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UniProtKB - Q68D85 (NR3L1_HUMAN)

Entry version 142 (02 Dec 2020)
Sequence version 1 (11 Oct 2004)
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Protein

Natural cytotoxicity triggering receptor 3 ligand 1

Gene

NCR3LG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Triggers NCR3-dependent natural killer cell activation.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q68D85

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Natural cytotoxicity triggering receptor 3 ligand 1
Alternative name(s):
B7 homolog 6
Short name:
B7-H6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NCR3LG1
Synonyms:B7H6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000188211.8

Human Gene Nomenclature Database

More...HGNCi		HGNC:42400, NCR3LG1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613714, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q68D85

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini25 – 262ExtracellularSequence analysisAdd BLAST238
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei263 – 283HelicalSequence analysisAdd BLAST21
Topological domaini284 – 454CytoplasmicSequence analysisAdd BLAST171

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		374383

Open Targets

More...OpenTargetsi		ENSG00000188211

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q68D85, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NCR3LG1

Domain mapping of disease mutations (DMDM)

More...DMDMi		74708829

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000039056425 – 454Natural cytotoxicity triggering receptor 3 ligand 1Add BLAST430

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi43N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi48 ↔ 122PROSITE-ProRule annotation1 Publication
Glycosylationi57N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi163 ↔ 228PROSITE-ProRule annotation1 Publication
Glycosylationi174N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi208N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi216N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi242N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi260N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q68D85

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q68D85

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q68D85

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q68D85

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q68D85

PeptideAtlas

More...PeptideAtlasi		Q68D85

PRoteomics IDEntifications database

More...PRIDEi		Q68D85

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		66058

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		642, 1 N-Linked glycan (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q68D85, 7 sites, 1 N-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q68D85

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q68D85

UniCarbKB; an annotated and curated database of glycan structures

More...UniCarbKBi		Q68D85

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Not detected in any normal tissue tested. Expressed at the surface of several tumor cell lines including T and B-lymphomas, myeloid leukemias, melanomas, carcinomas and large T SV40 antigen-transformed cells (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000188211, Expressed in intestine and 110 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q68D85, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000188211, Tissue enhanced (brain, parathyroid gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

Interacts specifically with NCR3, but not with other natural killer cell-activating receptors, including NCR1, NCR2 and KLRK1.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		131895, 62 interactors

Database of interacting proteins

More...DIPi		DIP-59940N

Protein interaction database and analysis system

More...IntActi		Q68D85, 39 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000341637

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q68D85, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1454
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q68D85

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q68D85

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 138Ig-like V-typeAdd BLAST112
Domaini143 – 244Ig-like C1-typeAdd BLAST102

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni59 – 62Interaction with NCR31 Publication4
Regioni127 – 130Interaction with NCR31 Publication4
Regioni291 – 429Retroviral-Gag-likeAdd BLAST139

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal part is similar to retroviral Gag protein. This putative protein seems to be the result of a fusion between an Ig-like domain-containing protein and a ERV.

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3866, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000163348

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_602620_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q68D85

Identification of Orthologs from Complete Genome Data

More...OMAi		INITWEK

Database of Orthologous Groups

More...OrthoDBi		1030784at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q68D85

TreeFam database of animal gene trees

More...TreeFami		TF331083

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.150.180, 1 hit
2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036946, G_retro_matrix_sf
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003006, Ig/MHC_CS
IPR003597, Ig_C1-set
IPR003599, Ig_sub
IPR010999, Retrovr_matrix

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07654, C1-set, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00409, IG, 1 hit
SM00407, IGc1, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47836, SSF47836, 1 hit
SSF48726, SSF48726, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50835, IG_LIKE, 2 hits
PS00290, IG_MHC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q68D85-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTWRAAASTC AALLILLWAL TTEGDLKVEM MAGGTQITPL NDNVTIFCNI 
        60         70         80         90        100
FYSQPLNITS MGITWFWKSL TFDKEVKVFE FFGDHQEAFR PGAIVSPWRL 
       110        120        130        140        150
KSGDASLRLP GIQLEEAGEY RCEVVVTPLK AQGTVQLEVV ASPASRLLLD 
       160        170        180        190        200
QVGMKENEDK YMCESSGFYP EAINITWEKQ TQKFPHPIEI SEDVITGPTI 
       210        220        230        240        250
KNMDGTFNVT SCLKLNSSQE DPGTVYQCVV RHASLHTPLR SNFTLTAARH 
       260        270        280        290        300
SLSETEKTDN FSIHWWPISF IGVGLVLLIV LIPWKKICNK SSSAYTPLKC 
       310        320        330        340        350
ILKHWNSFDT QTLKKEHLIF FCTRAWPSYQ LQDGEAWPPE GSVNINTIQQ 
       360        370        380        390        400
LDVFCRQEGK WSEVPYVQAF FALRDNPDLC QCCRIDPALL TVTSGKSIDD 
       410        420        430        440        450
NSTKSEKQTP REHSDAVPDA PILPVSPIWE PPPATTSTTP VLSSQPPTLL 

LPLQ
Length:454
Mass (Da):50,827
Last modified:October 11, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i433CE0B0EE0A4470
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAD97811 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti37I → V in CAD97811 (PubMed:17974005).Curated1
Sequence conflicti211S → N in CAD97811 (PubMed:17974005).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BX537685 mRNA Translation: CAD97811.1 Different initiation.
CR749521 mRNA Translation: CAH18335.1
AC124798 Genomic DNA No translation available.
BC136800 mRNA No translation available.
BC136797 mRNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS55748.1

NCBI Reference Sequences

More...RefSeqi		NP_001189368.1, NM_001202439.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000338965; ENSP00000341637; ENSG00000188211
ENST00000530403; ENSP00000434394; ENSG00000188211

Database of genes from NCBI RefSeq genomes

More...GeneIDi		374383

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:374383

UCSC genome browser

More...UCSCi		uc001mmz.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX537685 mRNA Translation: CAD97811.1 Different initiation.
CR749521 mRNA Translation: CAH18335.1
AC124798 Genomic DNA No translation available.
BC136800 mRNA No translation available.
BC136797 mRNA No translation available.
CCDSiCCDS55748.1
RefSeqiNP_001189368.1, NM_001202439.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3PV6X-ray2.30A25-262[»]
3PV7X-ray2.00A25-262[»]
4ZSOX-ray2.50E/F25-262[»]
6YJPX-ray3.10C/D/E24-244[»]
SMRiQ68D85
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi131895, 62 interactors
DIPiDIP-59940N
IntActiQ68D85, 39 interactors
STRINGi9606.ENSP00000341637

PTM databases

GlyConnecti642, 1 N-Linked glycan (1 site)
GlyGeniQ68D85, 7 sites, 1 N-linked glycan (1 site)
iPTMnetiQ68D85
PhosphoSitePlusiQ68D85
UniCarbKBiQ68D85

Polymorphism and mutation databases

BioMutaiNCR3LG1
DMDMi74708829

Proteomic databases

EPDiQ68D85
jPOSTiQ68D85
MassIVEiQ68D85
MaxQBiQ68D85
PaxDbiQ68D85
PeptideAtlasiQ68D85
PRIDEiQ68D85
ProteomicsDBi66058

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q68D85, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...Antibodypediai		6152, 312 antibodies

Genome annotation databases

EnsembliENST00000338965; ENSP00000341637; ENSG00000188211
ENST00000530403; ENSP00000434394; ENSG00000188211
GeneIDi374383
KEGGihsa:374383
UCSCiuc001mmz.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		374383
DisGeNETi374383
EuPathDBiHostDB:ENSG00000188211.8

GeneCards: human genes, protein and diseases

More...GeneCardsi		NCR3LG1
HGNCiHGNC:42400, NCR3LG1
HPAiENSG00000188211, Tissue enhanced (brain, parathyroid gland)
MIMi613714, gene
neXtProtiNX_Q68D85
OpenTargetsiENSG00000188211

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3866, Eukaryota
GeneTreeiENSGT00940000163348
HOGENOMiCLU_602620_0_0_1
InParanoidiQ68D85
OMAiINITWEK
OrthoDBi1030784at2759
PhylomeDBiQ68D85
TreeFamiTF331083

Enzyme and pathway databases

PathwayCommonsiQ68D85
ReactomeiR-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		374383, 8 hits in 841 CRISPR screens
EvolutionaryTraceiQ68D85

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		374383
PharosiQ68D85, Tbio

Protein Ontology

More...PROi		PR:Q68D85
RNActiQ68D85, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000188211, Expressed in intestine and 110 other tissues
GenevisibleiQ68D85, HS

Family and domain databases

Gene3Di1.10.150.180, 1 hit
2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR036946, G_retro_matrix_sf
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003006, Ig/MHC_CS
IPR003597, Ig_C1-set
IPR003599, Ig_sub
IPR010999, Retrovr_matrix
PfamiView protein in Pfam
PF07654, C1-set, 1 hit
SMARTiView protein in SMART
SM00409, IG, 1 hit
SM00407, IGc1, 1 hit
SUPFAMiSSF47836, SSF47836, 1 hit
SSF48726, SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835, IG_LIKE, 2 hits
PS00290, IG_MHC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNR3L1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q68D85
Secondary accession number(s): Q7Z3M6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: October 11, 2004
Last modified: December 2, 2020
This is version 142 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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