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Protein

Basic helix-loop-helix domain-containing protein USF3

Gene

USF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the negative regulation of epithelial-mesenchymal transition, the process by which epithelial cells lose their polarity and adhesion properties to become mesenchymal cells with enhanced migration and invasive properties.1 Publication

GO - Molecular functioni

GO - Biological processi

  • negative regulation of epithelial to mesenchymal transition Source: UniProtKB

Keywordsi

Molecular functionDNA-binding

Protein family/group databases

CAZyiGH47 Glycoside Hydrolase Family 47

Names & Taxonomyi

Protein namesi
Recommended name:
Basic helix-loop-helix domain-containing protein USF3Curated
Alternative name(s):
Upstream transcription factor 3
Gene namesi
Name:USF3Imported
Synonyms:KIAA2018
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000176542.9
HGNCiHGNC:30494 USF3
MIMi617568 gene
neXtProtiNX_Q68DE3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671594

Polymorphism and mutation databases

BioMutaiKIAA2018
DMDMi298286912

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002957541 – 2245Basic helix-loop-helix domain-containing protein USF3Add BLAST2245

Proteomic databases

PaxDbiQ68DE3
PeptideAtlasiQ68DE3
PRIDEiQ68DE3
ProteomicsDBi66078

PTM databases

iPTMnetiQ68DE3
PhosphoSitePlusiQ68DE3

Expressioni

Gene expression databases

BgeeiENSG00000176542 Expressed in 205 organ(s), highest expression level in kidney epithelium
CleanExiHS_KIAA2018
ExpressionAtlasiQ68DE3 baseline and differential
GenevisibleiQ68DE3 HS

Organism-specific databases

HPAiHPA029243
HPA029245

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ68DE3, 3 interactors
STRINGi9606.ENSP00000320794

Structurei

3D structure databases

ProteinModelPortaliQ68DE3
SMRiQ68DE3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 69bHLHPROSITE-ProRule annotationAdd BLAST52

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili77 – 112Sequence analysisAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi850 – 899Ser-richAdd BLAST50
Compositional biasi1415 – 1609Gln-richAdd BLAST195

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IK0Z Eukaryota
ENOG410Y31K LUCA
HOGENOMiHOG000060234
HOVERGENiHBG108052
InParanoidiQ68DE3
OrthoDBiEOG091G005Z
PhylomeDBiQ68DE3
TreeFamiTF332661

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q68DE3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPEMTENETP TKKQHRKKNR ETHNAVERHR KKKINAGINR IGELIPCSPA
60 70 80 90 100
LKQSKNMILD QAFKYITELK RQNDELLLNG GNNEQAEEIK KLRKQLEEIQ
110 120 130 140 150
KENGRYIELL KANDICLYDD PTIHWKGNLK NSKVSVVIPS DQVQKKIIVY
160 170 180 190 200
SNGNQPGGNS QGTAVQGITF NVSHNLQKQT ANVVPVQRTC NLVTPVSISG
210 220 230 240 250
VYPSENKPWH QTTVPALATN QPVPLCLPAA ISAQSILELP TSESESNVLG
260 270 280 290 300
ATSGSLIAVS IESEPHQHHS LHTCLNDQNS SENKNGQENP KVLKKMTPCV
310 320 330 340 350
TNIPHSSSAT ATKVHHGNKS CLSIQDFRGD FQNTFVVSVT TTVCSQPPRT
360 370 380 390 400
AGDSSPMSIS KSADLTSTAT VVASSAPGVG KATIPISTLS GNPLDNGWTL
410 420 430 440 450
SCSLPSSSVS TSDLKNINSL TRISSAGNTQ TTWTTLQLAG NTIQPLSQTP
460 470 480 490 500
SSAVTPVLNE SGTSPTTSNH SRYVATDINL NNSFPADGQP VEQVVVTLPS
510 520 530 540 550
CPSLPMQPLI AQPQVKSQPP KNILPLNSAM QVIQMAQPVG SAVNSAPTNQ
560 570 580 590 600
NVIILQPPST TPCPTVMRAE VSNQTVGQQI VIIQAANQNP LPLLPAPPPG
610 620 630 640 650
SVRLPINGAN TVIGSNNSVQ NVPTPQTFGG KHLVHILPRP SSLSASNSTQ
660 670 680 690 700
TFSVTMSNQQ PQTISLNGQL FALQPVMSSS GTTNQTPMQI IQPTTSEDPN
710 720 730 740 750
TNVALNTFGA LASLNQSISQ MAGQSCVQLS ISQPANSQTA ANSQTTTANC
760 770 780 790 800
VSLTTTAAPP VTTDSSATLA STYNLVSTSS MNTVACLPNM KSKRLNKKPG
810 820 830 840 850
GRKHLAANKS ACPLNSVRDV SKLDCPNTEG SAEPPCNDGL LESFPAVLPS
860 870 880 890 900
VSVSQANSVS VSASHSLGVL SSESLIPESV SKSKSAEKSS PPSQESVTSE
910 920 930 940 950
HFAMAAAKSK DSTPNLQQET SQDKPPSSLA LSDAAKPCAS ANVLIPSPSD
960 970 980 990 1000
PHILVSQVPG LSSTTSTTST DCVSEVEIIA EPCRVEQDSS DTMQTTGLLK
1010 1020 1030 1040 1050
GQGLTTLLSD LAKKKNPQKS SLSDQMDHPD FSSENPKIVD SSVNLHPKQE
1060 1070 1080 1090 1100
LLLMNNDDRD PPQHHSCLPD QEVINGSLIN GRQADSPMST SSGSSRSFSV
1110 1120 1130 1140 1150
ASMLPETTRE DVTSNATTNT CDSCTFVEQT DIVALAARAI FDQENLEKGR
1160 1170 1180 1190 1200
VGLQADIREV ASKPSEASLL EGDPPFKSQI PKESGTGQAE ATPNEFNSQG
1210 1220 1230 1240 1250
SIEATMERPL EKPSCSLGIK TSNASLQDST SQPPSITSLS VNNLIHQSSI
1260 1270 1280 1290 1300
SHPLASCAGL SPTSEQTTVP ATVNLTVSSS SYGSQPPGPS LMTEYSQEQL
1310 1320 1330 1340 1350
NTMTSTIPNS QIQEPLLKPS HESRKDSAKR AVQDDLLLSS AKRQKHCQPA
1360 1370 1380 1390 1400
PLRLESMSLM SRTPDTISDQ TQMMVSQIPP NSSNSVVPVS NPAHGDGLTR
1410 1420 1430 1440 1450
LFPPSNNFVT PALRQTEVQC GSQPSVAEQQ QTQASQHLQA LQQHVPAQGV
1460 1470 1480 1490 1500
SHLHSNHLYI KQQQQQQQQQ QQQQQQQQAG QLRERHHLYQ MQHHVPHAES
1510 1520 1530 1540 1550
SVHSQPHNVH QQRTLQQEVQ MQKKRNLVQG TQTSQLSLQP KHHGTDQSRS
1560 1570 1580 1590 1600
KTGQPHPHHQ QMQQQMQQHF GSSQTEKSCE NPSTSRNHHN HPQNHLNQDI
1610 1620 1630 1640 1650
MHQQQDVGSR QQGSGVSSEH VSGHNPMQRL LTSRGLEQQM VSQPSIVTRS
1660 1670 1680 1690 1700
SDMTCTPHRP ERNRVSSYSA EALIGKTSSN SEQRMGISIQ GSRVSDQLEM
1710 1720 1730 1740 1750
RSYLDVPRNK SLAIHNMQGR VDHTVASDIR LSDCQTFKPS GASQQPQSNF
1760 1770 1780 1790 1800
EVQSSRNNEI GNPVSSLRSM QSQAFRISQN TGPPPIDRQK RLSYPPVQSI
1810 1820 1830 1840 1850
PTGNGIPSRD SENTCHQSFM QSLLAPHLSD QVIGSQRSLS EHQRNTQCGP
1860 1870 1880 1890 1900
SSAIEYNCPP THENVHIRRE SESQNRESCD MSLGAINTRN STLNIPFSSS
1910 1920 1930 1940 1950
SSSGDIQGRN TSPNVSVQKS NPMRITESHA TKGHMNPPVT TNMHGVARPA
1960 1970 1980 1990 2000
LPHPSVSHGN GDQGPAVRQA NSSVPQRSRH PLQDSSGSKI RQPERNRSGN
2010 2020 2030 2040 2050
QRQSTVFDPS LPHLPLSTGG SMILGRQQPA TEKRGSIVRF MPDSPQVPND
2060 2070 2080 2090 2100
NSGPDQHTLS QNFGFSFIPE GGMNPPINAN ASFIPQVTQP SATRTPALIP
2110 2120 2130 2140 2150
VDPQNTLPSF YPPYSPAHPT LSNDISIPYF PNQMFSNPST EKVNSGSLNN
2160 2170 2180 2190 2200
RFGSILSPPR PVGFAQPSFP LLPDMPPMHM TNSHLSNFNM TSLFPEIATV
2210 2220 2230 2240
LPDGSAMSPL LTIANSSASD SSKQSSNRPA HNISHILGHD CSSAV
Length:2,245
Mass (Da):241,681
Last modified:June 15, 2010 - v3
Checksum:iD37A5B5FF04E68B0
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JBW0C9JBW0_HUMAN
Basic helix-loop-helix domain-conta...
USF3
88Annotation score:

Sequence cautioni

The sequence BAB14518 differs from that shown. Chimeric cDNA.Curated
The sequence CAH18277 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti328R → G in CAH18277 (PubMed:17974005).Curated1
Sequence conflicti862S → P in CAH18277 (PubMed:17974005).Curated1
Sequence conflicti1462 – 1464Missing in CAH18277 (PubMed:17974005).Curated3
Sequence conflicti1462Missing in BAC23114 (Ref. 3) Curated1
Sequence conflicti1953H → R in CAD97821 (PubMed:17974005).Curated1
Sequence conflicti2015P → S in BAB14518 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033363222P → A1 PublicationCorresponds to variant dbSNP:rs9866806Ensembl.1
Natural variantiVAR_055949907A → E. Corresponds to variant dbSNP:rs9852318Ensembl.1
Natural variantiVAR_055950943V → G. Corresponds to variant dbSNP:rs6770105Ensembl.1
Natural variantiVAR_0800411470 – 1472Missing Rare variant; may be a risk factor for epithelial thyroid carcinoma; results in increased epithelial-mesenchimal transition when coexpressed with Q-1472 del. 1 Publication3
Natural variantiVAR_0800421472Missing Rare variant; may be a risk factor for epithelial thyroid carcinoma; results in increased epithelial-mesenchimal transition when coexpressed with 1470-Q--Q-1472 del. 1 Publication1
Natural variantiVAR_0333641966A → V. Corresponds to variant dbSNP:rs2290477Ensembl.1
Natural variantiVAR_0632632200V → A2 PublicationsCorresponds to variant dbSNP:rs930818Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC055740 Genomic DNA No translation available.
BX537728 mRNA Translation: CAD97821.1
CR749439 mRNA Translation: CAH18277.1 Different initiation.
AB095938 mRNA Translation: BAC23114.1
AK023308 mRNA Translation: BAB14518.1 Sequence problems.
CCDSiCCDS43133.1
UniGeneiHs.632570

Genome annotation databases

EnsembliENST00000316407; ENSP00000320794; ENSG00000176542
ENST00000478658; ENSP00000420721; ENSG00000176542
UCSCiuc003eam.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC055740 Genomic DNA No translation available.
BX537728 mRNA Translation: CAD97821.1
CR749439 mRNA Translation: CAH18277.1 Different initiation.
AB095938 mRNA Translation: BAC23114.1
AK023308 mRNA Translation: BAB14518.1 Sequence problems.
CCDSiCCDS43133.1
UniGeneiHs.632570

3D structure databases

ProteinModelPortaliQ68DE3
SMRiQ68DE3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ68DE3, 3 interactors
STRINGi9606.ENSP00000320794

Protein family/group databases

CAZyiGH47 Glycoside Hydrolase Family 47

PTM databases

iPTMnetiQ68DE3
PhosphoSitePlusiQ68DE3

Polymorphism and mutation databases

BioMutaiKIAA2018
DMDMi298286912

Proteomic databases

PaxDbiQ68DE3
PeptideAtlasiQ68DE3
PRIDEiQ68DE3
ProteomicsDBi66078

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316407; ENSP00000320794; ENSG00000176542
ENST00000478658; ENSP00000420721; ENSG00000176542
UCSCiuc003eam.4 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000176542.9
GeneCardsiUSF3
HGNCiHGNC:30494 USF3
HPAiHPA029243
HPA029245
MIMi617568 gene
neXtProtiNX_Q68DE3
PharmGKBiPA142671594
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IK0Z Eukaryota
ENOG410Y31K LUCA
HOGENOMiHOG000060234
HOVERGENiHBG108052
InParanoidiQ68DE3
OrthoDBiEOG091G005Z
PhylomeDBiQ68DE3
TreeFamiTF332661

Miscellaneous databases

ChiTaRSiUSF3 human
PROiPR:Q68DE3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000176542 Expressed in 205 organ(s), highest expression level in kidney epithelium
CleanExiHS_KIAA2018
ExpressionAtlasiQ68DE3 baseline and differential
GenevisibleiQ68DE3 HS

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUSF3_HUMAN
AccessioniPrimary (citable) accession number: Q68DE3
Secondary accession number(s): Q7Z3L9, Q8IVF3, Q9H8T4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: June 15, 2010
Last modified: November 7, 2018
This is version 110 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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