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Entry version 159 (29 Sep 2021)
Sequence version 3 (31 May 2011)
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Protein

FERM and PDZ domain-containing protein 2

Gene

FRMPD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in the regulation of tight junction formation. Binds phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2).

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • 1-phosphatidylinositol binding Source: UniProtKB

GO - Biological processi

  • bicellular tight junction assembly Source: UniProtKB

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q68DX3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
FERM and PDZ domain-containing protein 2
Alternative name(s):
PDZ domain-containing protein 4
PDZ domain-containing protein 5C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FRMPD2
Synonyms:PDZD5C, PDZK4, PDZK5C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28572, FRMPD2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613323, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q68DX3

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000170324

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Tight junction

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi955K → E: Abolishes the basolateral membrane localization. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
143162

Open Targets

More...
OpenTargetsi
ENSG00000170324

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134947461

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q68DX3, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FRMPD2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
334302902

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003068541 – 1309FERM and PDZ domain-containing protein 2Add BLAST1309

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q68DX3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q68DX3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q68DX3

PeptideAtlas

More...
PeptideAtlasi
Q68DX3

PRoteomics IDEntifications database

More...
PRIDEi
Q68DX3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
66110 [Q68DX3-1]
66111 [Q68DX3-2]
66112 [Q68DX3-3]
66113 [Q68DX3-4]
66114 [Q68DX3-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q68DX3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q68DX3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in epithelial cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000170324, Expressed in anterior cingulate cortex and 107 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q68DX3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q68DX3, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000170324, Group enriched (brain, epididymis, fallopian tube, heart muscle, retina)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via the PDZ 2 domain) with CTNND2 (via the extreme C-terminus).

Interacts (via the PDZ 2 domain) with PKP4 (via the extreme C-terminus); this interaction directed FRMPD2 to the basolateral membranes.

Interacts (via the PDZ 2 domain) with ARVCF (via the extreme C-terminus).

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
126788, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q68DX3, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000363317

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q68DX3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q68DX3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini15 – 197KINDPROSITE-ProRule annotationAdd BLAST183
Domaini342 – 642FERMPROSITE-ProRule annotationAdd BLAST301
Domaini775 – 861PDZ 1PROSITE-ProRule annotationAdd BLAST87
Domaini950 – 1035PDZ 2PROSITE-ProRule annotationAdd BLAST86
Domaini1079 – 1167PDZ 3PROSITE-ProRule annotationAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni214 – 249DisorderedSequence analysisAdd BLAST36
Regioni266 – 302DisorderedSequence analysisAdd BLAST37
Regioni859 – 880DisorderedSequence analysisAdd BLAST22
Regioni1204 – 1228DisorderedSequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi235 – 249Polar residuesSequence analysisAdd BLAST15
Compositional biasi274 – 302Polar residuesSequence analysisAdd BLAST29

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The FERM and PDZ 2 domains are necessary for localization to the basolateral cell membrane. The FERM domain binds to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and is sufficient for membrane localization.

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0792, Eukaryota
KOG3528, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161964

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_079375_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q68DX3

Identification of Orthologs from Complete Genome Data

More...
OMAi
PRTAQQC

Database of Orthologous Groups

More...
OrthoDBi
411281at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q68DX3

TreeFam database of animal gene trees

More...
TreeFami
TF315388

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14473, FERM_B-lobe, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.80.10, 1 hit
2.30.29.30, 1 hit
2.30.42.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019749, Band_41_domain
IPR014352, FERM/acyl-CoA-bd_prot_sf
IPR035963, FERM_2
IPR019748, FERM_central
IPR000299, FERM_domain
IPR018979, FERM_N
IPR018980, FERM_PH-like_C
IPR029906, FRMPD2
IPR011019, KIND_dom
IPR001478, PDZ
IPR036034, PDZ_sf
IPR011993, PH-like_dom_sf
IPR029071, Ubiquitin-like_domsf

The PANTHER Classification System

More...
PANTHERi
PTHR19964:SF56, PTHR19964:SF56, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09380, FERM_C, 1 hit
PF00373, FERM_M, 1 hit
PF09379, FERM_N, 1 hit
PF00595, PDZ, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00935, BAND41

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00295, B41, 1 hit
SM01196, FERM_C, 1 hit
SM00750, KIND, 1 hit
SM00228, PDZ, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47031, SSF47031, 1 hit
SSF50156, SSF50156, 3 hits
SSF54236, SSF54236, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50057, FERM_3, 1 hit
PS51377, KIND, 1 hit
PS50106, PDZ, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q68DX3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQPLTKDAGM SLSSVTLASA LQVRGEALSE EEIWSLLFLA AEQLLEDLRN
60 70 80 90 100
DSSDYVVCPW SALLSAAGSL SFQGRVSHIE AAPFKAPELL QGQSEDEQPD
110 120 130 140 150
ASQMHVYSLG MTLYWSAGFH VPPHQPLQLC EPLHSILLTM CEDQPHRRCT
160 170 180 190 200
LQSVLEACRV HEKEVSVYPA PAGLHIRRLV GLVLGTISEV EKRVVEESSS
210 220 230 240 250
VQQNRSYLLR KRLRGTSSES PAAQAPECLH PCRVSERSTE TQSSPEPHWS
260 270 280 290 300
TLTHSHCSLL VNRALPGADP QDQQAGRRLS SGSVHSAADS SWPTTPSQRG
310 320 330 340 350
FLQRRSKFSR PEFILLAGEA PMTLHLPGSV VTKKGKSYLA LRDLCVVLLN
360 370 380 390 400
GQHLEVKCDV ESTVGAVFNA VTSFANLEEL TYFGLAYMKS KEFFFLDSET
410 420 430 440 450
RLCKIAPEGW REQPQKTSMN TFTLFLRIKF FVSHYGLLQH SLTRHQFYLQ
460 470 480 490 500
LRKDILEERL YCNEEILLQL GVLALQAEFG NYPKEQVESK PYFHVEDYIP
510 520 530 540 550
ASLIERMTAL RVQVEVSEMH RLSSALWGED AELKFLRVTQ QLPEYGVLVH
560 570 580 590 600
QVFSEKRRPE EEMALGICAK GVIVYEVKNN SRIAMLRFQW RETGKISTYQ
610 620 630 640 650
KKFTITSSVT GKKHTFVTDS AKTSKYLLDL CSAQHGFNAQ MGSGQPSHVL
660 670 680 690 700
FDHDKFVQMA NLSPAHQARS KPLIWIQRLS CSENELFVSR LQGAAGGLLS
710 720 730 740 750
TSMDNFNVDG SKEAGAEGIG RSPCTGREQL KSACVIQKPM TWDSLSGPPV
760 770 780 790 800
QSMHAGSKNN RRKSFIAEPG REIVRVTLKR DPHRGFGFVI NEGEYSGQAD
810 820 830 840 850
PGIFISSIIP GGPAEKAKTI KPGGQILALN HISLEGFTFN MAVRMIQNSP
860 870 880 890 900
DNIELIISQS KGVGGNNPDE EKNSTANSGV SSTDILSFGY QGSLLSHTQD
910 920 930 940 950
QDRNTEELDM AGVQSLVPRL RHQLSFLPLK GAGSSCPPSP PEISAGEIYF
960 970 980 990 1000
VELVKEDGTL GFSVTGGINT SVPYGGIYVK SIVPGGPAAK EGQILQGDRL
1010 1020 1030 1040 1050
LQVDGVILCG LTHKQAVQCL TGPGQVARLV LERRVPRSTQ QCPSANDSMG
1060 1070 1080 1090 1100
DERTAVSLVT ALPGRPSSCV SVTDGPKFEV KLKKNANGLG FSFVQMEKES
1110 1120 1130 1140 1150
CSHLKSDLVR IKRLFPGQPA EENGAIAAGD IILAVNGRST EGLIFQEVLH
1160 1170 1180 1190 1200
LLRGAPQEVT LLLCRPPPGA LPELEQEWQT PELSADKEFT RATCTDSCTS
1210 1220 1230 1240 1250
PILDQEDSWR DSASPDAGEG LGLRPESSQK AIREAQWGQN RERPWASSLT
1260 1270 1280 1290 1300
HSPESHPHLC KLHQERDEST LATSLEKDVR QNCYSVCDIM RLGRYSFSSP

LTRLSTDIF
Length:1,309
Mass (Da):144,282
Last modified:May 31, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7684E687FA8522B4
GO
Isoform 2 (identifier: Q68DX3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: MQPLTKDA → MHVFIV
     103-124: Missing.
     486-486: Missing.

Show »
Length:1,284
Mass (Da):141,455
Checksum:i89E7F9A7D011CD97
GO
Isoform 3 (identifier: Q68DX3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     391-392: KE → GE
     393-1309: Missing.

Show »
Length:392
Mass (Da):43,008
Checksum:iBA3B4B1C4C0FCC79
GO
Isoform 4 (identifier: Q68DX3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-989: Missing.
     990-996: KEGQILQ → MTSIPFP

Show »
Length:320
Mass (Da):35,116
Checksum:i518D2626AB9BA09A
GO
Isoform 5 (identifier: Q68DX3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1048: Missing.

Show »
Length:261
Mass (Da):28,774
Checksum:iC1B27BB4D815028A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GUQ4A0A1B0GUQ4_HUMAN
FERM and PDZ domain-containing prot...
FRMPD2
1,397Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GV40A0A1B0GV40_HUMAN
FERM and PDZ domain-containing prot...
FRMPD2
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti601K → E in CAH18097 (PubMed:17974005).Curated1
Sequence conflicti624S → G in CAH18097 (PubMed:17974005).Curated1
Sequence conflicti826I → T in CAH18097 (PubMed:17974005).Curated1
Sequence conflicti874S → G in BAC85520 (PubMed:14702039).Curated1
Sequence conflicti895L → S in BAC85520 (PubMed:14702039).Curated1
Sequence conflicti969N → M in AAH73954 (PubMed:15489334).Curated1
Sequence conflicti969N → M in AAI44636 (PubMed:15489334).Curated1
Sequence conflicti969N → M in AAI44640 (PubMed:15489334).Curated1
Sequence conflicti1077K → N in AAS79660 (Ref. 1) Curated1
Sequence conflicti1174L → M in BAC85520 (PubMed:14702039).Curated1
Sequence conflicti1214S → F in AAS79660 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05554020A → T. Corresponds to variant dbSNP:rs11101272Ensembl.1
Natural variantiVAR_061034239T → M. Corresponds to variant dbSNP:rs55802136Ensembl.1
Natural variantiVAR_072402351G → R1 PublicationCorresponds to variant dbSNP:rs116143480Ensembl.1
Natural variantiVAR_055541534K → E1 PublicationCorresponds to variant dbSNP:rs1864345Ensembl.1
Natural variantiVAR_035446727R → W in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs115907611Ensembl.1
Natural variantiVAR_0652531021T → K2 PublicationsCorresponds to variant dbSNP:rs1898784Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0285211 – 1048Missing in isoform 5. 2 PublicationsAdd BLAST1048
Alternative sequenceiVSP_0285221 – 989Missing in isoform 4. 1 PublicationAdd BLAST989
Alternative sequenceiVSP_0285231 – 8MQPLTKDA → MHVFIV in isoform 2. 1 Publication8
Alternative sequenceiVSP_028524103 – 124Missing in isoform 2. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_028525391 – 392KE → GE in isoform 3. 1 Publication2
Alternative sequenceiVSP_028526393 – 1309Missing in isoform 3. 1 PublicationAdd BLAST917
Alternative sequenceiVSP_028527486Missing in isoform 2. 1 Publication1
Alternative sequenceiVSP_028528990 – 996KEGQILQ → MTSIPFP in isoform 4. 1 Publication7

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY491519 mRNA Translation: AAS79660.1
AK123038 mRNA Translation: BAC85520.1
AK131386 mRNA Translation: BAD18537.1
CR749241 mRNA Translation: CAH18097.1
AC013284 Genomic DNA No translation available.
AC074325 Genomic DNA No translation available.
BC031614 mRNA Translation: AAH31614.1
BC073954 mRNA Translation: AAH73954.1
BC144635 mRNA Translation: AAI44636.1
BC144639 mRNA Translation: AAI44640.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS31195.1 [Q68DX3-1]
CCDS81460.1 [Q68DX3-2]

NCBI Reference Sequences

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RefSeqi
NP_001018081.3, NM_001018071.3 [Q68DX3-1]
NP_001035977.2, NM_001042512.2 [Q68DX3-4]
NP_001305120.1, NM_001318191.1
XP_016871233.1, XM_017015744.1 [Q68DX3-5]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000305531; ENSP00000307079; ENSG00000170324 [Q68DX3-2]
ENST00000374201; ENSP00000363317; ENSG00000170324 [Q68DX3-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
143162

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:143162

UCSC genome browser

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UCSCi
uc001jgg.5, human [Q68DX3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY491519 mRNA Translation: AAS79660.1
AK123038 mRNA Translation: BAC85520.1
AK131386 mRNA Translation: BAD18537.1
CR749241 mRNA Translation: CAH18097.1
AC013284 Genomic DNA No translation available.
AC074325 Genomic DNA No translation available.
BC031614 mRNA Translation: AAH31614.1
BC073954 mRNA Translation: AAH73954.1
BC144635 mRNA Translation: AAI44636.1
BC144639 mRNA Translation: AAI44640.1
CCDSiCCDS31195.1 [Q68DX3-1]
CCDS81460.1 [Q68DX3-2]
RefSeqiNP_001018081.3, NM_001018071.3 [Q68DX3-1]
NP_001035977.2, NM_001042512.2 [Q68DX3-4]
NP_001305120.1, NM_001318191.1
XP_016871233.1, XM_017015744.1 [Q68DX3-5]

3D structure databases

SMRiQ68DX3
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi126788, 4 interactors
IntActiQ68DX3, 2 interactors
STRINGi9606.ENSP00000363317

PTM databases

iPTMnetiQ68DX3
PhosphoSitePlusiQ68DX3

Genetic variation databases

BioMutaiFRMPD2
DMDMi334302902

Proteomic databases

jPOSTiQ68DX3
MassIVEiQ68DX3
PaxDbiQ68DX3
PeptideAtlasiQ68DX3
PRIDEiQ68DX3
ProteomicsDBi66110 [Q68DX3-1]
66111 [Q68DX3-2]
66112 [Q68DX3-3]
66113 [Q68DX3-4]
66114 [Q68DX3-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
13728, 62 antibodies

The DNASU plasmid repository

More...
DNASUi
143162

Genome annotation databases

EnsembliENST00000305531; ENSP00000307079; ENSG00000170324 [Q68DX3-2]
ENST00000374201; ENSP00000363317; ENSG00000170324 [Q68DX3-1]
GeneIDi143162
KEGGihsa:143162
UCSCiuc001jgg.5, human [Q68DX3-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
143162
DisGeNETi143162

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FRMPD2
HGNCiHGNC:28572, FRMPD2
HPAiENSG00000170324, Group enriched (brain, epididymis, fallopian tube, heart muscle, retina)
MIMi613323, gene
neXtProtiNX_Q68DX3
OpenTargetsiENSG00000170324
PharmGKBiPA134947461
VEuPathDBiHostDB:ENSG00000170324

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0792, Eukaryota
KOG3528, Eukaryota
GeneTreeiENSGT00940000161964
HOGENOMiCLU_079375_0_0_1
InParanoidiQ68DX3
OMAiPRTAQQC
OrthoDBi411281at2759
PhylomeDBiQ68DX3
TreeFamiTF315388

Enzyme and pathway databases

PathwayCommonsiQ68DX3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
143162, 4 hits in 1008 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
FRMPD2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
143162
PharosiQ68DX3, Tbio

Protein Ontology

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PROi
PR:Q68DX3
RNActiQ68DX3, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000170324, Expressed in anterior cingulate cortex and 107 other tissues
ExpressionAtlasiQ68DX3, baseline and differential
GenevisibleiQ68DX3, HS

Family and domain databases

CDDicd14473, FERM_B-lobe, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
2.30.42.10, 3 hits
InterProiView protein in InterPro
IPR019749, Band_41_domain
IPR014352, FERM/acyl-CoA-bd_prot_sf
IPR035963, FERM_2
IPR019748, FERM_central
IPR000299, FERM_domain
IPR018979, FERM_N
IPR018980, FERM_PH-like_C
IPR029906, FRMPD2
IPR011019, KIND_dom
IPR001478, PDZ
IPR036034, PDZ_sf
IPR011993, PH-like_dom_sf
IPR029071, Ubiquitin-like_domsf
PANTHERiPTHR19964:SF56, PTHR19964:SF56, 1 hit
PfamiView protein in Pfam
PF09380, FERM_C, 1 hit
PF00373, FERM_M, 1 hit
PF09379, FERM_N, 1 hit
PF00595, PDZ, 3 hits
PRINTSiPR00935, BAND41
SMARTiView protein in SMART
SM00295, B41, 1 hit
SM01196, FERM_C, 1 hit
SM00750, KIND, 1 hit
SM00228, PDZ, 3 hits
SUPFAMiSSF47031, SSF47031, 1 hit
SSF50156, SSF50156, 3 hits
SSF54236, SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50057, FERM_3, 1 hit
PS51377, KIND, 1 hit
PS50106, PDZ, 3 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFRPD2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q68DX3
Secondary accession number(s): B7WNW0
, B7ZML5, Q2VY07, Q6GMQ9, Q6ZN38, Q6ZWI2, Q8N5T9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: May 31, 2011
Last modified: September 29, 2021
This is version 159 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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