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Entry version 129 (08 May 2019)
Sequence version 3 (18 May 2010)
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Protein

Zinc finger FYVE domain-containing protein 26

Gene

ZFYVE26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1812 – 1872FYVE-typePROSITE-ProRule annotationAdd BLAST61

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, DNA damage, DNA repair
LigandLipid-binding, Metal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger FYVE domain-containing protein 26
Alternative name(s):
FYVE domain-containing centrosomal protein
Short name:
FYVE-CENT
Spastizin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZFYVE26
Synonyms:KIAA0321
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20761 ZFYVE26

Online Mendelian Inheritance in Man (OMIM)

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MIMi
612012 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q68DK2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Spastic paraplegia 15, autosomal recessive (SPG15)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. SPG15 is a complex form associated with additional neurological symptoms such as cognitive deterioration or mental retardation, axonal neuropathy, mild cerebellar signs, and, less frequently, a central hearing deficit, decreased visual acuity, or retinal degeneration.
See also OMIM:270700

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1836R → A: Abolishes phosphatidylinositol 3-phosphate-binding and localization to the midbody. 1 Publication1

Keywords - Diseasei

Hereditary spastic paraplegia, Neurodegeneration

Organism-specific databases

DisGeNET

More...
DisGeNETi
23503

MalaCards human disease database

More...
MalaCardsi
ZFYVE26
MIMi270700 phenotype

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
100996 Autosomal recessive spastic paraplegia type 15

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134904455

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZFYVE26

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296453077

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003146121 – 2539Zinc finger FYVE domain-containing protein 26Add BLAST2539

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei297PhosphoserineCombined sources1
Modified residuei615PhosphoserineBy similarity1
Modified residuei619PhosphoserineCombined sources1
Modified residuei703PhosphoserineCombined sources1
Modified residuei800PhosphoserineCombined sources1
Modified residuei1742PhosphoserineBy similarity1
Modified residuei1764PhosphoserineCombined sources1
Modified residuei1780PhosphoserineBy similarity1
Modified residuei1782PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q68DK2

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q68DK2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q68DK2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q68DK2

PeptideAtlas

More...
PeptideAtlasi
Q68DK2

PRoteomics IDEntifications database

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PRIDEi
Q68DK2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
66082
66083 [Q68DK2-2]
66084 [Q68DK2-3]
66085 [Q68DK2-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q68DK2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q68DK2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Strongest expression in the adrenal gland, bone marrow, adult brain, fetal brain, lung, placenta, prostate, skeletal muscle, testis, thymus, and retina. Intermediate levels are detected in other structures, including the spinal cord.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000072121 Expressed in 227 organ(s), highest expression level in tendon

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q68DK2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q68DK2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA055500

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with AP5Z1, AP5B1, AP5S1 and SPG11. Interacts with TTC19 and KIF13A.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
117050, 27 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q68DK2

Protein interaction database and analysis system

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IntActi
Q68DK2, 39 interactors

Molecular INTeraction database

More...
MINTi
Q68DK2

STRING: functional protein association networks

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STRINGi
9606.ENSP00000251119

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q68DK2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili868 – 895Sequence analysisAdd BLAST28

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The FYVE-type zinc finger mediates binding to phosphatidylinositol 3-phosphate and recruitment to the midbody during cytokinesis.1 Publication

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1812 – 1872FYVE-typePROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1811 Eukaryota
ENOG410XRV7 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000206029

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q68DK2

KEGG Orthology (KO)

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KOi
K19027

Database of Orthologous Groups

More...
OrthoDBi
1237900at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q68DK2

TreeFam database of animal gene trees

More...
TreeFami
TF324517

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028730 ZFYVE26
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD

The PANTHER Classification System

More...
PANTHERi
PTHR46591 PTHR46591, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01363 FYVE, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00064 FYVE, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57903 SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50178 ZF_FYVE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q68DK2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNHPFGKEEA ASQKQLFGFF CECLRRGEWE LAQACVPQLQ EGQGDIPKRV
60 70 80 90 100
EDILQALVVC PNLLRCGQDI NPQRVAWVWL LVLEKWLARE KKLLPVVFRR
110 120 130 140 150
KLEFLLLSED LQGDIPENIL EELYETLTQG AVGHVPDGNP RRESWTPRLS
160 170 180 190 200
SEAVSVLWDL LRQSPQPAQA LLELLLEEDD GTGLCHWPLQ NALVDLIRKA
210 220 230 240 250
LRALQGPDSV PPGVVDAIYG ALRTLRCPAE PLGVELHLLC EELLEACRTE
260 270 280 290 300
GSPLREERLL SCLLHKASRG LLSLYGHTYA EKVTEKPPRA TASGKVSPDH
310 320 330 340 350
LDPERAMLAL FSNPNPAEAW KVAYFYCLSN NKHFLEQILV TALTLLKEED
360 370 380 390 400
FPNLGCLLDR EFRPLSCLLV LLGWTHCQSL ESAKRLLQTL HRTQGPGCDE
410 420 430 440 450
LLRDACDGLW AHLEVLEWCI QQSSNPIPKR DLLYHLHGGD SHSVLYTLHH
460 470 480 490 500
LTNLPALREE DVLKLLQKVP AKDPQQEPDA VDAPVPEHLS QCQNLTLYQG
510 520 530 540 550
FCAMKYAIYA LCVNSHQHSQ CQDCKDSLSE DLASATEPAN DSLSSPGAAN
560 570 580 590 600
LFSTYLARCQ QYLCSIPDSL CLELLENIFS LLLITSADLH PEPHLPEDYA
610 620 630 640 650
EDDDIEGKSP SGLRSPSESP QHIAHPERKS ERGSLGVPKT LAYTMPSHVK
660 670 680 690 700
AEPKDSYPGP HRHSFLDLKH FTSGISGFLA DEFAIGAFLR LLQEQLDEIS
710 720 730 740 750
SRSPPEKPKQ ESQSCSGSRD GLQSRLHRLS KVVSEAQWRH KVVTSNHRSE
760 770 780 790 800
EQPSRRYQPA TRHPSLRRGR RTRRSQADGR DRGSNPSLES TSSELSTSTS
810 820 830 840 850
EGSLSAMSGR NELHSRLHPH PQSSLIPMMF SPPESLLASC ILRGNFAEAH
860 870 880 890 900
QVLFTFNLKS SPSSGELMFM ERYQEVIQEL AQVEHKIENQ NSDAGSSTIR
910 920 930 940 950
RTGSGRSTLQ AIGSAAAAGM VFYSISDVTD KLLNTSGDPI PMLQEDFWIS
960 970 980 990 1000
TALVEPTAPL REVLEDLSPP AMAAFDLACS QCQLWKTCKQ LLETAERRLN
1010 1020 1030 1040 1050
SSLERRGRRI DHVLLNADGI RGFPVVLQQI SKSLNYLLMS ASQTKSESVE
1060 1070 1080 1090 1100
EKGGGPPRCS ITELLQMCWP SLSEDCVASH TTLSQQLDQV LQSLREALEL
1110 1120 1130 1140 1150
PEPRTPPLSS LVEQAAQKAP EAEAHPVQIQ TQLLQKNLGK QTPSGSRQMD
1160 1170 1180 1190 1200
YLGTFFSYCS TLAAVLLQSL SSEPDHVEVK VGNPFVLLQQ SSSQLVSHLL
1210 1220 1230 1240 1250
FERQVPPERL AALLAQENLS LSVPQVIVSC CCEPLALCSS RQSQQTSSLL
1260 1270 1280 1290 1300
TRLGTLAQLH ASHCLDDLPL STPSSPRTTE NPTLERKPYS SPRDSSLPAL
1310 1320 1330 1340 1350
TSSALAFLKS RSKLLATVAC LGASPRLKVS KPSLSWKELR GRREVPLAAE
1360 1370 1380 1390 1400
QVARECERLL EQFPLFEAFL LAAWEPLRGS LQQGQSLAVN LCGWASLSTV
1410 1420 1430 1440 1450
LLGLHSPIAL DVLSEAFEES LVARDWSRAL QLTEVYGRDV DDLSSIKDAV
1460 1470 1480 1490 1500
LSCAVACDKE GWQYLFPVKD ASLRSRLALQ FVDRWPLESC LEILAYCISD
1510 1520 1530 1540 1550
TAVQEGLKCE LQRKLAELQV YQKILGLQSP PVWCDWQTLR SCCVEDPSTV
1560 1570 1580 1590 1600
MNMILEAQEY ELCEEWGCLY PIPREHLISL HQKHLLHLLE RRDHDKALQL
1610 1620 1630 1640 1650
LRRIPDPTMC LEVTEQSLDQ HTSLATSHFL ANYLTTHFYG QLTAVRHREI
1660 1670 1680 1690 1700
QALYVGSKIL LTLPEQHRAS YSHLSSNPLF MLEQLLMNMK VDWATVAVQT
1710 1720 1730 1740 1750
LQQLLVGQEI GFTMDEVDSL LSRYAEKALD FPYPQREKRS DSVIHLQEIV
1760 1770 1780 1790 1800
HQAADPETLP RSPSAEFSPA APPGISSIHS PSLRERSFPP TQPSQEFVPP
1810 1820 1830 1840 1850
ATPPARHQWV PDETESICMV CCREHFTMFN RRHHCRRCGR LVCSSCSTKK
1860 1870 1880 1890 1900
MVVEGCRENP ARVCDQCYSY CNKDVPEEPS EKPEALDSSK SESPPYSFVV
1910 1920 1930 1940 1950
RVPKADEVEW ILDLKEEENE LVRSEFYYEQ APSASLCIAI LNLHRDSIAC
1960 1970 1980 1990 2000
GHQLIEHCCR LSKGLTNPEV DAGLLTDIMK QLLFSAKMMF VKAGQSQDLA
2010 2020 2030 2040 2050
LCDSYISKVD VLNILVAAAY RHVPSLDQIL QPAAVTRLRN QLLEAEYYQL
2060 2070 2080 2090 2100
GVEVSTKTGL DTTGAWHAWG MACLKAGNLT AAREKFSRCL KPPFDLNQLN
2110 2120 2130 2140 2150
HGSRLVQDVV EYLESTVRPF VSLQDDDYFA TLRELEATLR TQSLSLAVIP
2160 2170 2180 2190 2200
EGKIMNNTYY QECLFYLHNY STNLAIISFY VRHSCLREAL LHLLNKESPP
2210 2220 2230 2240 2250
EVFIEGIFQP SYKSGKLHTL ENLLESIDPT LESWGKYLIA ACQHLQKKNY
2260 2270 2280 2290 2300
YHILYELQQF MKDQVRAAMT CIRFFSHKAK SYTELGEKLS WLLKAKDHLK
2310 2320 2330 2340 2350
IYLQETSRSS GRKKTTFFRK KMTAADVSRH MNTLQLQMEV TRFLHRCESA
2360 2370 2380 2390 2400
GTSQITTLPL PTLFGNNHMK MDVACKVMLG GKNVEDGFGI AFRVLQDFQL
2410 2420 2430 2440 2450
DAAMTYCRAA RQLVEKEKYS EIQQLLKCVS ESGMAAKSDG DTILLNCLEA
2460 2470 2480 2490 2500
FKRIPPQELE GLIQAIHNDD NKVRAYLICC KLRSAYLIAV KQEHSRATAL
2510 2520 2530
VQQVQQAAKS SGDAVVQDIC AQWLLTSHPR GAHGPGSRK
Length:2,539
Mass (Da):284,576
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i991862A89C8581F1
GO
Isoform 2 (identifier: Q68DK2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     203-223: Missing.

Note: No experimental confirmation available.
Show »
Length:2,518
Mass (Da):282,499
Checksum:i922EDB05E118C1DA
GO
Isoform 4 (identifier: Q68DK2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     778-791: DGRDRGSNPSLEST → GNLKSSFPCTRQVV
     792-2539: Missing.

Note: No experimental confirmation available.
Show »
Length:791
Mass (Da):88,820
Checksum:i380D3A84F74C1023
GO
Isoform 3 (identifier: Q68DK2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1809: Missing.
     1810-1828: VPDETESICMVCCREHFTM → MAISPSLLPLSSPPDGIPQ
     2473-2539: VRAYLICCKL...RGAHGPGSRK → IVPILAALRDRVHTEERGRSPSTLC

Note: No experimental confirmation available.
Show »
Length:688
Mass (Da):77,970
Checksum:i2229E6E433962E5B
GO
Isoform 5 (identifier: Q68DK2-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2474-2481: RAYLICCK → SGIVSKRW
     2482-2539: Missing.

Show »
Length:2,481
Mass (Da):278,335
Checksum:iF04FE560E7E1ABA5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V2D8G3V2D8_HUMAN
Zinc finger FYVE domain-containing ...
ZFYVE26
2,225Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2H2FF08A0A2H2FF08_HUMAN
Zinc finger FYVE domain-containing ...
ZFYVE26
327Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V230G3V230_HUMAN
Zinc finger FYVE domain-containing ...
ZFYVE26
444Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAG11658 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAD97882 differs from that shown. Reason: Erroneous termination at position 1463. Translated as Gln.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti243L → P in CAD97882 (PubMed:17974005).Curated1
Sequence conflicti556L → P in BAG11658 (PubMed:9205841).Curated1
Sequence conflicti586S → P in CAH18131 (PubMed:17974005).Curated1
Sequence conflicti629K → E in CAH18131 (PubMed:17974005).Curated1
Sequence conflicti946D → G in CAH18218 (PubMed:17974005).Curated1
Sequence conflicti1040S → T in BAG11658 (PubMed:9205841).Curated1
Sequence conflicti1115A → T in CAH18131 (PubMed:17974005).Curated1
Sequence conflicti1320C → S in CAH18218 (PubMed:17974005).Curated1
Sequence conflicti1358R → H in CAH18131 (PubMed:17974005).Curated1
Sequence conflicti1556E → V in CAH18131 (PubMed:17974005).Curated1
Sequence conflicti1597A → T in CAH10379 (PubMed:17974005).Curated1
Sequence conflicti1615E → K in CAH10379 (PubMed:17974005).Curated1
Sequence conflicti1670S → N in CAH18218 (PubMed:17974005).Curated1
Sequence conflicti1727K → R in CAH10379 (PubMed:17974005).Curated1
Sequence conflicti1774G → D in CAD97882 (PubMed:17974005).Curated1
Sequence conflicti2246Q → L in CAH18131 (PubMed:17974005).Curated1
Sequence conflicti2288K → R in CAD97882 (PubMed:17974005).Curated1
Sequence conflicti2434M → L in AAH33235 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_037987429K → E. Corresponds to variant dbSNP:rs34059852Ensembl.1
Natural variantiVAR_037988898T → S. Corresponds to variant dbSNP:rs17192170EnsemblClinVar.1
Natural variantiVAR_037989951T → M. Corresponds to variant dbSNP:rs35471427EnsemblClinVar.1
Natural variantiVAR_0379901071S → N. Corresponds to variant dbSNP:rs7156206Ensembl.1
Natural variantiVAR_0379911103P → L1 PublicationCorresponds to variant dbSNP:rs3742885EnsemblClinVar.1
Natural variantiVAR_0379921122A → V. Corresponds to variant dbSNP:rs3742884EnsemblClinVar.1
Natural variantiVAR_0379931164A → E in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0379941457C → Y2 PublicationsCorresponds to variant dbSNP:rs2235967EnsemblClinVar.1
Natural variantiVAR_0379951891S → N2 PublicationsCorresponds to variant dbSNP:rs3742883Ensembl.1
Natural variantiVAR_0379961945R → Q in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0379972411R → H. Corresponds to variant dbSNP:rs34373049EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0303381 – 1809Missing in isoform 3. 1 PublicationAdd BLAST1809
Alternative sequenceiVSP_030339203 – 223Missing in isoform 2. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_041049778 – 791DGRDR…SLEST → GNLKSSFPCTRQVV in isoform 4. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_041050792 – 2539Missing in isoform 4. 1 PublicationAdd BLAST1748
Alternative sequenceiVSP_0303401810 – 1828VPDET…EHFTM → MAISPSLLPLSSPPDGIPQ in isoform 3. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_0303412473 – 2539VRAYL…PGSRK → IVPILAALRDRVHTEERGRS PSTLC in isoform 3. 1 PublicationAdd BLAST67
Alternative sequenceiVSP_0589632474 – 2481RAYLICCK → SGIVSKRW in isoform 5. 8
Alternative sequenceiVSP_0589642482 – 2539Missing in isoform 5. Add BLAST58

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB002319 mRNA Translation: BAA20779.1
AB425197 mRNA Translation: BAG11658.1 Different initiation.
AK304428 mRNA Translation: BAG65255.1
AK128496 mRNA Translation: BAC87467.1
BX537886 mRNA Translation: CAD97882.1 Sequence problems.
BX538025 mRNA Translation: CAD97971.1
BX648683 mRNA Translation: CAH10379.1
CR749276 mRNA Translation: CAH18131.1
CR749365 mRNA Translation: CAH18218.1
AL049779 Genomic DNA No translation available.
AL121595 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW80954.1
BC008927 mRNA Translation: AAH08927.2
BC033235 mRNA Translation: AAH33235.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9788.1 [Q68DK2-1]

NCBI Reference Sequences

More...
RefSeqi
NP_056161.2, NM_015346.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000347230; ENSP00000251119; ENSG00000072121

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23503

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23503

UCSC genome browser

More...
UCSCi
uc001xka.2 human [Q68DK2-1]
uc001xkb.4 human

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002319 mRNA Translation: BAA20779.1
AB425197 mRNA Translation: BAG11658.1 Different initiation.
AK304428 mRNA Translation: BAG65255.1
AK128496 mRNA Translation: BAC87467.1
BX537886 mRNA Translation: CAD97882.1 Sequence problems.
BX538025 mRNA Translation: CAD97971.1
BX648683 mRNA Translation: CAH10379.1
CR749276 mRNA Translation: CAH18131.1
CR749365 mRNA Translation: CAH18218.1
AL049779 Genomic DNA No translation available.
AL121595 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW80954.1
BC008927 mRNA Translation: AAH08927.2
BC033235 mRNA Translation: AAH33235.2
CCDSiCCDS9788.1 [Q68DK2-1]
RefSeqiNP_056161.2, NM_015346.3

3D structure databases

SMRiQ68DK2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117050, 27 interactors
CORUMiQ68DK2
IntActiQ68DK2, 39 interactors
MINTiQ68DK2
STRINGi9606.ENSP00000251119

PTM databases

iPTMnetiQ68DK2
PhosphoSitePlusiQ68DK2

Polymorphism and mutation databases

BioMutaiZFYVE26
DMDMi296453077

Proteomic databases

EPDiQ68DK2
jPOSTiQ68DK2
MaxQBiQ68DK2
PaxDbiQ68DK2
PeptideAtlasiQ68DK2
PRIDEiQ68DK2
ProteomicsDBi66082
66083 [Q68DK2-2]
66084 [Q68DK2-3]
66085 [Q68DK2-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
23503
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000347230; ENSP00000251119; ENSG00000072121
GeneIDi23503
KEGGihsa:23503
UCSCiuc001xka.2 human [Q68DK2-1]
uc001xkb.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23503
DisGeNETi23503

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZFYVE26

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0011757
HGNCiHGNC:20761 ZFYVE26
HPAiHPA055500
MalaCardsiZFYVE26
MIMi270700 phenotype
612012 gene
neXtProtiNX_Q68DK2
Orphaneti100996 Autosomal recessive spastic paraplegia type 15
PharmGKBiPA134904455

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1811 Eukaryota
ENOG410XRV7 LUCA
HOGENOMiHOG000206029
InParanoidiQ68DK2
KOiK19027
OrthoDBi1237900at2759
PhylomeDBiQ68DK2
TreeFamiTF324517

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ZFYVE26 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23503

Protein Ontology

More...
PROi
PR:Q68DK2

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000072121 Expressed in 227 organ(s), highest expression level in tendon
ExpressionAtlasiQ68DK2 baseline and differential
GenevisibleiQ68DK2 HS

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR028730 ZFYVE26
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR46591 PTHR46591, 1 hit
PfamiView protein in Pfam
PF01363 FYVE, 1 hit
SMARTiView protein in SMART
SM00064 FYVE, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50178 ZF_FYVE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZFY26_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q68DK2
Secondary accession number(s): B1B5Y3
, B4E2U3, O15035, Q68DT9, Q6AW90, Q6ZR50, Q7Z3A4, Q7Z3I1, Q8N4W7, Q96H43
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 18, 2010
Last modified: May 8, 2019
This is version 129 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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