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Protein

Tensin-3

Gene

TNS3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in actin remodeling. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Seems to be involved in mammary cell migration. May be involved in cell migration and bone development (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8875513 MET interacts with TNS proteins

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
Q68CZ2

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q68CZ2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tensin-3
Alternative name(s):
Tensin-like SH2 domain-containing protein 1
Tumor endothelial marker 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNS3
Synonyms:TEM6, TENS1, TPP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000136205.16

Human Gene Nomenclature Database

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HGNCi
HGNC:21616 TNS3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606825 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q68CZ2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
64759

Open Targets

More...
OpenTargetsi
ENSG00000136205

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134888115

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TNS3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
156637424

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002959151 – 1445Tensin-3Add BLAST1445

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei332PhosphoserineCombined sources1
Modified residuei361PhosphoserineCombined sources1
Modified residuei440PhosphoserineCombined sources1
Modified residuei516PhosphoserineCombined sources1
Modified residuei571PhosphoserineBy similarity1
Modified residuei632PhosphothreonineCombined sources1
Modified residuei649PhosphoserineCombined sources1
Modified residuei660PhosphoserineCombined sources1
Modified residuei687PhosphoserineBy similarity1
Modified residuei690PhosphoserineBy similarity1
Modified residuei735PhosphoserineCombined sources1
Modified residuei776PhosphoserineCombined sources1
Modified residuei780PhosphotyrosineCombined sources1
Modified residuei811PhosphoserineCombined sources1
Modified residuei866PhosphoserineCombined sources1
Modified residuei901PhosphoserineCombined sources1
Modified residuei1149PhosphoserineCombined sources1
Modified residuei1154PhosphoserineCombined sources1
Modified residuei1293PhosphoserineCombined sources1
Modified residuei1441PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

EGF/epidermal growth factor induces tyrosine phosphorylation in a time- and dose-dependent manner.

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q68CZ2

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q68CZ2

MaxQB - The MaxQuant DataBase

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MaxQBi
Q68CZ2

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q68CZ2

PeptideAtlas

More...
PeptideAtlasi
Q68CZ2

PRoteomics IDEntifications database

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PRIDEi
Q68CZ2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
66036
66037 [Q68CZ2-2]
66038 [Q68CZ2-3]
66039 [Q68CZ2-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q68CZ2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q68CZ2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in umbilical vein endothelial cells, epithelial cells, and fibroblasts cells (at protein level). Highly expressed in thyroid, kidney and placenta. Low expression in heart, skeletal muscle, spleen, liver, and lung. Expressed in tumor endothelial cells. Expression seems to be down-regulated in thyroid tumor tissues and in anaplastic carcinomas.3 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated by EGF.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000136205 Expressed in 232 organ(s), highest expression level in metanephric glomerulus

CleanEx database of gene expression profiles

More...
CleanExi
HS_TNS3

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q68CZ2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q68CZ2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA055338
HPA056015

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

EGF promotes the interaction with EGFR. Interacts with PTK2/FAK1 and BCAR1. Tyrosine phosphorylation is critical for these interactions.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
122272, 25 interactors

Protein interaction database and analysis system

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IntActi
Q68CZ2, 21 interactors

Molecular INTeraction database

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MINTi
Q68CZ2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000312143

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q68CZ2

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 170Phosphatase tensin-typePROSITE-ProRule annotationAdd BLAST170
Domaini175 – 301C2 tensin-typePROSITE-ProRule annotationAdd BLAST127
Domaini1172 – 1282SH2PROSITE-ProRule annotationAdd BLAST111

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi941 – 944Poly-Ser4

Keywords - Domaini

SH2 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1930 Eukaryota
KOG2283 Eukaryota
COG2453 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156328

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG060186

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q68CZ2

KEGG Orthology (KO)

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KOi
K18080

Identification of Orthologs from Complete Genome Data

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OMAi
EPRGCPE

Database of Orthologous Groups

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OrthoDBi
172407at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q68CZ2

TreeFam database of animal gene trees

More...
TreeFami
TF315996

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01213 PTB_tensin, 1 hit
cd09927 SH2_Tensin_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.30.29.30, 1 hit
3.30.505.10, 1 hit
3.90.190.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011993 PH-like_dom_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR013625 PTB
IPR006020 PTB/PI_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR014020 Tensin_C2-dom
IPR035012 Tensin_like_SH2
IPR029023 Tensin_phosphatase
IPR033929 Tensin_PTB
IPR003595 Tyr_Pase_cat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08416 PTB, 1 hit
PF10409 PTEN_C2, 1 hit
PF00017 SH2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00462 PTB, 1 hit
SM01326 PTEN_C2, 1 hit
SM00404 PTPc_motif, 1 hit
SM00252 SH2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52799 SSF52799, 1 hit
SSF55550 SSF55550, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51182 C2_TENSIN, 1 hit
PS51181 PPASE_TENSIN, 1 hit
PS50001 SH2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q68CZ2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEEGHGLDLT YITERIIAVS FPAGCSEESY LHNLQEVTRM LKSKHGDNYL
60 70 80 90 100
VLNLSEKRYD LTKLNPKIMD VGWPELHAPP LDKMCTICKA QESWLNSNLQ
110 120 130 140 150
HVVVIHCRGG KGRIGVVISS YMHFTNVSAS ADQALDRFAM KKFYDDKVSA
160 170 180 190 200
LMQPSQKRYV QFLSGLLSGS VKMNASPLFL HFVILHGTPN FDTGGVCRPF
210 220 230 240 250
LKLYQAMQPV YTSGIYNVGP ENPSRICIVI EPAQLLKGDV MVKCYHKKYR
260 270 280 290 300
SATRDVIFRL QFHTGAVQGY GLVFGKEDLD NASKDDRFPD YGKVELVFSA
310 320 330 340 350
TPEKIQGSEH LYNDHGVIVD YNTTDPLIRW DSYENLSADG EVLHTQGPVD
360 370 380 390 400
GSLYAKVRKK SSSDPGIPGG PQAIPATNSP DHSDHTLSVS SDSGHSTASA
410 420 430 440 450
RTDKTEERLA PGTRRGLSAQ EKAELDQLLS GFGLEDPGSS LKEMTDARSK
460 470 480 490 500
YSGTRHVVPA QVHVNGDAAL KDRETDILDD EMPHHDLHSV DSLGTLSSSE
510 520 530 540 550
GPQSAHLGPF TCHKSSQNSL LSDGFGSNVG EDPQGTLVPD LGLGMDGPYE
560 570 580 590 600
RERTFGSREP KQPQPLLRKP SVSAQMQAYG QSSYSTQTWV RQQQMVVAHQ
610 620 630 640 650
YSFAPDGEAR LVSRCPADNP GLVQAQPRVP LTPTRGTSSR VAVQRGVGSG
660 670 680 690 700
PHPPDTQQPS PSKAFKPRFP GDQVVNGAGP ELSTGPSPGS PTLDIDQSIE
710 720 730 740 750
QLNRLILELD PTFEPIPTHM NALGSQANGS VSPDSVGGGL RASSRLPDTG
760 770 780 790 800
EGPSRATGRQ GSSAEQPLGG RLRKLSLGQY DNDAGGQLPF SKCAWGKAGV
810 820 830 840 850
DYAPNLPPFP SPADVKETMT PGYPQDLDII DGRILSSKES MCSTPAFPVS
860 870 880 890 900
PETPYVKTAL RHPPFSPPEP PLSSPASQHK GGREPRSCPE TLTHAVGMSE
910 920 930 940 950
SPIGPKSTML RADASSTPSF QQAFASSCTI SSNGPGQRRE SSSSAERQWV
960 970 980 990 1000
ESSPKPMVSL LGSGRPTGSP LSAEFSGTRK DSPVLSCFPP SELQAPFHSH
1010 1020 1030 1040 1050
ELSLAEPPDS LAPPSSQAFL GFGTAPVGSG LPPEEDLGAL LANSHGASPT
1060 1070 1080 1090 1100
PSIPLTATGA ADNGFLSHNF LTVAPGHSSH HSPGLQGQGV TLPGQPPLPE
1110 1120 1130 1140 1150
KKRASEGDRS LGSVSPSSSG FSSPHSGSTI SIPFPNVLPD FSKASEAASP
1160 1170 1180 1190 1200
LPDSPGDKLV IVKFVQDTSK FWYKADISRE QAIAMLKDKE PGSFIVRDSH
1210 1220 1230 1240 1250
SFRGAYGLAM KVATPPPSVL QLNKKAGDLA NELVRHFLIE CTPKGVRLKG
1260 1270 1280 1290 1300
CSNEPYFGSL TALVCQHSIT PLALPCKLLI PERDPLEEIA ESSPQTAANS
1310 1320 1330 1340 1350
AAELLKQGAA CNVWYLNSVE MESLTGHQAI QKALSITLVQ EPPPVSTVVH
1360 1370 1380 1390 1400
FKVSAQGITL TDNQRKLFFR RHYPVNSVIF CALDPQDRKW IKDGPSSKVF
1410 1420 1430 1440
GFVARKQGSA TDNVCHLFAE HDPEQPASAI VNFVSKVMIG SPKKV
Length:1,445
Mass (Da):155,266
Last modified:July 24, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i40B02C6269899320
GO
Isoform 2 (identifier: Q68CZ2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     241-480: Missing.

Show »
Length:1,205
Mass (Da):129,066
Checksum:i7E02E291D5DF030D
GO
Isoform 3 (identifier: Q68CZ2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     381-391: DHSDHTLSVSS → ANVLFELIGQV
     392-1445: Missing.

Show »
Length:391
Mass (Da):43,549
Checksum:iB35A18476C52C6F3
GO
Isoform 4 (identifier: Q68CZ2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     243-250: KCYHKKYR → MNYNIANI
     251-1445: Missing.

Show »
Length:250
Mass (Da):28,043
Checksum:i35E9ABB42FF739A5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PCX8E9PCX8_HUMAN
Tensin-3
TNS3
1,249Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JHU5C9JHU5_HUMAN
Tensin-3
TNS3
544Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JUW5C9JUW5_HUMAN
Tensin-3
TNS3
114Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JTD0C9JTD0_HUMAN
Tensin-3
TNS3
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JWN9C9JWN9_HUMAN
Tensin-3
TNS3
108Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZ64H7BZ64_HUMAN
Tensin-3
TNS3
21Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti31L → P in AAN32667 (PubMed:15140944).Curated1
Sequence conflicti458V → A in CAH18438 (PubMed:11230166).Curated1
Sequence conflicti505A → V in AAN32667 (PubMed:15140944).Curated1
Sequence conflicti917T → A in CAH18438 (PubMed:11230166).Curated1
Sequence conflicti1047A → T in CAH18438 (PubMed:11230166).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_034593600Q → H. Corresponds to variant dbSNP:rs2293362Ensembl.1
Natural variantiVAR_034594679G → S. Corresponds to variant dbSNP:rs7808646Ensembl.1
Natural variantiVAR_0525481034E → K. Corresponds to variant dbSNP:rs3807590Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_027123241 – 480Missing in isoform 2. 1 PublicationAdd BLAST240
Alternative sequenceiVSP_027124243 – 250KCYHKKYR → MNYNIANI in isoform 4. 1 Publication8
Alternative sequenceiVSP_027125251 – 1445Missing in isoform 4. 1 PublicationAdd BLAST1195
Alternative sequenceiVSP_027126381 – 391DHSDHTLSVSS → ANVLFELIGQV in isoform 3. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_027127392 – 1445Missing in isoform 3. 1 PublicationAdd BLAST1054

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF378756 mRNA Translation: AAL11993.1
AF417489 mRNA Translation: AAN32667.1
AK092864 mRNA Translation: BAC03993.1
CR749644 mRNA Translation: CAH18438.1
AC073341 Genomic DNA Translation: AAQ96841.1
CH471128 Genomic DNA Translation: EAW61011.1
BC071791 mRNA Translation: AAH71791.1
BC137133 mRNA Translation: AAI37134.1
BC137134 mRNA Translation: AAI37135.1
AB062750 mRNA Translation: BAB60681.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5506.2 [Q68CZ2-1]

NCBI Reference Sequences

More...
RefSeqi
NP_073585.8, NM_022748.11 [Q68CZ2-1]
XP_011513782.1, XM_011515480.2 [Q68CZ2-1]
XP_011513783.1, XM_011515481.2 [Q68CZ2-1]
XP_011513784.1, XM_011515482.2
XP_011513785.1, XM_011515483.2 [Q68CZ2-1]
XP_016868028.1, XM_017012539.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.520814

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000311160; ENSP00000312143; ENSG00000136205 [Q68CZ2-1]
ENST00000442536; ENSP00000389285; ENSG00000136205 [Q68CZ2-4]
ENST00000458317; ENSP00000388318; ENSG00000136205 [Q68CZ2-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
64759

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:64759

UCSC genome browser

More...
UCSCi
uc003tnw.3 human [Q68CZ2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF378756 mRNA Translation: AAL11993.1
AF417489 mRNA Translation: AAN32667.1
AK092864 mRNA Translation: BAC03993.1
CR749644 mRNA Translation: CAH18438.1
AC073341 Genomic DNA Translation: AAQ96841.1
CH471128 Genomic DNA Translation: EAW61011.1
BC071791 mRNA Translation: AAH71791.1
BC137133 mRNA Translation: AAI37134.1
BC137134 mRNA Translation: AAI37135.1
AB062750 mRNA Translation: BAB60681.1
CCDSiCCDS5506.2 [Q68CZ2-1]
RefSeqiNP_073585.8, NM_022748.11 [Q68CZ2-1]
XP_011513782.1, XM_011515480.2 [Q68CZ2-1]
XP_011513783.1, XM_011515481.2 [Q68CZ2-1]
XP_011513784.1, XM_011515482.2
XP_011513785.1, XM_011515483.2 [Q68CZ2-1]
XP_016868028.1, XM_017012539.1
UniGeneiHs.520814

3D structure databases

ProteinModelPortaliQ68CZ2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122272, 25 interactors
IntActiQ68CZ2, 21 interactors
MINTiQ68CZ2
STRINGi9606.ENSP00000312143

PTM databases

iPTMnetiQ68CZ2
PhosphoSitePlusiQ68CZ2

Polymorphism and mutation databases

BioMutaiTNS3
DMDMi156637424

Proteomic databases

EPDiQ68CZ2
jPOSTiQ68CZ2
MaxQBiQ68CZ2
PaxDbiQ68CZ2
PeptideAtlasiQ68CZ2
PRIDEiQ68CZ2
ProteomicsDBi66036
66037 [Q68CZ2-2]
66038 [Q68CZ2-3]
66039 [Q68CZ2-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311160; ENSP00000312143; ENSG00000136205 [Q68CZ2-1]
ENST00000442536; ENSP00000389285; ENSG00000136205 [Q68CZ2-4]
ENST00000458317; ENSP00000388318; ENSG00000136205 [Q68CZ2-4]
GeneIDi64759
KEGGihsa:64759
UCSCiuc003tnw.3 human [Q68CZ2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
64759
DisGeNETi64759
EuPathDBiHostDB:ENSG00000136205.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TNS3
HGNCiHGNC:21616 TNS3
HPAiHPA055338
HPA056015
MIMi606825 gene
neXtProtiNX_Q68CZ2
OpenTargetsiENSG00000136205
PharmGKBiPA134888115

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1930 Eukaryota
KOG2283 Eukaryota
COG2453 LUCA
GeneTreeiENSGT00940000156328
HOVERGENiHBG060186
InParanoidiQ68CZ2
KOiK18080
OMAiEPRGCPE
OrthoDBi172407at2759
PhylomeDBiQ68CZ2
TreeFamiTF315996

Enzyme and pathway databases

ReactomeiR-HSA-8875513 MET interacts with TNS proteins
SignaLinkiQ68CZ2
SIGNORiQ68CZ2

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TNS3 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
64759

Protein Ontology

More...
PROi
PR:Q68CZ2

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000136205 Expressed in 232 organ(s), highest expression level in metanephric glomerulus
CleanExiHS_TNS3
ExpressionAtlasiQ68CZ2 baseline and differential
GenevisibleiQ68CZ2 HS

Family and domain databases

CDDicd01213 PTB_tensin, 1 hit
cd09927 SH2_Tensin_like, 1 hit
Gene3Di2.30.29.30, 1 hit
3.30.505.10, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR013625 PTB
IPR006020 PTB/PI_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR014020 Tensin_C2-dom
IPR035012 Tensin_like_SH2
IPR029023 Tensin_phosphatase
IPR033929 Tensin_PTB
IPR003595 Tyr_Pase_cat
PfamiView protein in Pfam
PF08416 PTB, 1 hit
PF10409 PTEN_C2, 1 hit
PF00017 SH2, 1 hit
SMARTiView protein in SMART
SM00462 PTB, 1 hit
SM01326 PTEN_C2, 1 hit
SM00404 PTPc_motif, 1 hit
SM00252 SH2, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS51182 C2_TENSIN, 1 hit
PS51181 PPASE_TENSIN, 1 hit
PS50001 SH2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTENS3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q68CZ2
Secondary accession number(s): B2RNV1
, Q6IPQ2, Q8IZW7, Q8NAD0, Q96PE0, Q96S48
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: January 16, 2019
This is version 132 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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