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UniProtKB - Q68DB7 (Q68DB7_HUMAN)
Protein
Mothers against decapentaplegic homolog
Gene
DKFZp781O1323
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: Ensembl
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: Ensembl
GO - Biological processi
- BMP signaling pathway Source: Ensembl
- bone development Source: Ensembl
- cardiac muscle contraction Source: Ensembl
- cartilage development Source: Ensembl
- cellular response to organic cyclic compound Source: Ensembl
- erythrocyte differentiation Source: Ensembl
- germ cell development Source: Ensembl
- Mullerian duct regression Source: Ensembl
- negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway Source: UniProt
- osteoblast fate commitment Source: Ensembl
- positive regulation of osteoblast differentiation Source: Ensembl
- positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus Source: Ensembl
- protein phosphorylation Source: Ensembl
- regulation of cellular response to growth factor stimulus Source: UniProt
- SMAD protein signal transduction Source: Ensembl
- transforming growth factor beta receptor signaling pathway Source: Ensembl
- ureteric bud development Source: Ensembl
Keywordsi
Molecular function | DNA-bindingUniRule annotationARBA annotation |
Biological process | Transcription, Transcription regulationUniRule annotation |
Ligand | Metal-bindingARBA annotation, ZincARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Mothers against decapentaplegic homologUniRule annotationShort name: MAD homologUniRule annotation Short name: Mothers against DPP homologUniRule annotation Alternative name(s): SMAD family memberUniRule annotation |
Gene namesi | Name:DKFZp781O1323Imported Synonyms:DKFZp781C1895Imported, SMAD5Imported ORF Names:hCG_41402Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000113658 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
Other locations
- transcription regulator complex Source: InterPro
Keywords - Cellular componenti
CytoplasmUniRule annotation, NucleusUniRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000113658, Expressed in female gonad and 243 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 13 – 137 | MH1InterPro annotationAdd BLAST | 125 | |
Domaini | 271 – 465 | MH2InterPro annotationAdd BLAST | 195 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 163 – 249 | DisorderedSequence analysisAdd BLAST | 87 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 35 – 55 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 163 – 184 | Polar residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 185 – 201 | Pro residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 232 – 249 | Polar residuesSequence analysisAdd BLAST | 18 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
HOGENOMi | CLU_026736_0_2_1 |
OMAi | PPEEQMG |
OrthoDBi | 608001at2759 |
Family and domain databases
Gene3Di | 2.60.200.10, 1 hit 3.90.520.10, 1 hit |
InterProi | View protein in InterPro IPR013790, Dwarfin IPR003619, MAD_homology1_Dwarfin-type IPR013019, MAD_homology_MH1 IPR017855, SMAD-like_dom_sf IPR001132, SMAD_dom_Dwarfin-type IPR008984, SMAD_FHA_dom_sf IPR036578, SMAD_MH1_sf |
PANTHERi | PTHR13703, PTHR13703, 1 hit |
Pfami | View protein in Pfam PF03165, MH1, 1 hit PF03166, MH2, 1 hit |
SMARTi | View protein in SMART SM00523, DWA, 1 hit SM00524, DWB, 1 hit |
SUPFAMi | SSF49879, SSF49879, 1 hit SSF56366, SSF56366, 1 hit |
PROSITEi | View protein in PROSITE PS51075, MH1, 1 hit PS51076, MH2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q68DB7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTSMASLFSF TSPAVKRLLG WKQGDEEEKW AEKAVDALVK KLKKKKGAME
60 70 80 90 100
ELEKALSSPG QPSKCVTIPR SLDGRLQVSH RKGLPHVIYC RVWRWPDLQS
110 120 130 140 150
HHELKPLDIC EFPFGSKQKE VCINPYHYKR VESPVLPPVL VPRHNEFNPQ
160 170 180 190 200
HSLLVQFRNL SHNEPHMPQN ATFPDSFHQP NNTPFPLSPN SPYPPSPASS
210 220 230 240 250
TYPNSPASSG PGSPFQLPAD TPPPAYMPPD DQMGQDNSQP MDTSNNMIPQ
260 270 280 290 300
IMPSISSRDV QPVAYEEPKH WCSIVYYELN NRVGEAFHAS STSVLVDGFT
310 320 330 340 350
DPSNNKSRFC LGLLSNVNRN STIENTRRHI GKGVHLYYVG GEVYAECLSD
360 370 380 390 400
SSIFVQSRNC NFHHGFHPTT VCKIPSSCSL KIFNNQEFAQ LLAQSVNHGF
410 420 430 440 450
EAVYELTKMC TIRMSFVKGW GAEYHRQDVT STPCWIEIHL HGPLQWLDKV
460
LTQMGSPLNP ISSVS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK313397 mRNA Translation: BAG36195.1 CR749366 mRNA Translation: CAH18219.1 CR749473 mRNA Translation: CAH18303.1 CH471062 Genomic DNA Translation: EAW62195.1 CH471062 Genomic DNA Translation: EAW62196.1 |
RefSeqi | NP_001001419.1, NM_001001419.2 NP_001001420.1, NM_001001420.2 NP_005894.3, NM_005903.6 XP_016864959.1, XM_017009470.1 |
Genome annotation databases
GeneIDi | 4090 |
KEGGi | hsa:4090 |
MANE-Selecti | ENST00000545279.6; ENSP00000441954.2; NM_005903.7; NP_005894.3 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK313397 mRNA Translation: BAG36195.1 CR749366 mRNA Translation: CAH18219.1 CR749473 mRNA Translation: CAH18303.1 CH471062 Genomic DNA Translation: EAW62195.1 CH471062 Genomic DNA Translation: EAW62196.1 |
RefSeqi | NP_001001419.1, NM_001001419.2 NP_001001420.1, NM_001001420.2 NP_005894.3, NM_005903.6 XP_016864959.1, XM_017009470.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 7303, 609 antibodies from 41 providers |
DNASUi | 4090 |
Genome annotation databases
GeneIDi | 4090 |
KEGGi | hsa:4090 |
MANE-Selecti | ENST00000545279.6; ENSP00000441954.2; NM_005903.7; NP_005894.3 |
Organism-specific databases
CTDi | 4090 |
PharmGKBi | PA30528 |
VEuPathDBi | HostDB:ENSG00000113658 |
Phylogenomic databases
HOGENOMi | CLU_026736_0_2_1 |
OMAi | PPEEQMG |
OrthoDBi | 608001at2759 |
Miscellaneous databases
BioGRID-ORCSi | 4090, 11 hits in 290 CRISPR screens |
ChiTaRSi | SMAD5, human |
GenomeRNAii | 4090 |
Gene expression databases
Bgeei | ENSG00000113658, Expressed in female gonad and 243 other tissues |
Family and domain databases
Gene3Di | 2.60.200.10, 1 hit 3.90.520.10, 1 hit |
InterProi | View protein in InterPro IPR013790, Dwarfin IPR003619, MAD_homology1_Dwarfin-type IPR013019, MAD_homology_MH1 IPR017855, SMAD-like_dom_sf IPR001132, SMAD_dom_Dwarfin-type IPR008984, SMAD_FHA_dom_sf IPR036578, SMAD_MH1_sf |
PANTHERi | PTHR13703, PTHR13703, 1 hit |
Pfami | View protein in Pfam PF03165, MH1, 1 hit PF03166, MH2, 1 hit |
SMARTi | View protein in SMART SM00523, DWA, 1 hit SM00524, DWB, 1 hit |
SUPFAMi | SSF49879, SSF49879, 1 hit SSF56366, SSF56366, 1 hit |
PROSITEi | View protein in PROSITE PS51075, MH1, 1 hit PS51076, MH2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q68DB7_HUMAN | |
Accessioni | Q68DB7Primary (citable) accession number: Q68DB7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | May 25, 2022 | |
This is version 158 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |