TMEM215

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transmembrane protein 215
Gene namesⁱ	Name:TMEM215
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000188133.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:33816 TMEM215
neXtProtⁱ	NX_Q68D42

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	12 – 32	HelicalSequence analysisAdd BLAST		21
Transmembraneⁱ	40 – 60	HelicalSequence analysisAdd BLAST		21

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000188133
PharmGKBⁱ	PA162406544

Polymorphism and mutation databases

BioMutaⁱ	TMEM215
DMDMⁱ	74748275

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000319324	1 – 235	Transmembrane protein 215Add BLAST		235

Proteomic databases

PaxDbⁱ	Q68D42
PeptideAtlas More...PeptideAtlasⁱ	Q68D42
PRIDEⁱ	Q68D42
ProteomicsDBⁱ	66049

PTM databases

iPTMnetⁱ	Q68D42
PhosphoSitePlusⁱ	Q68D42

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000188133 Expressed in 30 organ(s), highest expression level in tibial nerve
CleanExⁱ	HS_TMEM215

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA052804 HPA063207

HPAⁱ

HPA052804
HPA063207

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q68D42
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IEYB Eukaryota ENOG4111KYX LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000006684
HOGENOMⁱ	HOG000082517
HOVERGENⁱ	HBG095177
InParanoidⁱ	Q68D42
OMAⁱ	KCSAWDR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0ILJ
PhylomeDBⁱ	Q68D42
TreeFamⁱ	TF335695

Family and domain databases

InterProⁱ	View protein in InterPro IPR031486 TMEM215
PANTHERⁱ	PTHR31922 PTHR31922, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15746 TMEM215, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q68D42-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRPDDINPRT GLVVALVSVF LVFGFMFTVS GMKGETLGNI PLLAIGPAIC 
        60         70         80         90        100
LPGIAAIALA RKTEGCTKWP ENELLWVRKL PCFRKPKDKE VVELLRTPSD 
       110        120        130        140        150
LESGKGSSDE LAKKAGLRGK PPPQSQGEVS VASSINSPTP TEEGECQSLV 
       160        170        180        190        200
QNGHQEETSR YLDGYCPSGS SLTYSALDVK CSARDRSECP EPEDSIFFVP 
       210        220        230 
QDSIIVCSYK QNSPYDRYCC YINQIQGRWD HETIV

Length:235

Mass (Da):25,806

Last modified:October 11, 2004 - v1

Checksum:ⁱB8381021EBBBB0F6

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	69	W → R in BAC86126 (PubMed:14702039).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK125320 mRNA Translation: BAC86126.1 BX647550 mRNA Translation: CAH56136.1 CR749589 mRNA Translation: CAH18388.1 CH471071 Genomic DNA Translation: EAW58539.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6530.1
NCBI Reference Sequences More...RefSeqⁱ	NP_997723.2, NM_212558.2
UniGeneⁱ	Hs.522063

Genome annotation databases

Ensemblⁱ	ENST00000342743; ENSP00000345468; ENSG00000188133
GeneIDⁱ	401498
KEGGⁱ	hsa:401498
UCSC genome browser More...UCSCⁱ	uc003zri.5 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q68D42	Transmembrane protein 215		MOUSE		235	UniRef90_A7E1Z1
Transmembrane protein 215		BOVIN		235
transmembrane protein 215		DIPOR		239
Transmembrane protein 215		wild yak		235
Transmembrane protein 215		MACMU		235
+104

Protein	Similar proteins		Species	Score	Length	Source
Q68D42	Transmembrane protein 215		MOUSE		235	UniRef50_A7E1Z1
Transmembrane protein 215		BOVIN		235
transmembrane protein 215		DIPOR		239
Transmembrane protein 215		PTEAL		235
Uncharacterized protein		RHIRO		235
+217

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK125320 mRNA Translation: BAC86126.1 BX647550 mRNA Translation: CAH56136.1 CR749589 mRNA Translation: CAH18388.1 CH471071 Genomic DNA Translation: EAW58539.1
CCDSⁱ	CCDS6530.1
RefSeqⁱ	NP_997723.2, NM_212558.2
UniGeneⁱ	Hs.522063

3D structure databases

ProteinModelPortalⁱ	Q68D42
ModBaseⁱ	Search...
MobiDBⁱ	Search...

PTM databases

iPTMnetⁱ	Q68D42
PhosphoSitePlusⁱ	Q68D42

Polymorphism and mutation databases

BioMutaⁱ	TMEM215
DMDMⁱ	74748275

Proteomic databases

PaxDbⁱ	Q68D42
PeptideAtlasⁱ	Q68D42
PRIDEⁱ	Q68D42
ProteomicsDBⁱ	66049

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000342743; ENSP00000345468; ENSG00000188133
GeneIDⁱ	401498
KEGGⁱ	hsa:401498
UCSCⁱ	uc003zri.5 human

Organism-specific databases

CTDⁱ	401498
EuPathDBⁱ	HostDB:ENSG00000188133.5
GeneCardsⁱ	TMEM215
H-InvDBⁱ	HIX0025727
HGNCⁱ	HGNC:33816 TMEM215
HPAⁱ	HPA052804 HPA063207
neXtProtⁱ	NX_Q68D42
OpenTargetsⁱ	ENSG00000188133
PharmGKBⁱ	PA162406544
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IEYB Eukaryota ENOG4111KYX LUCA
GeneTreeⁱ	ENSGT00390000006684
HOGENOMⁱ	HOG000082517
HOVERGENⁱ	HBG095177
InParanoidⁱ	Q68D42
OMAⁱ	KCSAWDR
OrthoDBⁱ	EOG091G0ILJ
PhylomeDBⁱ	Q68D42
TreeFamⁱ	TF335695

Miscellaneous databases

GenomeRNAiⁱ	401498
Protein Ontology More...PROⁱ	PR:Q68D42

Gene expression databases

Bgeeⁱ	ENSG00000188133 Expressed in 30 organ(s), highest expression level in tibial nerve
CleanExⁱ	HS_TMEM215

Family and domain databases

InterProⁱ	View protein in InterPro IPR031486 TMEM215
PANTHERⁱ	PTHR31922 PTHR31922, 1 hit
Pfamⁱ	View protein in Pfam PF15746 TMEM215, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TM215_HUMAN
Accessionⁱ	Q68D42Primary (citable) accession number: Q68D42 Secondary accession number(s): Q6ZUU2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
	Last sequence update:	October 11, 2004
	Last modified:	November 7, 2018
	This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q68D42 (TM215_HUMAN)

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Transmembrane protein 215

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<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ