UniProtKB - Q68DK7 (MSL1_HUMAN)
Male-specific lethal 1 homolog
MSL1
Functioni
GO - Molecular functioni
- chromatin binding Source: GO_Central
GO - Biological processi
- histone H4-K16 acetylation Source: UniProtKB
Keywordsi
Molecular function | Chromatin regulator |
Enzyme and pathway databases
PathwayCommonsi | Q68DK7 |
Reactomei | R-HSA-3214847, HATs acetylate histones |
Names & Taxonomyi
Protein namesi | Recommended name: Male-specific lethal 1 homologShort name: MSL-1 Alternative name(s): Male-specific lethal 1-like 1 Short name: MSL1-like 1 Male-specific lethal-1 homolog 1 |
Gene namesi | Name:MSL1 Synonyms:MSL1L1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000188895.11 |
HGNCi | HGNC:27905, MSL1 |
MIMi | 614801, gene |
neXtProti | NX_Q68DK7 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
- nucleoplasm By similarity
- Nucleus speckle By similarity
Nucleus
- MSL complex Source: UniProtKB
- nuclear speck Source: UniProtKB
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 339287 |
OpenTargetsi | ENSG00000188895 |
PharmGKBi | PA164723127 |
Miscellaneous databases
Pharosi | Q68DK7, Tbio |
Polymorphism and mutation databases
BioMutai | MSL1 |
DMDMi | 322510113 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000349236 | 1 – 614 | Male-specific lethal 1 homologAdd BLAST | 614 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 66 | PhosphoserineCombined sources | 1 | |
Modified residuei | 126 | PhosphoserineCombined sources | 1 | |
Modified residuei | 205 | PhosphoserineCombined sources | 1 | |
Cross-linki | 301 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 353 | N6-acetyllysineCombined sources | 1 | |
Cross-linki | 365 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 378 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 393 | PhosphoserineCombined sources | 1 | |
Modified residuei | 396 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 442 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q68DK7 |
jPOSTi | Q68DK7 |
MassIVEi | Q68DK7 |
MaxQBi | Q68DK7 |
PaxDbi | Q68DK7 |
PeptideAtlasi | Q68DK7 |
PRIDEi | Q68DK7 |
ProteomicsDBi | 66086 [Q68DK7-1] 66087 [Q68DK7-2] 66088 [Q68DK7-3] |
TopDownProteomicsi | Q68DK7-2 [Q68DK7-2] |
PTM databases
iPTMneti | Q68DK7 |
PhosphoSitePlusi | Q68DK7 |
Expressioni
Inductioni
Gene expression databases
Bgeei | ENSG00000188895, Expressed in ventricular zone and 242 other tissues |
ExpressionAtlasi | Q68DK7, baseline and differential |
Genevisiblei | Q68DK7, HS |
Organism-specific databases
HPAi | ENSG00000188895, Low tissue specificity |
Interactioni
Subunit structurei
Component of a multisubunit histone acetyltransferase complex (MSL) at least composed of the KAT8/MOF/MYST1, MSL1/hampin, MSL2 and MSL3 (PubMed:16227571, PubMed:16543150).
Forms a MSL heterotetrameric core with MSL2 (PubMed:16227571).
Interacts with KAT8 and MSL3; both interactions are direct (PubMed:22547026, PubMed:21217699, PubMed:30224647). Directly interacts with NUPR1 (PubMed:19650074).
Interacts with TP53BP1; this interaction may be required for MSL1 DNA repair activity, but not for histone acetyltransferase activity (PubMed:19650074).
Interacts with TTC4, ECM2 and PIHD1 (By similarity).
By similarity6 PublicationsProtein-protein interaction databases
BioGRIDi | 130859, 44 interactors |
ComplexPortali | CPX-815, MSL histone acetyltransferase complex |
CORUMi | Q68DK7 |
DIPi | DIP-56862N |
IntActi | Q68DK7, 19 interactors |
STRINGi | 9606.ENSP00000462945 |
Miscellaneous databases
RNActi | Q68DK7, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q68DK7 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 223 – 237 | Interaction with MSL2Add BLAST | 15 | |
Regioni | 498 – 518 | Interaction with KAT8Add BLAST | 21 | |
Regioni | 550 – 591 | Sufficient for interaction with MSL3 MRG domainAdd BLAST | 42 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 213 – 282 | 1 PublicationAdd BLAST | 70 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 317 – 346 | Nuclear localization signalBy similarityAdd BLAST | 30 | |
Motifi | 505 – 519 | Bipartite nuclear localization signalBy similarityAdd BLAST | 15 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 10 – 15 | Poly-Ala | 6 | |
Compositional biasi | 55 – 185 | Pro-richAdd BLAST | 131 | |
Compositional biasi | 208 – 214 | Poly-Gly | 7 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QQ0S, Eukaryota |
GeneTreei | ENSGT00390000018292 |
HOGENOMi | CLU_030878_1_0_1 |
InParanoidi | Q68DK7 |
OMAi | GPSGHPK |
OrthoDBi | 560559at2759 |
PhylomeDBi | Q68DK7 |
TreeFami | TF330735 |
Family and domain databases
DisProti | DP01278 |
InterProi | View protein in InterPro IPR026711, Msl-1 IPR031840, MSL1_dimer IPR029332, PEHE_dom |
PANTHERi | PTHR21656, PTHR21656, 1 hit |
Pfami | View protein in Pfam PF16801, MSL1_dimer, 1 hit PF15275, PEHE, 1 hit |
SMARTi | View protein in SMART SM01300, PEHE, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTMRSAVFKA AAAPAGGNPE QRLDYERAAA LGGPEDEPGA AEAHFLPRHR
60 70 80 90 100
KLKEPGPPLA SSQGGSPAPS PAGCGGKGRG LLLPAGAAPG QQEESWGGSV
110 120 130 140 150
PLPCPPPATK QAGIGGEPAA AGAGCSPRPK YQAVLPIQTG SLVAAAKEPT
160 170 180 190 200
PWAGDKGGAA SPAATASDPA GPPPLPLPGP PPLAPTATAG TLAASEGRWK
210 220 230 240 250
SMRKSPLGGG GGSGASSQAA CLKQILLLQL DLIEQQQQQL QAKEKEIEEL
260 270 280 290 300
KSERDTLLAR IERMERRMQL VKKDNEKERH KLFQGYETEE REETELSEKI
310 320 330 340 350
KLECQPELSE TSQTLPPKPF SCGRSGKGHK RKSPFGSTER KTPVKKLAPE
360 370 380 390 400
FSKVKTKTPK HSPIKEEPCG SLSETVCKRE LRSQETPEKP RSSVDTPPRL
410 420 430 440 450
STPQKGPSTH PKEKAFSSEI EDLPYLSTTE MYLCRWHQPP PSPLPLRESS
460 470 480 490 500
PKKEETVARC LMPSSVAGET SVLAVPSWRD HSVEPLRDPN PSDLLENLDD
510 520 530 540 550
SVFSKRHAKL ELDEKRRKRW DIQRIREQRI LQRLQLRMYK KKGIQESEPE
560 570 580 590 600
VTSFFPEPDD VESLMITPFL PVVAFGRPLP KLTPQNFELP WLDERSRCRL
610
EIQKKQTPHR TCRK
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3KSZ8 | J3KSZ8_HUMAN | Male-specific lethal 1 homolog | MSL1 | 598 | Annotation score: | ||
J3QQY0 | J3QQY0_HUMAN | Male-specific lethal 1 homolog | MSL1 | 461 | Annotation score: | ||
J3KRQ4 | J3KRQ4_HUMAN | Male-specific lethal 1 homolog | MSL1 | 116 | Annotation score: | ||
J3KTC2 | J3KTC2_HUMAN | Male-specific lethal 1 homolog | MSL1 | 146 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 427 | S → P in CAH18213 (PubMed:17974005).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_035236 | 1 – 263 | Missing in isoform 3. 1 PublicationAdd BLAST | 263 | |
Alternative sequenceiVSP_035237 | 1 – 201 | Missing in isoform 2. 1 PublicationAdd BLAST | 201 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL049450 mRNA Translation: CAH10734.1 CR749360 mRNA Translation: CAH18213.1 AC068669 Genomic DNA No translation available. BC118997 mRNA Translation: AAI18998.1 BC122543 mRNA Translation: AAI22544.1 |
CCDSi | CCDS45670.1 [Q68DK7-3] |
RefSeqi | NP_001012241.1, NM_001012241.1 [Q68DK7-3] XP_005257355.1, XM_005257298.4 |
Genome annotation databases
Ensembli | ENST00000398532; ENSP00000381543; ENSG00000188895 [Q68DK7-1] ENST00000579565; ENSP00000462945; ENSG00000188895 [Q68DK7-3] |
GeneIDi | 339287 |
KEGGi | hsa:339287 |
UCSCi | uc002hua.6, human [Q68DK7-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL049450 mRNA Translation: CAH10734.1 CR749360 mRNA Translation: CAH18213.1 AC068669 Genomic DNA No translation available. BC118997 mRNA Translation: AAI18998.1 BC122543 mRNA Translation: AAI22544.1 |
CCDSi | CCDS45670.1 [Q68DK7-3] |
RefSeqi | NP_001012241.1, NM_001012241.1 [Q68DK7-3] XP_005257355.1, XM_005257298.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4B7Y | X-ray | 3.25 | A/B | 212-252 | [»] | |
4B86 | X-ray | 3.50 | A/B/E/F/I/J | 212-267 | [»] | |
4DNC | X-ray | 2.05 | D/E | 473-520 | [»] | |
SMRi | Q68DK7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 130859, 44 interactors |
ComplexPortali | CPX-815, MSL histone acetyltransferase complex |
CORUMi | Q68DK7 |
DIPi | DIP-56862N |
IntActi | Q68DK7, 19 interactors |
STRINGi | 9606.ENSP00000462945 |
PTM databases
iPTMneti | Q68DK7 |
PhosphoSitePlusi | Q68DK7 |
Polymorphism and mutation databases
BioMutai | MSL1 |
DMDMi | 322510113 |
Proteomic databases
EPDi | Q68DK7 |
jPOSTi | Q68DK7 |
MassIVEi | Q68DK7 |
MaxQBi | Q68DK7 |
PaxDbi | Q68DK7 |
PeptideAtlasi | Q68DK7 |
PRIDEi | Q68DK7 |
ProteomicsDBi | 66086 [Q68DK7-1] 66087 [Q68DK7-2] 66088 [Q68DK7-3] |
TopDownProteomicsi | Q68DK7-2 [Q68DK7-2] |
Protocols and materials databases
Antibodypediai | 7890, 87 antibodies |
DNASUi | 339287 |
Genome annotation databases
Ensembli | ENST00000398532; ENSP00000381543; ENSG00000188895 [Q68DK7-1] ENST00000579565; ENSP00000462945; ENSG00000188895 [Q68DK7-3] |
GeneIDi | 339287 |
KEGGi | hsa:339287 |
UCSCi | uc002hua.6, human [Q68DK7-1] |
Organism-specific databases
CTDi | 339287 |
DisGeNETi | 339287 |
EuPathDBi | HostDB:ENSG00000188895.11 |
GeneCardsi | MSL1 |
HGNCi | HGNC:27905, MSL1 |
HPAi | ENSG00000188895, Low tissue specificity |
MIMi | 614801, gene |
neXtProti | NX_Q68DK7 |
OpenTargetsi | ENSG00000188895 |
PharmGKBi | PA164723127 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QQ0S, Eukaryota |
GeneTreei | ENSGT00390000018292 |
HOGENOMi | CLU_030878_1_0_1 |
InParanoidi | Q68DK7 |
OMAi | GPSGHPK |
OrthoDBi | 560559at2759 |
PhylomeDBi | Q68DK7 |
TreeFami | TF330735 |
Enzyme and pathway databases
PathwayCommonsi | Q68DK7 |
Reactomei | R-HSA-3214847, HATs acetylate histones |
Miscellaneous databases
BioGRID-ORCSi | 339287, 127 hits in 848 CRISPR screens |
ChiTaRSi | MSL1, human |
GenomeRNAii | 339287 |
Pharosi | Q68DK7, Tbio |
PROi | PR:Q68DK7 |
RNActi | Q68DK7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000188895, Expressed in ventricular zone and 242 other tissues |
ExpressionAtlasi | Q68DK7, baseline and differential |
Genevisiblei | Q68DK7, HS |
Family and domain databases
DisProti | DP01278 |
InterProi | View protein in InterPro IPR026711, Msl-1 IPR031840, MSL1_dimer IPR029332, PEHE_dom |
PANTHERi | PTHR21656, PTHR21656, 1 hit |
Pfami | View protein in Pfam PF16801, MSL1_dimer, 1 hit PF15275, PEHE, 1 hit |
SMARTi | View protein in SMART SM01300, PEHE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MSL1_HUMAN | |
Accessioni | Q68DK7Primary (citable) accession number: Q68DK7 Secondary accession number(s): Q0VF46, Q69Z03 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 2, 2008 |
Last sequence update: | February 8, 2011 | |
Last modified: | December 2, 2020 | |
This is version 122 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM