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Entry version 127 (02 Dec 2020)
Sequence version 2 (05 Sep 2006)
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Protein

Tubulin polyglutamylase complex subunit 2

Gene

TPGS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q68CL5

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8955332, Carboxyterminal post-translational modifications of tubulin

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tubulin polyglutamylase complex subunit 2
Short name:
PGs2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TPGS2
Synonyms:C18orf10
ORF Names:HMFN0601, L17
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

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EuPathDBi
HostDB:ENSG00000134779.14

Human Gene Nomenclature Database

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HGNCi
HGNC:24561, TPGS2

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q68CL5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
25941

Open Targets

More...
OpenTargetsi
ENSG00000134779

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA128394637

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q68CL5, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TPGS2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
114152891

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000793041 – 300Tubulin polyglutamylase complex subunit 2Add BLAST300

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q68CL5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q68CL5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q68CL5

PeptideAtlas

More...
PeptideAtlasi
Q68CL5

PRoteomics IDEntifications database

More...
PRIDEi
Q68CL5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
66006 [Q68CL5-2]
66007 [Q68CL5-1]
66008 [Q68CL5-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q68CL5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q68CL5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000134779, Expressed in testis and 238 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q68CL5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q68CL5, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000134779, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of the neuronal tubulin polyglutamylase complex which contains TPGS1, TPGS2, TTLL1, LRRC49 and NICN1.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
117438, 15 interactors

Protein interaction database and analysis system

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IntActi
Q68CL5, 11 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000464780

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q68CL5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q68CL5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502R21Z, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000018344

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_079178_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q68CL5

Database of Orthologous Groups

More...
OrthoDBi
1286883at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q68CL5

TreeFam database of animal gene trees

More...
TreeFami
TF325540

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR018958, Knr4/Smi1-like_dom
IPR039231, TPGS2

The PANTHER Classification System

More...
PANTHERi
PTHR31854, PTHR31854, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00860, SMI1_KNR4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All

Isoform 2 (identifier: Q68CL5-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEEEASSPGL GCSKPHLEKL TLGITRILES SPGVTEVTII EKPPAERHMI
60 70 80 90 100
SSWEQKNNCV MPEDVKNFYL MTNGFHMTWS VKLDEHIIPL GSMAINSISK
110 120 130 140 150
LTQLTQSSMY SLPNAPTLAD LEDDTHEASD DQPEKPHFDS RSVIFELDSC
160 170 180 190 200
NGSGKVCLVY KSGKPALAED TEIWFLDRAL YWHFLTDTFT AYYRLLITHL
210 220 230 240 250
GLPQWQYAFT SYGISPQAKQ WFSMYKPITY NTNLLTEETD SFVNKLDPSK
260 270 280 290 300
VFKSKNKIVI PKKKGPVQPA GGQKGPSGPS GPSTSSTSKS SSGSGNPTRK
Length:300
Mass (Da):33,318
Last modified:September 5, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF3AADD55882EC1E5
GO
Isoform 1 (identifier: Q68CL5-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     85-127: Missing.

Show »
Length:257
Mass (Da):28,653
Checksum:i4E3780AD249BBD57
GO
Isoform 3 (identifier: Q68CL5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     220-227: QWFSMYKP → VREEHLPL
     228-300: Missing.

Show »
Length:227
Mass (Da):25,665
Checksum:i7021B602DBC24361
GO
Isoform 4 (identifier: Q68CL5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     85-119: Missing.

Show »
Length:265
Mass (Da):29,607
Checksum:iE10DBB66D27A01B8
GO
Isoform 5 (identifier: Q68CL5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     220-300: QWFSMYKPIT...SSGSGNPTRK → ITYNIKMNRR...VLFFTVRCCF

Show »
Length:304
Mass (Da):34,399
Checksum:i5D2E6312F59D33CF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EP30K7EP30_HUMAN
Tubulin polyglutamylase complex sub...
TPGS2
208Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ERK3K7ERK3_HUMAN
Tubulin polyglutamylase complex sub...
TPGS2
188Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ELA6K7ELA6_HUMAN
Tubulin polyglutamylase complex sub...
TPGS2
49Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EKC0K7EKC0_HUMAN
Tubulin polyglutamylase complex sub...
TPGS2
248Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WUC8A0A087WUC8_HUMAN
Tubulin polyglutamylase complex sub...
TPGS2
232Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X1R7A0A087X1R7_HUMAN
Tubulin polyglutamylase complex sub...
TPGS2
130Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EN50K7EN50_HUMAN
Tubulin polyglutamylase complex sub...
TPGS2
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EK44K7EK44_HUMAN
Tubulin polyglutamylase complex sub...
TPGS2
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WZ07A0A087WZ07_HUMAN
Tubulin polyglutamylase complex sub...
TPGS2
162Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X0Q8A0A087X0Q8_HUMAN
Tubulin polyglutamylase complex sub...
TPGS2
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH22199 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB43322 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti44P → S in CAB43322 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02741047R → C. Corresponds to variant dbSNP:rs2303507Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02011385 – 127Missing in isoform 1. 2 PublicationsAdd BLAST43
Alternative sequenceiVSP_05452585 – 119Missing in isoform 4. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_055634220 – 300QWFSM…NPTRK → ITYNIKMNRRKCVHWKLAVE PLQWELRSCVSAGMGTGHKQ RVSSMKPRSCSVCSRRQSNS MGTTVSQSFLSYGKNVLFFT VRCCF in isoform 5. CuratedAdd BLAST81
Alternative sequenceiVSP_014884220 – 227QWFSMYKP → VREEHLPL in isoform 3. 1 Publication8
Alternative sequenceiVSP_014885228 – 300Missing in isoform 3. 1 PublicationAdd BLAST73

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK295817 mRNA Translation: BAG58634.1
AB073382 mRNA Translation: BAD38633.1
AC009854 Genomic DNA No translation available.
AC090333 Genomic DNA No translation available.
BC015178 mRNA Translation: AAH15178.2
BC022199 mRNA Translation: AAH22199.2 Different initiation.
BC087845 mRNA Translation: AAH87845.1
AL050225 mRNA Translation: CAB43322.2 Different initiation.
AY598336 mRNA Translation: AAT06747.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32817.1 [Q68CL5-2]
CCDS62421.1 [Q68CL5-1]
CCDS62422.1 [Q68CL5-4]
CCDS62423.1 [Q68CL5-3]
CCDS62424.1 [Q68CL5-5]

Protein sequence database of the Protein Information Resource

More...
PIRi
T08811

NCBI Reference Sequences

More...
RefSeqi
NP_001258878.1, NM_001271949.1 [Q68CL5-4]
NP_001258879.1, NM_001271950.1 [Q68CL5-1]
NP_001258880.1, NM_001271951.1 [Q68CL5-5]
NP_001258881.1, NM_001271952.1
NP_001258883.1, NM_001271954.1 [Q68CL5-3]
NP_056291.2, NM_015476.3 [Q68CL5-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000334295; ENSP00000335144; ENSG00000134779 [Q68CL5-2]
ENST00000383056; ENSP00000372530; ENSG00000134779 [Q68CL5-1]
ENST00000589049; ENSP00000466973; ENSG00000134779 [Q68CL5-3]
ENST00000590842; ENSP00000464780; ENSG00000134779 [Q68CL5-5]
ENST00000593035; ENSP00000467392; ENSG00000134779 [Q68CL5-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
25941

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:25941

UCSC genome browser

More...
UCSCi
uc002kzw.3, human [Q68CL5-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295817 mRNA Translation: BAG58634.1
AB073382 mRNA Translation: BAD38633.1
AC009854 Genomic DNA No translation available.
AC090333 Genomic DNA No translation available.
BC015178 mRNA Translation: AAH15178.2
BC022199 mRNA Translation: AAH22199.2 Different initiation.
BC087845 mRNA Translation: AAH87845.1
AL050225 mRNA Translation: CAB43322.2 Different initiation.
AY598336 mRNA Translation: AAT06747.1
CCDSiCCDS32817.1 [Q68CL5-2]
CCDS62421.1 [Q68CL5-1]
CCDS62422.1 [Q68CL5-4]
CCDS62423.1 [Q68CL5-3]
CCDS62424.1 [Q68CL5-5]
PIRiT08811
RefSeqiNP_001258878.1, NM_001271949.1 [Q68CL5-4]
NP_001258879.1, NM_001271950.1 [Q68CL5-1]
NP_001258880.1, NM_001271951.1 [Q68CL5-5]
NP_001258881.1, NM_001271952.1
NP_001258883.1, NM_001271954.1 [Q68CL5-3]
NP_056291.2, NM_015476.3 [Q68CL5-2]

3D structure databases

SMRiQ68CL5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi117438, 15 interactors
IntActiQ68CL5, 11 interactors
STRINGi9606.ENSP00000464780

PTM databases

iPTMnetiQ68CL5
PhosphoSitePlusiQ68CL5

Polymorphism and mutation databases

BioMutaiTPGS2
DMDMi114152891

Proteomic databases

jPOSTiQ68CL5
MassIVEiQ68CL5
PaxDbiQ68CL5
PeptideAtlasiQ68CL5
PRIDEiQ68CL5
ProteomicsDBi66006 [Q68CL5-2]
66007 [Q68CL5-1]
66008 [Q68CL5-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
22336, 114 antibodies

The DNASU plasmid repository

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DNASUi
25941

Genome annotation databases

EnsembliENST00000334295; ENSP00000335144; ENSG00000134779 [Q68CL5-2]
ENST00000383056; ENSP00000372530; ENSG00000134779 [Q68CL5-1]
ENST00000589049; ENSP00000466973; ENSG00000134779 [Q68CL5-3]
ENST00000590842; ENSP00000464780; ENSG00000134779 [Q68CL5-5]
ENST00000593035; ENSP00000467392; ENSG00000134779 [Q68CL5-4]
GeneIDi25941
KEGGihsa:25941
UCSCiuc002kzw.3, human [Q68CL5-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
25941
DisGeNETi25941
EuPathDBiHostDB:ENSG00000134779.14

GeneCards: human genes, protein and diseases

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GeneCardsi
TPGS2
HGNCiHGNC:24561, TPGS2
HPAiENSG00000134779, Low tissue specificity
neXtProtiNX_Q68CL5
OpenTargetsiENSG00000134779
PharmGKBiPA128394637

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502R21Z, Eukaryota
GeneTreeiENSGT00390000018344
HOGENOMiCLU_079178_0_0_1
InParanoidiQ68CL5
OrthoDBi1286883at2759
PhylomeDBiQ68CL5
TreeFamiTF325540

Enzyme and pathway databases

PathwayCommonsiQ68CL5
ReactomeiR-HSA-8955332, Carboxyterminal post-translational modifications of tubulin

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
25941, 2 hits in 842 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TPGS2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
25941
PharosiQ68CL5, Tdark

Protein Ontology

More...
PROi
PR:Q68CL5
RNActiQ68CL5, protein

Gene expression databases

BgeeiENSG00000134779, Expressed in testis and 238 other tissues
ExpressionAtlasiQ68CL5, baseline and differential
GenevisibleiQ68CL5, HS

Family and domain databases

InterProiView protein in InterPro
IPR018958, Knr4/Smi1-like_dom
IPR039231, TPGS2
PANTHERiPTHR31854, PTHR31854, 1 hit
SMARTiView protein in SMART
SM00860, SMI1_KNR4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTPGS2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q68CL5
Secondary accession number(s): B4DIX2
, K7EIJ9, Q4KN59, Q8WTU3, Q96BT9, Q9Y435
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: September 5, 2006
Last modified: December 2, 2020
This is version 127 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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