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Protein

Zinc finger protein 57

Gene

ZNF57

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri140 – 162C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri196 – 218C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri224 – 246C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri252 – 274C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 302C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri308 – 330C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri336 – 358C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri364 – 386C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 414C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri420 – 442C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri448 – 470C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri476 – 498C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri504 – 526C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 57
Alternative name(s):
Zinc finger protein 424
Gene namesi
Name:ZNF57
Synonyms:ZNF424
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000171970.12
HGNCiHGNC:13125 ZNF57
neXtProtiNX_Q68EA5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000171970
PharmGKBiPA37699

Polymorphism and mutation databases

BioMutaiZNF57
DMDMi143811479

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002748781 – 555Zinc finger protein 57Add BLAST555

Proteomic databases

MaxQBiQ68EA5
PaxDbiQ68EA5
PeptideAtlasiQ68EA5
PRIDEiQ68EA5
ProteomicsDBi66128

PTM databases

iPTMnetiQ68EA5
PhosphoSitePlusiQ68EA5

Expressioni

Gene expression databases

BgeeiENSG00000171970 Expressed in 160 organ(s), highest expression level in amniotic fluid
CleanExiHS_ZNF57
ExpressionAtlasiQ68EA5 baseline and differential
GenevisibleiQ68EA5 HS

Organism-specific databases

HPAiHPA061915

Interactioni

Protein-protein interaction databases

BioGridi125974, 1 interactor
IntActiQ68EA5, 11 interactors
MINTiQ68EA5
STRINGi9606.ENSP00000303696

Structurei

3D structure databases

ProteinModelPortaliQ68EA5
SMRiQ68EA5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 76KRABPROSITE-ProRule annotationAdd BLAST73

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri140 – 162C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri196 – 218C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri224 – 246C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri252 – 274C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 302C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri308 – 330C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri336 – 358C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri364 – 386C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 414C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri420 – 442C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri448 – 470C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri476 – 498C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri504 – 526C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00920000149035
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ68EA5
KOiK09228
PhylomeDBiQ68EA5
TreeFamiTF338854

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 9 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 13 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.iShow all

Q68EA5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSVVFEDVA VDFTLEEWAL LDSAQRDLYR DVMLETFRNL ASVDDGTQFK
60 70 80 90 100
ANGSVSLQDM YGQEKSKEQT IPNFTGNNSC AYTLEKNCEG YGTEDHHKNL
110 120 130 140 150
RNHMVDRFCT HNEGNQYGEA IHQMPDLTLH KKVSAGEKPY ECTKCRTVFT
160 170 180 190 200
HLSSLKRHVK SHCGRKAPPG EECKQACICP SHLHSHGRTD TEEKPYKCQA
210 220 230 240 250
CGQTFQHPRY LSHHVKTHTA EKTYKCEQCR MAFNGFASFT RHVRTHTKDR
260 270 280 290 300
PYKCQECGRA FIYPSTFQRH MTTHTGEKPY KCQHCGKAFT YPQAFQRHEK
310 320 330 340 350
THTGEKPYEC KQCGKTFSWS ETLRVHMRIH TGDKLYKCEH CGKAFTSSRS
360 370 380 390 400
FQGHLRTHTG EKPYECKQCG KAFTWSSTFR EHVRIHTQEQ LYKCEQCGKA
410 420 430 440 450
FTSSRSFRGH LRTHTGEKPY ECKQCGKTFT WSSTFREHVR IHTQEQLHKC
460 470 480 490 500
EHCGKAFTSS RAFQGHLRMH TGEKPYECKQ CGKTFTWSST LHNHVRMHTG
510 520 530 540 550
EKPHKCKQCG MSFKWHSSFR NHLRMHTGQK SHECQSYSKA FSCQVILSKT

SESTH
Length:555
Mass (Da):64,428
Last modified:April 3, 2007 - v3
Checksum:i295DD933C850397F
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WUM7A0A087WUM7_HUMAN
Zinc finger protein 57
ZNF57
557Annotation score:
G3V131G3V131_HUMAN
Zinc finger protein 57
ZNF57 LOC126295, hCG_2039133
523Annotation score:
E5RHE3E5RHE3_HUMAN
Zinc finger protein 57
ZNF57
147Annotation score:
K7ERB8K7ERB8_HUMAN
Zinc finger protein 57
ZNF57
151Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti198C → R in CAH18455 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052760223T → N. Corresponds to variant dbSNP:rs2288958Ensembl.1
Natural variantiVAR_052761230R → W. Corresponds to variant dbSNP:rs2288957Ensembl.1
Natural variantiVAR_061931357T → M. Corresponds to variant dbSNP:rs55682587Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX537601 mRNA Translation: CAH18455.2
BC028974 mRNA Translation: AAH28974.1
CCDSiCCDS12098.1
PIRiB45193
RefSeqiNP_001306012.1, NM_001319083.1
NP_775751.1, NM_173480.2
UniGeneiHs.591378

Genome annotation databases

EnsembliENST00000306908; ENSP00000303696; ENSG00000171970
GeneIDi126295
KEGGihsa:126295
UCSCiuc002lwr.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX537601 mRNA Translation: CAH18455.2
BC028974 mRNA Translation: AAH28974.1
CCDSiCCDS12098.1
PIRiB45193
RefSeqiNP_001306012.1, NM_001319083.1
NP_775751.1, NM_173480.2
UniGeneiHs.591378

3D structure databases

ProteinModelPortaliQ68EA5
SMRiQ68EA5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125974, 1 interactor
IntActiQ68EA5, 11 interactors
MINTiQ68EA5
STRINGi9606.ENSP00000303696

PTM databases

iPTMnetiQ68EA5
PhosphoSitePlusiQ68EA5

Polymorphism and mutation databases

BioMutaiZNF57
DMDMi143811479

Proteomic databases

MaxQBiQ68EA5
PaxDbiQ68EA5
PeptideAtlasiQ68EA5
PRIDEiQ68EA5
ProteomicsDBi66128

Protocols and materials databases

DNASUi126295
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306908; ENSP00000303696; ENSG00000171970
GeneIDi126295
KEGGihsa:126295
UCSCiuc002lwr.3 human

Organism-specific databases

CTDi126295
EuPathDBiHostDB:ENSG00000171970.12
GeneCardsiZNF57
HGNCiHGNC:13125 ZNF57
HPAiHPA061915
neXtProtiNX_Q68EA5
OpenTargetsiENSG00000171970
PharmGKBiPA37699
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00920000149035
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ68EA5
KOiK09228
PhylomeDBiQ68EA5
TreeFamiTF338854

Miscellaneous databases

ChiTaRSiZNF57 human
GenomeRNAii126295
PROiPR:Q68EA5

Gene expression databases

BgeeiENSG00000171970 Expressed in 160 organ(s), highest expression level in amniotic fluid
CleanExiHS_ZNF57
ExpressionAtlasiQ68EA5 baseline and differential
GenevisibleiQ68EA5 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 9 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 13 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZNF57_HUMAN
AccessioniPrimary (citable) accession number: Q68EA5
Secondary accession number(s): Q8N6R9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: April 3, 2007
Last modified: September 12, 2018
This is version 126 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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