Integrator complex subunit 4

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MAAHLKKRVY EEFTRVVQQQ PLEEPSAKKL RLTKPSKSAA LHIDLCKATS 
        60         70         80         90        100
PADALQYLLQ FARKPVEAES VEGVVRILLE HYYKENDTSV RLKIASLLGL 
       110        120        130        140        150
LSKTAGFCPD SIVDDVINTL QNEKSHQVLA QLLDTLLEIG LKLLDIVSHR 
       160        170        180        190        200
MRLVDVACKH LSDTSHGVRN KCLQLLGCLG SVEASPAKEV ENAVAKDVQK 
       210        220        230        240        250
IIGDYFIDQD PRVRTAAIKA MLQLHERGLK LQQAMYNQAC KLLTDDYEQV 
       260        270        280        290        300
RSAAVELSWV LSQLYSESIV PIPSSNEEIR LVDDAFGKVC HMVSDGSWVV 
       310        320        330        340        350
RVQACKLLGS MLQVSPHFLE QTLDKKLMSD LRRKRTAHER AKELYSSGEF 
       360        370        380        390        400
SSGRKWGDDA PKEELDTGAV NLIDSGACGA FVHGLEDEMY EVRIAAVESL 
       410        420        430        440        450
CLLARSSAPF AEKCLDFLVD MFNDEIEEVR LQSIHTMRKI SDNITLREDQ 
       460        470        480        490        500
LDTVLAVLED KSRDIREALH ELLCCTNVST KECIQLALVE LLKNLSKYPT 
       510        520        530        540        550
DRESIWKCLK FLGSRHPTLV LSLVPELLST HPFFDTPEPD MDDPAYIAVL 
       560        570        580        590        600
VLIFNAAKCC PTMPALFSDH TFRHYTYLRD SLSHLVPALN LPSVRWSWIP 
       610        620        630        640        650
DVITEAPPED PSQQFLQLSL ERVHNLQHLG SQGTQELLEF TIRDLQRIGE 
       660        670        680        690        700
LQSDLAGMAD FSATYLRCHL LLTKALNEKL WNLAAPLFLK NSLTTNAVKQ 
       710        720        730        740        750
ILEETYKMEF MYSGLETRQV AIIHHMRLQA KALQLLVTAR TTKGAEPLFG 
       760        770        780        790        800
MCEEFLQEVD FFQRCFISEL PHMQDSFVDK LLDLVPRLVN SKPLEMVKIL 
       810        820        830        840        850
QTTLRQCTFL RLTLPEQIHR ASSHIIEPAE ESDNPIRFTS GLVVALDVDA 
       860        870        880        890        900
TLEHVQEPQS TVKVQVVYPD GQVQIIHPKP ADFRNPGPGR HRLITQVYLS 
       910        920        930        940        950
HTAWTEPCQI EVRLLLAYSS SRSKVMSRAS NSTWGESTET VPSTESSTEG 
       960 
TIPFSKPVKV FLMPKPARR                                   

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families