UniProtKB - Q68D91 (MBLC2_HUMAN)
Protein
Metallo-beta-lactamase domain-containing protein 2
Gene
MBLAC2
Organism
Homo sapiens (Human)
Status
Functioni
Cofactori
Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 83 | Zinc 1By similarity | 1 | |
Metal bindingi | 85 | Zinc 1By similarity | 1 | |
Metal bindingi | 87 | Zinc 2By similarity | 1 | |
Metal bindingi | 88 | Zinc 2By similarity | 1 | |
Metal bindingi | 170 | Zinc 1By similarity | 1 | |
Metal bindingi | 189 | Zinc 1By similarity | 1 | |
Metal bindingi | 189 | Zinc 2By similarity | 1 | |
Metal bindingi | 231 | Zinc 2By similarity | 1 |
GO - Molecular functioni
- hydrolase activity Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q68D91 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:MBLAC2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:33711, MBLAC2 |
neXtProti | NX_Q68D91 |
VEuPathDBi | HostDB:ENSG00000176055.9 |
Subcellular locationi
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000176055 |
PharmGKBi | PA164722236 |
Miscellaneous databases
Pharosi | Q68D91, Tdark |
Genetic variation databases
BioMutai | MBLAC2 |
DMDMi | 311033427 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000325935 | 2 – 279 | Metallo-beta-lactamase domain-containing protein 2Add BLAST | 278 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q68D91 |
jPOSTi | Q68D91 |
MassIVEi | Q68D91 |
MaxQBi | Q68D91 |
PaxDbi | Q68D91 |
PeptideAtlasi | Q68D91 |
PRIDEi | Q68D91 |
ProteomicsDBi | 66062 [Q68D91-1] 66063 [Q68D91-2] |
PTM databases
iPTMneti | Q68D91 |
PhosphoSitePlusi | Q68D91 |
SwissPalmi | Q68D91 |
Expressioni
Gene expression databases
Bgeei | ENSG00000176055, Expressed in cerebellar vermis and 204 other tissues |
Genevisiblei | Q68D91, HS |
Organism-specific databases
HPAi | ENSG00000176055, Low tissue specificity |
Interactioni
Binary interactionsi
Q68D91
With | #Exp. | IntAct |
---|---|---|
PBX3 [Q96AL5] | 3 | EBI-21018038,EBI-741171 |
Protein-protein interaction databases
BioGRIDi | 127492, 50 interactors |
IntActi | Q68D91, 35 interactors |
STRINGi | 9606.ENSP00000314776 |
Miscellaneous databases
RNActi | Q68D91, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0813, Eukaryota |
GeneTreei | ENSGT00390000017819 |
HOGENOMi | CLU_030571_0_2_1 |
InParanoidi | Q68D91 |
OMAi | GAMIDWL |
OrthoDBi | 1203911at2759 |
PhylomeDBi | Q68D91 |
TreeFami | TF319889 |
Family and domain databases
Gene3Di | 3.60.15.10, 1 hit |
InterProi | View protein in InterPro IPR001279, Metallo-B-lactamas IPR036866, RibonucZ/Hydroxyglut_hydro |
Pfami | View protein in Pfam PF00753, Lactamase_B, 1 hit |
SMARTi | View protein in SMART SM00849, Lactamase_B, 1 hit |
SUPFAMi | SSF56281, SSF56281, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q68D91-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSALEWYAHK SLGDGIFWIQ ERFYESGNRA NIWLVRGSEQ DVVIDTGLGL
60 70 80 90 100
RSLPEYLYSS GLLQDREAKE DAARRPLLAV ATHVHFDHSG GLYQFDRVAV
110 120 130 140 150
HHAEAEALAR GDNFETVTWL SDSEVVRTPS PGWRARQFRV QAVQPTLILQ
160 170 180 190 200
DGDVINLGDR QLTVMHMPGH SRGSICLHDK DRKILFSGDV VYDGSLIDWL
210 220 230 240 250
PYSRISDYVG TCERLIELVD RGLVEKVLPG HFNTFGAERL FRLASNYISK
260 270
AGICHKVSTF AMRSLASLAL RVTNSRTSP
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 25 | E → G in BAC04908 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_039956 | 128 | T → A3 PublicationsCorresponds to variant dbSNP:rs2162986Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_032490 | 153 – 279 | DVINL…SRTSP → NGPPRARALVKGGYWEETVR VPHVADLRGHKGDYFGTSQS HFCFTLP in isoform 2. 1 PublicationAdd BLAST | 127 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK096942 mRNA Translation: BAC04908.1 AK289778 mRNA Translation: BAF82467.1 AC093510 Genomic DNA No translation available. CH471084 Genomic DNA Translation: EAW95979.1 BC038230 mRNA Translation: AAH38230.1 CR749512 mRNA Translation: CAH18329.1 |
CCDSi | CCDS4067.1 [Q68D91-1] |
RefSeqi | NP_981951.1, NM_203406.1 [Q68D91-1] |
Genome annotation databases
Ensembli | ENST00000316610; ENSP00000314776; ENSG00000176055 [Q68D91-1] ENST00000514906; ENSP00000425600; ENSG00000176055 [Q68D91-2] |
GeneIDi | 153364 |
KEGGi | hsa:153364 |
UCSCi | uc003kjp.3, human [Q68D91-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK096942 mRNA Translation: BAC04908.1 AK289778 mRNA Translation: BAF82467.1 AC093510 Genomic DNA No translation available. CH471084 Genomic DNA Translation: EAW95979.1 BC038230 mRNA Translation: AAH38230.1 CR749512 mRNA Translation: CAH18329.1 |
CCDSi | CCDS4067.1 [Q68D91-1] |
RefSeqi | NP_981951.1, NM_203406.1 [Q68D91-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 127492, 50 interactors |
IntActi | Q68D91, 35 interactors |
STRINGi | 9606.ENSP00000314776 |
PTM databases
iPTMneti | Q68D91 |
PhosphoSitePlusi | Q68D91 |
SwissPalmi | Q68D91 |
Genetic variation databases
BioMutai | MBLAC2 |
DMDMi | 311033427 |
Proteomic databases
EPDi | Q68D91 |
jPOSTi | Q68D91 |
MassIVEi | Q68D91 |
MaxQBi | Q68D91 |
PaxDbi | Q68D91 |
PeptideAtlasi | Q68D91 |
PRIDEi | Q68D91 |
ProteomicsDBi | 66062 [Q68D91-1] 66063 [Q68D91-2] |
Protocols and materials databases
Antibodypediai | 50739, 16 antibodies |
Genome annotation databases
Ensembli | ENST00000316610; ENSP00000314776; ENSG00000176055 [Q68D91-1] ENST00000514906; ENSP00000425600; ENSG00000176055 [Q68D91-2] |
GeneIDi | 153364 |
KEGGi | hsa:153364 |
UCSCi | uc003kjp.3, human [Q68D91-1] |
Organism-specific databases
CTDi | 153364 |
GeneCardsi | MBLAC2 |
HGNCi | HGNC:33711, MBLAC2 |
HPAi | ENSG00000176055, Low tissue specificity |
neXtProti | NX_Q68D91 |
OpenTargetsi | ENSG00000176055 |
PharmGKBi | PA164722236 |
VEuPathDBi | HostDB:ENSG00000176055.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0813, Eukaryota |
GeneTreei | ENSGT00390000017819 |
HOGENOMi | CLU_030571_0_2_1 |
InParanoidi | Q68D91 |
OMAi | GAMIDWL |
OrthoDBi | 1203911at2759 |
PhylomeDBi | Q68D91 |
TreeFami | TF319889 |
Enzyme and pathway databases
PathwayCommonsi | Q68D91 |
Miscellaneous databases
BioGRID-ORCSi | 153364, 4 hits in 871 CRISPR screens |
ChiTaRSi | MBLAC2, human |
GenomeRNAii | 153364 |
Pharosi | Q68D91, Tdark |
PROi | PR:Q68D91 |
RNActi | Q68D91, protein |
Gene expression databases
Bgeei | ENSG00000176055, Expressed in cerebellar vermis and 204 other tissues |
Genevisiblei | Q68D91, HS |
Family and domain databases
Gene3Di | 3.60.15.10, 1 hit |
InterProi | View protein in InterPro IPR001279, Metallo-B-lactamas IPR036866, RibonucZ/Hydroxyglut_hydro |
Pfami | View protein in Pfam PF00753, Lactamase_B, 1 hit |
SMARTi | View protein in SMART SM00849, Lactamase_B, 1 hit |
SUPFAMi | SSF56281, SSF56281, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MBLC2_HUMAN | |
Accessioni | Q68D91Primary (citable) accession number: Q68D91 Secondary accession number(s): D6RJI1, Q8IY16, Q8N8D8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 18, 2008 |
Last sequence update: | November 2, 2010 | |
Last modified: | February 10, 2021 | |
This is version 113 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families