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Protein

Leucine-rich repeat-containing protein 66

Gene

LRRC66

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 66
Gene namesi
Name:LRRC66
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000188993.3
HGNCiHGNC:34299 LRRC66
neXtProtiNX_Q68CR7

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 24HelicalSequence analysisAdd BLAST21
Transmembranei376 – 396HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000188993
PharmGKBiPA162394587

Polymorphism and mutation databases

BioMutaiLRRC66
DMDMi74757322

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003294331 – 880Leucine-rich repeat-containing protein 66Add BLAST880

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi45N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi115N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei723PhosphoserineBy similarity1
Glycosylationi746N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei752PhosphoserineBy similarity1
Glycosylationi756N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ68CR7
PaxDbiQ68CR7
PeptideAtlasiQ68CR7
PRIDEiQ68CR7
ProteomicsDBi66026

PTM databases

iPTMnetiQ68CR7
PhosphoSitePlusiQ68CR7

Expressioni

Gene expression databases

BgeeiENSG00000188993 Expressed in 109 organ(s), highest expression level in duodenum
CleanExiHS_LRRC66
GenevisibleiQ68CR7 HS

Organism-specific databases

HPAiHPA014549
HPA027839

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000341944

Structurei

3D structure databases

ProteinModelPortaliQ68CR7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati86 – 107LRR 1Add BLAST22
Repeati110 – 130LRR 2Add BLAST21
Repeati149 – 171LRR 3Add BLAST23
Repeati172 – 193LRR 4Add BLAST22
Repeati196 – 217LRR 5Add BLAST22
Repeati220 – 241LRR 6Add BLAST22

Keywords - Domaini

Leucine-rich repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00390000014817
HOGENOMiHOG000113377
HOVERGENiHBG095656
InParanoidiQ68CR7
OMAiDFHNCLQ
OrthoDBiEOG091G00T1
PhylomeDBiQ68CR7
TreeFamiTF332577

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF00560 LRR_1, 1 hit
PF13855 LRR_8, 2 hits
SMARTiView protein in SMART
SM00369 LRR_TYP, 5 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 6 hits

Sequencei

Sequence statusi: Complete.

Q68CR7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKNLYFRVIT IVIGLYFTGI MTNASRKSNI LFNSECQWNE YILTNCSFTG
60 70 80 90 100
KCDIPVDISQ TAATVDVSFN FFRVLLQSHT KKEEWKIKHL DLSNNLISKI
110 120 130 140 150
TLSPFAYLHA LEVLNLSNNA IHSLSLDLLS PKSSWVKRHR SSFRNRFPLL
160 170 180 190 200
KVLILQRNKL SDTPKGLWKL KSLQSLDLSF NGILQIGWSD FHNCLQLENL
210 220 230 240 250
CLKSNKIFKI PPQAFKDLKK LQVIDLSNNA LITILPMMII ALEFPHLVVD
260 270 280 290 300
LADNNWQCDD SVAVFQNFIS ESWRKKWNVI CNRSIGSEEA NGGTPQSRIS
310 320 330 340 350
RETRLPPIHL HRMKSLIRSK AERPQGGRHT GISTLGKKAK AGSGLRKKQR
360 370 380 390 400
RLPRSVRSTR DVQAAGKKED APQDLALAVC LSVFITFLVA FSLGAFTRPY
410 420 430 440 450
VDRLWQKKCQ SKSPGLDNAY SNEGFYDDME AAGHTPHPET HLRQVFPHLS
460 470 480 490 500
LYENQTPFWV TQPHPHATVI PDRTLGRSRK DPGSSQSPGQ CGDNTGAGSG
510 520 530 540 550
NDGAVYSILQ RHPHAGNREL MSAAQDHIHR NDILGEWTYE TVAQEEPLSA
560 570 580 590 600
HSVGVSSVAG TSHAVSGSSR YDSNELDPSL SGEITASLCK MLTHAEAQRT
610 620 630 640 650
GDSKERGGTE QSLWDSQMEF SKERQVSSSI DLLSIQQPRL SGARAEEALS
660 670 680 690 700
AHYSEVPYGD PRDTGPSVFP PRWDSGLDVT PANKEPVQKS TPSDTCCELE
710 720 730 740 750
SDCDSDEGSL FTLSSISSES ARSKTEEAVP DEESLQDESS GASKDNVTAV
760 770 780 790 800
DSLEENVTFQ TIPGKCKNQE DPFEKPLISA PDSGMYKTHL ENASDTDRSE
810 820 830 840 850
GLSPWPRSPG NSPLGDEFPG MFTYDYDTAL QSKAAEWHCS LRDLEFSNVD
860 870 880
VLQQTPPCSA EVPSDPDKAA FHERDSDILK
Length:880
Mass (Da):97,778
Last modified:October 11, 2004 - v1
Checksum:i1C1C5C3CF4D33287
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051124342G → A. Corresponds to variant dbSNP:rs17081784Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR749811 mRNA Translation: CAH18671.1
CCDSiCCDS43229.1
RefSeqiNP_001019782.1, NM_001024611.2
UniGeneiHs.661450

Genome annotation databases

EnsembliENST00000343457; ENSP00000341944; ENSG00000188993
GeneIDi339977
KEGGihsa:339977
UCSCiuc003gzi.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR749811 mRNA Translation: CAH18671.1
CCDSiCCDS43229.1
RefSeqiNP_001019782.1, NM_001024611.2
UniGeneiHs.661450

3D structure databases

ProteinModelPortaliQ68CR7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000341944

PTM databases

iPTMnetiQ68CR7
PhosphoSitePlusiQ68CR7

Polymorphism and mutation databases

BioMutaiLRRC66
DMDMi74757322

Proteomic databases

MaxQBiQ68CR7
PaxDbiQ68CR7
PeptideAtlasiQ68CR7
PRIDEiQ68CR7
ProteomicsDBi66026

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343457; ENSP00000341944; ENSG00000188993
GeneIDi339977
KEGGihsa:339977
UCSCiuc003gzi.4 human

Organism-specific databases

CTDi339977
EuPathDBiHostDB:ENSG00000188993.3
GeneCardsiLRRC66
H-InvDBiHIX0200670
HGNCiHGNC:34299 LRRC66
HPAiHPA014549
HPA027839
neXtProtiNX_Q68CR7
OpenTargetsiENSG00000188993
PharmGKBiPA162394587
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00390000014817
HOGENOMiHOG000113377
HOVERGENiHBG095656
InParanoidiQ68CR7
OMAiDFHNCLQ
OrthoDBiEOG091G00T1
PhylomeDBiQ68CR7
TreeFamiTF332577

Miscellaneous databases

GenomeRNAii339977
PROiPR:Q68CR7

Gene expression databases

BgeeiENSG00000188993 Expressed in 109 organ(s), highest expression level in duodenum
CleanExiHS_LRRC66
GenevisibleiQ68CR7 HS

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF00560 LRR_1, 1 hit
PF13855 LRR_8, 2 hits
SMARTiView protein in SMART
SM00369 LRR_TYP, 5 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiLRC66_HUMAN
AccessioniPrimary (citable) accession number: Q68CR7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: October 11, 2004
Last modified: September 12, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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