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UniProtKB - Q68DD2 (PA24F_HUMAN)

Entry version 132 (25 May 2022)
Sequence version 3 (11 Jan 2011)
Previous versions | rss
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Protein

Cytosolic phospholipase A2 zeta

Gene

PLA2G4F

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has calcium-dependent phospholipase and lysophospholipase activities with a potential role in membrane lipid remodeling and biosynthesis of lipid mediators (PubMed:29158256).

Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed:29158256).

Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis (PubMed:29158256).

In myocardial mitochondria, plays a major role in arachidonate release that is metabolically channeled to the formation of cardioprotective eicosanoids, epoxyeicosatrienoates (EETs) (PubMed:29158256).

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+PROSITE-ProRule annotationBy similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Stimulated by cytosolic Ca2+.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi60Calcium 1PROSITE-ProRule annotation1
Metal bindingi60Calcium 2PROSITE-ProRule annotation1
Metal bindingi66Calcium 1PROSITE-ProRule annotation1
Metal bindingi116Calcium 1PROSITE-ProRule annotation1
Metal bindingi116Calcium 2PROSITE-ProRule annotation1
Metal bindingi118Calcium 1PROSITE-ProRule annotation1
Metal bindingi118Calcium 2PROSITE-ProRule annotation1
Metal bindingi123Calcium 2PROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei395NucleophileBy similarity1
Active sitei680Proton acceptorBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism, Phospholipid degradation, Phospholipid metabolism
LigandCalcium, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q68DD2

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1482788, Acyl chain remodelling of PC
R-HSA-1482801, Acyl chain remodelling of PS
R-HSA-1482839, Acyl chain remodelling of PE
R-HSA-1482922, Acyl chain remodelling of PI
R-HSA-1482925, Acyl chain remodelling of PG
R-HSA-1483115, Hydrolysis of LPC

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q68DD2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytosolic phospholipase A2 zeta (EC:3.1.1.41 Publication)
Short name:
cPLA2-zeta
Alternative name(s):
Phospholipase A2 group IVF
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLA2G4F
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:27396, PLA2G4F

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q68DD2

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000168907

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		255189

Open Targets

More...OpenTargetsi		ENSG00000168907

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142671170

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q68DD2, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PLA2G4F

Domain mapping of disease mutations (DMDM)

More...DMDMi		317373489

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002470271 – 849Cytosolic phospholipase A2 zetaAdd BLAST849

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q68DD2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q68DD2

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q68DD2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q68DD2

PeptideAtlas

More...PeptideAtlasi		Q68DD2

PRoteomics IDEntifications database

More...PRIDEi		Q68DD2

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		66075 [Q68DD2-1]
66076 [Q68DD2-2]
66077 [Q68DD2-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q68DD2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q68DD2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in myocardium (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000168907, Expressed in zone of skin and 122 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q68DD2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q68DD2, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000168907, Tissue enriched (skin)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		129083, 9 interactors

Protein interaction database and analysis system

More...IntActi		Q68DD2, 10 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000380442

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q68DD2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q68DD2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q68DD2

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 145C2PROSITE-ProRule annotationAdd BLAST119
Domaini306 – 849PLA2cPROSITE-ProRule annotationAdd BLAST544

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca2+ (By similarity).By similarity

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1028, Eukaryota
KOG1325, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01030000234606

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_011663_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q68DD2

Identification of Orthologs from Complete Genome Data

More...OMAi		WPEPRIC

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q68DD2

TreeFam database of animal gene trees

More...TreeFami		TF325228

Family and domain databases

Conserved Domains Database

More...CDDi		cd04036, C2_cPLA2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016035, Acyl_Trfase/lysoPLipase
IPR041847, C2_cPLA2
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR040723, cPLA2_C2
IPR002642, LysoPLipase_cat_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00168, C2, 1 hit
PF18695, cPLA2_C2, 1 hit
PF01735, PLA2_B, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00239, C2, 1 hit
SM00022, PLAc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49562, SSF49562, 1 hit
SSF52151, SSF52151, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50004, C2, 1 hit
PS51210, PLA2C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q68DD2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLWALWPRWL ADKMLPLLGA VLLQKREKRG PLWRHWRRET YPYYDLQVKV 
        60         70         80         90        100
LRATNIRGTD LLSKADCYVQ LWLPTASPSP AQTRIVANCS DPEWNETFHY 
       110        120        130        140        150
QIHGAVKNVL ELTLYDKDIL GSDQLSLLLF DLRSLKCGQP HKHTFPLNHQ 
       160        170        180        190        200
DSQELQVEFV LEKSQVPASE VITNGVLVAH PCLRIQGTLR GDGTAPREEY 
       210        220        230        240        250
GSRQLQLAVP GAYEKPQLLP LQPPTEPGLP PTFTFHVNPV LSSRLHVELM 
       260        270        280        290        300
ELLAAVQSGP SAELEAQTSK LGEGGILLSS LPLGQEEQCS VALGEGQEVA 
       310        320        330        340        350
LSMKVEMSSG DLDLRLGFDL SDGEQEFLDR RKQVVSKALQ QVLGLSEALD 
       360        370        380        390        400
SGQVPVVAVL GSGGGTRAMS SLYGSLAGLQ ELGLLDTVTY LSGVSGSTWC 
       410        420        430        440        450
ISTLYRDPAW SQVALQGPIE RAQVHVCSSK MGALSTERLQ YYTQELGVRE 
       460        470        480        490        500
RSGHSVSLID LWGLLVEYLL YQEENPAKLS DQQEAVRQGQ NPYPIYTSVN 
       510        520        530        540        550
VRTNLSGEDF AEWCEFTPYE VGFPKYGAYV PTELFGSELF MGRLLQLQPE 
       560        570        580        590        600
PRICYLQGMW GSAFATSLDE IFLKTAGSGL SFLEWYRGSV NITDDCQKPQ 
       610        620        630        640        650
LHNPSRLRTR LLTPQGPFSQ AVLDIFTSRF TSAQSFNFTR GLCLHKDYVA 
       660        670        680        690        700
GREFVAWKDT HPDAFPNQLT PMRDCLYLVD GGFAINSPFP LALLPQRAVD 
       710        720        730        740        750
LILSFDYSLE APFEVLKMTE KYCLDRGIPF PSIEVGPEDM EEARECYLFA 
       760        770        780        790        800
KAEDPRSPIV LHFPLVNRTF RTHLAPGVER QTAEEKAFGD FVINRPDTPY 
       810        820        830        840 
GMMNFTYEPQ DFYRLVALSR YNVLNNVETL KCALQLALDR HQARERAGA
Length:849
Mass (Da):95,082
Last modified:January 11, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB2231EC3A9494598
GO
Isoform 2 (identifier: Q68DD2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     433-454: ALSTERLQYYTQELGVRERSGH → DVRVSPCQLPRLHSSNLDHSLW
     455-849: Missing.

Show »
Length:454
Mass (Da):50,003
Checksum:i4EFC69C84A65CCD7
GO
Isoform 3 (identifier: Q68DD2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     352-352: G → GQV

Show »
Length:851
Mass (Da):95,310
Checksum:i0367FEB0244B6293
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BMD0H3BMD0_HUMAN
Cytosolic phospholipase A2 zeta
PLA2G4F
296Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BSG9H3BSG9_HUMAN
Cytosolic phospholipase A2 zeta
PLA2G4F
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BXJ8H7BXJ8_HUMAN
Cytosolic phospholipase A2 zeta
PLA2G4F
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BPX7H3BPX7_HUMAN
Cytosolic phospholipase A2 zeta
PLA2G4F
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BNW4H3BNW4_HUMAN
Cytosolic phospholipase A2 zeta
PLA2G4F
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti203R → G in BAD18801 (PubMed:14702039).Curated1
Sequence conflicti262A → T in BAD18801 (PubMed:14702039).Curated1
Sequence conflicti363G → E in CAH18288 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05355330G → V. Corresponds to variant dbSNP:rs636604Ensembl.1
Natural variantiVAR_027054740M → V1 PublicationCorresponds to variant dbSNP:rs1356410Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_019887352G → GQV in isoform 3. 1 Publication1
Alternative sequenceiVSP_019888433 – 454ALSTE…ERSGH → DVRVSPCQLPRLHSSNLDHS LW in isoform 2. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_019889455 – 849Missing in isoform 2. 1 PublicationAdd BLAST395

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK172836 mRNA Translation: BAD18801.1
AC036103 Genomic DNA No translation available.
CR749451 mRNA Translation: CAH18288.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS32204.1 [Q68DD2-1]

NCBI Reference Sequences

More...RefSeqi		NP_998765.3, NM_213600.3 [Q68DD2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000397272.7; ENSP00000380442.4; ENSG00000168907.13

Database of genes from NCBI RefSeq genomes

More...GeneIDi		255189

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:255189

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000397272.7; ENSP00000380442.4; NM_213600.4; NP_998765.3

UCSC genome browser

More...UCSCi		uc001zoz.4, human [Q68DD2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK172836 mRNA Translation: BAD18801.1
AC036103 Genomic DNA No translation available.
CR749451 mRNA Translation: CAH18288.1
CCDSiCCDS32204.1 [Q68DD2-1]
RefSeqiNP_998765.3, NM_213600.3 [Q68DD2-1]

3D structure databases

AlphaFoldDBiQ68DD2
SMRiQ68DD2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi129083, 9 interactors
IntActiQ68DD2, 10 interactors
STRINGi9606.ENSP00000380442

PTM databases

iPTMnetiQ68DD2
PhosphoSitePlusiQ68DD2

Genetic variation databases

BioMutaiPLA2G4F
DMDMi317373489

Proteomic databases

jPOSTiQ68DD2
MassIVEiQ68DD2
MaxQBiQ68DD2
PaxDbiQ68DD2
PeptideAtlasiQ68DD2
PRIDEiQ68DD2
ProteomicsDBi66075 [Q68DD2-1]
66076 [Q68DD2-2]
66077 [Q68DD2-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		42117, 68 antibodies from 25 providers

The DNASU plasmid repository

More...DNASUi		255189

Genome annotation databases

EnsembliENST00000397272.7; ENSP00000380442.4; ENSG00000168907.13
GeneIDi255189
KEGGihsa:255189
MANE-SelectiENST00000397272.7; ENSP00000380442.4; NM_213600.4; NP_998765.3
UCSCiuc001zoz.4, human [Q68DD2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		255189
DisGeNETi255189

GeneCards: human genes, protein and diseases

More...GeneCardsi		PLA2G4F
HGNCiHGNC:27396, PLA2G4F
HPAiENSG00000168907, Tissue enriched (skin)
neXtProtiNX_Q68DD2
OpenTargetsiENSG00000168907
PharmGKBiPA142671170
VEuPathDBiHostDB:ENSG00000168907

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1028, Eukaryota
KOG1325, Eukaryota
GeneTreeiENSGT01030000234606
HOGENOMiCLU_011663_0_0_1
InParanoidiQ68DD2
OMAiWPEPRIC
PhylomeDBiQ68DD2
TreeFamiTF325228

Enzyme and pathway databases

PathwayCommonsiQ68DD2
ReactomeiR-HSA-1482788, Acyl chain remodelling of PC
R-HSA-1482801, Acyl chain remodelling of PS
R-HSA-1482839, Acyl chain remodelling of PE
R-HSA-1482922, Acyl chain remodelling of PI
R-HSA-1482925, Acyl chain remodelling of PG
R-HSA-1483115, Hydrolysis of LPC
SignaLinkiQ68DD2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		255189, 6 hits in 1066 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		255189
PharosiQ68DD2, Tdark

Protein Ontology

More...PROi		PR:Q68DD2
RNActiQ68DD2, protein

Gene expression databases

BgeeiENSG00000168907, Expressed in zone of skin and 122 other tissues
ExpressionAtlasiQ68DD2, baseline and differential
GenevisibleiQ68DD2, HS

Family and domain databases

CDDicd04036, C2_cPLA2, 1 hit
Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR016035, Acyl_Trfase/lysoPLipase
IPR041847, C2_cPLA2
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR040723, cPLA2_C2
IPR002642, LysoPLipase_cat_dom
PfamiView protein in Pfam
PF00168, C2, 1 hit
PF18695, cPLA2_C2, 1 hit
PF01735, PLA2_B, 1 hit
SMARTiView protein in SMART
SM00239, C2, 1 hit
SM00022, PLAc, 1 hit
SUPFAMiSSF49562, SSF49562, 1 hit
SSF52151, SSF52151, 1 hit
PROSITEiView protein in PROSITE
PS50004, C2, 1 hit
PS51210, PLA2C, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPA24F_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q68DD2
Secondary accession number(s): Q6ZMC8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: January 11, 2011
Last modified: May 25, 2022
This is version 132 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
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