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UniProtKB - Q68DH5 (LMBD2_HUMAN)

Entry version 95 (08 May 2019)
Sequence version 1 (11 Oct 2004)
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Protein

LMBR1 domain-containing protein 2

Gene

LMBRD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
LMBR1 domain-containing protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LMBRD2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:25287 LMBRD2

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q68DH5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 5ExtracellularSequence analysis5
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei6 – 21HelicalSequence analysisAdd BLAST16
Topological domaini22 – 32CytoplasmicSequence analysisAdd BLAST11
Transmembranei33 – 53HelicalSequence analysisAdd BLAST21
Topological domaini54 – 105ExtracellularSequence analysisAdd BLAST52
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
Topological domaini127 – 150CytoplasmicSequence analysisAdd BLAST24
Transmembranei151 – 171HelicalSequence analysisAdd BLAST21
Topological domaini172 – 186ExtracellularSequence analysisAdd BLAST15
Transmembranei187 – 207HelicalSequence analysisAdd BLAST21
Topological domaini208 – 387CytoplasmicSequence analysisAdd BLAST180
Transmembranei388 – 408HelicalSequence analysisAdd BLAST21
Topological domaini409 – 432ExtracellularSequence analysisAdd BLAST24
Transmembranei433 – 453HelicalSequence analysisAdd BLAST21
Topological domaini454 – 473CytoplasmicSequence analysisAdd BLAST20
Transmembranei474 – 494HelicalSequence analysisAdd BLAST21
Topological domaini495 – 521ExtracellularSequence analysisAdd BLAST27
Transmembranei522 – 542HelicalSequence analysisAdd BLAST21
Topological domaini543 – 695CytoplasmicSequence analysisAdd BLAST153

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		92255

Open Targets

More...OpenTargetsi		ENSG00000164187

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142671541

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		LMBRD2

Domain mapping of disease mutations (DMDM)

More...DMDMi		74708880

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002991611 – 695LMBR1 domain-containing protein 2Add BLAST695

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi78N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei633PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q68DH5

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q68DH5

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q68DH5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q68DH5

PeptideAtlas

More...PeptideAtlasi		Q68DH5

PRoteomics IDEntifications database

More...PRIDEi		Q68DH5

ProteomicsDB human proteome resource

More...ProteomicsDBi		66080

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q68DH5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q68DH5

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q68DH5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000164187 Expressed in 205 organ(s), highest expression level in dorsolateral prefrontal cortex

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q68DH5 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA012165

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		124923, 25 interactors

Protein interaction database and analysis system

More...IntActi		Q68DH5, 3 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000296603

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q68DH5

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili227 – 262Sequence analysisAdd BLAST36
Coiled coili571 – 603Sequence analysisAdd BLAST33

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LIMR family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2296 Eukaryota
ENOG410XR8P LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000018651

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000007029

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q68DH5

Identification of Orthologs from Complete Genome Data

More...OMAi		LPLMQSY

Database of Orthologous Groups

More...OrthoDBi		778022at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q68DH5

TreeFam database of animal gene trees

More...TreeFami		TF314938

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006876 LMBR1-like_membr_prot

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04791 LMBR1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q68DH5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGAALGLEI VFVFFLALFL LHRYGDFKKQ HRLVIIGTLL AWYLCFLIVF 
        60         70         80         90        100
ILPLDVSTTI YNRCKHAAAN SSPPENSNIT GLYATANPVP SQHPCFKPWS 
       110        120        130        140        150
YIPDGIMPIF WRVVYWTSQF LTWILLPFMQ SYARSGGFSI TGKIKTALIE 
       160        170        180        190        200
NAIYYGTYLL IFGAFLIYVA VNPHLHLEWN QLQTIGIAAA NTWGLFLLVL 
       210        220        230        240        250
LLGYGLVEIP RSYWNGAKRG YLLMKTYFKA AKLMTEKADA EENLEDAMEE 
       260        270        280        290        300
VRKVNESIKY NHPLRKCVDT ILKKCPTEYQ EKMGRNMDDY EDFDEKHSIY 
       310        320        330        340        350
PSEKSLVKLH KQVIYSVQRH RRTQVQWQIL LEQAFYLEDV AKNETSATHQ 
       360        370        380        390        400
FVHTFQSPEP ENRFIQYFYN PTFEWYWECL LRPWFYKILA VVLSIFSVIV 
       410        420        430        440        450
VWSECTFFST TPVLSLFAVF IQLAEKTYNY IYIEIACFLS IFFLSICVYS 
       460        470        480        490        500
TVFRIRVFNY YYLASHHQTD AYSLLFSGML FCRLTPPLCL NFLGLTHMDS 
       510        520        530        540        550
SISHKNTQPT AYTSIMGSMK VLSFIADGFY IYYPMLVVIL CIATYFSLGT 
       560        570        580        590        600
RCLNLLGFQQ FMGDDDMTSD LVNEGKELIR KEKRKRQRQE EGENRRREWK 
       610        620        630        640        650
ERYGHNREDS TRNRNIHTDP KESNFSDVNT NRSAFKYTRA NNRTERDRIE 
       660        670        680        690 
LLQDAEPLDF NAETFTDDPL ESESGRYQPG GRYLSMSRSD IFNDV
Length:695
Mass (Da):81,172
Last modified:October 11, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i653291F14D535BC0
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK091295 mRNA Translation: BAG52328.1
CR749399 mRNA Translation: CAH18245.1
AL137370 mRNA Translation: CAB70714.1
BC110506 mRNA Translation: AAI10507.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS34145.1

Protein sequence database of the Protein Information Resource

More...PIRi		T46434

NCBI Reference Sequences

More...RefSeqi		NP_001007528.1, NM_001007527.1
XP_011512464.1, XM_011514162.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000296603; ENSP00000296603; ENSG00000164187

Database of genes from NCBI RefSeq genomes

More...GeneIDi		92255

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:92255

UCSC genome browser

More...UCSCi		uc003jka.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091295 mRNA Translation: BAG52328.1
CR749399 mRNA Translation: CAH18245.1
AL137370 mRNA Translation: CAB70714.1
BC110506 mRNA Translation: AAI10507.1
CCDSiCCDS34145.1
PIRiT46434
RefSeqiNP_001007528.1, NM_001007527.1
XP_011512464.1, XM_011514162.2

3D structure databases

SMRiQ68DH5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124923, 25 interactors
IntActiQ68DH5, 3 interactors
STRINGi9606.ENSP00000296603

PTM databases

iPTMnetiQ68DH5
PhosphoSitePlusiQ68DH5
SwissPalmiQ68DH5

Polymorphism and mutation databases

BioMutaiLMBRD2
DMDMi74708880

Proteomic databases

EPDiQ68DH5
jPOSTiQ68DH5
MaxQBiQ68DH5
PaxDbiQ68DH5
PeptideAtlasiQ68DH5
PRIDEiQ68DH5
ProteomicsDBi66080

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296603; ENSP00000296603; ENSG00000164187
GeneIDi92255
KEGGihsa:92255
UCSCiuc003jka.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		92255
DisGeNETi92255

GeneCards: human genes, protein and diseases

More...GeneCardsi		LMBRD2

H-Invitational Database, human transcriptome db

More...H-InvDBi		HIX0004810
HGNCiHGNC:25287 LMBRD2
HPAiHPA012165
neXtProtiNX_Q68DH5
OpenTargetsiENSG00000164187
PharmGKBiPA142671541

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2296 Eukaryota
ENOG410XR8P LUCA
GeneTreeiENSGT00390000018651
HOGENOMiHOG000007029
InParanoidiQ68DH5
OMAiLPLMQSY
OrthoDBi778022at2759
PhylomeDBiQ68DH5
TreeFamiTF314938

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		92255

Protein Ontology

More...PROi		PR:Q68DH5

Gene expression databases

BgeeiENSG00000164187 Expressed in 205 organ(s), highest expression level in dorsolateral prefrontal cortex
GenevisibleiQ68DH5 HS

Family and domain databases

InterProiView protein in InterPro
IPR006876 LMBR1-like_membr_prot
PfamiView protein in Pfam
PF04791 LMBR1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLMBD2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q68DH5
Secondary accession number(s): B3KRB6, Q9NTC7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: October 11, 2004
Last modified: May 8, 2019
This is version 95 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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