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UniProtKB - Q68DH5 (LMBD2_HUMAN)
Protein
G-protein coupled receptor-associated protein LMBRD2
Gene
LMBRD2
Organism
Homo sapiens (Human)
Status
Functioni
Recruited to ligand-activated beta-2 adrenergic receptor/ADRB2, it negatively regulates the adrenergic receptor signaling pathway (PubMed:28388415).
May also regulate other G-protein coupled receptors including type-1 angiotensin II receptor/AGTR1 (Probable).
1 Publication1 PublicationGO - Biological processi
- adrenergic receptor signaling pathway Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q68DH5 |
SignaLinki | Q68DH5 |
Names & Taxonomyi
Protein namesi | Recommended name: G-protein coupled receptor-associated protein LMBRD21 PublicationAlternative name(s): LMBR1 domain-containing protein 2Imported |
Gene namesi | Name:LMBRD2Imported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25287, LMBRD2 |
MIMi | 619490, gene |
neXtProti | NX_Q68DH5 |
VEuPathDBi | HostDB:ENSG00000164187 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 5 | ExtracellularSequence analysis | 5 | |
Transmembranei | 6 – 21 | HelicalSequence analysisAdd BLAST | 16 | |
Topological domaini | 22 – 32 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 33 – 53 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 54 – 105 | ExtracellularSequence analysisAdd BLAST | 52 | |
Transmembranei | 106 – 126 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 127 – 150 | CytoplasmicSequence analysisAdd BLAST | 24 | |
Transmembranei | 151 – 171 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 172 – 186 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 187 – 207 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 208 – 387 | CytoplasmicSequence analysisAdd BLAST | 180 | |
Transmembranei | 388 – 408 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 409 – 432 | ExtracellularSequence analysisAdd BLAST | 24 | |
Transmembranei | 433 – 453 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 454 – 473 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 474 – 494 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 495 – 521 | ExtracellularSequence analysisAdd BLAST | 27 | |
Transmembranei | 522 – 542 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 543 – 695 | CytoplasmicSequence analysisAdd BLAST | 153 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 92255 |
OpenTargetsi | ENSG00000164187 |
PharmGKBi | PA142671541 |
Miscellaneous databases
Pharosi | Q68DH5, Tdark |
Genetic variation databases
BioMutai | LMBRD2 |
DMDMi | 74708880 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000299161 | 1 – 695 | G-protein coupled receptor-associated protein LMBRD2Add BLAST | 695 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 78 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 633 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q68DH5 |
jPOSTi | Q68DH5 |
MassIVEi | Q68DH5 |
MaxQBi | Q68DH5 |
PaxDbi | Q68DH5 |
PeptideAtlasi | Q68DH5 |
PRIDEi | Q68DH5 |
ProteomicsDBi | 66080 |
PTM databases
GlyGeni | Q68DH5, 1 site |
iPTMneti | Q68DH5 |
PhosphoSitePlusi | Q68DH5 |
SwissPalmi | Q68DH5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000164187, Expressed in dorsolateral prefrontal cortex and 220 other tissues |
Genevisiblei | Q68DH5, HS |
Organism-specific databases
HPAi | ENSG00000164187, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 124923, 59 interactors |
IntActi | Q68DH5, 22 interactors |
MINTi | Q68DH5 |
STRINGi | 9606.ENSP00000296603 |
Miscellaneous databases
RNActi | Q68DH5, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 581 – 628 | DisorderedSequence analysisAdd BLAST | 48 | |
Regioni | 662 – 682 | DisorderedSequence analysisAdd BLAST | 21 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 227 – 262 | Sequence analysisAdd BLAST | 36 | |
Coiled coili | 571 – 603 | Sequence analysisAdd BLAST | 33 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 581 – 621 | Basic and acidic residuesSequence analysisAdd BLAST | 41 |
Sequence similaritiesi
Belongs to the LIMR family.Curated
Keywords - Domaini
Coiled coil, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2296, Eukaryota |
GeneTreei | ENSGT00390000018651 |
HOGENOMi | CLU_018886_0_0_1 |
InParanoidi | Q68DH5 |
OMAi | LPLMQSY |
OrthoDBi | 694650at2759 |
PhylomeDBi | Q68DH5 |
TreeFami | TF314938 |
Family and domain databases
InterProi | View protein in InterPro IPR006876, LMBR1-like_membr_prot |
Pfami | View protein in Pfam PF04791, LMBR1, 1 hit |
i Sequence
Sequence statusi: Complete.
Q68DH5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSGAALGLEI VFVFFLALFL LHRYGDFKKQ HRLVIIGTLL AWYLCFLIVF
60 70 80 90 100
ILPLDVSTTI YNRCKHAAAN SSPPENSNIT GLYATANPVP SQHPCFKPWS
110 120 130 140 150
YIPDGIMPIF WRVVYWTSQF LTWILLPFMQ SYARSGGFSI TGKIKTALIE
160 170 180 190 200
NAIYYGTYLL IFGAFLIYVA VNPHLHLEWN QLQTIGIAAA NTWGLFLLVL
210 220 230 240 250
LLGYGLVEIP RSYWNGAKRG YLLMKTYFKA AKLMTEKADA EENLEDAMEE
260 270 280 290 300
VRKVNESIKY NHPLRKCVDT ILKKCPTEYQ EKMGRNMDDY EDFDEKHSIY
310 320 330 340 350
PSEKSLVKLH KQVIYSVQRH RRTQVQWQIL LEQAFYLEDV AKNETSATHQ
360 370 380 390 400
FVHTFQSPEP ENRFIQYFYN PTFEWYWECL LRPWFYKILA VVLSIFSVIV
410 420 430 440 450
VWSECTFFST TPVLSLFAVF IQLAEKTYNY IYIEIACFLS IFFLSICVYS
460 470 480 490 500
TVFRIRVFNY YYLASHHQTD AYSLLFSGML FCRLTPPLCL NFLGLTHMDS
510 520 530 540 550
SISHKNTQPT AYTSIMGSMK VLSFIADGFY IYYPMLVVIL CIATYFSLGT
560 570 580 590 600
RCLNLLGFQQ FMGDDDMTSD LVNEGKELIR KEKRKRQRQE EGENRRREWK
610 620 630 640 650
ERYGHNREDS TRNRNIHTDP KESNFSDVNT NRSAFKYTRA NNRTERDRIE
660 670 680 690
LLQDAEPLDF NAETFTDDPL ESESGRYQPG GRYLSMSRSD IFNDV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK091295 mRNA Translation: BAG52328.1 CR749399 mRNA Translation: CAH18245.1 AL137370 mRNA Translation: CAB70714.1 BC110506 mRNA Translation: AAI10507.1 |
CCDSi | CCDS34145.1 |
PIRi | T46434 |
RefSeqi | NP_001007528.1, NM_001007527.1 XP_011512464.1, XM_011514162.2 |
Genome annotation databases
Ensembli | ENST00000296603; ENSP00000296603; ENSG00000164187 |
GeneIDi | 92255 |
KEGGi | hsa:92255 |
MANE-Selecti | ENST00000296603.5; ENSP00000296603.4; NM_001007527.2; NP_001007528.1 |
UCSCi | uc003jka.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK091295 mRNA Translation: BAG52328.1 CR749399 mRNA Translation: CAH18245.1 AL137370 mRNA Translation: CAB70714.1 BC110506 mRNA Translation: AAI10507.1 |
CCDSi | CCDS34145.1 |
PIRi | T46434 |
RefSeqi | NP_001007528.1, NM_001007527.1 XP_011512464.1, XM_011514162.2 |
3D structure databases
SMRi | Q68DH5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 124923, 59 interactors |
IntActi | Q68DH5, 22 interactors |
MINTi | Q68DH5 |
STRINGi | 9606.ENSP00000296603 |
PTM databases
GlyGeni | Q68DH5, 1 site |
iPTMneti | Q68DH5 |
PhosphoSitePlusi | Q68DH5 |
SwissPalmi | Q68DH5 |
Genetic variation databases
BioMutai | LMBRD2 |
DMDMi | 74708880 |
Proteomic databases
EPDi | Q68DH5 |
jPOSTi | Q68DH5 |
MassIVEi | Q68DH5 |
MaxQBi | Q68DH5 |
PaxDbi | Q68DH5 |
PeptideAtlasi | Q68DH5 |
PRIDEi | Q68DH5 |
ProteomicsDBi | 66080 |
Protocols and materials databases
Antibodypediai | 2569, 15 antibodies from 10 providers |
DNASUi | 92255 |
Genome annotation databases
Ensembli | ENST00000296603; ENSP00000296603; ENSG00000164187 |
GeneIDi | 92255 |
KEGGi | hsa:92255 |
MANE-Selecti | ENST00000296603.5; ENSP00000296603.4; NM_001007527.2; NP_001007528.1 |
UCSCi | uc003jka.2, human |
Organism-specific databases
CTDi | 92255 |
DisGeNETi | 92255 |
GeneCardsi | LMBRD2 |
HGNCi | HGNC:25287, LMBRD2 |
HPAi | ENSG00000164187, Low tissue specificity |
MIMi | 619490, gene |
neXtProti | NX_Q68DH5 |
OpenTargetsi | ENSG00000164187 |
PharmGKBi | PA142671541 |
VEuPathDBi | HostDB:ENSG00000164187 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2296, Eukaryota |
GeneTreei | ENSGT00390000018651 |
HOGENOMi | CLU_018886_0_0_1 |
InParanoidi | Q68DH5 |
OMAi | LPLMQSY |
OrthoDBi | 694650at2759 |
PhylomeDBi | Q68DH5 |
TreeFami | TF314938 |
Enzyme and pathway databases
PathwayCommonsi | Q68DH5 |
SignaLinki | Q68DH5 |
Miscellaneous databases
BioGRID-ORCSi | 92255, 8 hits in 1044 CRISPR screens |
GenomeRNAii | 92255 |
Pharosi | Q68DH5, Tdark |
PROi | PR:Q68DH5 |
RNActi | Q68DH5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000164187, Expressed in dorsolateral prefrontal cortex and 220 other tissues |
Genevisiblei | Q68DH5, HS |
Family and domain databases
InterProi | View protein in InterPro IPR006876, LMBR1-like_membr_prot |
Pfami | View protein in Pfam PF04791, LMBR1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | LMBD2_HUMAN | |
Accessioni | Q68DH5Primary (citable) accession number: Q68DH5 Secondary accession number(s): B3KRB6, Q9NTC7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 21, 2007 |
Last sequence update: | October 11, 2004 | |
Last modified: | February 23, 2022 | |
This is version 110 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families