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Protein

Tensin-3

Gene

TNS3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in actin remodeling. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Seems to be involved in mammary cell migration. May be involved in cell migration and bone development (By similarity).By similarity1 Publication

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-8875513 MET interacts with TNS proteins
SignaLinkiQ68CZ2
SIGNORiQ68CZ2

Names & Taxonomyi

Protein namesi
Recommended name:
Tensin-3
Alternative name(s):
Tensin-like SH2 domain-containing protein 1
Tumor endothelial marker 6
Gene namesi
Name:TNS3
Synonyms:TEM6, TENS1, TPP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000136205.16
HGNCiHGNC:21616 TNS3
MIMi606825 gene
neXtProtiNX_Q68CZ2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction

Pathology & Biotechi

Organism-specific databases

DisGeNETi64759
OpenTargetsiENSG00000136205
PharmGKBiPA134888115

Polymorphism and mutation databases

BioMutaiTNS3
DMDMi156637424

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002959151 – 1445Tensin-3Add BLAST1445

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei332PhosphoserineCombined sources1
Modified residuei361PhosphoserineCombined sources1
Modified residuei440PhosphoserineCombined sources1
Modified residuei516PhosphoserineCombined sources1
Modified residuei571PhosphoserineBy similarity1
Modified residuei632PhosphothreonineCombined sources1
Modified residuei649PhosphoserineCombined sources1
Modified residuei660PhosphoserineCombined sources1
Modified residuei687PhosphoserineBy similarity1
Modified residuei690PhosphoserineBy similarity1
Modified residuei735PhosphoserineCombined sources1
Modified residuei776PhosphoserineCombined sources1
Modified residuei780PhosphotyrosineCombined sources1
Modified residuei811PhosphoserineCombined sources1
Modified residuei866PhosphoserineCombined sources1
Modified residuei901PhosphoserineCombined sources1
Modified residuei1149PhosphoserineCombined sources1
Modified residuei1154PhosphoserineCombined sources1
Modified residuei1293PhosphoserineCombined sources1
Modified residuei1441PhosphoserineCombined sources1

Post-translational modificationi

EGF/epidermal growth factor induces tyrosine phosphorylation in a time- and dose-dependent manner.

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ68CZ2
MaxQBiQ68CZ2
PaxDbiQ68CZ2
PeptideAtlasiQ68CZ2
PRIDEiQ68CZ2
ProteomicsDBi66036
66037 [Q68CZ2-2]
66038 [Q68CZ2-3]
66039 [Q68CZ2-4]

PTM databases

iPTMnetiQ68CZ2
PhosphoSitePlusiQ68CZ2

Expressioni

Tissue specificityi

Expressed in umbilical vein endothelial cells, epithelial cells, and fibroblasts cells (at protein level). Highly expressed in thyroid, kidney and placenta. Low expression in heart, skeletal muscle, spleen, liver, and lung. Expressed in tumor endothelial cells. Expression seems to be down-regulated in thyroid tumor tissues and in anaplastic carcinomas.3 Publications

Inductioni

Down-regulated by EGF.2 Publications

Gene expression databases

BgeeiENSG00000136205 Expressed in 232 organ(s), highest expression level in metanephric glomerulus
CleanExiHS_TNS3
ExpressionAtlasiQ68CZ2 baseline and differential
GenevisibleiQ68CZ2 HS

Organism-specific databases

HPAiHPA055338
HPA056015

Interactioni

Subunit structurei

EGF promotes the interaction with EGFR. Interacts with PTK2/FAK1 and BCAR1. Tyrosine phosphorylation is critical for these interactions.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi122272, 24 interactors
IntActiQ68CZ2, 21 interactors
MINTiQ68CZ2
STRINGi9606.ENSP00000312143

Structurei

3D structure databases

ProteinModelPortaliQ68CZ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 170Phosphatase tensin-typePROSITE-ProRule annotationAdd BLAST170
Domaini175 – 301C2 tensin-typePROSITE-ProRule annotationAdd BLAST127
Domaini1172 – 1282SH2PROSITE-ProRule annotationAdd BLAST111

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi941 – 944Poly-Ser4

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG1930 Eukaryota
KOG2283 Eukaryota
COG2453 LUCA
GeneTreeiENSGT00760000119113
HOVERGENiHBG060186
InParanoidiQ68CZ2
KOiK18080
OMAiEPRGCPE
OrthoDBiEOG091G0G8Y
PhylomeDBiQ68CZ2
TreeFamiTF315996

Family and domain databases

CDDicd01213 PTB_tensin, 1 hit
cd09927 SH2_Tensin_like, 1 hit
Gene3Di2.30.29.30, 1 hit
3.30.505.10, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR013625 PTB
IPR006020 PTB/PI_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR014020 Tensin_C2-dom
IPR035012 Tensin_like_SH2
IPR029023 Tensin_phosphatase
IPR033929 Tensin_PTB
IPR003595 Tyr_Pase_cat
PfamiView protein in Pfam
PF08416 PTB, 1 hit
PF10409 PTEN_C2, 1 hit
PF00017 SH2, 1 hit
SMARTiView protein in SMART
SM00462 PTB, 1 hit
SM01326 PTEN_C2, 1 hit
SM00404 PTPc_motif, 1 hit
SM00252 SH2, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS51182 C2_TENSIN, 1 hit
PS51181 PPASE_TENSIN, 1 hit
PS50001 SH2, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q68CZ2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEEGHGLDLT YITERIIAVS FPAGCSEESY LHNLQEVTRM LKSKHGDNYL
60 70 80 90 100
VLNLSEKRYD LTKLNPKIMD VGWPELHAPP LDKMCTICKA QESWLNSNLQ
110 120 130 140 150
HVVVIHCRGG KGRIGVVISS YMHFTNVSAS ADQALDRFAM KKFYDDKVSA
160 170 180 190 200
LMQPSQKRYV QFLSGLLSGS VKMNASPLFL HFVILHGTPN FDTGGVCRPF
210 220 230 240 250
LKLYQAMQPV YTSGIYNVGP ENPSRICIVI EPAQLLKGDV MVKCYHKKYR
260 270 280 290 300
SATRDVIFRL QFHTGAVQGY GLVFGKEDLD NASKDDRFPD YGKVELVFSA
310 320 330 340 350
TPEKIQGSEH LYNDHGVIVD YNTTDPLIRW DSYENLSADG EVLHTQGPVD
360 370 380 390 400
GSLYAKVRKK SSSDPGIPGG PQAIPATNSP DHSDHTLSVS SDSGHSTASA
410 420 430 440 450
RTDKTEERLA PGTRRGLSAQ EKAELDQLLS GFGLEDPGSS LKEMTDARSK
460 470 480 490 500
YSGTRHVVPA QVHVNGDAAL KDRETDILDD EMPHHDLHSV DSLGTLSSSE
510 520 530 540 550
GPQSAHLGPF TCHKSSQNSL LSDGFGSNVG EDPQGTLVPD LGLGMDGPYE
560 570 580 590 600
RERTFGSREP KQPQPLLRKP SVSAQMQAYG QSSYSTQTWV RQQQMVVAHQ
610 620 630 640 650
YSFAPDGEAR LVSRCPADNP GLVQAQPRVP LTPTRGTSSR VAVQRGVGSG
660 670 680 690 700
PHPPDTQQPS PSKAFKPRFP GDQVVNGAGP ELSTGPSPGS PTLDIDQSIE
710 720 730 740 750
QLNRLILELD PTFEPIPTHM NALGSQANGS VSPDSVGGGL RASSRLPDTG
760 770 780 790 800
EGPSRATGRQ GSSAEQPLGG RLRKLSLGQY DNDAGGQLPF SKCAWGKAGV
810 820 830 840 850
DYAPNLPPFP SPADVKETMT PGYPQDLDII DGRILSSKES MCSTPAFPVS
860 870 880 890 900
PETPYVKTAL RHPPFSPPEP PLSSPASQHK GGREPRSCPE TLTHAVGMSE
910 920 930 940 950
SPIGPKSTML RADASSTPSF QQAFASSCTI SSNGPGQRRE SSSSAERQWV
960 970 980 990 1000
ESSPKPMVSL LGSGRPTGSP LSAEFSGTRK DSPVLSCFPP SELQAPFHSH
1010 1020 1030 1040 1050
ELSLAEPPDS LAPPSSQAFL GFGTAPVGSG LPPEEDLGAL LANSHGASPT
1060 1070 1080 1090 1100
PSIPLTATGA ADNGFLSHNF LTVAPGHSSH HSPGLQGQGV TLPGQPPLPE
1110 1120 1130 1140 1150
KKRASEGDRS LGSVSPSSSG FSSPHSGSTI SIPFPNVLPD FSKASEAASP
1160 1170 1180 1190 1200
LPDSPGDKLV IVKFVQDTSK FWYKADISRE QAIAMLKDKE PGSFIVRDSH
1210 1220 1230 1240 1250
SFRGAYGLAM KVATPPPSVL QLNKKAGDLA NELVRHFLIE CTPKGVRLKG
1260 1270 1280 1290 1300
CSNEPYFGSL TALVCQHSIT PLALPCKLLI PERDPLEEIA ESSPQTAANS
1310 1320 1330 1340 1350
AAELLKQGAA CNVWYLNSVE MESLTGHQAI QKALSITLVQ EPPPVSTVVH
1360 1370 1380 1390 1400
FKVSAQGITL TDNQRKLFFR RHYPVNSVIF CALDPQDRKW IKDGPSSKVF
1410 1420 1430 1440
GFVARKQGSA TDNVCHLFAE HDPEQPASAI VNFVSKVMIG SPKKV
Length:1,445
Mass (Da):155,266
Last modified:July 24, 2007 - v2
Checksum:i40B02C6269899320
GO
Isoform 2 (identifier: Q68CZ2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     241-480: Missing.

Show »
Length:1,205
Mass (Da):129,066
Checksum:i7E02E291D5DF030D
GO
Isoform 3 (identifier: Q68CZ2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     381-391: DHSDHTLSVSS → ANVLFELIGQV
     392-1445: Missing.

Show »
Length:391
Mass (Da):43,549
Checksum:iB35A18476C52C6F3
GO
Isoform 4 (identifier: Q68CZ2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     243-250: KCYHKKYR → MNYNIANI
     251-1445: Missing.

Show »
Length:250
Mass (Da):28,043
Checksum:i35E9ABB42FF739A5
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PCX8E9PCX8_HUMAN
Tensin-3
TNS3
1,249Annotation score:
C9JHU5C9JHU5_HUMAN
Tensin-3
TNS3
544Annotation score:
C9JUW5C9JUW5_HUMAN
Tensin-3
TNS3
114Annotation score:
C9JTD0C9JTD0_HUMAN
Tensin-3
TNS3
138Annotation score:
C9JWN9C9JWN9_HUMAN
Tensin-3
TNS3
108Annotation score:
H7BZ64H7BZ64_HUMAN
Tensin-3
TNS3
21Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31L → P in AAN32667 (PubMed:15140944).Curated1
Sequence conflicti458V → A in CAH18438 (PubMed:11230166).Curated1
Sequence conflicti505A → V in AAN32667 (PubMed:15140944).Curated1
Sequence conflicti917T → A in CAH18438 (PubMed:11230166).Curated1
Sequence conflicti1047A → T in CAH18438 (PubMed:11230166).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034593600Q → H. Corresponds to variant dbSNP:rs2293362Ensembl.1
Natural variantiVAR_034594679G → S. Corresponds to variant dbSNP:rs7808646Ensembl.1
Natural variantiVAR_0525481034E → K. Corresponds to variant dbSNP:rs3807590Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_027123241 – 480Missing in isoform 2. 1 PublicationAdd BLAST240
Alternative sequenceiVSP_027124243 – 250KCYHKKYR → MNYNIANI in isoform 4. 1 Publication8
Alternative sequenceiVSP_027125251 – 1445Missing in isoform 4. 1 PublicationAdd BLAST1195
Alternative sequenceiVSP_027126381 – 391DHSDHTLSVSS → ANVLFELIGQV in isoform 3. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_027127392 – 1445Missing in isoform 3. 1 PublicationAdd BLAST1054

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF378756 mRNA Translation: AAL11993.1
AF417489 mRNA Translation: AAN32667.1
AK092864 mRNA Translation: BAC03993.1
CR749644 mRNA Translation: CAH18438.1
AC073341 Genomic DNA Translation: AAQ96841.1
CH471128 Genomic DNA Translation: EAW61011.1
BC071791 mRNA Translation: AAH71791.1
BC137133 mRNA Translation: AAI37134.1
BC137134 mRNA Translation: AAI37135.1
AB062750 mRNA Translation: BAB60681.1
CCDSiCCDS5506.2 [Q68CZ2-1]
RefSeqiNP_073585.8, NM_022748.11 [Q68CZ2-1]
XP_011513782.1, XM_011515480.2 [Q68CZ2-1]
XP_011513783.1, XM_011515481.2 [Q68CZ2-1]
XP_011513784.1, XM_011515482.2
XP_011513785.1, XM_011515483.2 [Q68CZ2-1]
XP_016868028.1, XM_017012539.1
UniGeneiHs.520814

Genome annotation databases

EnsembliENST00000311160; ENSP00000312143; ENSG00000136205 [Q68CZ2-1]
ENST00000442536; ENSP00000389285; ENSG00000136205 [Q68CZ2-4]
ENST00000458317; ENSP00000388318; ENSG00000136205 [Q68CZ2-4]
GeneIDi64759
KEGGihsa:64759
UCSCiuc003tnw.3 human [Q68CZ2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF378756 mRNA Translation: AAL11993.1
AF417489 mRNA Translation: AAN32667.1
AK092864 mRNA Translation: BAC03993.1
CR749644 mRNA Translation: CAH18438.1
AC073341 Genomic DNA Translation: AAQ96841.1
CH471128 Genomic DNA Translation: EAW61011.1
BC071791 mRNA Translation: AAH71791.1
BC137133 mRNA Translation: AAI37134.1
BC137134 mRNA Translation: AAI37135.1
AB062750 mRNA Translation: BAB60681.1
CCDSiCCDS5506.2 [Q68CZ2-1]
RefSeqiNP_073585.8, NM_022748.11 [Q68CZ2-1]
XP_011513782.1, XM_011515480.2 [Q68CZ2-1]
XP_011513783.1, XM_011515481.2 [Q68CZ2-1]
XP_011513784.1, XM_011515482.2
XP_011513785.1, XM_011515483.2 [Q68CZ2-1]
XP_016868028.1, XM_017012539.1
UniGeneiHs.520814

3D structure databases

ProteinModelPortaliQ68CZ2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122272, 24 interactors
IntActiQ68CZ2, 21 interactors
MINTiQ68CZ2
STRINGi9606.ENSP00000312143

PTM databases

iPTMnetiQ68CZ2
PhosphoSitePlusiQ68CZ2

Polymorphism and mutation databases

BioMutaiTNS3
DMDMi156637424

Proteomic databases

EPDiQ68CZ2
MaxQBiQ68CZ2
PaxDbiQ68CZ2
PeptideAtlasiQ68CZ2
PRIDEiQ68CZ2
ProteomicsDBi66036
66037 [Q68CZ2-2]
66038 [Q68CZ2-3]
66039 [Q68CZ2-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311160; ENSP00000312143; ENSG00000136205 [Q68CZ2-1]
ENST00000442536; ENSP00000389285; ENSG00000136205 [Q68CZ2-4]
ENST00000458317; ENSP00000388318; ENSG00000136205 [Q68CZ2-4]
GeneIDi64759
KEGGihsa:64759
UCSCiuc003tnw.3 human [Q68CZ2-1]

Organism-specific databases

CTDi64759
DisGeNETi64759
EuPathDBiHostDB:ENSG00000136205.16
GeneCardsiTNS3
HGNCiHGNC:21616 TNS3
HPAiHPA055338
HPA056015
MIMi606825 gene
neXtProtiNX_Q68CZ2
OpenTargetsiENSG00000136205
PharmGKBiPA134888115
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1930 Eukaryota
KOG2283 Eukaryota
COG2453 LUCA
GeneTreeiENSGT00760000119113
HOVERGENiHBG060186
InParanoidiQ68CZ2
KOiK18080
OMAiEPRGCPE
OrthoDBiEOG091G0G8Y
PhylomeDBiQ68CZ2
TreeFamiTF315996

Enzyme and pathway databases

ReactomeiR-HSA-8875513 MET interacts with TNS proteins
SignaLinkiQ68CZ2
SIGNORiQ68CZ2

Miscellaneous databases

ChiTaRSiTNS3 human
GenomeRNAii64759
PROiPR:Q68CZ2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136205 Expressed in 232 organ(s), highest expression level in metanephric glomerulus
CleanExiHS_TNS3
ExpressionAtlasiQ68CZ2 baseline and differential
GenevisibleiQ68CZ2 HS

Family and domain databases

CDDicd01213 PTB_tensin, 1 hit
cd09927 SH2_Tensin_like, 1 hit
Gene3Di2.30.29.30, 1 hit
3.30.505.10, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR013625 PTB
IPR006020 PTB/PI_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR014020 Tensin_C2-dom
IPR035012 Tensin_like_SH2
IPR029023 Tensin_phosphatase
IPR033929 Tensin_PTB
IPR003595 Tyr_Pase_cat
PfamiView protein in Pfam
PF08416 PTB, 1 hit
PF10409 PTEN_C2, 1 hit
PF00017 SH2, 1 hit
SMARTiView protein in SMART
SM00462 PTB, 1 hit
SM01326 PTEN_C2, 1 hit
SM00404 PTPc_motif, 1 hit
SM00252 SH2, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS51182 C2_TENSIN, 1 hit
PS51181 PPASE_TENSIN, 1 hit
PS50001 SH2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTENS3_HUMAN
AccessioniPrimary (citable) accession number: Q68CZ2
Secondary accession number(s): B2RNV1
, Q6IPQ2, Q8IZW7, Q8NAD0, Q96PE0, Q96S48
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: October 10, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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