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UniProtKB - Q68D91 (MBLC2_HUMAN)

Entry version 115 (02 Jun 2021)
Sequence version 3 (02 Nov 2010)
Previous versions | rss
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Protein

Metallo-beta-lactamase domain-containing protein 2

Gene

MBLAC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi83Zinc 1By similarity1
Metal bindingi85Zinc 1By similarity1
Metal bindingi87Zinc 2By similarity1
Metal bindingi88Zinc 2By similarity1
Metal bindingi170Zinc 1By similarity1
Metal bindingi189Zinc 1By similarity1
Metal bindingi189Zinc 2By similarity1
Metal bindingi231Zinc 2By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q68D91

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Metallo-beta-lactamase domain-containing protein 2 (EC:3.-.-.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MBLAC2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:33711, MBLAC2

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q68D91

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000176055.9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000176055

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA164722236

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q68D91, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MBLAC2

Domain mapping of disease mutations (DMDM)

More...DMDMi		311033427

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003259352 – 279Metallo-beta-lactamase domain-containing protein 2Add BLAST278

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q68D91

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q68D91

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q68D91

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q68D91

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q68D91

PeptideAtlas

More...PeptideAtlasi		Q68D91

PRoteomics IDEntifications database

More...PRIDEi		Q68D91

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		66062 [Q68D91-1]
66063 [Q68D91-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q68D91

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q68D91

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q68D91

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000176055, Expressed in cerebellar vermis and 205 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q68D91, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000176055, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		127492, 50 interactors

Protein interaction database and analysis system

More...IntActi		Q68D91, 35 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000314776

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q68D91, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0813, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000017819

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_030571_0_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q68D91

Identification of Orthologs from Complete Genome Data

More...OMAi		GAMIDWL

Database of Orthologous Groups

More...OrthoDBi		1203911at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q68D91

TreeFam database of animal gene trees

More...TreeFami		TF319889

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.60.15.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001279, Metallo-B-lactamas
IPR036866, RibonucZ/Hydroxyglut_hydro

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00753, Lactamase_B, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00849, Lactamase_B, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56281, SSF56281, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q68D91-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSALEWYAHK SLGDGIFWIQ ERFYESGNRA NIWLVRGSEQ DVVIDTGLGL 
        60         70         80         90        100
RSLPEYLYSS GLLQDREAKE DAARRPLLAV ATHVHFDHSG GLYQFDRVAV 
       110        120        130        140        150
HHAEAEALAR GDNFETVTWL SDSEVVRTPS PGWRARQFRV QAVQPTLILQ 
       160        170        180        190        200
DGDVINLGDR QLTVMHMPGH SRGSICLHDK DRKILFSGDV VYDGSLIDWL 
       210        220        230        240        250
PYSRISDYVG TCERLIELVD RGLVEKVLPG HFNTFGAERL FRLASNYISK 
       260        270 
AGICHKVSTF AMRSLASLAL RVTNSRTSP
Length:279
Mass (Da):31,372
Last modified:November 2, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i14C9C03B62C81867
GO
Isoform 2 (identifier: Q68D91-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     153-279: DVINLGDRQL...LRVTNSRTSP → NGPPRARALV...SQSHFCFTLP

Show »
Length:199
Mass (Da):22,432
Checksum:i66FF3B0A88976181
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti25E → G in BAC04908 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_039956128T → A3 PublicationsCorresponds to variant dbSNP:rs2162986Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_032490153 – 279DVINL…SRTSP → NGPPRARALVKGGYWEETVR VPHVADLRGHKGDYFGTSQS HFCFTLP in isoform 2. 1 PublicationAdd BLAST127

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK096942 mRNA Translation: BAC04908.1
AK289778 mRNA Translation: BAF82467.1
AC093510 Genomic DNA No translation available.
CH471084 Genomic DNA Translation: EAW95979.1
BC038230 mRNA Translation: AAH38230.1
CR749512 mRNA Translation: CAH18329.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4067.1 [Q68D91-1]

NCBI Reference Sequences

More...RefSeqi		NP_981951.1, NM_203406.1 [Q68D91-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000316610; ENSP00000314776; ENSG00000176055 [Q68D91-1]
ENST00000514906; ENSP00000425600; ENSG00000176055 [Q68D91-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		153364

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:153364

UCSC genome browser

More...UCSCi		uc003kjp.3, human [Q68D91-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096942 mRNA Translation: BAC04908.1
AK289778 mRNA Translation: BAF82467.1
AC093510 Genomic DNA No translation available.
CH471084 Genomic DNA Translation: EAW95979.1
BC038230 mRNA Translation: AAH38230.1
CR749512 mRNA Translation: CAH18329.1
CCDSiCCDS4067.1 [Q68D91-1]
RefSeqiNP_981951.1, NM_203406.1 [Q68D91-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi127492, 50 interactors
IntActiQ68D91, 35 interactors
STRINGi9606.ENSP00000314776

PTM databases

iPTMnetiQ68D91
PhosphoSitePlusiQ68D91
SwissPalmiQ68D91

Genetic variation databases

BioMutaiMBLAC2
DMDMi311033427

Proteomic databases

EPDiQ68D91
jPOSTiQ68D91
MassIVEiQ68D91
MaxQBiQ68D91
PaxDbiQ68D91
PeptideAtlasiQ68D91
PRIDEiQ68D91
ProteomicsDBi66062 [Q68D91-1]
66063 [Q68D91-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		50739, 16 antibodies

The DNASU plasmid repository

More...DNASUi		153364

Genome annotation databases

EnsembliENST00000316610; ENSP00000314776; ENSG00000176055 [Q68D91-1]
ENST00000514906; ENSP00000425600; ENSG00000176055 [Q68D91-2]
GeneIDi153364
KEGGihsa:153364
UCSCiuc003kjp.3, human [Q68D91-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		153364

GeneCards: human genes, protein and diseases

More...GeneCardsi		MBLAC2
HGNCiHGNC:33711, MBLAC2
HPAiENSG00000176055, Low tissue specificity
neXtProtiNX_Q68D91
OpenTargetsiENSG00000176055
PharmGKBiPA164722236
VEuPathDBiHostDB:ENSG00000176055.9

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0813, Eukaryota
GeneTreeiENSGT00390000017819
HOGENOMiCLU_030571_0_2_1
InParanoidiQ68D91
OMAiGAMIDWL
OrthoDBi1203911at2759
PhylomeDBiQ68D91
TreeFamiTF319889

Enzyme and pathway databases

PathwayCommonsiQ68D91

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		153364, 4 hits in 989 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MBLAC2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		153364
PharosiQ68D91, Tdark

Protein Ontology

More...PROi		PR:Q68D91
RNActiQ68D91, protein

Gene expression databases

BgeeiENSG00000176055, Expressed in cerebellar vermis and 205 other tissues
GenevisibleiQ68D91, HS

Family and domain databases

Gene3Di3.60.15.10, 1 hit
InterProiView protein in InterPro
IPR001279, Metallo-B-lactamas
IPR036866, RibonucZ/Hydroxyglut_hydro
PfamiView protein in Pfam
PF00753, Lactamase_B, 1 hit
SMARTiView protein in SMART
SM00849, Lactamase_B, 1 hit
SUPFAMiSSF56281, SSF56281, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMBLC2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q68D91
Secondary accession number(s): D6RJI1, Q8IY16, Q8N8D8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: November 2, 2010
Last modified: June 2, 2021
This is version 115 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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