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Entry version 122 (17 Jun 2020)
Sequence version 4 (08 May 2019)
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Protein

Basic helix-loop-helix domain-containing protein USF3

Gene

USF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the negative regulation of epithelial-mesenchymal transition, the process by which epithelial cells lose their polarity and adhesion properties to become mesenchymal cells with enhanced migration and invasive properties.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GH47 Glycoside Hydrolase Family 47

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Basic helix-loop-helix domain-containing protein USF3Curated
Alternative name(s):
Upstream transcription factor 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:USF3Imported
Synonyms:KIAA2018
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000176542.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30494 USF3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617568 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q68DE3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
205717

Open Targets

More...
OpenTargetsi
ENSG00000176542

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
201 Cowden syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671594

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q68DE3 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
USF3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
298286912

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002957541 – 2245Basic helix-loop-helix domain-containing protein USF3Add BLAST2245

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q68DE3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q68DE3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q68DE3

PeptideAtlas

More...
PeptideAtlasi
Q68DE3

PRoteomics IDEntifications database

More...
PRIDEi
Q68DE3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
66078

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q68DE3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q68DE3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000176542 Expressed in kidney epithelium and 204 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q68DE3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q68DE3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000176542 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q68DE3, 14 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000320794

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q68DE3 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q68DE3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini18 – 69bHLHPROSITE-ProRule annotationAdd BLAST52

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili77 – 112Sequence analysisAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi850 – 899Ser-richAdd BLAST50
Compositional biasi1415 – 1609Gln-richAdd BLAST195

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IK0Z Eukaryota
ENOG410Y31K LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015759

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001249_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q68DE3

Identification of Orthologs from Complete Genome Data

More...
OMAi
DMTCAPH

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q68DE3

TreeFam database of animal gene trees

More...
TreeFami
TF332661

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00083 HLH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.280.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00010 HLH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00353 HLH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47459 SSF47459, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50888 BHLH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q68DE3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPEMTENETP TKKQHRKKNR ETHNAVERHR KKKINAGINR IGELIPCSPA
60 70 80 90 100
LKQSKNMILD QAFKYITELK RQNDELLLNG GNNEQAEEIK KLRKQLEEIQ
110 120 130 140 150
KENGRYIELL KANDICLYDD PTIHWKGNLK NSKVSVVIPS DQVQKKIIVY
160 170 180 190 200
SNGNQPGGNS QGTAVQGITF NVSHNLQKQT ANVVPVQRTC NLVTPVSISG
210 220 230 240 250
VYPSENKPWH QTTVPALATN QPVPLCLPAA ISAQSILELP TSESESNVLG
260 270 280 290 300
ATSGSLIAVS IESEPHQHHS LHTCLNDQNS SENKNGQENP KVLKKMTPCV
310 320 330 340 350
TNIPHSSSAT ATKVHHGNKS CLSIQDFRGD FQNTFVVSVT TTVCSQPPRT
360 370 380 390 400
AGDSSPMSIS KSADLTSTAT VVASSAPGVG KATIPISTLS GNPLDNGWTL
410 420 430 440 450
SCSLPSSSVS TSDLKNINSL TRISSAGNTQ TTWTTLQLAG NTIQPLSQTP
460 470 480 490 500
SSAVTPVLNE SGTSPTTSNH SRYVATDINL NNSFPADGQP VEQVVVTLPS
510 520 530 540 550
CPSLPMQPLI AQPQVKSQPP KNILPLNSAM QVIQMAQPVG SAVNSAPTNQ
560 570 580 590 600
NVIILQPPST TPCPTVMRAE VSNQTVGQQI VIIQAANQNP LPLLPAPPPG
610 620 630 640 650
SVRLPINGAN TVIGSNNSVQ NVPTPQTFGG KHLVHILPRP SSLSASNSTQ
660 670 680 690 700
TFSVTMSNQQ PQTISLNGQL FALQPVMSSS GTTNQTPMQI IQPTTSEDPN
710 720 730 740 750
TNVALNTFGA LASLNQSISQ MAGQSCVQLS ISQPANSQTA ANSQTTTANC
760 770 780 790 800
VSLTTTAAPP VTTDSSATLA STYNLVSTSS MNTVACLPNM KSKRLNKKPG
810 820 830 840 850
GRKHLAANKS ACPLNSVRDV SKLDCPNTEG SAEPPCNDGL LESFPAVLPS
860 870 880 890 900
VSVSQANSVS VSASHSLGVL SSESLIPESV SKSKSAEKSS PPSQESVTSE
910 920 930 940 950
HFAMAAAKSK DSTPNLQQET SQDKPPSSLA LSDAAKPCAS ANVLIPSPSD
960 970 980 990 1000
PHILVSQVPG LSSTTSTTST DCVSEVEIIA EPCRVEQDSS DTMQTTGLLK
1010 1020 1030 1040 1050
GQGLTTLLSD LAKKKNPQKS SLSDQMDHPD FSSENPKIVD SSVNLHPKQE
1060 1070 1080 1090 1100
LLLMNNDDRD PPQHHSCLPD QEVINGSLIN GRQADSPMST SSGSSRSFSV
1110 1120 1130 1140 1150
ASMLPETTRE DVTSNATTNT CDSCTFVEQT DIVALAARAI FDQENLEKGR
1160 1170 1180 1190 1200
VGLQADIREV ASKPSEASLL EGDPPFKSQI PKESGTGQAE ATPNEFNSQG
1210 1220 1230 1240 1250
SIEATMERPL EKPSCSLGIK TSNASLQDST SQPPSITSLS VNNLIHQSSI
1260 1270 1280 1290 1300
SHPLASCAGL SPTSEQTTVP ATVNLTVSSS SYGSQPPGPS LMTEYSQEQL
1310 1320 1330 1340 1350
NTMTSTIPNS QIQEPLLKPS HESRKDSAKR AVQDDLLLSS AKRQKHCQPA
1360 1370 1380 1390 1400
PLRLESMSLM SRTPDTISDQ TQMMVSQIPP NSSNSVVPVS NPAHGDGLTR
1410 1420 1430 1440 1450
LFPPSNNFVT PALRQTEVQC GSQPSVAEQQ QTQASQHLQA LQQHVPAQGV
1460 1470 1480 1490 1500
SHLHSNHLYI KQQQQQQQQQ QQQQQQQQAG QLRERHHLYQ MQHHVPHAES
1510 1520 1530 1540 1550
SVHSQPHNVH QQRTLQQEVQ MQKKRNLVQG TQTSQLSLQP KHHGTDQSRS
1560 1570 1580 1590 1600
KTGQPHPHHQ QMQQQMQQHF GSSQTEKSCE NPSTSRNHHN HPQNHLNQDI
1610 1620 1630 1640 1650
MHQQQDVGSR QQGSGVSSEH VSGHNPMQRL LTSRGLEQQM VSQPSIVTRS
1660 1670 1680 1690 1700
SDMTCTPHRP ERNRVSSYSA EALIGKTSSN SEQRMGISIQ GSRVSDQLEM
1710 1720 1730 1740 1750
RSYLDVPRNK SLAIHNMQGR VDHTVASDIR LSDCQTFKPS GASQQPQSNF
1760 1770 1780 1790 1800
EVQSSRNNEI GNPVSSLRSM QSQAFRISQN TGPPPIDRQK RLSYPPVQSI
1810 1820 1830 1840 1850
PTGNGIPSRD SENTCHQSFM QSLLAPHLSD QVIGSQRSLS EHQRNTQCGP
1860 1870 1880 1890 1900
SSAIEYNCPP THENVHIRRE SESQNRESCD MSLGAINTRN STLNIPFSSS
1910 1920 1930 1940 1950
SSSGDIQGRN TSPNVSVQKS NPMRITESHA TKGHMNPPVT TNMHGVARPA
1960 1970 1980 1990 2000
LPHPSVSHGN GDQGPAVRQA NSSVPQRSRH PLQDSSGSKI RQPERNRSGN
2010 2020 2030 2040 2050
QRQSTVFDPS LPHLPLSTGG SMILGRQQPA TEKRGSIVRF MPDSPQVPND
2060 2070 2080 2090 2100
NSGPDQHTLS QNFGFSFIPE GGMNPPINAN ASFIPQVTQP SATRTPALIP
2110 2120 2130 2140 2150
VDPQNTLPSF YPPYSPAHPT LSNDISIPYF PNQMFSNPST EKVNSGSLNN
2160 2170 2180 2190 2200
RFGSILSPPR PVGFAQPSFP LLPDMPPMHM TNSHLSNFNM TSLFPEIATA
2210 2220 2230 2240
LPDGSAMSPL LTIANSSASD SSKQSSNRPA HNISHILGHD CSSAV
Length:2,245
Mass (Da):241,653
Last modified:May 8, 2019 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF12A5B5FF05DCA3A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JBW0C9JBW0_HUMAN
Basic helix-loop-helix domain-conta...
USF3
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB14518 differs from that shown. Chimeric cDNA.Curated
The sequence CAH18277 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti328R → G in CAH18277 (PubMed:17974005).Curated1
Sequence conflicti862S → P in CAH18277 (PubMed:17974005).Curated1
Sequence conflicti1462 – 1464Missing in CAH18277 (PubMed:17974005).Curated3
Sequence conflicti1462Missing in BAC23114 (Ref. 3) Curated1
Sequence conflicti1953H → R in CAD97821 (PubMed:17974005).Curated1
Sequence conflicti2015P → S in BAB14518 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_033363222P → A1 PublicationCorresponds to variant dbSNP:rs9866806Ensembl.1
Natural variantiVAR_055949907A → E. Corresponds to variant dbSNP:rs9852318Ensembl.1
Natural variantiVAR_055950943V → G. Corresponds to variant dbSNP:rs6770105Ensembl.1
Natural variantiVAR_0800411470 – 1472Missing Rare variant; may be a risk factor for epithelial thyroid carcinoma; results in increased epithelial-mesenchimal transition when coexpressed with Q-1472 del. 1 Publication3
Natural variantiVAR_0800421472Missing Rare variant; may be a risk factor for epithelial thyroid carcinoma; results in increased epithelial-mesenchimal transition when coexpressed with 1470-Q--Q-1472 del. 1 Publication1
Natural variantiVAR_0333641966A → V. Corresponds to variant dbSNP:rs2290477Ensembl.1
Natural variantiVAR_0632632200A → V. Corresponds to variant dbSNP:rs930818Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC055740 Genomic DNA No translation available.
BX537728 mRNA Translation: CAD97821.1
CR749439 mRNA Translation: CAH18277.1 Different initiation.
AB095938 mRNA Translation: BAC23114.1
AK023308 mRNA Translation: BAB14518.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43133.1

NCBI Reference Sequences

More...
RefSeqi
NP_001009899.3, NM_001009899.3
XP_016861360.1, XM_017005871.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000316407; ENSP00000320794; ENSG00000176542
ENST00000478658; ENSP00000420721; ENSG00000176542

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
205717

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:205717

UCSC genome browser

More...
UCSCi
uc003eam.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC055740 Genomic DNA No translation available.
BX537728 mRNA Translation: CAD97821.1
CR749439 mRNA Translation: CAH18277.1 Different initiation.
AB095938 mRNA Translation: BAC23114.1
AK023308 mRNA Translation: BAB14518.1 Sequence problems.
CCDSiCCDS43133.1
RefSeqiNP_001009899.3, NM_001009899.3
XP_016861360.1, XM_017005871.1

3D structure databases

SMRiQ68DE3
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ68DE3, 14 interactors
STRINGi9606.ENSP00000320794

Protein family/group databases

CAZyiGH47 Glycoside Hydrolase Family 47

PTM databases

iPTMnetiQ68DE3
PhosphoSitePlusiQ68DE3

Polymorphism and mutation databases

BioMutaiUSF3
DMDMi298286912

Proteomic databases

jPOSTiQ68DE3
MassIVEiQ68DE3
PaxDbiQ68DE3
PeptideAtlasiQ68DE3
PRIDEiQ68DE3
ProteomicsDBi66078

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
32593 21 antibodies

Genome annotation databases

EnsembliENST00000316407; ENSP00000320794; ENSG00000176542
ENST00000478658; ENSP00000420721; ENSG00000176542
GeneIDi205717
KEGGihsa:205717
UCSCiuc003eam.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
205717
DisGeNETi205717
EuPathDBiHostDB:ENSG00000176542.9

GeneCards: human genes, protein and diseases

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GeneCardsi
USF3
HGNCiHGNC:30494 USF3
HPAiENSG00000176542 Low tissue specificity
MIMi617568 gene
neXtProtiNX_Q68DE3
OpenTargetsiENSG00000176542
Orphaneti201 Cowden syndrome
PharmGKBiPA142671594

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IK0Z Eukaryota
ENOG410Y31K LUCA
GeneTreeiENSGT00390000015759
HOGENOMiCLU_001249_0_0_1
InParanoidiQ68DE3
OMAiDMTCAPH
PhylomeDBiQ68DE3
TreeFamiTF332661

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
USF3 human
PharosiQ68DE3 Tdark

Protein Ontology

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PROi
PR:Q68DE3
RNActiQ68DE3 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000176542 Expressed in kidney epithelium and 204 other tissues
ExpressionAtlasiQ68DE3 baseline and differential
GenevisibleiQ68DE3 HS

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUSF3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q68DE3
Secondary accession number(s): Q7Z3L9, Q8IVF3, Q9H8T4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: May 8, 2019
Last modified: June 17, 2020
This is version 122 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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