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Protein

Formin-1

Gene

FMN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the formation of adherens junction and the polymerization of linear actin cables.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Formin-1
Alternative name(s):
Limb deformity protein homolog
Gene namesi
Name:FMN1
Synonyms:FMN, LD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000248905.8
HGNCiHGNC:3768 FMN1
MIMi136535 gene
neXtProtiNX_Q68DA7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi342184
OpenTargetsiENSG00000248905

Polymorphism and mutation databases

DMDMi327478585

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002963611 – 1419Formin-1Add BLAST1419

Post-translational modificationi

Phosphorylated on serine and possibly threonine residues.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ68DA7
PaxDbiQ68DA7
PeptideAtlasiQ68DA7
PRIDEiQ68DA7
ProteomicsDBi66065
66066 [Q68DA7-2]
66067 [Q68DA7-3]
66068 [Q68DA7-5]

PTM databases

iPTMnetiQ68DA7
PhosphoSitePlusiQ68DA7

Expressioni

Developmental stagei

Expressed in fetal kidney and fetal lung.1 Publication

Gene expression databases

BgeeiENSG00000248905 Expressed in 117 organ(s), highest expression level in kidney
CleanExiHS_FMN1
ExpressionAtlasiQ68DA7 baseline and differential
GenevisibleiQ68DA7 HS

Organism-specific databases

HPAiHPA005465
HPA046786

Interactioni

Subunit structurei

Interacts with alpha-catenin and may interact with tubulin.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi131167, 7 interactors
ELMiQ68DA7
IntActiQ68DA7, 3 interactors
STRINGi9606.ENSP00000333950

Structurei

3D structure databases

ProteinModelPortaliQ68DA7
SMRiQ68DA7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini870 – 957FH1Add BLAST88
Domaini972 – 1388FH2PROSITE-ProRule annotationAdd BLAST417

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 622Microtubule-bindingBy similarityAdd BLAST622
Regioni456 – 842Mediates interaction with alpha-cateninBy similarityAdd BLAST387

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili720 – 774Sequence analysisAdd BLAST55

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi869 – 984Pro-richAdd BLAST116

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1922 Eukaryota
ENOG411149J LUCA
GeneTreeiENSGT00870000136417
HOGENOMiHOG000112617
HOVERGENiHBG107922
InParanoidiQ68DA7
KOiK10367
OMAiGFNEQTP
OrthoDBiEOG091G0BH5
PhylomeDBiQ68DA7
TreeFamiTF326072

Family and domain databases

InterProiView protein in InterPro
IPR015425 FH2_Formin
IPR001265 Formin_Cappuccino_subfam
PfamiView protein in Pfam
PF02181 FH2, 1 hit
PRINTSiPR00828 FORMIN
SMARTiView protein in SMART
SM00498 FH2, 1 hit
PROSITEiView protein in PROSITE
PS51444 FH2, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q68DA7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGTHCTLQL HKPITELCYI SFCLPKGEVR GFSYKGTVTL DRSNKGFHNC
60 70 80 90 100
YQVREESDII SLSQEPDEHP GDIFFKQTPT KDILTELYKL TTERERLLTN
110 120 130 140 150
LLSSDHILGI TMGNQEGKLQ ELSVSLAPED DCFQSAGDWQ GELPVGPLNK
160 170 180 190 200
RSTHGNKKPR RSSGRRESFG ALPQKRTKRK GRGGRESAPL MGKDKICSSH
210 220 230 240 250
SLPLSRTRPN LWVLEEKGNL LPNGALACSL QRRESCPPDI PKTPDTDLGF
260 270 280 290 300
GSFETAFKDT GLGREVLPPD CSSTEAGGDG IRRPPSGLEH QQTGLSESHQ
310 320 330 340 350
DPEKHPEAEK DEMEKPAKRT CKQKPVSKVV AKVQDLSSQV QRVVKTHSKG
360 370 380 390 400
KETIAIRPAA HAEFVPKADL LTLPGAEAGA HGSRRQGKER QGDRSSQSPA
410 420 430 440 450
GETASISSVS ASAEGAVNKV PLKVIESEKL DEAPEGKRLG FPVHTSVPHT
460 470 480 490 500
RPETRNKRRA GLPLGGHKSL FLDLPHKVGP DSSQPRGDKK KPSPPAPAAL
510 520 530 540 550
GKVFNNSASQ SSTHKQTSPV PSPLSPRLPS PQQHHRILRL PALPGEREAA
560 570 580 590 600
LNDSPCRKSR VFSGCVSADT LEPPSSAKVT ETKGASPAFL RAGQPRLVPG
610 620 630 640 650
ETLEKSLGPG KTTAEPQHQS PPGISSEGFP WDGFNEQTPK DLPNRDGGAW
660 670 680 690 700
VLGYRAGPAC PFLLHEEREK SNRSELYLDL HPDHSLTEQD DRTPGRLQAV
710 720 730 740 750
WPPPKTKDTE EKVGLKYTEA EYQAAILHLK REHKEEIENL QAQFELRAFH
760 770 780 790 800
IRGEHAMITA RLEETIENLK HELEHRWRGG CEERKDVCIS TDDDCPPKTF
810 820 830 840 850
RNVCVQTDRE TFLKPCESES KTTRSNQLVP KKLNISSLSQ LSPPNDHKDI
860 870 880 890 900
HAALQPMEGM ASNQQKALPP PPASIPPPPP LPSGLGSLSP APPMPPVSAG
910 920 930 940 950
PPLPPPPPPP PPLPPPSSAG PPPPPPPPPL PNSPAPPNPG GPPPAPPPPG
960 970 980 990 1000
LAPPPPPGLF FGLGSSSSQC PRKPAIEPSC PMKPLYWTRI QISDRSQNAT
1010 1020 1030 1040 1050
PTLWDSLEEP DIRDPSEFEY LFSKDTTQQK KKPLSETYEK KNKVKKIIKL
1060 1070 1080 1090 1100
LDGKRSQTVG ILISSLHLEM KDIQQAIFNV DDSVVDLETL AALYENRAQE
1110 1120 1130 1140 1150
DELVKIRKYY ETSKEEELKL LDKPEQFLHE LAQIPNFAER AQCIIFRSVF
1160 1170 1180 1190 1200
SEGITSLHRK VEIITRASKD LLHVKSVKDI LALILAFGNY MNGGNRTRGQ
1210 1220 1230 1240 1250
ADGYSLEILP KLKDVKSRDN GINLVDYVVK YYLRYYDQEA GTEKSVFPLP
1260 1270 1280 1290 1300
EPQDFFLASQ VKFEDLIKDL RKLKRQLEAS EKQMVVVCKE SPKEYLQPFK
1310 1320 1330 1340 1350
DKLEEFFQKA KKEHKMEESH LENAQKSFET TVRYFGMKPK SGEKEITPSY
1360 1370 1380 1390 1400
VFMVWYEFCS DFKTIWKRES KNISKERLKM AQESVSKLTS EKKVETKKIN
1410
PTASLKERLR QKEASVTTN
Length:1,419
Mass (Da):157,578
Last modified:April 5, 2011 - v3
Checksum:i6ED2783FC8151A43
GO
Isoform 2 (identifier: Q68DA7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     623-662: GISSEGFPWD...GYRAGPACPF → AFHWDLQQHF...AGKGKESRSG
     663-1419: Missing.

Note: No experimental confirmation available.
Show »
Length:662
Mass (Da):71,892
Checksum:iC119E228B5F717DE
GO
Isoform 3 (identifier: Q68DA7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-680: Missing.
     681-681: H → MENVDNSLDG...PADGPSDSKS
     721-726: EYQAAI → GNVKGS
     727-1419: Missing.

Show »
Length:503
Mass (Da):53,619
Checksum:i0636873ED8470DF0
GO
Isoform 5 (identifier: Q68DA7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-680: Missing.
     681-681: H → MENVDNSLDG...PADGPSDSKS

Show »
Length:1,196
Mass (Da):132,156
Checksum:i29D19AC2C4245CD9
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YM30H0YM30_HUMAN
Formin-1
FMN1
1,321Annotation score:
H0YLM7H0YLM7_HUMAN
Formin-1
FMN1
181Annotation score:
H0YL93H0YL93_HUMAN
Formin-1
FMN1
114Annotation score:
H0YMP0H0YMP0_HUMAN
Formin-1
FMN1
58Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti57S → A in CAH18313 (PubMed:17974005).Curated1
Sequence conflicti221L → P in CAH18313 (PubMed:17974005).Curated1
Isoform 3 (identifier: Q68DA7-3)
Sequence conflicti171G → V in AAI03693 (PubMed:15489334).Curated1
Sequence conflicti171G → V in AAI07594 (PubMed:15489334).Curated1
Sequence conflicti239G → E in AAI07594 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034630686L → P2 PublicationsCorresponds to variant dbSNP:rs2306277Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0272081 – 680Missing in isoform 3 and isoform 5. 1 PublicationAdd BLAST680
Alternative sequenceiVSP_027209623 – 662GISSE…PACPF → AFHWDLQQHFQEPVIRTVSI SCASNLIKEEAGKGKESRSG in isoform 2. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_027210663 – 1419Missing in isoform 2. 1 PublicationAdd BLAST757
Alternative sequenceiVSP_027211681H → MENVDNSLDGSDVSEPAKPE AGLEVAQSILSKFSMKSLFG FTSKLESVNPEEEDAVLKAF HSLDVNPTSQQDDSSNGLDP QEAGSRVSPDLGNDEKIASV ETESEGSQRKEAGTSLLAQE LLPLSTLKGTKDDVICVRGT LVHTTSDSDSDDGGQEPEEG SSTNGPKSPSGVLSEPSQES KENPGGFRENTVTGEMNGAE LCAEDPQRIPPEMSSKLEAG NGGLQTERRPSQDQVGEEGS QDLPAVTNQNSSVGITESAS SKKEVSGEKSFQLPAFFSGL RVLKKGATAEGGETITEIKP KDGDLALLKLTQPVQKSLVQ AGLQTVKSEKKATDPKATPT LLEQLSLLLNIDMPKTEPKG ADPESPRREEMGCNADQESQ SGPGVPQTQGGEVKPKSPET ALEAFKALFIRPPRKGTTAD TSELEALKRKMRHEKESLRA VFERSNSKPADGPSDSKS in isoform 3 and isoform 5. 1 Publication1
Alternative sequenceiVSP_027212721 – 726EYQAAI → GNVKGS in isoform 3. 1 Publication6
Alternative sequenceiVSP_027213727 – 1419Missing in isoform 3. 1 PublicationAdd BLAST693

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR749487 mRNA Translation: CAH18313.1
AC090098 Genomic DNA No translation available.
AC090877 Genomic DNA No translation available.
AC090982 Genomic DNA No translation available.
AC018515 Genomic DNA No translation available.
AC019278 Genomic DNA No translation available.
BC103692 mRNA Translation: AAI03693.1
BC107593 mRNA Translation: AAI07594.1
AK127078 mRNA No translation available.
CCDSiCCDS45209.1 [Q68DA7-5]
CCDS61581.1 [Q68DA7-1]
CCDS61582.1 [Q68DA7-2]
RefSeqiNP_001096654.1, NM_001103184.3 [Q68DA7-5]
NP_001264242.1, NM_001277313.1 [Q68DA7-1]
NP_001264243.1, NM_001277314.1 [Q68DA7-2]
XP_011519806.1, XM_011521504.2 [Q68DA7-1]
XP_016877619.1, XM_017022130.1 [Q68DA7-1]
UniGeneiHs.657649

Genome annotation databases

EnsembliENST00000320930; ENSP00000325166; ENSG00000248905 [Q68DA7-2]
ENST00000334528; ENSP00000333950; ENSG00000248905 [Q68DA7-5]
ENST00000558197; ENSP00000452984; ENSG00000248905 [Q68DA7-3]
ENST00000559047; ENSP00000454047; ENSG00000248905 [Q68DA7-1]
ENST00000616417; ENSP00000479134; ENSG00000248905 [Q68DA7-1]
ENST00000631469; ENSP00000488866; ENSG00000282513 [Q68DA7-3]
ENST00000631756; ENSP00000488300; ENSG00000282513 [Q68DA7-1]
ENST00000631811; ENSP00000488198; ENSG00000282513 [Q68DA7-5]
ENST00000632024; ENSP00000488532; ENSG00000282513 [Q68DA7-1]
ENST00000633316; ENSP00000487643; ENSG00000282513 [Q68DA7-2]
GeneIDi342184
KEGGihsa:342184
UCSCiuc001zhf.6 human [Q68DA7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR749487 mRNA Translation: CAH18313.1
AC090098 Genomic DNA No translation available.
AC090877 Genomic DNA No translation available.
AC090982 Genomic DNA No translation available.
AC018515 Genomic DNA No translation available.
AC019278 Genomic DNA No translation available.
BC103692 mRNA Translation: AAI03693.1
BC107593 mRNA Translation: AAI07594.1
AK127078 mRNA No translation available.
CCDSiCCDS45209.1 [Q68DA7-5]
CCDS61581.1 [Q68DA7-1]
CCDS61582.1 [Q68DA7-2]
RefSeqiNP_001096654.1, NM_001103184.3 [Q68DA7-5]
NP_001264242.1, NM_001277313.1 [Q68DA7-1]
NP_001264243.1, NM_001277314.1 [Q68DA7-2]
XP_011519806.1, XM_011521504.2 [Q68DA7-1]
XP_016877619.1, XM_017022130.1 [Q68DA7-1]
UniGeneiHs.657649

3D structure databases

ProteinModelPortaliQ68DA7
SMRiQ68DA7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131167, 7 interactors
ELMiQ68DA7
IntActiQ68DA7, 3 interactors
STRINGi9606.ENSP00000333950

PTM databases

iPTMnetiQ68DA7
PhosphoSitePlusiQ68DA7

Polymorphism and mutation databases

DMDMi327478585

Proteomic databases

MaxQBiQ68DA7
PaxDbiQ68DA7
PeptideAtlasiQ68DA7
PRIDEiQ68DA7
ProteomicsDBi66065
66066 [Q68DA7-2]
66067 [Q68DA7-3]
66068 [Q68DA7-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320930; ENSP00000325166; ENSG00000248905 [Q68DA7-2]
ENST00000334528; ENSP00000333950; ENSG00000248905 [Q68DA7-5]
ENST00000558197; ENSP00000452984; ENSG00000248905 [Q68DA7-3]
ENST00000559047; ENSP00000454047; ENSG00000248905 [Q68DA7-1]
ENST00000616417; ENSP00000479134; ENSG00000248905 [Q68DA7-1]
ENST00000631469; ENSP00000488866; ENSG00000282513 [Q68DA7-3]
ENST00000631756; ENSP00000488300; ENSG00000282513 [Q68DA7-1]
ENST00000631811; ENSP00000488198; ENSG00000282513 [Q68DA7-5]
ENST00000632024; ENSP00000488532; ENSG00000282513 [Q68DA7-1]
ENST00000633316; ENSP00000487643; ENSG00000282513 [Q68DA7-2]
GeneIDi342184
KEGGihsa:342184
UCSCiuc001zhf.6 human [Q68DA7-1]

Organism-specific databases

CTDi342184
DisGeNETi342184
EuPathDBiHostDB:ENSG00000248905.8
GeneCardsiFMN1
H-InvDBiHIX0012079
HGNCiHGNC:3768 FMN1
HPAiHPA005465
HPA046786
MIMi136535 gene
neXtProtiNX_Q68DA7
OpenTargetsiENSG00000248905
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1922 Eukaryota
ENOG411149J LUCA
GeneTreeiENSGT00870000136417
HOGENOMiHOG000112617
HOVERGENiHBG107922
InParanoidiQ68DA7
KOiK10367
OMAiGFNEQTP
OrthoDBiEOG091G0BH5
PhylomeDBiQ68DA7
TreeFamiTF326072

Miscellaneous databases

ChiTaRSiFMN1 human
GenomeRNAii342184
PROiPR:Q68DA7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000248905 Expressed in 117 organ(s), highest expression level in kidney
CleanExiHS_FMN1
ExpressionAtlasiQ68DA7 baseline and differential
GenevisibleiQ68DA7 HS

Family and domain databases

InterProiView protein in InterPro
IPR015425 FH2_Formin
IPR001265 Formin_Cappuccino_subfam
PfamiView protein in Pfam
PF02181 FH2, 1 hit
PRINTSiPR00828 FORMIN
SMARTiView protein in SMART
SM00498 FH2, 1 hit
PROSITEiView protein in PROSITE
PS51444 FH2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFMN1_HUMAN
AccessioniPrimary (citable) accession number: Q68DA7
Secondary accession number(s): Q3B7I6, Q3ZAR4, Q6ZSY1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 113 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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