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Protein

HAUS augmin-like complex subunit 3

Gene

HAUS3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.2 Publications

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-8854518 AURKA Activation by TPX2

Names & Taxonomyi

Protein namesi
Recommended name:
HAUS augmin-like complex subunit 3
Gene namesi
Name:HAUS3
Synonyms:C4orf15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000214367.7
HGNCiHGNC:28719 HAUS3
MIMi613430 gene
neXtProtiNX_Q68CZ6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000214367
PharmGKBiPA165664132

Polymorphism and mutation databases

BioMutaiHAUS3
DMDMi74708788

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00003019512 – 603HAUS augmin-like complex subunit 3Add BLAST602

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ68CZ6
MaxQBiQ68CZ6
PaxDbiQ68CZ6
PeptideAtlasiQ68CZ6
PRIDEiQ68CZ6
ProteomicsDBi66040

PTM databases

iPTMnetiQ68CZ6
PhosphoSitePlusiQ68CZ6

Expressioni

Gene expression databases

BgeeiENSG00000214367 Expressed in 201 organ(s), highest expression level in mononuclear cell
CleanExiHS_C4orf15
ExpressionAtlasiQ68CZ6 baseline and differential
GenevisibleiQ68CZ6 HS

Organism-specific databases

HPAiHPA040649
HPA048190

Interactioni

Subunit structurei

Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly.2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi122667, 46 interactors
ComplexPortaliCPX-1847 HAUS complex
CORUMiQ68CZ6
DIPiDIP-48832N
IntActiQ68CZ6, 55 interactors
MINTiQ68CZ6
STRINGi9606.ENSP00000243706

Structurei

3D structure databases

ProteinModelPortaliQ68CZ6
SMRiQ68CZ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili93 – 177Sequence analysisAdd BLAST85
Coiled coili305 – 336Sequence analysisAdd BLAST32
Coiled coili389 – 426Sequence analysisAdd BLAST38
Coiled coili458 – 495Sequence analysisAdd BLAST38

Sequence similaritiesi

Belongs to the HAUS3 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IG8W Eukaryota
ENOG4111N2F LUCA
GeneTreeiENSGT00390000011904
HOGENOMiHOG000054217
HOVERGENiHBG060746
InParanoidiQ68CZ6
KOiK16586
OMAiEQFHQVE
OrthoDBiEOG091G0M4W
PhylomeDBiQ68CZ6
TreeFamiTF331151

Family and domain databases

InterProiView protein in InterPro
IPR026206 HAUS3
IPR032733 HAUS3_N
PANTHERiPTHR19378 PTHR19378, 1 hit
PfamiView protein in Pfam
PF14932 HAUS-augmin3, 1 hit
PRINTSiPR02089 HAUSAUGMINL3

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q68CZ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSCGNEFVET LKKIGYPKAD NLNGEDFDWL FEGVEDESFL KWFCGNVNEQ
60 70 80 90 100
NVLSERELEA FSILQKSGKP ILEGAALDEA LKTCKTSDLK TPRLDDKELE
110 120 130 140 150
KLEDEVQTLL KLKNLKIQRR NKCQLMASVT SHKSLRLNAK EEEATKKLKQ
160 170 180 190 200
SQGILNAMIT KISNELQALT DEVTQLMMFF RHSNLGQGTN PLVFLSQFSL
210 220 230 240 250
EKYLSQEEQS TAALTLYTKK QFFQGIHEVV ESSNEDNFQL LDIQTPSICD
260 270 280 290 300
NQEILEERRL EMARLQLAYI CAQHQLIHLK ASNSSMKSSI KWAEESLHSL
310 320 330 340 350
TSKAVDKENL DAKISSLTSE IMKLEKEVTQ IKDRSLPAVV RENAQLLNMP
360 370 380 390 400
VVKGDFDLQI AKQDYYTARQ ELVLNQLIKQ KASFELLQLS YEIELRKHRD
410 420 430 440 450
IYRQLENLVQ ELSQSNMMLY KQLEMLTDPS VSQQINPRNT IDTKDYSTHR
460 470 480 490 500
LYQVLEGENK KKELFLTHGN LEEVAEKLKQ NISLVQDQLA VSAQEHSFFL
510 520 530 540 550
SKRNKDVDML CDTLYQGGNQ LLLSDQELTE QFHKVESQLN KLNHLLTDIL
560 570 580 590 600
ADVKTKRKTL ANNKLHQMER EFYVYFLKDE DYLKDIVENL ETQSKIKAVS

LED
Length:603
Mass (Da):69,650
Last modified:October 11, 2004 - v1
Checksum:iC65B80CC58F326E9
GO
Isoform 2 (identifier: Q68CZ6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     477-489: KLKQNISLVQDQL → AGEWHEPRRRGLQ
     490-603: Missing.

Note: No experimental confirmation available.
Show »
Length:489
Mass (Da):56,384
Checksum:i5538DA1354A2E7C9
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6R993D6R993_HUMAN
HAUS augmin-like complex subunit 3
HAUS3
33Annotation score:
A0A1D5RMS3A0A1D5RMS3_HUMAN
HAUS augmin-like complex subunit 3
HAUS3
10Annotation score:

Sequence cautioni

The sequence AAB97010 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAH03648 differs from that shown. Reason: Frameshift at position 12.Curated
The sequence AAH03648 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH25356 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034912586I → T. Corresponds to variant dbSNP:rs11937432Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_057022477 – 489KLKQN…VQDQL → AGEWHEPRRRGLQ in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_057023490 – 603Missing in isoform 2. 1 PublicationAdd BLAST114

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040964 mRNA Translation: AAB97010.1 Different initiation.
AK293948 mRNA Translation: BAG57325.1
CR749640 mRNA Translation: CAH18434.1
AL158068 Genomic DNA No translation available.
CH471131 Genomic DNA Translation: EAW82537.1
BC003648 mRNA Translation: AAH03648.1 Frameshift.
BC025356 mRNA Translation: AAH25356.1 Different initiation.
CCDSiCCDS33941.1 [Q68CZ6-1]
RefSeqiNP_001290072.1, NM_001303143.1 [Q68CZ6-1]
NP_078787.2, NM_024511.6 [Q68CZ6-1]
UniGeneiHs.665869

Genome annotation databases

EnsembliENST00000243706; ENSP00000243706; ENSG00000214367 [Q68CZ6-1]
ENST00000443786; ENSP00000392903; ENSG00000214367 [Q68CZ6-1]
ENST00000506763; ENSP00000427350; ENSG00000214367 [Q68CZ6-2]
GeneIDi79441
KEGGihsa:79441
UCSCiuc003ges.2 human [Q68CZ6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040964 mRNA Translation: AAB97010.1 Different initiation.
AK293948 mRNA Translation: BAG57325.1
CR749640 mRNA Translation: CAH18434.1
AL158068 Genomic DNA No translation available.
CH471131 Genomic DNA Translation: EAW82537.1
BC003648 mRNA Translation: AAH03648.1 Frameshift.
BC025356 mRNA Translation: AAH25356.1 Different initiation.
CCDSiCCDS33941.1 [Q68CZ6-1]
RefSeqiNP_001290072.1, NM_001303143.1 [Q68CZ6-1]
NP_078787.2, NM_024511.6 [Q68CZ6-1]
UniGeneiHs.665869

3D structure databases

ProteinModelPortaliQ68CZ6
SMRiQ68CZ6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122667, 46 interactors
ComplexPortaliCPX-1847 HAUS complex
CORUMiQ68CZ6
DIPiDIP-48832N
IntActiQ68CZ6, 55 interactors
MINTiQ68CZ6
STRINGi9606.ENSP00000243706

PTM databases

iPTMnetiQ68CZ6
PhosphoSitePlusiQ68CZ6

Polymorphism and mutation databases

BioMutaiHAUS3
DMDMi74708788

Proteomic databases

EPDiQ68CZ6
MaxQBiQ68CZ6
PaxDbiQ68CZ6
PeptideAtlasiQ68CZ6
PRIDEiQ68CZ6
ProteomicsDBi66040

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000243706; ENSP00000243706; ENSG00000214367 [Q68CZ6-1]
ENST00000443786; ENSP00000392903; ENSG00000214367 [Q68CZ6-1]
ENST00000506763; ENSP00000427350; ENSG00000214367 [Q68CZ6-2]
GeneIDi79441
KEGGihsa:79441
UCSCiuc003ges.2 human [Q68CZ6-1]

Organism-specific databases

CTDi79441
EuPathDBiHostDB:ENSG00000214367.7
GeneCardsiHAUS3
HGNCiHGNC:28719 HAUS3
HPAiHPA040649
HPA048190
MIMi613430 gene
neXtProtiNX_Q68CZ6
OpenTargetsiENSG00000214367
PharmGKBiPA165664132
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG8W Eukaryota
ENOG4111N2F LUCA
GeneTreeiENSGT00390000011904
HOGENOMiHOG000054217
HOVERGENiHBG060746
InParanoidiQ68CZ6
KOiK16586
OMAiEQFHQVE
OrthoDBiEOG091G0M4W
PhylomeDBiQ68CZ6
TreeFamiTF331151

Enzyme and pathway databases

ReactomeiR-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-8854518 AURKA Activation by TPX2

Miscellaneous databases

GeneWikiiHAUS3
GenomeRNAii79441
PROiPR:Q68CZ6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000214367 Expressed in 201 organ(s), highest expression level in mononuclear cell
CleanExiHS_C4orf15
ExpressionAtlasiQ68CZ6 baseline and differential
GenevisibleiQ68CZ6 HS

Family and domain databases

InterProiView protein in InterPro
IPR026206 HAUS3
IPR032733 HAUS3_N
PANTHERiPTHR19378 PTHR19378, 1 hit
PfamiView protein in Pfam
PF14932 HAUS-augmin3, 1 hit
PRINTSiPR02089 HAUSAUGMINL3
ProtoNetiSearch...

Entry informationi

Entry nameiHAUS3_HUMAN
AccessioniPrimary (citable) accession number: Q68CZ6
Secondary accession number(s): B4DF64
, O43606, Q8TAZ5, Q9BTJ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 11, 2004
Last modified: November 7, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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