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Protein

Zinc finger protein 626

Gene

ZNF626

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri173 – 195C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri201 – 223C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri229 – 251C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri257 – 279C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri453 – 475C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri481 – 503C2H2-type 12; degeneratePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 626
Gene namesi
Name:ZNF626
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000188171.15
HGNCiHGNC:30461 ZNF626
neXtProtiNX_Q68DY1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000188171
PharmGKBiPA134875370

Polymorphism and mutation databases

BioMutaiZNF626
DMDMi215273916

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002709941 – 528Zinc finger protein 626Add BLAST528

Proteomic databases

PaxDbiQ68DY1
PeptideAtlasiQ68DY1
PRIDEiQ68DY1
ProteomicsDBi66115
66116 [Q68DY1-2]
66117 [Q68DY1-3]

PTM databases

iPTMnetiQ68DY1
PhosphoSitePlusiQ68DY1

Expressioni

Gene expression databases

BgeeiENSG00000188171 Expressed in 177 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_ZNF626
ExpressionAtlasiQ68DY1 baseline and differential
GenevisibleiQ68DY1 HS

Organism-specific databases

HPAiHPA045631

Interactioni

Protein-protein interaction databases

BioGridi128273, 2 interactors
IntActiQ68DY1, 3 interactors
STRINGi9606.ENSP00000469958

Structurei

3D structure databases

ProteinModelPortaliQ68DY1
SMRiQ68DY1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 75KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri173 – 195C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri201 – 223C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri229 – 251C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri257 – 279C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri453 – 475C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri481 – 503C2H2-type 12; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144042
HOGENOMiHOG000231475
HOVERGENiHBG018163
InParanoidiQ68DY1
PhylomeDBiQ68DY1
TreeFamiTF342117

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 12 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q68DY1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGPLQFRDVA IEFSLEEWHC LDTAQRNLYR NVMLENYSNL VFLGITVSKP
60 70 80 90 100
DLITCLEQGR KPLTMKRNEM IAKPSVMCSH FAQDLWPEQS MKDSFQKVVL
110 120 130 140 150
RRYEKCEHDN LQLKKGCISV DECKVHKEGY NELNQCLTTT PRKICQCDKY
160 170 180 190 200
VKVLHQFPNS NGQKRGHTGK KPFKYIECGK AFKQFSTLTT HKKIHTGGKP
210 220 230 240 250
YKCEECGKAF NHSCSLTRHK KIHTGEKPYK CEECGKAFKH SSTLTTHKRN
260 270 280 290 300
HTGEKPYKCD KCGKAFMSSS TLSKHEIIHT EKKPYKCEEC GKAFNRSSTL
310 320 330 340 350
TTHKIIHTGE KPYKCEECDK AFKYSYTLTT HKRIHTEDKP YKCEECGKAF
360 370 380 390 400
KYSSTLTTHK RIHTGEKPYK CEECGKAFKR SSDLTTHKII HTGEKPYKCE
410 420 430 440 450
ECGKAFKYSS NLTTHKKIHT GERPYKCEEC GKAFNQSSIL TTHRRIHTGE
460 470 480 490 500
KFYKCEECGK AFKCSSNLTT HKKIHTGERP YKCEECGKAF NQSSILTTHE
510 520
RIILERNSTN VKNVAKPSSG PHTLLHIR
Length:528
Mass (Da):60,893
Last modified:November 25, 2008 - v2
Checksum:i4F631D271B872653
GO
Isoform 2 (identifier: Q68DY1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: Missing.

Note: No experimental confirmation available.
Show »
Length:452
Mass (Da):52,097
Checksum:iBEBB1EE32FB68C7B
GO
Isoform 3 (identifier: Q68DY1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     77-92: MCSHFAQDLWPEQSMK → SFLQVHSESQSPLHDI
     93-528: Missing.

Note: No experimental confirmation available.
Show »
Length:92
Mass (Da):10,620
Checksum:i5F8BE284A21A4213
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X1I5A0A087X1I5_HUMAN
Zinc finger protein 626
ZNF626
540Annotation score:
M0QY39M0QY39_HUMAN
Zinc finger protein 626
ZNF626
135Annotation score:

Sequence cautioni

The sequence BAC04729 differs from that shown. Intron-exon boundaries of the last intron are not canonical, they have a CT-AG boundary.Curated
The sequence CAH18089 differs from that shown. Intron-exon boundaries of the last intron are not canonical, they have a CT-AG boundary.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04733865M → T. Corresponds to variant dbSNP:rs8106117Ensembl.1
Natural variantiVAR_02983768N → H. Corresponds to variant dbSNP:rs3209058Ensembl.1
Natural variantiVAR_04733989Q → E. Corresponds to variant dbSNP:rs8111015Ensembl.1
Natural variantiVAR_04734090S → N. Corresponds to variant dbSNP:rs8110802Ensembl.1
Natural variantiVAR_047341464C → Y. Corresponds to variant dbSNP:rs4809072Ensembl.1
Natural variantiVAR_047342500E → K. Corresponds to variant dbSNP:rs10408597Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0222631 – 76Missing in isoform 2. 1 PublicationAdd BLAST76
Alternative sequenceiVSP_04327077 – 92MCSHF…EQSMK → SFLQVHSESQSPLHDI in isoform 3. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_04327193 – 528Missing in isoform 3. 1 PublicationAdd BLAST436

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096221 mRNA Translation: BAC04729.1 Sequence problems.
AK131567 mRNA No translation available.
CR749233 mRNA Translation: CAH18089.1 Sequence problems.
AC010636 Genomic DNA No translation available.
CH471106 Genomic DNA Translation: EAW84879.1
BC007116 mRNA Translation: AAH07116.1
BC107803 mRNA Translation: AAI07804.1
CCDSiCCDS32976.1 [Q68DY1-3]
CCDS42535.1 [Q68DY1-1]
RefSeqiNP_001070143.1, NM_001076675.2 [Q68DY1-1]
NP_660340.1, NM_145297.3 [Q68DY1-3]
UniGeneiHs.657001

Genome annotation databases

EnsembliENST00000291750; ENSP00000291750; ENSG00000188171 [Q68DY1-3]
ENST00000601440; ENSP00000469958; ENSG00000188171 [Q68DY1-1]
GeneIDi199777
KEGGihsa:199777
UCSCiuc002npb.2 human [Q68DY1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN626_HUMAN
AccessioniPrimary (citable) accession number: Q68DY1
Secondary accession number(s): Q8N8T4, Q96QM1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: November 25, 2008
Last modified: September 12, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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