UniProtKB - Q68D86 (C102B_HUMAN)
Protein
Coiled-coil domain-containing protein 102B
Gene
CCDC102B
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Coiled-coil domain-containing protein 102B |
Gene namesi | Name:CCDC102B Synonyms:C18orf14 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26295, CCDC102B |
neXtProti | NX_Q68D86 |
VEuPathDBi | HostDB:ENSG00000150636.15 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 79839 |
OpenTargetsi | ENSG00000150636 |
PharmGKBi | PA134948675 |
Miscellaneous databases
Pharosi | Q68D86, Tdark |
Genetic variation databases
BioMutai | CCDC102B |
DMDMi | 215274243 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000079308 | 1 – 513 | Coiled-coil domain-containing protein 102BAdd BLAST | 513 |
Proteomic databases
EPDi | Q68D86 |
jPOSTi | Q68D86 |
PaxDbi | Q68D86 |
PeptideAtlasi | Q68D86 |
PRIDEi | Q68D86 |
ProteomicsDBi | 66059 [Q68D86-1] 66060 [Q68D86-2] |
PTM databases
iPTMneti | Q68D86 |
PhosphoSitePlusi | Q68D86 |
Expressioni
Gene expression databases
Bgeei | ENSG00000150636, Expressed in stomach and 162 other tissues |
ExpressionAtlasi | Q68D86, baseline and differential |
Genevisiblei | Q68D86, HS |
Organism-specific databases
HPAi | ENSG00000150636, Tissue enhanced (placenta) |
Interactioni
Binary interactionsi
Q68D86
Protein-protein interaction databases
BioGRIDi | 122930, 153 interactors |
IntActi | Q68D86, 149 interactors |
STRINGi | 9606.ENSP00000353377 |
Miscellaneous databases
RNActi | Q68D86, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 72 – 142 | Sequence analysisAdd BLAST | 71 | |
Coiled coili | 268 – 337 | Sequence analysisAdd BLAST | 70 | |
Coiled coili | 363 – 513 | Sequence analysisAdd BLAST | 151 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QSJ6, Eukaryota |
GeneTreei | ENSGT00940000163731 |
HOGENOMi | CLU_033486_2_0_1 |
InParanoidi | Q68D86 |
OMAi | LRHLQNW |
OrthoDBi | 1304833at2759 |
PhylomeDBi | Q68D86 |
TreeFami | TF320856 |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q68D86-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNLDSIHRLI EETQIFQMQQ SSIKSRGDMV APASPPRDTC NTCFPLHGLQ
60 70 80 90 100
SHAAHNFCAH SYNTNKWDIC EELRLRELEE VKARAAQMEK TMRWWSDCTA
110 120 130 140 150
NWREKWSKVR AERNSAREEG RQLRIKLEMA MKELSTLKKK QSLPPQKEAL
160 170 180 190 200
EAKVTQDLKL PGFVEESCEH TDQFQLSSQM HESIREYLVK RQFSTKEDTN
210 220 230 240 250
NKEQGVVIDS LKLSEEMKPN LDGVDLFNNG GSGNGETKTG LRLKAINLPL
260 270 280 290 300
ENEVTEISAL QVHLDEFQKI LWKEREMRTA LEKEIERLES ALSLWKWKYE
310 320 330 340 350
ELKESKPKNV KEFDILLGQH NDEMQELSGN IKEESKSQNS KDRVICELRA
360 370 380 390 400
ELERLQAENT SEWDKREILE REKQGLEREN RRLKIQVKEM EELLDKKNRL
410 420 430 440 450
SANSQSPDFK MSQIDLQEKN QELLNLQHAY YKLNRQYQAN IAELTHANNR
460 470 480 490 500
VDQNEAEVKK LRLRVEELKQ GLNQKEDELD DSLNQIRKLQ RSLDEEKERN
510
ENLETELRHL QNW
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3KRT2 | J3KRT2_HUMAN | Coiled-coil domain-containing prote... | CCDC102B | 137 | Annotation score: | ||
J3QLG6 | J3QLG6_HUMAN | Coiled-coil domain-containing prote... | CCDC102B | 325 | Annotation score: | ||
J3KRG3 | J3KRG3_HUMAN | Coiled-coil domain-containing prote... | CCDC102B | 92 | Annotation score: | ||
J3QL62 | J3QL62_HUMAN | Coiled-coil domain-containing prote... | CCDC102B | 124 | Annotation score: |
Sequence cautioni
The sequence AAI26449 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAI26451 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB15706 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAD38721 differs from that shown. Reason: Frameshift.Curated
The sequence CAD38721 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 131 | M → T in CAH18334 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 382 | R → G in CAH18334 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 469 | K → R in CAH18334 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_047331 | 153 | K → N1 PublicationCorresponds to variant dbSNP:rs572020Ensembl. | 1 | |
Natural variantiVAR_047332 | 298 | K → R1 PublicationCorresponds to variant dbSNP:rs2187094Ensembl. | 1 | |
Natural variantiVAR_022893 | 346 | C → F. Corresponds to variant dbSNP:rs745894Ensembl. | 1 | |
Natural variantiVAR_047333 | 370 | E → G. Corresponds to variant dbSNP:rs34102373EnsemblClinVar. | 1 | |
Natural variantiVAR_047334 | 425 | N → K. Corresponds to variant dbSNP:rs17080065EnsemblClinVar. | 1 | |
Natural variantiVAR_022894 | 429 | A → P. Corresponds to variant dbSNP:rs9963788Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_014688 | 479 – 483 | LDDSL → VLLYE in isoform 2. 1 Publication | 5 | |
Alternative sequenceiVSP_014689 | 484 – 513 | Missing in isoform 2. 1 PublicationAdd BLAST | 30 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR749520 mRNA Translation: CAH18334.2 AL833863 mRNA Translation: CAD38721.2 Sequence problems. AC022035 Genomic DNA No translation available. AC096708 Genomic DNA No translation available. AC011087 Genomic DNA No translation available. BC056269 mRNA Translation: AAH56269.1 Sequence problems. BC126448 mRNA Translation: AAI26449.1 Different initiation. BC126450 mRNA Translation: AAI26451.1 Different initiation. AK027247 mRNA Translation: BAB15706.1 Different initiation. |
CCDSi | CCDS11996.2 [Q68D86-1] |
RefSeqi | NP_001087198.1, NM_001093729.1 [Q68D86-1] NP_079057.2, NM_024781.2 [Q68D86-1] XP_016881464.1, XM_017025975.1 [Q68D86-1] |
Genome annotation databases
Ensembli | ENST00000360242; ENSP00000353377; ENSG00000150636 [Q68D86-1] ENST00000584156; ENSP00000463111; ENSG00000150636 [Q68D86-2] |
GeneIDi | 79839 |
KEGGi | hsa:79839 |
UCSCi | uc002lki.2, human [Q68D86-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR749520 mRNA Translation: CAH18334.2 AL833863 mRNA Translation: CAD38721.2 Sequence problems. AC022035 Genomic DNA No translation available. AC096708 Genomic DNA No translation available. AC011087 Genomic DNA No translation available. BC056269 mRNA Translation: AAH56269.1 Sequence problems. BC126448 mRNA Translation: AAI26449.1 Different initiation. BC126450 mRNA Translation: AAI26451.1 Different initiation. AK027247 mRNA Translation: BAB15706.1 Different initiation. |
CCDSi | CCDS11996.2 [Q68D86-1] |
RefSeqi | NP_001087198.1, NM_001093729.1 [Q68D86-1] NP_079057.2, NM_024781.2 [Q68D86-1] XP_016881464.1, XM_017025975.1 [Q68D86-1] |
3D structure databases
SMRi | Q68D86 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 122930, 153 interactors |
IntActi | Q68D86, 149 interactors |
STRINGi | 9606.ENSP00000353377 |
PTM databases
iPTMneti | Q68D86 |
PhosphoSitePlusi | Q68D86 |
Genetic variation databases
BioMutai | CCDC102B |
DMDMi | 215274243 |
Proteomic databases
EPDi | Q68D86 |
jPOSTi | Q68D86 |
PaxDbi | Q68D86 |
PeptideAtlasi | Q68D86 |
PRIDEi | Q68D86 |
ProteomicsDBi | 66059 [Q68D86-1] 66060 [Q68D86-2] |
Protocols and materials databases
Antibodypediai | 49098, 118 antibodies |
DNASUi | 79839 |
Genome annotation databases
Ensembli | ENST00000360242; ENSP00000353377; ENSG00000150636 [Q68D86-1] ENST00000584156; ENSP00000463111; ENSG00000150636 [Q68D86-2] |
GeneIDi | 79839 |
KEGGi | hsa:79839 |
UCSCi | uc002lki.2, human [Q68D86-1] |
Organism-specific databases
CTDi | 79839 |
DisGeNETi | 79839 |
GeneCardsi | CCDC102B |
HGNCi | HGNC:26295, CCDC102B |
HPAi | ENSG00000150636, Tissue enhanced (placenta) |
neXtProti | NX_Q68D86 |
OpenTargetsi | ENSG00000150636 |
PharmGKBi | PA134948675 |
VEuPathDBi | HostDB:ENSG00000150636.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QSJ6, Eukaryota |
GeneTreei | ENSGT00940000163731 |
HOGENOMi | CLU_033486_2_0_1 |
InParanoidi | Q68D86 |
OMAi | LRHLQNW |
OrthoDBi | 1304833at2759 |
PhylomeDBi | Q68D86 |
TreeFami | TF320856 |
Enzyme and pathway databases
PathwayCommonsi | Q68D86 |
Miscellaneous databases
BioGRID-ORCSi | 79839, 10 hits in 993 CRISPR screens |
ChiTaRSi | CCDC102B, human |
GenomeRNAii | 79839 |
Pharosi | Q68D86, Tdark |
PROi | PR:Q68D86 |
RNActi | Q68D86, protein |
Gene expression databases
Bgeei | ENSG00000150636, Expressed in stomach and 162 other tissues |
ExpressionAtlasi | Q68D86, baseline and differential |
Genevisiblei | Q68D86, HS |
Family and domain databases
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | C102B_HUMAN | |
Accessioni | Q68D86Primary (citable) accession number: Q68D86 Secondary accession number(s): A1A4H1 Q9H5C1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2005 |
Last sequence update: | November 25, 2008 | |
Last modified: | April 7, 2021 | |
This is version 131 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports