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UniProtKB - Q68D86 (C102B_HUMAN)

Entry version 127 (12 Aug 2020)
Sequence version 4 (25 Nov 2008)
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Protein

Coiled-coil domain-containing protein 102B

Gene

CCDC102B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q68D86

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coiled-coil domain-containing protein 102B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCDC102B
Synonyms:C18orf14
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000150636.15

Human Gene Nomenclature Database

More...HGNCi		HGNC:26295, CCDC102B

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q68D86

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		79839

Open Targets

More...OpenTargetsi		ENSG00000150636

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134948675

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q68D86, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CCDC102B

Domain mapping of disease mutations (DMDM)

More...DMDMi		215274243

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000793081 – 513Coiled-coil domain-containing protein 102BAdd BLAST513

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q68D86

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q68D86

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q68D86

PeptideAtlas

More...PeptideAtlasi		Q68D86

PRoteomics IDEntifications database

More...PRIDEi		Q68D86

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		66059 [Q68D86-1]
66060 [Q68D86-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q68D86

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q68D86

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000150636, Expressed in stomach and 162 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q68D86, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q68D86, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000150636, Tissue enhanced (placenta)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q68D86
With#Exp.IntAct
ABI2 [Q9NYB9]5EBI-10171570,EBI-743598
ABI2 - isoform 2 [Q9NYB9-2]3EBI-10171570,EBI-11096309
AK8 [Q96MA6]3EBI-10171570,EBI-8466265
ANKRD23 [Q86SG2]3EBI-10171570,EBI-5661893
ARL4A [P40617]3EBI-10171570,EBI-2875746
ARL4D [P49703]4EBI-10171570,EBI-711726
BYSL [Q13895]6EBI-10171570,EBI-358049
C16orf70 [Q9BSU1]5EBI-10171570,EBI-946080
C20orf202 [A1L168]3EBI-10171570,EBI-18396958
CACNB4 [O00305]3EBI-10171570,EBI-714838
CAPN3 - isoform IV [P20807-4]3EBI-10171570,EBI-11532021
CCDC120 [Q96HB5]3EBI-10171570,EBI-744556
CCDC120 - isoform 4 [Q96HB5-4]4EBI-10171570,EBI-10185348
CCHCR1 - isoform 3 [Q8TD31-3]6EBI-10171570,EBI-10175300
CDK18 [Q07002]3EBI-10171570,EBI-746238
CEP19 [Q96LK0]6EBI-10171570,EBI-741885
CEP57L1 - isoform 2 [Q8IYX8-2]3EBI-10171570,EBI-10181988
CWF19L2 [Q2TBE0]3EBI-10171570,EBI-5453285
DISC1 - isoform 2 [Q9NRI5-2]3EBI-10171570,EBI-11988027
DOCK10 [Q96BY6]3EBI-10171570,EBI-748520
EFHC2 [Q5JST6]3EBI-10171570,EBI-2349927
EHHADH [Q08426]4EBI-10171570,EBI-2339219
ENKD1 [Q9H0I2]6EBI-10171570,EBI-744099
EXOC5 [O00471]3EBI-10171570,EBI-949824
FAM161A [Q3B820]6EBI-10171570,EBI-719941
FAM217B [Q9NTX9]3EBI-10171570,EBI-19153639
FBF1 - isoform 6 [Q8TES7-6]3EBI-10171570,EBI-10244131
FH [P07954]3EBI-10171570,EBI-1050358
FLOT1 [O75955]3EBI-10171570,EBI-603643
FNDC11 [Q9BVV2]3EBI-10171570,EBI-744935
GEM [P55040]3EBI-10171570,EBI-744104
GOPC [Q9HD26]3EBI-10171570,EBI-349832
GOPC - isoform 2 [Q9HD26-2]4EBI-10171570,EBI-11102276
HMG20B [Q9P0W2]6EBI-10171570,EBI-713401
IKZF3 [Q9UKT9]3EBI-10171570,EBI-747204
KIFC3 [Q9BVG8]3EBI-10171570,EBI-2125614
KPNA3 [O00505]3EBI-10171570,EBI-358297
KRT75 [O95678]3EBI-10171570,EBI-2949715
KRTAP13-3 [Q3SY46]3EBI-10171570,EBI-10241252
LENG1 [Q96BZ8]3EBI-10171570,EBI-726510
LMO4 [P61968]6EBI-10171570,EBI-2798728
LNX1 [Q8TBB1]4EBI-10171570,EBI-739832
LZTS1 [Q9Y250]3EBI-10171570,EBI-1216080
MAB21L2 [Q9Y586]3EBI-10171570,EBI-6659161
MAGOHB [Q96A72]6EBI-10171570,EBI-746778
MCM7 [P33993]3EBI-10171570,EBI-355924
MEOX1 [P50221]3EBI-10171570,EBI-2864512
MEOX2 [Q6FHY5]3EBI-10171570,EBI-16439278
MFAP1 [P55081]3EBI-10171570,EBI-1048159
MGC50722 [Q8IVT4]3EBI-10171570,EBI-14086479
MOS [P00540]3EBI-10171570,EBI-1757866
MSX2 [P35548]3EBI-10171570,EBI-6447480
NIF3L1 [Q9GZT8]6EBI-10171570,EBI-740897
NME4 [O00746]3EBI-10171570,EBI-744871
NXT2 [Q9NPJ8]3EBI-10171570,EBI-752122
PFKFB4 [Q16877]3EBI-10171570,EBI-764534
PICK1 [Q9NRD5]3EBI-10171570,EBI-79165
PNMA5 [Q96PV4]8EBI-10171570,EBI-10171633
POMC [P01189]3EBI-10171570,EBI-12219503
POP5 [Q969H6]6EBI-10171570,EBI-366525
PPP1R13B [Q96KQ4]3EBI-10171570,EBI-1105153
PPP1R18 [Q6NYC8]6EBI-10171570,EBI-2557469
PRPF18 [Q99633]3EBI-10171570,EBI-2798416
PSMA1 [P25786]6EBI-10171570,EBI-359352
RASAL3 [Q86YV0]3EBI-10171570,EBI-3437896
RCOR3 [Q9P2K3]3EBI-10171570,EBI-743428
RSPH14 [Q9UHP6]6EBI-10171570,EBI-748350
RTL8A [Q9BWD3]3EBI-10171570,EBI-741643
RTL8B [Q17RB0]3EBI-10171570,EBI-10238588
RTL8C [A6ZKI3]3EBI-10171570,EBI-10174072
SDCBP [O00560]3EBI-10171570,EBI-727004
SFN [P31947]3EBI-10171570,EBI-476295
SGF29 [Q96ES7]3EBI-10171570,EBI-743117
SH3RF2 [Q8TEC5]3EBI-10171570,EBI-2130111
SLIRP [Q9GZT3]3EBI-10171570,EBI-1050793
SMARCD1 [Q96GM5]3EBI-10171570,EBI-358489
SNAPIN [O95295]3EBI-10171570,EBI-296723
SORBS3 [O60504]3EBI-10171570,EBI-741237
SPATA18 [Q8TC71]3EBI-10171570,EBI-11334239
SPATA2 [Q9UM82]3EBI-10171570,EBI-744066
SPG21 [Q9NZD8]6EBI-10171570,EBI-742688
SYCE1 [Q8N0S2]3EBI-10171570,EBI-6872807
SYT17 [Q9BSW7]3EBI-10171570,EBI-745392
TCEANC - isoform 2 [Q8N8B7-2]3EBI-10171570,EBI-11955057
TCP10L [Q8TDR4]3EBI-10171570,EBI-3923210
TFIP11 [Q9UBB9]3EBI-10171570,EBI-1105213
TNNI1 [P19237]3EBI-10171570,EBI-746692
TPM3 [Q5VU62]3EBI-10171570,EBI-10184033
TRIM27 [P14373]6EBI-10171570,EBI-719493
TRIM54 [Q9BYV2]6EBI-10171570,EBI-2130429
TSGA10IP [Q3SY00]3EBI-10171570,EBI-10241197
TTC23 - isoform 3 [Q5W5X9-3]3EBI-10171570,EBI-9090990
VPS52 [Q8N1B4]3EBI-10171570,EBI-2799833
WDYHV1 [Q96HA8]4EBI-10171570,EBI-741158
ZBTB32 [A0A0C4DGF1]3EBI-10171570,EBI-10188476
ZBTB42 [B2RXF5]3EBI-10171570,EBI-12287587
ZC2HC1C - isoform 2 [Q53FD0-2]6EBI-10171570,EBI-14104088
ZNF20 [P17024]6EBI-10171570,EBI-717634
ZNF250 - isoform 3 [P15622-3]3EBI-10171570,EBI-10177272
ZNF572 [Q7Z3I7]6EBI-10171570,EBI-10172590
ZNF620 [Q6ZNG0]3EBI-10171570,EBI-4395669
ZNF688 [P0C7X2]3EBI-10171570,EBI-4395732
ZNF774 [Q6NX45]3EBI-10171570,EBI-10251462

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		122930, 102 interactors

Protein interaction database and analysis system

More...IntActi		Q68D86, 149 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000353377

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q68D86, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q68D86

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili72 – 142Sequence analysisAdd BLAST71
Coiled coili268 – 337Sequence analysisAdd BLAST70
Coiled coili363 – 513Sequence analysisAdd BLAST151

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QSJ6, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000163731

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_033486_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q68D86

Identification of Orthologs from Complete Genome Data

More...OMAi		LRHLQNW

Database of Orthologous Groups

More...OrthoDBi		1304833at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q68D86

TreeFam database of animal gene trees

More...TreeFami		TF320856

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q68D86-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNLDSIHRLI EETQIFQMQQ SSIKSRGDMV APASPPRDTC NTCFPLHGLQ 
        60         70         80         90        100
SHAAHNFCAH SYNTNKWDIC EELRLRELEE VKARAAQMEK TMRWWSDCTA 
       110        120        130        140        150
NWREKWSKVR AERNSAREEG RQLRIKLEMA MKELSTLKKK QSLPPQKEAL 
       160        170        180        190        200
EAKVTQDLKL PGFVEESCEH TDQFQLSSQM HESIREYLVK RQFSTKEDTN 
       210        220        230        240        250
NKEQGVVIDS LKLSEEMKPN LDGVDLFNNG GSGNGETKTG LRLKAINLPL 
       260        270        280        290        300
ENEVTEISAL QVHLDEFQKI LWKEREMRTA LEKEIERLES ALSLWKWKYE 
       310        320        330        340        350
ELKESKPKNV KEFDILLGQH NDEMQELSGN IKEESKSQNS KDRVICELRA 
       360        370        380        390        400
ELERLQAENT SEWDKREILE REKQGLEREN RRLKIQVKEM EELLDKKNRL 
       410        420        430        440        450
SANSQSPDFK MSQIDLQEKN QELLNLQHAY YKLNRQYQAN IAELTHANNR 
       460        470        480        490        500
VDQNEAEVKK LRLRVEELKQ GLNQKEDELD DSLNQIRKLQ RSLDEEKERN 
       510 
ENLETELRHL QNW
Length:513
Mass (Da):60,448
Last modified:November 25, 2008 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i450D36A80D6D88C8
GO
Isoform 2 (identifier: Q68D86-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     479-483: LDDSL → VLLYE
     484-513: Missing.

Show »
Length:483
Mass (Da):56,720
Checksum:i58CB338DE6B55098
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KRT2J3KRT2_HUMAN
Coiled-coil domain-containing prote...
CCDC102B
137Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QLG6J3QLG6_HUMAN
Coiled-coil domain-containing prote...
CCDC102B
325Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KRG3J3KRG3_HUMAN
Coiled-coil domain-containing prote...
CCDC102B
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QL62J3QL62_HUMAN
Coiled-coil domain-containing prote...
CCDC102B
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH56269 differs from that shown. wrong intron-exon boundaries.Curated
The sequence AAI26449 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAI26451 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB15706 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAD38721 differs from that shown. Reason: Frameshift.Curated
The sequence CAD38721 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti131M → T in CAH18334 (PubMed:17974005).Curated1
Sequence conflicti382R → G in CAH18334 (PubMed:17974005).Curated1
Sequence conflicti469K → R in CAH18334 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_047331153K → N1 PublicationCorresponds to variant dbSNP:rs572020Ensembl.1
Natural variantiVAR_047332298K → R1 PublicationCorresponds to variant dbSNP:rs2187094Ensembl.1
Natural variantiVAR_022893346C → F. Corresponds to variant dbSNP:rs745894Ensembl.1
Natural variantiVAR_047333370E → G. Corresponds to variant dbSNP:rs34102373Ensembl.1
Natural variantiVAR_047334425N → K. Corresponds to variant dbSNP:rs17080065Ensembl.1
Natural variantiVAR_022894429A → P. Corresponds to variant dbSNP:rs9963788Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_014688479 – 483LDDSL → VLLYE in isoform 2. 1 Publication5
Alternative sequenceiVSP_014689484 – 513Missing in isoform 2. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CR749520 mRNA Translation: CAH18334.2
AL833863 mRNA Translation: CAD38721.2 Sequence problems.
AC022035 Genomic DNA No translation available.
AC096708 Genomic DNA No translation available.
AC011087 Genomic DNA No translation available.
BC056269 mRNA Translation: AAH56269.1 Sequence problems.
BC126448 mRNA Translation: AAI26449.1 Different initiation.
BC126450 mRNA Translation: AAI26451.1 Different initiation.
AK027247 mRNA Translation: BAB15706.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11996.2 [Q68D86-1]

NCBI Reference Sequences

More...RefSeqi		NP_001087198.1, NM_001093729.1 [Q68D86-1]
NP_079057.2, NM_024781.2 [Q68D86-1]
XP_016881464.1, XM_017025975.1 [Q68D86-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000360242; ENSP00000353377; ENSG00000150636 [Q68D86-1]
ENST00000584156; ENSP00000463111; ENSG00000150636 [Q68D86-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		79839

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:79839

UCSC genome browser

More...UCSCi		uc002lki.2, human [Q68D86-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR749520 mRNA Translation: CAH18334.2
AL833863 mRNA Translation: CAD38721.2 Sequence problems.
AC022035 Genomic DNA No translation available.
AC096708 Genomic DNA No translation available.
AC011087 Genomic DNA No translation available.
BC056269 mRNA Translation: AAH56269.1 Sequence problems.
BC126448 mRNA Translation: AAI26449.1 Different initiation.
BC126450 mRNA Translation: AAI26451.1 Different initiation.
AK027247 mRNA Translation: BAB15706.1 Different initiation.
CCDSiCCDS11996.2 [Q68D86-1]
RefSeqiNP_001087198.1, NM_001093729.1 [Q68D86-1]
NP_079057.2, NM_024781.2 [Q68D86-1]
XP_016881464.1, XM_017025975.1 [Q68D86-1]

3D structure databases

SMRiQ68D86
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi122930, 102 interactors
IntActiQ68D86, 149 interactors
STRINGi9606.ENSP00000353377

PTM databases

iPTMnetiQ68D86
PhosphoSitePlusiQ68D86

Polymorphism and mutation databases

BioMutaiCCDC102B
DMDMi215274243

Proteomic databases

EPDiQ68D86
jPOSTiQ68D86
PaxDbiQ68D86
PeptideAtlasiQ68D86
PRIDEiQ68D86
ProteomicsDBi66059 [Q68D86-1]
66060 [Q68D86-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		49098, 114 antibodies

The DNASU plasmid repository

More...DNASUi		79839

Genome annotation databases

EnsembliENST00000360242; ENSP00000353377; ENSG00000150636 [Q68D86-1]
ENST00000584156; ENSP00000463111; ENSG00000150636 [Q68D86-2]
GeneIDi79839
KEGGihsa:79839
UCSCiuc002lki.2, human [Q68D86-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		79839
DisGeNETi79839
EuPathDBiHostDB:ENSG00000150636.15

GeneCards: human genes, protein and diseases

More...GeneCardsi		CCDC102B
HGNCiHGNC:26295, CCDC102B
HPAiENSG00000150636, Tissue enhanced (placenta)
neXtProtiNX_Q68D86
OpenTargetsiENSG00000150636
PharmGKBiPA134948675

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QSJ6, Eukaryota
GeneTreeiENSGT00940000163731
HOGENOMiCLU_033486_2_0_1
InParanoidiQ68D86
OMAiLRHLQNW
OrthoDBi1304833at2759
PhylomeDBiQ68D86
TreeFamiTF320856

Enzyme and pathway databases

PathwayCommonsiQ68D86

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		79839, 8 hits in 874 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CCDC102B, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		79839
PharosiQ68D86, Tdark

Protein Ontology

More...PROi		PR:Q68D86
RNActiQ68D86, protein

Gene expression databases

BgeeiENSG00000150636, Expressed in stomach and 162 other tissues
ExpressionAtlasiQ68D86, baseline and differential
GenevisibleiQ68D86, HS

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiC102B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q68D86
Secondary accession number(s): A1A4H1
, Q7Z467, Q8NDK7, Q9H5C1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: November 25, 2008
Last modified: August 12, 2020
This is version 127 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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