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Entry version 149 (13 Feb 2019)
Sequence version 2 (30 Aug 2005)
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Protein

AT-rich interactive domain-containing protein 2

Gene

ARID2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). May be involved in targeting the complex to different genes. May be involved in regulating transcriptional activation of cardiac genes.2 Publications1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi524 – 603RFX-type winged-helixPROSITE-ProRule annotationAdd BLAST80
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1632 – 1657C2H2-typeAdd BLAST26

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-3214858 RMTs methylate histone arginines
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

SIGNOR Signaling Network Open Resource

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SIGNORi
Q68CP9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
AT-rich interactive domain-containing protein 2Curated
Short name:
ARID domain-containing protein 2Curated
Alternative name(s):
BRG1-associated factor 200Curated
Short name:
BAF200Curated
Zinc finger protein with activation potentialCurated
Zipzap/p2001 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARID2Imported
Synonyms:BAF200, KIAA1557
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000189079.15

Human Gene Nomenclature Database

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HGNCi
HGNC:18037 ARID2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
609539 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q68CP9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Coffin-Siris syndrome 6 (CSS6)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Coffin-Siris syndrome, a congenital multiple malformation syndrome with broad phenotypic and genetic variability. Cardinal features are intellectual disability, coarse facial features, hypertrichosis, and hypoplastic or absent fifth digit nails or phalanges. Additional features include malformations of the cardiac, gastrointestinal, genitourinary, and/or central nervous systems. Sucking/feeding difficulties, poor growth, ophthalmologic abnormalities, hearing impairment, and spinal anomalies are common findings. Both autosomal dominant and autosomal recessive inheritance patterns have been reported. CSS6 inheritance is autosomal dominant.
See also OMIM:617808
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_080566343 – 1835Missing in CSS6. 1 PublicationAdd BLAST1493
Natural variantiVAR_0805671440 – 1835Missing in CSS6. 1 PublicationAdd BLAST396

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

DisGeNET

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DisGeNETi
196528

MalaCards human disease database

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MalaCardsi
ARID2
MIMi617808 phenotype

Open Targets

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OpenTargetsi
ENSG00000189079

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
1465 Coffin-Siris syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134916396

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
ARID2

Domain mapping of disease mutations (DMDM)

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DMDMi
73921721

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002005772 – 1835AT-rich interactive domain-containing protein 2Add BLAST1834

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei4PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki7Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki15Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki119Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki555Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei631PhosphoserineCombined sources1
Modified residuei635PhosphoserineCombined sources1
Modified residuei653PhosphothreonineCombined sources1
Modified residuei689PhosphoserineCombined sources1
Modified residuei692PhosphothreonineCombined sources1
Modified residuei1300PhosphoserineCombined sources1
Modified residuei1391PhosphoserineCombined sources1
Modified residuei1496PhosphoserineCombined sources1
Cross-linki1701Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1716Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1731Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q68CP9

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q68CP9

MaxQB - The MaxQuant DataBase

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MaxQBi
Q68CP9

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q68CP9

PeptideAtlas

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PeptideAtlasi
Q68CP9

PRoteomics IDEntifications database

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PRIDEi
Q68CP9

ProteomicsDB human proteome resource

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ProteomicsDBi
66011
66013 [Q68CP9-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q68CP9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q68CP9

Miscellaneous databases

CutDB - Proteolytic event database

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PMAP-CutDBi
Q68CP9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in heart.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Up-regulated in adult heart (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000189079 Expressed in 201 organ(s), highest expression level in kidney

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q68CP9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q68CP9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA063044

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the SWI/SNF-B (PBAF) chromatin remodeling complex, at least composed of SMARCA4/BRG1, SMARCB1/BAF47/SNF5, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, perhaps SMARCD3/BAF60C, SMARCC1/BAF155, SMARCC2/BAF170, PBRM1/BAF180, ARID2/BAF200 and actin. Interacts with SRF. Forms complexes with SRF and SRF cofactors MYOCD, NKX2-5 and SRFBP1.2 Publications2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
128219, 35 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-1196 Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B variant
CPX-1199 Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A variant

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q68CP9

Database of interacting proteins

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DIPi
DIP-33391N

Protein interaction database and analysis system

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IntActi
Q68CP9, 24 interactors

Molecular INTeraction database

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MINTi
Q68CP9

STRING: functional protein association networks

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STRINGi
9606.ENSP00000335044

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q68CP9

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini13 – 105ARIDPROSITE-ProRule annotationAdd BLAST93

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi313 – 317LXXLL5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi793 – 1128Gln-richAdd BLAST336

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1632 – 1657C2H2-typeAdd BLAST26

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2312 Eukaryota
KOG2744 Eukaryota
ENOG410XT3H LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000016138

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG068777

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q68CP9

KEGG Orthology (KO)

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KOi
K11765

Identification of Orthologs from Complete Genome Data

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OMAi
ICDWRNC

Database of Orthologous Groups

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OrthoDBi
39440at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q68CP9

TreeFam database of animal gene trees

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TreeFami
TF106406

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.10.10, 1 hit
1.10.150.60, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001606 ARID_dom
IPR036431 ARID_dom_sf
IPR016024 ARM-type_fold
IPR003150 DNA-bd_RFX
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

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Pfami
View protein in Pfam
PF01388 ARID, 1 hit
PF02257 RFX_DNA_binding, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00501 BRIGHT, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF46774 SSF46774, 1 hit
SSF46785 SSF46785, 1 hit
SSF48371 SSF48371, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51011 ARID, 1 hit
PS51526 RFX_DBD, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q68CP9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MANSTGKAPP DERRKGLAFL DELRQFHHSR GSPFKKIPAV GGKELDLHGL
60 70 80 90 100
YTRVTTLGGF AKVSEKNQWG EIVEEFNFPR SCSNAAFALK QYYLRYLEKY
110 120 130 140 150
EKVHHFGEDD DEVPPGNPKP QLPIGAIPSS YNYQQHSVSD YLRQSYGLSM
160 170 180 190 200
DFNSPNDYNK LVLSLLSGLP NEVDFAINVC TLLSNESKHV MQLEKDPKII
210 220 230 240 250
TLLLANAGVF DDTLGSFSTV FGEEWKEKTD RDFVKFWKDI VDDNEVRDLI
260 270 280 290 300
SDRNKSHEGT SGEWIWESLF HPPRKLGIND IEGQRVLQIA VILRNLSFEE
310 320 330 340 350
GNVKLLAANR TCLRFLLLSA HSHFISLRQL GLDTLGNIAA ELLLDPVDFK
360 370 380 390 400
TTHLMFHTVT KCLMSRDRFL KMRGMEILGN LCKAEDNGVL ICEYVDQDSY
410 420 430 440 450
REIICHLTLP DVLLVISTLE VLYMLTEMGD VACTKIAKVE KSIDMLVCLV
460 470 480 490 500
SMDIQMFGPD ALAAVKLIEH PSSSHQMLSE IRPQAIEQVQ TQTHVASAPA
510 520 530 540 550
SRAVVAQHVA PPPGIVEIDS EKFACQWLNA HFEVNPDCSV SRAEMYSEYL
560 570 580 590 600
STCSKLARGG ILTSTGFYKC LRTVFPNHTV KRVEDSSSNG QAHIHVVGVK
610 620 630 640 650
RRAIPLPIQM YYQQQPVSTS VVRVDSVPDV SPAPSPAGIP HGSQTIGNHF
660 670 680 690 700
QRTPVANQSS NLTATQMSFP VQGVHTVAQT VSRIPQNPSP HTHQQQNAPV
710 720 730 740 750
TVIQSKAPIP CEVVKATVIQ NSIPQTGVPV SIAVGGGPPQ SSVVQNHSTG
760 770 780 790 800
PQPVTVVNSQ TLLHHPSVIP QQSPLHTVVP GQIPSGTPVT VIQQAVPQSH
810 820 830 840 850
MFGRVQNIPA CTSTVSQGQQ LITTSPQPVQ TSSQQTSAGS QSQDTVIIAP
860 870 880 890 900
PQYVTTSASN IVSATSVQNF QVATGQMVTI AGVPSPQASR VGFQNIAPKP
910 920 930 940 950
LPSQQVSSTV VQQPIQQPQQ PTQQSVVIVS QPAQQGQTYA PAIHQIVLAN
960 970 980 990 1000
PAALPAGQTV QLTGQPNITP SSSPSPVPAT NNQVPTAMSS SSTPQSQGPP
1010 1020 1030 1040 1050
PTVSQMLSVK RQQQQQHSPA PPPQQVQVQV QQPQQVQMQV QPQQSNAGVG
1060 1070 1080 1090 1100
QPASGESSLI KQLLLPKRGP STPGGKLILP APQIPPPNNA RAPSPQVVYQ
1110 1120 1130 1140 1150
VASNQAAGFG VQGQTPAQQL LVGQQNVQLV PSAMPPSGGV QTVPISNLQI
1160 1170 1180 1190 1200
LPGPLISNSP ATIFQGTSGN QVTITVVPNT SFAPATVSQG NATQLIAPAG
1210 1220 1230 1240 1250
ITMSGTQTGV GLPVQTLPAT QASPAGQSSC TTATPPFKGD KIICQKEEEA
1260 1270 1280 1290 1300
KEATGLHVHE RKIEVMENPS CRRGATNTSN GDTKENEMHV GSLLNGRKYS
1310 1320 1330 1340 1350
DSSLPPSNSG KIQSETNQCS LISNGPSLEL GENGASGKQN SEQIDMQDIK
1360 1370 1380 1390 1400
SDLRKPLVNG ICDFDKGDGS HLSKNIPNHK TSNHVGNGEI SPMEPQGTLD
1410 1420 1430 1440 1450
ITQQDTAKGD QLERISNGPV LTLGGSSVSS IQEASNAATQ QFSGTDLLNG
1460 1470 1480 1490 1500
PLASSLNSDV PQQRPSVVVS PHSTTSVIQG HQIIAVPDSG SKVSHSPALS
1510 1520 1530 1540 1550
SDVRSTNGTA ECKTVKRPAE DTDRETVAGI PNKVGVRIVT ISDPNNAGCS
1560 1570 1580 1590 1600
ATMVAVPAGA DPSTVAKVAI ESAVQQKQQH PPTYVQNVVP QNTPMPPSPA
1610 1620 1630 1640 1650
VQVQGQPNSS QPSPFSGSSQ PGDPMRKPGQ NFMCLWQSCK KWFQTPSQVF
1660 1670 1680 1690 1700
YHAATEHGGK DVYPGQCLWE GCEPFQRQRF SFITHLQDKH CSKDALLAGL
1710 1720 1730 1740 1750
KQDEPGQAGS QKSSTKQPTV GGTSSTPRAQ KAIVNHPSAA LMALRRGSRN
1760 1770 1780 1790 1800
LVFRDFTDEK EGPITKHIRL TAALILKNIG KYSECGRRLL KRHENNLSVL
1810 1820 1830
AISNMEASST LAKCLYELNF TVQSKEQEKD SEMLQ
Length:1,835
Mass (Da):197,391
Last modified:August 30, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF540A029FA2264D4
GO
Isoform 2 (identifier: Q68CP9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1784-1835: Missing.

Note: No experimental confirmation available.
Show »
Length:1,783
Mass (Da):191,422
Checksum:iDD2BB28AF96DC860
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WCU9F8WCU9_HUMAN
AT-rich interactive domain-containi...
ARID2
1,639Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W108F8W108_HUMAN
AT-rich interactive domain-containi...
ARID2
1,445Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VWP4F8VWP4_HUMAN
AT-rich interactive domain-containi...
ARID2
401Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WY37A0A087WY37_HUMAN
AT-rich interactive domain-containi...
ARID2
64Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAU20329 differs from that shown. Differs from position 1094 onward for unknown reason.Curated
The sequence BAB55320 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC87171 differs from that shown. Unlikely isoform. Cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti169L → P in CAH18689 (PubMed:17974005).Curated1
Sequence conflicti217F → L in CAD91164 (PubMed:17974005).Curated1
Sequence conflicti665T → I in CAD91164 (PubMed:17974005).Curated1
Sequence conflicti801M → T in AAZ74794 (PubMed:16782067).Curated1
Sequence conflicti825S → P in CAH18689 (PubMed:17974005).Curated1
Sequence conflicti906V → F in CAD91164 (PubMed:17974005).Curated1
Sequence conflicti956A → V in CAD91164 (PubMed:17974005).Curated1
Sequence conflicti988M → T in CAH18689 (PubMed:17974005).Curated1
Sequence conflicti989S → P in CAD97878 (PubMed:17974005).Curated1
Sequence conflicti1035Q → R in BAB55320 (PubMed:14702039).Curated1
Sequence conflicti1062Q → R in CAH18689 (PubMed:17974005).Curated1
Sequence conflicti1204S → G in CAD97878 (PubMed:17974005).Curated1
Sequence conflicti1292S → N in CAD97878 (PubMed:17974005).Curated1
Sequence conflicti1460V → A in CAD97878 (PubMed:17974005).Curated1
Sequence conflicti1543D → G in CAD91164 (PubMed:17974005).Curated1
Sequence conflicti1543D → N in BAC87171 (PubMed:14702039).Curated1
Sequence conflicti1647S → P in CAD97878 (PubMed:17974005).Curated1
Sequence conflicti1700L → S in CAD91164 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_080566343 – 1835Missing in CSS6. 1 PublicationAdd BLAST1493
Natural variantiVAR_0805671440 – 1835Missing in CSS6. 1 PublicationAdd BLAST396

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0152301784 – 1835Missing in isoform 2. 1 PublicationAdd BLAST52

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ096628 mRNA Translation: AAZ74794.1
AY727870 mRNA Translation: AAU20329.2 Different termination.
AL832200 mRNA Translation: CAD91164.1
BX537879 mRNA Translation: CAD97878.1
CR749833 mRNA Translation: CAH18689.1
AK027718 mRNA Translation: BAB55320.1 Different initiation.
AK127872 mRNA Translation: BAC87171.1 Sequence problems.
BC090062 mRNA Translation: AAH90062.1
AB046777 mRNA Translation: BAB13383.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31783.1 [Q68CP9-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001334768.1, NM_001347839.1
NP_689854.2, NM_152641.3 [Q68CP9-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.317304

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000334344; ENSP00000335044; ENSG00000189079 [Q68CP9-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
196528

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:196528

UCSC genome browser

More...
UCSCi
uc001ros.2 human [Q68CP9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ096628 mRNA Translation: AAZ74794.1
AY727870 mRNA Translation: AAU20329.2 Different termination.
AL832200 mRNA Translation: CAD91164.1
BX537879 mRNA Translation: CAD97878.1
CR749833 mRNA Translation: CAH18689.1
AK027718 mRNA Translation: BAB55320.1 Different initiation.
AK127872 mRNA Translation: BAC87171.1 Sequence problems.
BC090062 mRNA Translation: AAH90062.1
AB046777 mRNA Translation: BAB13383.1
CCDSiCCDS31783.1 [Q68CP9-1]
RefSeqiNP_001334768.1, NM_001347839.1
NP_689854.2, NM_152641.3 [Q68CP9-1]
UniGeneiHs.317304

3D structure databases

ProteinModelPortaliQ68CP9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128219, 35 interactors
ComplexPortaliCPX-1196 Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B variant
CPX-1199 Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A variant
CORUMiQ68CP9
DIPiDIP-33391N
IntActiQ68CP9, 24 interactors
MINTiQ68CP9
STRINGi9606.ENSP00000335044

PTM databases

iPTMnetiQ68CP9
PhosphoSitePlusiQ68CP9

Polymorphism and mutation databases

BioMutaiARID2
DMDMi73921721

Proteomic databases

EPDiQ68CP9
jPOSTiQ68CP9
MaxQBiQ68CP9
PaxDbiQ68CP9
PeptideAtlasiQ68CP9
PRIDEiQ68CP9
ProteomicsDBi66011
66013 [Q68CP9-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
196528
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334344; ENSP00000335044; ENSG00000189079 [Q68CP9-1]
GeneIDi196528
KEGGihsa:196528
UCSCiuc001ros.2 human [Q68CP9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
196528
DisGeNETi196528
EuPathDBiHostDB:ENSG00000189079.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ARID2
HGNCiHGNC:18037 ARID2
HPAiHPA063044
MalaCardsiARID2
MIMi609539 gene
617808 phenotype
neXtProtiNX_Q68CP9
OpenTargetsiENSG00000189079
Orphaneti1465 Coffin-Siris syndrome
PharmGKBiPA134916396

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2312 Eukaryota
KOG2744 Eukaryota
ENOG410XT3H LUCA
GeneTreeiENSGT00390000016138
HOVERGENiHBG068777
InParanoidiQ68CP9
KOiK11765
OMAiICDWRNC
OrthoDBi39440at2759
PhylomeDBiQ68CP9
TreeFamiTF106406

Enzyme and pathway databases

ReactomeiR-HSA-3214858 RMTs methylate histone arginines
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
SIGNORiQ68CP9

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ARID2 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ARID2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
196528
PMAP-CutDBiQ68CP9

Protein Ontology

More...
PROi
PR:Q68CP9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000189079 Expressed in 201 organ(s), highest expression level in kidney
ExpressionAtlasiQ68CP9 baseline and differential
GenevisibleiQ68CP9 HS

Family and domain databases

Gene3Di1.10.10.10, 1 hit
1.10.150.60, 1 hit
InterProiView protein in InterPro
IPR001606 ARID_dom
IPR036431 ARID_dom_sf
IPR016024 ARM-type_fold
IPR003150 DNA-bd_RFX
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01388 ARID, 1 hit
PF02257 RFX_DNA_binding, 1 hit
SMARTiView protein in SMART
SM00501 BRIGHT, 1 hit
SUPFAMiSSF46774 SSF46774, 1 hit
SSF46785 SSF46785, 1 hit
SSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51011 ARID, 1 hit
PS51526 RFX_DBD, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARID2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q68CP9
Secondary accession number(s): Q15KG9
, Q5EB51, Q645I3, Q6ZRY5, Q7Z3I5, Q86T28, Q96SJ6, Q9HCL5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: August 30, 2005
Last modified: February 13, 2019
This is version 149 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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