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Protein

CREB-regulated transcription coactivator 1

Gene

Crtc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells (By similarity). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons. In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock.By similarity3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei571Required for ubiquitination and degradationBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processBiological rhythms, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
CREB-regulated transcription coactivator 1
Alternative name(s):
Mucoepidermoid carcinoma translocated protein 1 homolog
Transducer of regulated cAMP response element-binding protein 1
Short name:
TORC-1
Short name:
Transducer of CREB protein 1
Gene namesi
Name:Crtc1Imported
Synonyms:Kiaa0616Imported, Mect1Imported, Torc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2142523 Crtc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi64S → A: Up-regulates CREB transcription factor activity. 1 Publication1
Mutagenesisi151S → A: Up-regulates CREB transcription factor activity. Reduces interaction with 14-3-3 proteins. 1 Publication1
Mutagenesisi245S → A: No effect on interaction with 14-3-3 proteins. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000963551 – 630CREB-regulated transcription coactivator 1Add BLAST630

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei64Phosphoserine1 Publication1
Modified residuei113PhosphoserineBy similarity1
Modified residuei149Phosphothreonine1 Publication1
Modified residuei151PhosphoserineCombined sources1 Publication1
Modified residuei161PhosphothreonineBy similarity1

Post-translational modificationi

Phosphorylation/dephosphorylation states of Ser-151 are required for regulating transduction of CREB activity. TORCs are inactive when phosphorylated, and active when dephosphorylated at this site. This primary site of phosphorylation is mediated by SIKs (SIK1 and SIK2), is regulated by cAMP and calcium levels and is dependent on the phosphorylation of SIKs by LKB1.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ68ED7
PaxDbiQ68ED7
PeptideAtlasiQ68ED7
PRIDEiQ68ED7

PTM databases

iPTMnetiQ68ED7
PhosphoSitePlusiQ68ED7

Expressioni

Tissue specificityi

Highly expressed in specific regions of the brain including the cortex, hippocampus and striatum.1 Publication

Inductioni

Expressed in a circadian manner in the suprachiasmatic nucleus (SCN) of the brain. Expression is highest during the day and reaches a nadir during the early subjective night.1 Publication

Gene expression databases

BgeeiENSMUSG00000003575 Expressed in 169 organ(s), highest expression level in cerebellum
CleanExiMM_CRTC1
GenevisibleiQ68ED7 MM

Interactioni

Subunit structurei

Binds, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1. 'Arg-314' in the bZIP domain of CREB1 is essential for this interaction. Interaction, via its C-terminal, with TAF4, enhances recruitment of TAF4 to CREB1. Interacts with 14-3-3 proteins (PubMed:28235073).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi238211, 1 interactor
STRINGi10090.ENSMUSP00000075916

Structurei

3D structure databases

ProteinModelPortaliQ68ED7
SMRiQ68ED7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi242 – 258Nuclear export signalBy similarityAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi295 – 365Ser-richAdd BLAST71

Sequence similaritiesi

Belongs to the TORC family.Curated

Phylogenomic databases

eggNOGiENOG410IGNT Eukaryota
ENOG410XPDQ LUCA
GeneTreeiENSGT00390000010652
HOGENOMiHOG000111980
HOVERGENiHBG058314
InParanoidiQ68ED7
KOiK15309
OMAiPSMGIDI
OrthoDBiEOG091G03YN
PhylomeDBiQ68ED7
TreeFamiTF321571

Family and domain databases

InterProiView protein in InterPro
IPR024786 TORC
IPR024785 TORC_C
IPR024784 TORC_M
IPR024783 TORC_N
PANTHERiPTHR13589 PTHR13589, 1 hit
PfamiView protein in Pfam
PF12886 TORC_C, 1 hit
PF12885 TORC_M, 1 hit
PF12884 TORC_N, 1 hit

Sequencei

Sequence statusi: Complete.

Q68ED7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATSNNPRKF SEKIALHNQK QAEETAAFEE VMKDLSLTRA ARLQLQKSQY
60 70 80 90 100
LQLGPSRGQY YGGSLPNVNQ IGSSSVDLAF QTPFQSSGLD TSRTTRHHGL
110 120 130 140 150
VDRVYRERGR LGSPHRRPLS VDKHGRQADS CPYGTVYLSP PADTSWRRTN
160 170 180 190 200
SDSALHQSTM TPSQAESFTG GSQDAHQKRV LLLTVPGMED TGAETDKTLS
210 220 230 240 250
KQSWDSKKAG SRPKSCEVPG INIFPSADQE NTTALIPATH NTGGSLPDLT
260 270 280 290 300
NIHFPSPLPT PLDPEEPPFP ALTSSSSTGS LAHLGVGGAG QGMNTPSSSP
310 320 330 340 350
QHRPAVVSPL SLSTEARRQQ AQQVSPTLSP LSPITQAVAM DALSLEQQLP
360 370 380 390 400
YAFFTQTGSQ QPPPQPQPPP PPPPVSQQQP PPPQVSVGLP QGGPLLPSAS
410 420 430 440 450
LTRGPQLPPL SVTVPSTLPQ SPTENPGQSP MGIDATSAPA LQYRTSAGSP
460 470 480 490 500
ATQSPTSPVS NQGFSPGSSP QHTSTLGSVF GDAYYEQQMT ARQANALSRQ
510 520 530 540 550
LEQFNMMENA ISSSSLYNPG STLNYSQAAM MGLSGSHGGL QDPQQLGYTG
560 570 580 590 600
HGGIPNIILT VTGESPPSLS KELSSTLAGV SDVSFDSDHQ FPLDELKIDP
610 620 630
LTLDGLHMLN DPDMVLADPA TEDTFRMDRL
Length:630
Mass (Da):66,945
Last modified:October 11, 2004 - v1
Checksum:iFD0C37B48301471C
GO

Sequence cautioni

The sequence BAC97983 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC080308 mRNA Translation: AAH80308.1
AK129173 mRNA Translation: BAC97983.1 Different initiation.
CCDSiCCDS40372.1
RefSeqiNP_001004062.1, NM_001004062.2
UniGeneiMm.227767

Genome annotation databases

EnsembliENSMUST00000076615; ENSMUSP00000075916; ENSMUSG00000003575
GeneIDi382056
KEGGimmu:382056
UCSCiuc009mae.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC080308 mRNA Translation: AAH80308.1
AK129173 mRNA Translation: BAC97983.1 Different initiation.
CCDSiCCDS40372.1
RefSeqiNP_001004062.1, NM_001004062.2
UniGeneiMm.227767

3D structure databases

ProteinModelPortaliQ68ED7
SMRiQ68ED7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi238211, 1 interactor
STRINGi10090.ENSMUSP00000075916

PTM databases

iPTMnetiQ68ED7
PhosphoSitePlusiQ68ED7

Proteomic databases

MaxQBiQ68ED7
PaxDbiQ68ED7
PeptideAtlasiQ68ED7
PRIDEiQ68ED7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000076615; ENSMUSP00000075916; ENSMUSG00000003575
GeneIDi382056
KEGGimmu:382056
UCSCiuc009mae.1 mouse

Organism-specific databases

CTDi23373
MGIiMGI:2142523 Crtc1
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IGNT Eukaryota
ENOG410XPDQ LUCA
GeneTreeiENSGT00390000010652
HOGENOMiHOG000111980
HOVERGENiHBG058314
InParanoidiQ68ED7
KOiK15309
OMAiPSMGIDI
OrthoDBiEOG091G03YN
PhylomeDBiQ68ED7
TreeFamiTF321571

Miscellaneous databases

PROiPR:Q68ED7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000003575 Expressed in 169 organ(s), highest expression level in cerebellum
CleanExiMM_CRTC1
GenevisibleiQ68ED7 MM

Family and domain databases

InterProiView protein in InterPro
IPR024786 TORC
IPR024785 TORC_C
IPR024784 TORC_M
IPR024783 TORC_N
PANTHERiPTHR13589 PTHR13589, 1 hit
PfamiView protein in Pfam
PF12886 TORC_C, 1 hit
PF12885 TORC_M, 1 hit
PF12884 TORC_N, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCRTC1_MOUSE
AccessioniPrimary (citable) accession number: Q68ED7
Secondary accession number(s): Q6ZQ85
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: October 11, 2004
Last modified: October 10, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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