7
TreeFamiTF324090

Enzyme and pathway databases

ReactomeiR-MMU-9639288, Amino acids regulate mTORC1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
216742, 5 hits in 53 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Fnip1, mouse

Protein Ontology

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PROi
PR:Q68FD7
RNActiQ68FD7, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000035992, Expressed in quadriceps femoris and 257 other tissues
ExpressionAtlasiQ68FD7, baseline and differential
GenevisibleiQ68FD7, MM

Family and domain databases

InterProiView protein in InterPro
IPR037545, DENN_FNIP1/2
IPR028086, FNIP_C_dom
IPR026156, FNIP_fam
IPR028085, FNIP_mid_dom
IPR028084, FNIP_N_dom
PfamiView protein in Pfam
PF14638, FNIP_C, 1 hit
PF14637, FNIP_M, 1 hit
PF14636, FNIP_N, 1 hit
PRINTSiPR02073, FOLLICULNIP1
PROSITEiView protein in PROSITE
PS51836, DENN_FNIP12, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFNIP1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q68FD7
Secondary accession number(s): Q80T72, Q8BQM0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 11, 2004
Last modified: April 7, 2021
This is version 117 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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