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Entry version 145 (17 Jun 2020)
Sequence version 2 (25 Nov 2008)
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Protein

Zinc finger protein 626

Gene

ZNF626

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri173 – 195C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri201 – 223C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri229 – 251C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri257 – 279C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri453 – 475C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri481 – 503C2H2-type 12; degeneratePROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436 Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 626
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF626
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000188171.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30461 ZNF626

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q68DY1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000188171

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134875370

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q68DY1 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF626

Domain mapping of disease mutations (DMDM)

More...
DMDMi
215273916

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002709941 – 528Zinc finger protein 626Add BLAST528

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q68DY1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q68DY1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q68DY1

PeptideAtlas

More...
PeptideAtlasi
Q68DY1

PRoteomics IDEntifications database

More...
PRIDEi
Q68DY1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
66115 [Q68DY1-1]
66116 [Q68DY1-2]
66117 [Q68DY1-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q68DY1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q68DY1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000188171 Expressed in buccal mucosa cell and 176 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q68DY1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q68DY1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000188171 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
128273, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q68DY1, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000469958

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q68DY1 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q68DY1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 75KRABPROSITE-ProRule annotationAdd BLAST72

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri173 – 195C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri201 – 223C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri229 – 251C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri257 – 279C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri453 – 475C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri481 – 503C2H2-type 12; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00990000203478

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002678_44_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q68DY1

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q68DY1

TreeFam database of animal gene trees

More...
TreeFami
TF342117

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 11 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 12 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q68DY1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGPLQFRDVA IEFSLEEWHC LDTAQRNLYR NVMLENYSNL VFLGITVSKP
60 70 80 90 100
DLITCLEQGR KPLTMKRNEM IAKPSVMCSH FAQDLWPEQS MKDSFQKVVL
110 120 130 140 150
RRYEKCEHDN LQLKKGCISV DECKVHKEGY NELNQCLTTT PRKICQCDKY
160 170 180 190 200
VKVLHQFPNS NGQKRGHTGK KPFKYIECGK AFKQFSTLTT HKKIHTGGKP
210 220 230 240 250
YKCEECGKAF NHSCSLTRHK KIHTGEKPYK CEECGKAFKH SSTLTTHKRN
260 270 280 290 300
HTGEKPYKCD KCGKAFMSSS TLSKHEIIHT EKKPYKCEEC GKAFNRSSTL
310 320 330 340 350
TTHKIIHTGE KPYKCEECDK AFKYSYTLTT HKRIHTEDKP YKCEECGKAF
360 370 380 390 400
KYSSTLTTHK RIHTGEKPYK CEECGKAFKR SSDLTTHKII HTGEKPYKCE
410 420 430 440 450
ECGKAFKYSS NLTTHKKIHT GERPYKCEEC GKAFNQSSIL TTHRRIHTGE
460 470 480 490 500
KFYKCEECGK AFKCSSNLTT HKKIHTGERP YKCEECGKAF NQSSILTTHE
510 520
RIILERNSTN VKNVAKPSSG PHTLLHIR
Length:528
Mass (Da):60,893
Last modified:November 25, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4F631D271B872653
GO
Isoform 2 (identifier: Q68DY1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: Missing.

Show »
Length:452
Mass (Da):52,097
Checksum:iBEBB1EE32FB68C7B
GO
Isoform 3 (identifier: Q68DY1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     77-92: MCSHFAQDLWPEQSMK → SFLQVHSESQSPLHDI
     93-528: Missing.

Show »
Length:92
Mass (Da):10,620
Checksum:i5F8BE284A21A4213
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X1I5A0A087X1I5_HUMAN
Zinc finger protein 626
ZNF626
540Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QY39M0QY39_HUMAN
Zinc finger protein 626
ZNF626
135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC04729 differs from that shown. Intron-exon boundaries of the last intron are not canonical, they have a CT-AG boundary.Curated
The sequence CAH18089 differs from that shown. Intron-exon boundaries of the last intron are not canonical, they have a CT-AG boundary.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04733865M → T. Corresponds to variant dbSNP:rs8106117Ensembl.1
Natural variantiVAR_02983768N → H. Corresponds to variant dbSNP:rs3209058Ensembl.1
Natural variantiVAR_04733989Q → E. Corresponds to variant dbSNP:rs8111015Ensembl.1
Natural variantiVAR_04734090S → N. Corresponds to variant dbSNP:rs8110802Ensembl.1
Natural variantiVAR_047341464C → Y. Corresponds to variant dbSNP:rs4809072Ensembl.1
Natural variantiVAR_047342500E → K. Corresponds to variant dbSNP:rs10408597Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0222631 – 76Missing in isoform 2. 1 PublicationAdd BLAST76
Alternative sequenceiVSP_04327077 – 92MCSHF…EQSMK → SFLQVHSESQSPLHDI in isoform 3. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_04327193 – 528Missing in isoform 3. 1 PublicationAdd BLAST436

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK096221 mRNA Translation: BAC04729.1 Sequence problems.
AK131567 mRNA No translation available.
CR749233 mRNA Translation: CAH18089.1 Sequence problems.
AC010636 Genomic DNA No translation available.
CH471106 Genomic DNA Translation: EAW84879.1
BC007116 mRNA Translation: AAH07116.1
BC107803 mRNA Translation: AAI07804.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32976.1 [Q68DY1-3]
CCDS42535.1 [Q68DY1-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001070143.1, NM_001076675.2 [Q68DY1-1]
NP_660340.1, NM_145297.3 [Q68DY1-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000291750; ENSP00000291750; ENSG00000188171 [Q68DY1-3]
ENST00000601440; ENSP00000469958; ENSG00000188171 [Q68DY1-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
199777

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:199777

UCSC genome browser

More...
UCSCi
uc002npb.2 human [Q68DY1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096221 mRNA Translation: BAC04729.1 Sequence problems.
AK131567 mRNA No translation available.
CR749233 mRNA Translation: CAH18089.1 Sequence problems.
AC010636 Genomic DNA No translation available.
CH471106 Genomic DNA Translation: EAW84879.1
BC007116 mRNA Translation: AAH07116.1
BC107803 mRNA Translation: AAI07804.1
CCDSiCCDS32976.1 [Q68DY1-3]
CCDS42535.1 [Q68DY1-1]
RefSeqiNP_001070143.1, NM_001076675.2 [Q68DY1-1]
NP_660340.1, NM_145297.3 [Q68DY1-3]

3D structure databases

SMRiQ68DY1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi128273, 2 interactors
IntActiQ68DY1, 3 interactors
STRINGi9606.ENSP00000469958

PTM databases

iPTMnetiQ68DY1
PhosphoSitePlusiQ68DY1

Polymorphism and mutation databases

BioMutaiZNF626
DMDMi215273916

Proteomic databases

jPOSTiQ68DY1
MassIVEiQ68DY1
PaxDbiQ68DY1
PeptideAtlasiQ68DY1
PRIDEiQ68DY1
ProteomicsDBi66115 [Q68DY1-1]
66116 [Q68DY1-2]
66117 [Q68DY1-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
56812 27 antibodies

The DNASU plasmid repository

More...
DNASUi
199777

Genome annotation databases

EnsembliENST00000291750; ENSP00000291750; ENSG00000188171 [Q68DY1-3]
ENST00000601440; ENSP00000469958; ENSG00000188171 [Q68DY1-1]
GeneIDi199777
KEGGihsa:199777
UCSCiuc002npb.2 human [Q68DY1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
199777
EuPathDBiHostDB:ENSG00000188171.15

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF626
HGNCiHGNC:30461 ZNF626
HPAiENSG00000188171 Low tissue specificity
neXtProtiNX_Q68DY1
OpenTargetsiENSG00000188171
PharmGKBiPA134875370

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00990000203478
HOGENOMiCLU_002678_44_0_1
InParanoidiQ68DY1
OrthoDBi1318335at2759
PhylomeDBiQ68DY1
TreeFamiTF342117

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
199777 2 hits in 801 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF626 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
199777
PharosiQ68DY1 Tdark

Protein Ontology

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PROi
PR:Q68DY1
RNActiQ68DY1 protein

Gene expression databases

BgeeiENSG00000188171 Expressed in buccal mucosa cell and 176 other tissues
ExpressionAtlasiQ68DY1 baseline and differential
GenevisibleiQ68DY1 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 11 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 12 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN626_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q68DY1
Secondary accession number(s): Q8N8T4, Q96QM1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: November 25, 2008
Last modified: June 17, 2020
This is version 145 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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