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Entry version 108 (08 May 2019)
Sequence version 1 (11 Oct 2004)
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Protein

Uncharacterized protein KIAA0895-like

Gene

KIAA0895L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized protein KIAA0895-like
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:34408 KIAA0895L

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q68EN5

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
653319

Open Targets

More...
OpenTargetsi
ENSG00000196123

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164721818

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KIAA0895L

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74736337

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003206191 – 471Uncharacterized protein KIAA0895-likeAdd BLAST471

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q68EN5

PeptideAtlas

More...
PeptideAtlasi
Q68EN5

PRoteomics IDEntifications database

More...
PRIDEi
Q68EN5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
66136
66137 [Q68EN5-2]
66138 [Q68EN5-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q68EN5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q68EN5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000196123 Expressed in 139 organ(s), highest expression level in right hemisphere of cerebellum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q68EN5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q68EN5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA065996

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
575692, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q68EN5, 1 interactor

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi14 – 65Pro-richAdd BLAST52

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IGSS Eukaryota
ENOG410YKC2 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000004417

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000069902

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q68EN5

Identification of Orthologs from Complete Genome Data

More...
OMAi
HQAVGII

Database of Orthologous Groups

More...
OrthoDBi
749754at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q68EN5

TreeFam database of animal gene trees

More...
TreeFami
TF329621

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012548 DUF1704

The PANTHER Classification System

More...
PANTHERi
PTHR31817 PTHR31817, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08014 DUF1704, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01154 DUF1704, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q68EN5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVLDSGAQAY DQAPPSPPTS PPSLRHRLKP SDRDGPPLYP WSQSLALPLA
60 70 80 90 100
LAVPPALQPQ PEQQPFSQML LGHRGHMRRS ESTYSVNSTG RRGRGTLGRP
110 120 130 140 150
PPGRGRNPGG GTLRPAASLP HIAKTQRDAG HIASKSPCML VALRPTNMDR
160 170 180 190 200
ERDKFFQSHY TYNPQFEYQE PMPTAVLEKY CEASGQFIHQ AVGIIEAVLE
210 220 230 240 250
KFGTYEHFEA ATGGQLLTKC QIWSIVRKYM QKEGCAGEVV VQLSEDLLSQ
260 270 280 290 300
AVMMVENSRP TLAINLTGAR QYWLEGMLRH EIGTHYLRGV NNARQPWHNA
310 320 330 340 350
EGRLRYGLRP ANPTEEGLAS LHSVLFRKQP FLWRAALLYY TIHRAARMSF
360 370 380 390 400
RQLFQDLERY VQDADVRWEY CVRAKRGQTD TSLPGCFSKD QVYLDGIVRI
410 420 430 440 450
LRHRQTIDFP LLTSLGKVSY EDVDHLRPHG VLDNTRVPHF MQDLARYRQQ
460 470
LEHIMATNRL DEAELGRLLP D
Length:471
Mass (Da):53,446
Last modified:October 11, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC60BC58B867DB156
GO
Isoform 2 (identifier: Q68EN5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     385-408: GCFSKDQVYLDGIVRILRHRQTID → ARTRCTWTASCAFCDIARPSISRC
     409-471: Missing.

Show »
Length:408
Mass (Da):45,967
Checksum:i8DFC1AEFE101E564
GO
Isoform 3 (identifier: Q68EN5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-282: MVLDSGAQAY...WLEGMLRHEI → MTVQDDMGTQ...PAPPPLAFPA

Show »
Length:316
Mass (Da):35,387
Checksum:i08D8C5F25039BE45
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L230I3L230_HUMAN
Uncharacterized protein KIAA0895-li...
KIAA0895L
205Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI28540 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAD38862 differs from that shown. Reason: Erroneous translation. Erroneous translation incorporating non-existent frameshift.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0316891 – 282MVLDS…LRHEI → MTVQDDMGTQDVGQGGICIL VPRRAGGNVSLGEFVHVCGC VGVGWGADGWERIHVCEPLW ILGCESTGGGASRCLGLGEP VCEPEFRSMRMEVSRPEPRP DGTGPGLGSQAGPRTPRPAP PPLAFPA in isoform 3. 1 PublicationAdd BLAST282
Alternative sequenceiVSP_031690385 – 408GCFSK…RQTID → ARTRCTWTASCAFCDIARPS ISRC in isoform 2. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_031691409 – 471Missing in isoform 2. 1 PublicationAdd BLAST63

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK092303 mRNA Translation: BAC03856.1
AL834156 mRNA Translation: CAD38862.1 Sequence problems.
CH471092 Genomic DNA Translation: EAW83091.1
BC007594 mRNA Translation: AAH07594.1
BC080183 mRNA Translation: AAH80183.1
BC128539 mRNA Translation: AAI28540.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS42177.1 [Q68EN5-1]

NCBI Reference Sequences

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RefSeqi
NP_001035805.1, NM_001040715.1 [Q68EN5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000290881; ENSP00000290881; ENSG00000196123 [Q68EN5-1]
ENST00000561621; ENSP00000457099; ENSG00000196123 [Q68EN5-2]
ENST00000563902; ENSP00000456838; ENSG00000196123 [Q68EN5-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
653319

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:653319

UCSC genome browser

More...
UCSCi
uc002ert.4 human [Q68EN5-1]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092303 mRNA Translation: BAC03856.1
AL834156 mRNA Translation: CAD38862.1 Sequence problems.
CH471092 Genomic DNA Translation: EAW83091.1
BC007594 mRNA Translation: AAH07594.1
BC080183 mRNA Translation: AAH80183.1
BC128539 mRNA Translation: AAI28540.1 Different initiation.
CCDSiCCDS42177.1 [Q68EN5-1]
RefSeqiNP_001035805.1, NM_001040715.1 [Q68EN5-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi575692, 1 interactor
IntActiQ68EN5, 1 interactor

PTM databases

iPTMnetiQ68EN5
PhosphoSitePlusiQ68EN5

Polymorphism and mutation databases

BioMutaiKIAA0895L
DMDMi74736337

Proteomic databases

PaxDbiQ68EN5
PeptideAtlasiQ68EN5
PRIDEiQ68EN5
ProteomicsDBi66136
66137 [Q68EN5-2]
66138 [Q68EN5-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000290881; ENSP00000290881; ENSG00000196123 [Q68EN5-1]
ENST00000561621; ENSP00000457099; ENSG00000196123 [Q68EN5-2]
ENST00000563902; ENSP00000456838; ENSG00000196123 [Q68EN5-1]
GeneIDi653319
KEGGihsa:653319
UCSCiuc002ert.4 human [Q68EN5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
653319
DisGeNETi653319

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KIAA0895L
HGNCiHGNC:34408 KIAA0895L
HPAiHPA065996
neXtProtiNX_Q68EN5
OpenTargetsiENSG00000196123
PharmGKBiPA164721818

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IGSS Eukaryota
ENOG410YKC2 LUCA
GeneTreeiENSGT00390000004417
HOGENOMiHOG000069902
InParanoidiQ68EN5
OMAiHQAVGII
OrthoDBi749754at2759
PhylomeDBiQ68EN5
TreeFamiTF329621

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
KIAA0895L human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
KIAA0895L

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
653319

Protein Ontology

More...
PROi
PR:Q68EN5

Gene expression databases

BgeeiENSG00000196123 Expressed in 139 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasiQ68EN5 baseline and differential
GenevisibleiQ68EN5 HS

Family and domain databases

InterProiView protein in InterPro
IPR012548 DUF1704
PANTHERiPTHR31817 PTHR31817, 1 hit
PfamiView protein in Pfam
PF08014 DUF1704, 1 hit
SMARTiView protein in SMART
SM01154 DUF1704, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiK895L_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q68EN5
Secondary accession number(s): A2VCS8
, Q8N3H9, Q8NAQ5, Q96IE5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 11, 2004
Last modified: May 8, 2019
This is version 108 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
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