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UniProtKB - Q68D42 (TM215_HUMAN)

Entry version 99 (10 Feb 2021)
Sequence version 1 (11 Oct 2004)
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Protein

Transmembrane protein 215

Gene

TMEM215

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q68D42

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protein 215
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM215
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:33816, TMEM215

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q68D42

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000188133.5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Transmembranei40 – 60HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		401498

Open Targets

More...OpenTargetsi		ENSG00000188133

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162406544

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q68D42, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TMEM215

Domain mapping of disease mutations (DMDM)

More...DMDMi		74748275

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003193241 – 235Transmembrane protein 215Add BLAST235

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q68D42

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q68D42

PeptideAtlas

More...PeptideAtlasi		Q68D42

PRoteomics IDEntifications database

More...PRIDEi		Q68D42

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		66049

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q68D42

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q68D42

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000188133, Expressed in tibial nerve and 40 other tissues

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000188133, Tissue enhanced (endometrium, retina, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000345468

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q68D42, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QZ55, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000006684

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_1165487_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q68D42

Identification of Orthologs from Complete Genome Data

More...OMAi		CCYINQS

Database of Orthologous Groups

More...OrthoDBi		1440273at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q68D42

TreeFam database of animal gene trees

More...TreeFami		TF335695

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR031486, TMEM215

The PANTHER Classification System

More...PANTHERi		PTHR31922, PTHR31922, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15746, TMEM215, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q68D42-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRPDDINPRT GLVVALVSVF LVFGFMFTVS GMKGETLGNI PLLAIGPAIC 
        60         70         80         90        100
LPGIAAIALA RKTEGCTKWP ENELLWVRKL PCFRKPKDKE VVELLRTPSD 
       110        120        130        140        150
LESGKGSSDE LAKKAGLRGK PPPQSQGEVS VASSINSPTP TEEGECQSLV 
       160        170        180        190        200
QNGHQEETSR YLDGYCPSGS SLTYSALDVK CSARDRSECP EPEDSIFFVP 
       210        220        230 
QDSIIVCSYK QNSPYDRYCC YINQIQGRWD HETIV
Length:235
Mass (Da):25,806
Last modified:October 11, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB8381021EBBBB0F6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti69W → R in BAC86126 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK125320 mRNA Translation: BAC86126.1
BX647550 mRNA Translation: CAH56136.1
CR749589 mRNA Translation: CAH18388.1
CH471071 Genomic DNA Translation: EAW58539.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS6530.1

NCBI Reference Sequences

More...RefSeqi		NP_997723.2, NM_212558.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000342743; ENSP00000345468; ENSG00000188133

Database of genes from NCBI RefSeq genomes

More...GeneIDi		401498

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:401498

UCSC genome browser

More...UCSCi		uc003zri.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125320 mRNA Translation: BAC86126.1
BX647550 mRNA Translation: CAH56136.1
CR749589 mRNA Translation: CAH18388.1
CH471071 Genomic DNA Translation: EAW58539.1
CCDSiCCDS6530.1
RefSeqiNP_997723.2, NM_212558.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi9606.ENSP00000345468

PTM databases

iPTMnetiQ68D42
PhosphoSitePlusiQ68D42

Genetic variation databases

BioMutaiTMEM215
DMDMi74748275

Proteomic databases

MassIVEiQ68D42
PaxDbiQ68D42
PeptideAtlasiQ68D42
PRIDEiQ68D42
ProteomicsDBi66049

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		63219, 26 antibodies

Genome annotation databases

EnsembliENST00000342743; ENSP00000345468; ENSG00000188133
GeneIDi401498
KEGGihsa:401498
UCSCiuc003zri.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		401498
DisGeNETi401498

GeneCards: human genes, protein and diseases

More...GeneCardsi		TMEM215
HGNCiHGNC:33816, TMEM215
HPAiENSG00000188133, Tissue enhanced (endometrium, retina, testis)
neXtProtiNX_Q68D42
OpenTargetsiENSG00000188133
PharmGKBiPA162406544
VEuPathDBiHostDB:ENSG00000188133.5

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QZ55, Eukaryota
GeneTreeiENSGT00390000006684
HOGENOMiCLU_1165487_0_0_1
InParanoidiQ68D42
OMAiCCYINQS
OrthoDBi1440273at2759
PhylomeDBiQ68D42
TreeFamiTF335695

Enzyme and pathway databases

PathwayCommonsiQ68D42

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		401498, 2 hits in 868 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		401498
PharosiQ68D42, Tdark

Protein Ontology

More...PROi		PR:Q68D42
RNActiQ68D42, protein

Gene expression databases

BgeeiENSG00000188133, Expressed in tibial nerve and 40 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR031486, TMEM215
PANTHERiPTHR31922, PTHR31922, 1 hit
PfamiView protein in Pfam
PF15746, TMEM215, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTM215_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q68D42
Secondary accession number(s): Q6ZUU2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 11, 2004
Last modified: February 10, 2021
This is version 99 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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