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Protein

DENN domain-containing protein 1A

Gene

dennd1a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes. Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns3P.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factor
Biological processProtein transport, Transport
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DENN domain-containing protein 1A
Alternative name(s):
Connecdenn
Gene namesi
Name:dennd1a
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-5729864 dennd1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasmic vesicle, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003426221 – 1010DENN domain-containing protein 1AAdd BLAST1010

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ68F67
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 143uDENNPROSITE-ProRule annotationAdd BLAST131
Domaini160 – 296cDENNPROSITE-ProRule annotationAdd BLAST137
Domaini298 – 375dDENNPROSITE-ProRule annotationAdd BLAST78

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi378 – 382FXDXF motifBy similarity5
Motifi560 – 569Clathrin boxBy similarity10

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi698 – 703Poly-Pro6

Phylogenomic databases

HOVERGENiHBG059210
KOiK20160

Family and domain databases

InterProiView protein in InterPro
IPR001194 cDENN_dom
IPR005112 dDENN_dom
IPR040032 DENND1A/B/C
IPR037516 Tripartite_DENN
IPR005113 uDENN_dom
PANTHERiPTHR13196 PTHR13196, 1 hit
PfamiView protein in Pfam
PF03455 dDENN, 1 hit
PF02141 DENN, 1 hit
PF03456 uDENN, 1 hit
SMARTiView protein in SMART
SM00801 dDENN, 1 hit
SM00799 DENN, 1 hit
SM00800 uDENN, 1 hit
PROSITEiView protein in PROSITE
PS50211 DENN, 1 hit

Sequencei

Sequence statusi: Complete.

Q68F67-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSRLKQNPD TTFEVYIEVN RPGSTDEDPE LQRIFPEDFS DQEVLQTVTK
60 70 80 90 100
FCFPFSLDSL TSSHVGQNFT FVLTDIDSKQ RFGFCRLSSG AKSCFCILSY
110 120 130 140 150
LPWFEAFYKL LNILAEYSSK NQDSQRNELL KTLHGHPIPE PGTPMHLSVH
160 170 180 190 200
SHFTVPDSQE LPSIPENRNL TEYFVAVDVN NMLHLYASML YERRILICCS
210 220 230 240 250
KLSTLTACIH GSSAMLFPMY WQHVYIPVLP PHLLDYCCAP MPYLIGIHSS
260 270 280 290 300
LMEKVKGMSL DDVVFLNVDT NTLETPFDDL QNLPNEVVSA LKNRIRKMST
310 320 330 340 350
TTGDGVARAF LKAQASLFGS YRNALKIEPE EPITFCEETF VSHRSSGLRP
360 370 380 390 400
FLQNAIQLQL FKQFIDGRLD LLNSGNGFSD VFEEEINMGE YAGSDKLYHQ
410 420 430 440 450
WLSTVKKGSG AFINTMKTRA NPAMKTVYKF AKDHAKMGIK EVKNRLKQKD
460 470 480 490 500
MAENGFSTAT EEPLPQISPS SIEKKRGEER RPITVHFGQV RPPRPHVPRR
510 520 530 540 550
PKSNAVVESR TTAGSSPDQP QQYRTLKESD ADGDEAISPE KDSSEATVKE
560 570 580 590 600
PQSTEVKHVS LLEDIFSNLQ TEPPLLSQAK SLEDLRTPKE DHENQFTFDY
610 620 630 640 650
QRMDLTAQER TRTIPAMKHG HPYNKLWSMG HDDMAIPNKY LQISPERHLT
660 670 680 690 700
LPSNSTVTPH KDSALTNIEK EVTIASSQGN ITIPRPHGRK TPELGIVPPP
710 720 730 740 750
PAPRGIKLQT AMTDANKQQT GDSSNYHGQI TEGSLRELSA DNGEKETAGS
760 770 780 790 800
STSEILKPVK VSTEVGMNDD DLLSLLDPLK AGRYQTASQP PMGTLPHSFE
810 820 830 840 850
TPCCSSTPLL TSLQSDFVSP AFSHQLGFAP QPAFLHSPLN PFAQALAAEK
860 870 880 890 900
TASVMGPPMG VFKAPVATAL GSHSFLPTPG IYHSPRPLTS ALQGSNLFGQ
910 920 930 940 950
ISSGTPLNPV IRQSHSLSET QSNMPLMTSI PAGHRTLPMV QSRSKHQDGK
960 970 980 990 1000
PREYPPIPPR PAKLLEPALL PTKSDQPIDP FEDLLNKTKQ TVTPASGKVE
1010
HLRKQWETFE
Length:1,010
Mass (Da):112,377
Last modified:October 11, 2004 - v1
Checksum:iCFA08F5335CBE0C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079977 mRNA Translation: AAH79977.1
RefSeqiNP_001087471.1, NM_001094002.1
UniGeneiXl.48668

Genome annotation databases

GeneIDi447295
KEGGixla:447295

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079977 mRNA Translation: AAH79977.1
RefSeqiNP_001087471.1, NM_001094002.1
UniGeneiXl.48668

3D structure databases

SMRiQ68F67
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi447295
KEGGixla:447295

Organism-specific databases

CTDi447295
XenbaseiXB-GENE-5729864 dennd1a

Phylogenomic databases

HOVERGENiHBG059210
KOiK20160

Family and domain databases

InterProiView protein in InterPro
IPR001194 cDENN_dom
IPR005112 dDENN_dom
IPR040032 DENND1A/B/C
IPR037516 Tripartite_DENN
IPR005113 uDENN_dom
PANTHERiPTHR13196 PTHR13196, 1 hit
PfamiView protein in Pfam
PF03455 dDENN, 1 hit
PF02141 DENN, 1 hit
PF03456 uDENN, 1 hit
SMARTiView protein in SMART
SM00801 dDENN, 1 hit
SM00799 DENN, 1 hit
SM00800 uDENN, 1 hit
PROSITEiView protein in PROSITE
PS50211 DENN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDEN1A_XENLA
AccessioniPrimary (citable) accession number: Q68F67
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: October 11, 2004
Last modified: November 7, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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