UniProtKB - Q68CQ4 (UTP25_HUMAN)
U3 small nucleolar RNA-associated protein 25 homolog
UTP25
Functioni
Component of the ribosomal small subunit processome for the biogenesis of ribosomes, functions in pre-ribosomal RNA (pre-rRNA) processing (By similarity).
Essential for embryonic development in part through the regulation of p53 pathway. Controls the expansion growth of digestive organs and liver (PubMed:25007945, PubMed:27657329, PubMed:23357851).
Also involved in the sympathetic neuronal development (By similarity).
Mediates, with CAPN3, the proteasome-independent degradation of p53/TP53 (PubMed:23357851, PubMed:27657329).
By similarity3 PublicationsGO - Molecular functioni
- RNA binding Source: UniProtKB
- rRNA binding Source: GO_Central
- U3 snoRNA binding Source: GO_Central
GO - Biological processi
- embryonic organ development Source: UniProtKB
- maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: GO_Central
- positive regulation of embryonic development Source: UniProtKB
- protein catabolic process Source: UniProtKB
- protein destabilization Source: UniProtKB
- protein localization to nucleolus Source: UniProtKB
Keywordsi
Molecular function | Developmental protein |
Enzyme and pathway databases
PathwayCommonsi | Q68CQ4 |
Reactomei | R-HSA-6790901, rRNA modification in the nucleus and cytosol R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol |
SignaLinki | Q68CQ4 |
Names & Taxonomyi
Protein namesi | Recommended name: U3 small nucleolar RNA-associated protein 25 homologCuratedAlternative name(s): Digestive organ expansion factor homolog UTP25 small subunit processor componentImported |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28440, UTP25 |
neXtProti | NX_Q68CQ4 |
VEuPathDBi | HostDB:ENSG00000117597 |
Subcellular locationi
Nucleus
- nucleolus 2 Publications
Nucleus
- nucleolus Source: UniProtKB
- nucleoplasm Source: Reactome
Other locations
- small-subunit processome Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 27042 |
OpenTargetsi | ENSG00000117597 |
PharmGKBi | PA142672491 |
Miscellaneous databases
Pharosi | Q68CQ4, Tbio |
Genetic variation databases
BioMutai | DIEXF |
DMDMi | 117949399 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000254149 | 1 – 756 | U3 small nucleolar RNA-associated protein 25 homologAdd BLAST | 756 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 10 | PhosphoserineCombined sources | 1 | |
Modified residuei | 50 | Phosphoserine1 Publication | 1 | |
Modified residuei | 52 | PhosphoserineBy similarity | 1 | |
Modified residuei | 58 | Phosphoserine1 Publication | 1 | |
Modified residuei | 60 | PhosphoserineBy similarity | 1 | |
Modified residuei | 62 | Phosphoserine1 Publication | 1 | |
Modified residuei | 64 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q68CQ4 |
jPOSTi | Q68CQ4 |
MassIVEi | Q68CQ4 |
MaxQBi | Q68CQ4 |
PaxDbi | Q68CQ4 |
PeptideAtlasi | Q68CQ4 |
PRIDEi | Q68CQ4 |
ProteomicsDBi | 66020 |
PTM databases
GlyGeni | Q68CQ4, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q68CQ4 |
PhosphoSitePlusi | Q68CQ4 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000117597, Expressed in endothelial cell and 236 other tissues |
ExpressionAtlasi | Q68CQ4, baseline and differential |
Genevisiblei | Q68CQ4, HS |
Organism-specific databases
HPAi | ENSG00000117597, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with CAPN3; the interaction is required for CAPN3 translocation to the nucleolus.
2 PublicationsBinary interactionsi
Q68CQ4
Protein-protein interaction databases
BioGRIDi | 117972, 76 interactors |
IntActi | Q68CQ4, 21 interactors |
MINTi | Q68CQ4 |
STRINGi | 9606.ENSP00000419005 |
Miscellaneous databases
RNActi | Q68CQ4, protein |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 185 | Promotes p53/TP53 degradationBy similarityAdd BLAST | 185 | |
Regioni | 1 – 159 | DisorderedSequence analysisAdd BLAST | 159 | |
Regioni | 573 – 635 | Promotes p53/TP53 degradationBy similarityAdd BLAST | 63 | |
Regioni | 636 – 697 | Represses p53/TP53 degradationBy similarityAdd BLAST | 62 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 17 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 19 – 42 | Basic and acidic residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 83 – 124 | Acidic residuesSequence analysisAdd BLAST | 42 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2340, Eukaryota |
GeneTreei | ENSGT00390000000709 |
HOGENOMi | CLU_018705_1_1_1 |
InParanoidi | Q68CQ4 |
OMAi | FVRVRNH |
OrthoDBi | 257318at2759 |
PhylomeDBi | Q68CQ4 |
TreeFami | TF105930 |
Family and domain databases
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR010678, UTP25 |
PANTHERi | PTHR12933, PTHR12933, 1 hit |
Pfami | View protein in Pfam PF06862, UTP25, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MGKRGSRSQS QLLNTLTKKQ KKHLRDFGEE HPFYDRVSRK EAKPQICQLS
60 70 80 90 100
ESSDSSDSES DSESEPQQVS GYHRLLATLK NVSEEEEEDE EEEEEEDSIV
110 120 130 140 150
DDAEMNDEDG GSDVSVEEEM AAESTESPEN VALSADPEGK EDGEEPPGTS
160 170 180 190 200
QTSPEEFTDA KHESLFSLET NFLEEESGDN SSLKASQDPF LQHVNKELKE
210 220 230 240 250
KAIQAVATNP KTTHELKWPI LGQLFFSSKF QKLETFKPPK DIDLKSLHLQ
260 270 280 290 300
KPLESTWTKT NSQFLSGPQK SSSPFTPLQK ELFLIMNSYR DLFYPERTAL
310 320 330 340 350
KNGEEIRHVY CLHVINHILK ANAQVLGNNS RRRSQKFGVG DDDDFRDQGL
360 370 380 390 400
TRPKVLIVVP FREAALRVVQ LFISLLEGDS KKKIIVSNKK RFQGEYGSDP
410 420 430 440 450
EERPPNLKRP EDYEAVFVGN IDDHFRIGVA ILQRSIRLYA PFYSSDILIA
460 470 480 490 500
SPLGLRTIIG GEGEKKRDFD FLSSIELLII DQADIYLMQN WEHVLHLMNH
510 520 530 540 550
MNLLPLDSHG VDFSRVRMWS LNNWSKYYRQ TLLFGALQDA QINSVFNKYC
560 570 580 590 600
VNMQGQVAVR NVPMTGSISH VLVQLPHVFQ RMEAENLASV IDARFNFFVN
610 620 630 640 650
KILPQYRDAV MSHTLIYIPS YFDFVRLRNY FKKEELNFTH ICEYTQKSGV
660 670 680 690 700
SRARHFFLQG EKQFLLFTER FHFYKRYTIK GIRNLIFYEL PTYPHFYSEI
710 720 730 740 750
CNMLRATNRG EEATWTCTVL YSKYDAQRLA AVVGVERAAQ MLQSNKNVHL
FITGEK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH7C2R4 | H7C2R4_HUMAN | U3 small nucleolar RNA-associated p... | UTP25 | 248 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 258 | T → A in CAH56170 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_028827 | 67 | Q → E Decreases degradation of p53/TP53. 2 PublicationsCorresponds to variant dbSNP:rs585627Ensembl. | 1 | |
Natural variantiVAR_084648 | 111 | G → D Decreases degradation of p53/TP53. 2 PublicationsCorresponds to variant dbSNP:rs61747285Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR749825 mRNA Translation: CAH18684.1 BX648514 mRNA Translation: CAH56170.1 AL022398 Genomic DNA No translation available. BC022964 mRNA Translation: AAH22964.1 |
CCDSi | CCDS1493.1 |
RefSeqi | NP_055203.4, NM_014388.6 |
Genome annotation databases
Ensembli | ENST00000491415; ENSP00000419005; ENSG00000117597 |
GeneIDi | 27042 |
KEGGi | hsa:27042 |
MANE-Selecti | ENST00000491415.7; ENSP00000419005.1; NM_014388.7; NP_055203.4 |
UCSCi | uc001hhr.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR749825 mRNA Translation: CAH18684.1 BX648514 mRNA Translation: CAH56170.1 AL022398 Genomic DNA No translation available. BC022964 mRNA Translation: AAH22964.1 |
CCDSi | CCDS1493.1 |
RefSeqi | NP_055203.4, NM_014388.6 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 117972, 76 interactors |
IntActi | Q68CQ4, 21 interactors |
MINTi | Q68CQ4 |
STRINGi | 9606.ENSP00000419005 |
PTM databases
GlyGeni | Q68CQ4, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q68CQ4 |
PhosphoSitePlusi | Q68CQ4 |
Genetic variation databases
BioMutai | DIEXF |
DMDMi | 117949399 |
Proteomic databases
EPDi | Q68CQ4 |
jPOSTi | Q68CQ4 |
MassIVEi | Q68CQ4 |
MaxQBi | Q68CQ4 |
PaxDbi | Q68CQ4 |
PeptideAtlasi | Q68CQ4 |
PRIDEi | Q68CQ4 |
ProteomicsDBi | 66020 |
Protocols and materials databases
Antibodypediai | 20703, 77 antibodies from 20 providers |
DNASUi | 27042 |
Genome annotation databases
Ensembli | ENST00000491415; ENSP00000419005; ENSG00000117597 |
GeneIDi | 27042 |
KEGGi | hsa:27042 |
MANE-Selecti | ENST00000491415.7; ENSP00000419005.1; NM_014388.7; NP_055203.4 |
UCSCi | uc001hhr.3, human |
Organism-specific databases
CTDi | 27042 |
DisGeNETi | 27042 |
GeneCardsi | UTP25 |
HGNCi | HGNC:28440, UTP25 |
HPAi | ENSG00000117597, Low tissue specificity |
neXtProti | NX_Q68CQ4 |
OpenTargetsi | ENSG00000117597 |
PharmGKBi | PA142672491 |
VEuPathDBi | HostDB:ENSG00000117597 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2340, Eukaryota |
GeneTreei | ENSGT00390000000709 |
HOGENOMi | CLU_018705_1_1_1 |
InParanoidi | Q68CQ4 |
OMAi | FVRVRNH |
OrthoDBi | 257318at2759 |
PhylomeDBi | Q68CQ4 |
TreeFami | TF105930 |
Enzyme and pathway databases
PathwayCommonsi | Q68CQ4 |
Reactomei | R-HSA-6790901, rRNA modification in the nucleus and cytosol R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol |
SignaLinki | Q68CQ4 |
Miscellaneous databases
BioGRID-ORCSi | 27042, 647 hits in 1047 CRISPR screens |
ChiTaRSi | DIEXF, human |
GenomeRNAii | 27042 |
Pharosi | Q68CQ4, Tbio |
PROi | PR:Q68CQ4 |
RNActi | Q68CQ4, protein |
Gene expression databases
Bgeei | ENSG00000117597, Expressed in endothelial cell and 236 other tissues |
ExpressionAtlasi | Q68CQ4, baseline and differential |
Genevisiblei | Q68CQ4, HS |
Family and domain databases
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR010678, UTP25 |
PANTHERi | PTHR12933, PTHR12933, 1 hit |
Pfami | View protein in Pfam PF06862, UTP25, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | UTP25_HUMAN | |
Accessioni | Q68CQ4Primary (citable) accession number: Q68CQ4 Secondary accession number(s): O75992, Q4VY00, Q63HL9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 31, 2006 |
Last sequence update: | October 31, 2006 | |
Last modified: | February 23, 2022 | |
This is version 131 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families