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Protein

Maestro heat-like repeat-containing protein family member 7

Gene

MROH7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Maestro heat-like repeat-containing protein family member 7
Alternative name(s):
HEAT repeat-containing protein 8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MROH7
Synonyms:C1orf175, HEATR8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000184313.19

Human Gene Nomenclature Database

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HGNCi
HGNC:24802 MROH7

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q68CQ1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei593 – 613HelicalSequence analysisAdd BLAST21
Transmembranei767 – 787HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
374977

Open Targets

More...
OpenTargetsi
ENSG00000184313
ENSG00000271723

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142672423

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
MROH7

Domain mapping of disease mutations (DMDM)

More...
DMDMi
317373558

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002868661 – 1323Maestro heat-like repeat-containing protein family member 7Add BLAST1323

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi318N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi438N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi586N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q68CQ1

PeptideAtlas

More...
PeptideAtlasi
Q68CQ1

PRoteomics IDEntifications database

More...
PRIDEi
Q68CQ1

ProteomicsDB human proteome resource

More...
ProteomicsDBi
66014
66015 [Q68CQ1-1]
66016 [Q68CQ1-2]
66017 [Q68CQ1-4]
66018 [Q68CQ1-8]
66019 [Q68CQ1-9]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q68CQ1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q68CQ1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000184313 Expressed in 89 organ(s), highest expression level in right testis

CleanEx database of gene expression profiles

More...
CleanExi
HS_C1orf175

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q68CQ1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q68CQ1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA071840

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q68CQ1

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati957 – 995HEAT 1Add BLAST39
Repeati1036 – 1074HEAT 2Add BLAST39
Repeati1079 – 1117HEAT 3Add BLAST39
Repeati1125 – 1162HEAT 4Add BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi252 – 355Ser-richAdd BLAST104

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2032 Eukaryota
ENOG410XQE8 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000161775

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG107563

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q68CQ1

Database of Orthologous Groups

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OrthoDBi
EOG091G00DQ

Database for complete collections of gene phylogenies

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PhylomeDBi
Q68CQ1

TreeFam database of animal gene trees

More...
TreeFami
TF337538

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q68CQ1-7) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALSPGANLV FHEDPKMTPS PPSCGAPGLG SGTIPQPHPD MAQVPMLNLL
60 70 80 90 100
PSPGLALVPD LNDSLSPVSG EASGLVSENT PRPDDSRAIA PASLQITSSC
110 120 130 140 150
SGEALDLDSK DVSRPDSQGR LCPASNPILS PSSTEAPRLS SGNHPQSNSE
160 170 180 190 200
DAFKCLSSKI FKLGQRNSNP SRHELNPFIR HHSREGLVLG HCISRPSSKA
210 220 230 240 250
LLIPTSNSSL DLDSNPLLNM GSRNTSKLNL NVAPDSHGTL IPDTNETITL
260 270 280 290 300
ASHNISESVS KGAFSTTWST SSKETMNVAS SGHSRSDLSV TITQASYVTL
310 320 330 340 350
IPGSSYGISL HSSTHEPNST ISPPSCMTLI LGSNETLSLD SSLLFSDTST
360 370 380 390 400
LTLSSQQDDA KDNSIHTVPL EENLESWSEM ASIKVGQFPL GFPISNPAGK
410 420 430 440 450
DAVTLQGIPE GAFDEVTSCL VKVPEKTEGG NNMALVENVT TLQKSQDLLE
460 470 480 490 500
AEGEKKTMIK KIMRQIQEEP LDSLSSSVRK QAMEILTQLS HTQPTLGMRE
510 520 530 540 550
RSELVNVCVH SVFSLPSVQA MQEKDEAKAE TIQALYHQTL EALQTLLKAL
560 570 580 590 600
FIEDPTPAGL KSILEALGPW MNSGKAHERA RAVNTNVSVL NHMLLTLPFF
610 620 630 640 650
MPLGFPALGL LLGRLILHIG DPDEEIGCEA LDGIIILYTI LELQKRARDK
660 670 680 690 700
EETNKKELYE SNKHFLGPYN PVSPCQNILR VIEEFGDFLG PQQIKDLLLA
710 720 730 740 750
ALEGLKGSSE APGKDSREMM QLASEVMLSS VLEWYRHRAL EVIPEIMQGI
760 770 780 790 800
YMQLSHIQEP RARQVALLPV SLLASSFMTE VVVALLMCPL PLNSNGAEMW
810 820 830 840 850
RQLILCKPSC DVRDLLDLLL GSLKEKPVTK EGRASIVPLA AASGLCELLS
860 870 880 890 900
VNSCMGRVRR IYPQLLLALL IQVHYHIGLN LPGCVAPPKD TKKGAQPSPF
910 920 930 940 950
VPVRWVVKVV KTLLLRMGCS YETTFLEDQG GWELMEQVES HHRGVALLAR
960 970 980 990 1000
AMVQYSCQEL CRILYLLIPL LERGDEKHRI TATAFFVELL QMEQVRRIPE
1010 1020 1030 1040 1050
EYSLGRMAEG LSHHDPIMKV LSIRGLVILA RRSEKTAKVK ALLPSMVKGL
1060 1070 1080 1090 1100
KNMDGMLVVE AVHNLKAVFK GRDQKLMDSA VYVEMLQILL PHFSDAREVV
1110 1120 1130 1140 1150
RSSCINLYGK VVQKLRAPRT QAMEEQLVST LVPLLLTMQE GNSKVSQKCV
1160 1170 1180 1190 1200
KTLLRCSYFM AWELPKRAYS RKPWDNQQQT VAKICKCLVN THRDSAFIFL
1210 1220 1230 1240 1250
SQSLEYAKNS RASLRKCSVM FIGSLVPCME SIMTEDRLNE VKAALDNLRH
1260 1270 1280 1290 1300
DPEASVCIYA AQVQDHILAS CWQNSWLPHG NSWVCYSATT HRWSPSCENL
1310 1320
PTSHQRRSWI MQALGSWKMS LKK
Note: No experimental confirmation available.
Length:1,323
Mass (Da):145,647
Last modified:January 11, 2011 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i77CB3B2A21D545AA
GO
Isoform 2 (identifier: Q68CQ1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     989-1030: LLQMEQVRRI...LSIRGLVILA → QPCEEGIVIL...SDTLSFATWC
     1031-1323: Missing.

Show »
Length:1,030
Mass (Da):112,064
Checksum:i2D99C0C986E58785
GO
Isoform 3 (identifier: Q68CQ1-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     601-627: MPLGFPALGLLLGRLILHIGDPDEEIG → IAIQTDALGVPGAGASAGETHPSHWGS
     628-1323: Missing.

Note: No experimental confirmation available.
Show »
Length:627
Mass (Da):66,649
Checksum:i1E1D2A1E12DFC14C
GO
Isoform 4 (identifier: Q68CQ1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     412-421: AFDEVTSCLV → VSGSSWTFPA
     422-1323: Missing.

Show »
Length:421
Mass (Da):44,104
Checksum:i7AC61B1F57726799
GO
Isoform 5 (identifier: Q68CQ1-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1148-1148: Missing.

Note: No experimental confirmation available.
Show »
Length:1,322
Mass (Da):145,519
Checksum:i0491BB6713BA532E
GO
Isoform 6 (identifier: Q68CQ1-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     410-410: E → EDGVSLLLPRLECNGAISAHCNLCLP
     600-600: F → FIAIQT
     1223-1323: GSLVPCMESI...LGSWKMSLKK → ATPRGQRFHL...AKNLKRSPYL

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:1,290
Mass (Da):141,516
Checksum:iFF38AA4EBFF094B3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7ZBM2B7ZBM2_HUMAN
Maestro heat-like repeat-containing...
MROH7
891Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W8P2F8W8P2_HUMAN
Maestro heat-like repeat-containing...
MROH7
1,044Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WE25F8WE25_HUMAN
Maestro heat-like repeat-containing...
MROH7
754Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WFA2F8WFA2_HUMAN
Maestro heat-like repeat-containing...
MROH7
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC87334 differs from that shown. Cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti583V → A in BAC85285 (PubMed:14702039).Curated1
Sequence conflicti1099V → D in CAH18687 (PubMed:17974005).Curated1
Sequence conflicti1099V → D in BAC87334 (PubMed:14702039).Curated1
Sequence conflicti1099V → D in AAH29191 (PubMed:15489334).Curated1
Sequence conflicti1155R → C in BAC87334 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_032218182H → R2 PublicationsCorresponds to variant dbSNP:rs11206407Ensembl.1
Natural variantiVAR_035495183S → Y in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_032219290V → M. Corresponds to variant dbSNP:rs12094920Ensembl.1
Natural variantiVAR_032220306Y → D1 PublicationCorresponds to variant dbSNP:rs1655519Ensembl.1
Natural variantiVAR_032221312S → F1 PublicationCorresponds to variant dbSNP:rs17399810Ensembl.1
Natural variantiVAR_032222316E → G3 PublicationsCorresponds to variant dbSNP:rs1655518Ensembl.1
Natural variantiVAR_032223352T → M. Corresponds to variant dbSNP:rs12074499Ensembl.1
Natural variantiVAR_055042455K → R. Corresponds to variant dbSNP:rs2304314Ensembl.1
Natural variantiVAR_055043509V → A1 PublicationCorresponds to variant dbSNP:rs480963Ensembl.1
Natural variantiVAR_055044618H → R3 PublicationsCorresponds to variant dbSNP:rs570218Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_037024410E → EDGVSLLLPRLECNGAISAH CNLCLP in isoform 6. 1 Publication1
Alternative sequenceiVSP_037025412 – 421AFDEVTSCLV → VSGSSWTFPA in isoform 4. 1 Publication10
Alternative sequenceiVSP_037026422 – 1323Missing in isoform 4. 1 PublicationAdd BLAST902
Alternative sequenceiVSP_037027600F → FIAIQT in isoform 6. 1 Publication1
Alternative sequenceiVSP_037028601 – 627MPLGF…DEEIG → IAIQTDALGVPGAGASAGET HPSHWGS in isoform 3. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_037029628 – 1323Missing in isoform 3. 1 PublicationAdd BLAST696
Alternative sequenceiVSP_037030989 – 1030LLQME…LVILA → QPCEEGIVILMLRPQDLMGK ATTSSHRGSELESDTLSFAT WC in isoform 2. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_0370311031 – 1323Missing in isoform 2. 1 PublicationAdd BLAST293
Alternative sequenceiVSP_0370321148Missing in isoform 5. 1 Publication1
Alternative sequenceiVSP_0370331223 – 1323GSLVP…MSLKK → ATPRGQRFHLPCPPLYSQPL EQAGSAERAKNLKRSPYL in isoform 6. 1 PublicationAdd BLAST101

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK093272 mRNA Translation: BAC04116.1
AK128221 mRNA Translation: BAC87334.1 Sequence problems.
AK130047 mRNA Translation: BAC85285.1
CR749830 mRNA Translation: CAH18687.1
AL139244 Genomic DNA No translation available.
AL590093 Genomic DNA No translation available.
BC029191 mRNA Translation: AAH29191.1
BC126126 mRNA Translation: AAI26127.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41342.2 [Q68CQ1-7]

NCBI Reference Sequences

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RefSeqi
NP_001034553.2, NM_001039464.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.412482

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000395690; ENSP00000379044; ENSG00000184313 [Q68CQ1-2]
ENST00000413188; ENSP00000394373; ENSG00000184313 [Q68CQ1-8]
ENST00000421030; ENSP00000396622; ENSG00000184313 [Q68CQ1-7]
ENST00000422659; ENSP00000388181; ENSG00000184313 [Q68CQ1-8]
ENST00000438846; ENSP00000404780; ENSG00000184313 [Q68CQ1-8]

Database of genes from NCBI RefSeq genomes

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GeneIDi
374977

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:374977

UCSC genome browser

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UCSCi
uc001cxr.2 human [Q68CQ1-7]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093272 mRNA Translation: BAC04116.1
AK128221 mRNA Translation: BAC87334.1 Sequence problems.
AK130047 mRNA Translation: BAC85285.1
CR749830 mRNA Translation: CAH18687.1
AL139244 Genomic DNA No translation available.
AL590093 Genomic DNA No translation available.
BC029191 mRNA Translation: AAH29191.1
BC126126 mRNA Translation: AAI26127.1
CCDSiCCDS41342.2 [Q68CQ1-7]
RefSeqiNP_001034553.2, NM_001039464.3
UniGeneiHs.412482

3D structure databases

ProteinModelPortaliQ68CQ1
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ68CQ1
PhosphoSitePlusiQ68CQ1

Polymorphism and mutation databases

BioMutaiMROH7
DMDMi317373558

Proteomic databases

PaxDbiQ68CQ1
PeptideAtlasiQ68CQ1
PRIDEiQ68CQ1
ProteomicsDBi66014
66015 [Q68CQ1-1]
66016 [Q68CQ1-2]
66017 [Q68CQ1-4]
66018 [Q68CQ1-8]
66019 [Q68CQ1-9]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000395690; ENSP00000379044; ENSG00000184313 [Q68CQ1-2]
ENST00000413188; ENSP00000394373; ENSG00000184313 [Q68CQ1-8]
ENST00000421030; ENSP00000396622; ENSG00000184313 [Q68CQ1-7]
ENST00000422659; ENSP00000388181; ENSG00000184313 [Q68CQ1-8]
ENST00000438846; ENSP00000404780; ENSG00000184313 [Q68CQ1-8]
GeneIDi374977
KEGGihsa:374977
UCSCiuc001cxr.2 human [Q68CQ1-7]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
374977
DisGeNETi374977
EuPathDBiHostDB:ENSG00000184313.19

GeneCards: human genes, protein and diseases

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GeneCardsi
MROH7
HGNCiHGNC:24802 MROH7
HPAiHPA071840
neXtProtiNX_Q68CQ1
OpenTargetsiENSG00000184313
ENSG00000271723
PharmGKBiPA142672423

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2032 Eukaryota
ENOG410XQE8 LUCA
GeneTreeiENSGT00940000161775
HOVERGENiHBG107563
InParanoidiQ68CQ1
OrthoDBiEOG091G00DQ
PhylomeDBiQ68CQ1
TreeFamiTF337538

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MROH7 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
374977

Protein Ontology

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PROi
PR:Q68CQ1

Gene expression databases

BgeeiENSG00000184313 Expressed in 89 organ(s), highest expression level in right testis
CleanExiHS_C1orf175
ExpressionAtlasiQ68CQ1 baseline and differential
GenevisibleiQ68CQ1 HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
SUPFAMiSSF48371 SSF48371, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMROH7_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q68CQ1
Secondary accession number(s): A0AUX8
, Q5TA99, Q6ZP40, Q6ZRH6, Q8N311, Q8NA14
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: January 11, 2011
Last modified: December 5, 2018
This is version 126 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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