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Protein

Rap guanine nucleotide exchange factor-like 1

Gene

Rapgefl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable guanine nucleotide exchange factor (GEF).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
Rap guanine nucleotide exchange factor-like 1
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:3611446 Rapgefl1

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003492031 – 662Rap guanine nucleotide exchange factor-like 1Add BLAST662

Proteomic databases

EPDiQ68EF8
PaxDbiQ68EF8
PRIDEiQ68EF8

PTM databases

iPTMnetiQ68EF8
PhosphoSitePlusiQ68EF8

Expressioni

Gene expression databases

BgeeiENSMUSG00000038020
GenevisibleiQ68EF8 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000103103

Structurei

3D structure databases

ProteinModelPortaliQ68EF8
SMRiQ68EF8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini424 – 660Ras-GEFPROSITE-ProRule annotationAdd BLAST237

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi17 – 49Gly-richAdd BLAST33

Phylogenomic databases

eggNOGiKOG2378 Eukaryota
ENOG410XPX9 LUCA
GeneTreeiENSGT00880000137870
HOGENOMiHOG000230545
HOVERGENiHBG056985
InParanoidiQ68EF8
OMAiDPCRNHK
OrthoDBiEOG091G0HKG
PhylomeDBiQ68EF8
TreeFamiTF313184

Family and domain databases

CDDicd00155 RasGEF, 1 hit
Gene3Di1.10.840.10, 1 hit
InterProiView protein in InterPro
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR036964 RASGEF_cat_dom_sf
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF00617 RasGEF, 1 hit
SMARTiView protein in SMART
SM00147 RasGEF, 1 hit
SUPFAMiSSF48366 SSF48366, 2 hits
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50009 RASGEF_CAT, 1 hit

Sequencei

Sequence statusi: Complete.

Q68EF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPLEKFLKK QTSQLAGRAV TGGPGGGPGC CGGPGGGGGP GGGGGPAGGL
60 70 80 90 100
RPLQRRQSVS RLLLPAFLRE PPTEPGLEPP VEEEGGEPLG VSEEPGSGGP
110 120 130 140 150
CWLQLEEVPG PGPIGSGVPL RSPSSYSSDE LSPGEPLASP PWAPLGAPER
160 170 180 190 200
PEHLLNRVLE RLAGGTTRDS SASDILLDDI VLTHSLFLPT EKFLQELHQY
210 220 230 240 250
FVQSRNVEGP EGLGRKQACL ALLLHFLDTY QGLLQEEEGA GHIIKELYLL
260 270 280 290 300
IMKDESLYQD LREDTLRLHQ LVETVELKIP EESQPPSKQV KPLFRHFRRI
310 320 330 340 350
DSCLQTRVAF RGSDEIFCRV YMPDHSYVTI RSRLSASVQD ILGSVTEKLQ
360 370 380 390 400
YSEEPAERED ALILVAVASS GEKVLLQPTE DCVFTTLGIN SHLFACTRDS
410 420 430 440 450
YEALVPLPEE VQVSPGDTEI HRVEPEDVAN HLTAFHWELF RCVHELEFVD
460 470 480 490 500
YVFHGERGRR ETANLELLLQ RCSEVTHWVA TEVLLCEAPG KRVQLLKKFI
510 520 530 540 550
KIAAICKQNQ DLLSFYAVVM GLDNAAVSRL RLTWEKLPGK FKNLFRKFEG
560 570 580 590 600
LTDPCRNHKS YREVISKMKP PLIPFVPLIL KDLTFLHEGS KTLVDGLVNI
610 620 630 640 650
EKLHSVAEKV RTIRKYRSRP LCLDMEASPH HLQTKAYVRQ FQVIDNQNHL
660
FELSYKLEAN SQ
Length:662
Mass (Da):73,695
Last modified:September 2, 2008 - v2
Checksum:iDDF5A16277585F6B
GO

Sequence cautioni

The sequence AAI30267 differs from that shown. Aberrant splicing.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590963 Genomic DNA Translation: CAM46180.1
CH466556 Genomic DNA Translation: EDL16171.1
BC080279 mRNA Translation: AAH80279.1
BC130266 mRNA Translation: AAI30267.1 Sequence problems.
CCDSiCCDS36303.1
RefSeqiNP_001074394.1, NM_001080925.1
UniGeneiMm.340766

Genome annotation databases

EnsembliENSMUST00000107479; ENSMUSP00000103103; ENSMUSG00000038020
GeneIDi268480
KEGGimmu:268480
UCSCiuc007lhr.1 mouse

Similar proteinsi

Entry informationi

Entry nameiRPGFL_MOUSE
AccessioniPrimary (citable) accession number: Q68EF8
Secondary accession number(s): A1L3T1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: November 22, 2017
This is version 97 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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