UniProtKB - Q68CL5 (TPGS2_HUMAN)
Protein
Tubulin polyglutamylase complex subunit 2
Gene
TPGS2
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- protein polyglutamylation Source: InterPro
Enzyme and pathway databases
PathwayCommonsi | Q68CL5 |
Reactomei | R-HSA-8955332, Carboxyterminal post-translational modifications of tubulin |
Names & Taxonomyi
Protein namesi | Recommended name: Tubulin polyglutamylase complex subunit 2Short name: PGs2 |
Gene namesi | Name:TPGS2 Synonyms:C18orf10 ORF Names:HMFN0601, L17 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000134779.14 |
HGNCi | HGNC:24561, TPGS2 |
neXtProti | NX_Q68CL5 |
Subcellular locationi
Cytoskeleton
- cytoskeleton By similarity
Cytoskeleton
- microtubule Source: UniProtKB-KW
Other locations
- cytoplasm Source: UniProtKB-KW
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, MicrotubulePathology & Biotechi
Organism-specific databases
DisGeNETi | 25941 |
OpenTargetsi | ENSG00000134779 |
PharmGKBi | PA128394637 |
Miscellaneous databases
Pharosi | Q68CL5, Tdark |
Polymorphism and mutation databases
BioMutai | TPGS2 |
DMDMi | 114152891 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000079304 | 1 – 300 | Tubulin polyglutamylase complex subunit 2Add BLAST | 300 |
Proteomic databases
jPOSTi | Q68CL5 |
MassIVEi | Q68CL5 |
PaxDbi | Q68CL5 |
PeptideAtlasi | Q68CL5 |
PRIDEi | Q68CL5 |
ProteomicsDBi | 66006 [Q68CL5-2] 66007 [Q68CL5-1] 66008 [Q68CL5-3] |
PTM databases
iPTMneti | Q68CL5 |
PhosphoSitePlusi | Q68CL5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000134779, Expressed in testis and 238 other tissues |
ExpressionAtlasi | Q68CL5, baseline and differential |
Genevisiblei | Q68CL5, HS |
Organism-specific databases
HPAi | ENSG00000134779, Low tissue specificity |
Interactioni
Subunit structurei
Part of the neuronal tubulin polyglutamylase complex which contains TPGS1, TPGS2, TTLL1, LRRC49 and NICN1.
By similarityBinary interactionsi
Q68CL5
With | #Exp. | IntAct |
---|---|---|
OTP [Q5XKR4] | 3 | EBI-748091,EBI-12865884 |
Protein-protein interaction databases
BioGRIDi | 117438, 15 interactors |
IntActi | Q68CL5, 11 interactors |
STRINGi | 9606.ENSP00000464780 |
Miscellaneous databases
RNActi | Q68CL5, protein |
Family & Domainsi
Phylogenomic databases
eggNOGi | ENOG502R21Z, Eukaryota |
GeneTreei | ENSGT00390000018344 |
HOGENOMi | CLU_079178_0_0_1 |
InParanoidi | Q68CL5 |
OrthoDBi | 1286883at2759 |
PhylomeDBi | Q68CL5 |
TreeFami | TF325540 |
Family and domain databases
InterProi | View protein in InterPro IPR018958, Knr4/Smi1-like_dom IPR039231, TPGS2 |
PANTHERi | PTHR31854, PTHR31854, 1 hit |
SMARTi | View protein in SMART SM00860, SMI1_KNR4, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All
Isoform 2 (identifier: Q68CL5-2) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEEEASSPGL GCSKPHLEKL TLGITRILES SPGVTEVTII EKPPAERHMI
60 70 80 90 100
SSWEQKNNCV MPEDVKNFYL MTNGFHMTWS VKLDEHIIPL GSMAINSISK
110 120 130 140 150
LTQLTQSSMY SLPNAPTLAD LEDDTHEASD DQPEKPHFDS RSVIFELDSC
160 170 180 190 200
NGSGKVCLVY KSGKPALAED TEIWFLDRAL YWHFLTDTFT AYYRLLITHL
210 220 230 240 250
GLPQWQYAFT SYGISPQAKQ WFSMYKPITY NTNLLTEETD SFVNKLDPSK
260 270 280 290 300
VFKSKNKIVI PKKKGPVQPA GGQKGPSGPS GPSTSSTSKS SSGSGNPTRK
Computationally mapped potential isoform sequencesi
There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7EP30 | K7EP30_HUMAN | Tubulin polyglutamylase complex sub... | TPGS2 | 208 | Annotation score: | ||
K7ERK3 | K7ERK3_HUMAN | Tubulin polyglutamylase complex sub... | TPGS2 | 188 | Annotation score: | ||
K7ELA6 | K7ELA6_HUMAN | Tubulin polyglutamylase complex sub... | TPGS2 | 49 | Annotation score: | ||
K7EKC0 | K7EKC0_HUMAN | Tubulin polyglutamylase complex sub... | TPGS2 | 248 | Annotation score: | ||
A0A087WUC8 | A0A087WUC8_HUMAN | Tubulin polyglutamylase complex sub... | TPGS2 | 232 | Annotation score: | ||
A0A087X1R7 | A0A087X1R7_HUMAN | Tubulin polyglutamylase complex sub... | TPGS2 | 130 | Annotation score: | ||
K7EN50 | K7EN50_HUMAN | Tubulin polyglutamylase complex sub... | TPGS2 | 119 | Annotation score: | ||
K7EK44 | K7EK44_HUMAN | Tubulin polyglutamylase complex sub... | TPGS2 | 75 | Annotation score: | ||
A0A087WZ07 | A0A087WZ07_HUMAN | Tubulin polyglutamylase complex sub... | TPGS2 | 162 | Annotation score: | ||
A0A087X0Q8 | A0A087X0Q8_HUMAN | Tubulin polyglutamylase complex sub... | TPGS2 | 59 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
The sequence AAH22199 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB43322 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 44 | P → S in CAB43322 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_027410 | 47 | R → C. Corresponds to variant dbSNP:rs2303507Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_020113 | 85 – 127 | Missing in isoform 1. 2 PublicationsAdd BLAST | 43 | |
Alternative sequenceiVSP_054525 | 85 – 119 | Missing in isoform 4. 1 PublicationAdd BLAST | 35 | |
Alternative sequenceiVSP_055634 | 220 – 300 | QWFSM…NPTRK → ITYNIKMNRRKCVHWKLAVE PLQWELRSCVSAGMGTGHKQ RVSSMKPRSCSVCSRRQSNS MGTTVSQSFLSYGKNVLFFT VRCCF in isoform 5. CuratedAdd BLAST | 81 | |
Alternative sequenceiVSP_014884 | 220 – 227 | QWFSMYKP → VREEHLPL in isoform 3. 1 Publication | 8 | |
Alternative sequenceiVSP_014885 | 228 – 300 | Missing in isoform 3. 1 PublicationAdd BLAST | 73 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK295817 mRNA Translation: BAG58634.1 AB073382 mRNA Translation: BAD38633.1 AC009854 Genomic DNA No translation available. AC090333 Genomic DNA No translation available. BC015178 mRNA Translation: AAH15178.2 BC022199 mRNA Translation: AAH22199.2 Different initiation. BC087845 mRNA Translation: AAH87845.1 AL050225 mRNA Translation: CAB43322.2 Different initiation. AY598336 mRNA Translation: AAT06747.1 |
CCDSi | CCDS32817.1 [Q68CL5-2] CCDS62421.1 [Q68CL5-1] CCDS62422.1 [Q68CL5-4] CCDS62423.1 [Q68CL5-3] CCDS62424.1 [Q68CL5-5] |
PIRi | T08811 |
RefSeqi | NP_001258878.1, NM_001271949.1 [Q68CL5-4] NP_001258879.1, NM_001271950.1 [Q68CL5-1] NP_001258880.1, NM_001271951.1 [Q68CL5-5] NP_001258881.1, NM_001271952.1 NP_001258883.1, NM_001271954.1 [Q68CL5-3] NP_056291.2, NM_015476.3 [Q68CL5-2] |
Genome annotation databases
Ensembli | ENST00000334295; ENSP00000335144; ENSG00000134779 [Q68CL5-2] ENST00000383056; ENSP00000372530; ENSG00000134779 [Q68CL5-1] ENST00000589049; ENSP00000466973; ENSG00000134779 [Q68CL5-3] ENST00000590842; ENSP00000464780; ENSG00000134779 [Q68CL5-5] ENST00000593035; ENSP00000467392; ENSG00000134779 [Q68CL5-4] |
GeneIDi | 25941 |
KEGGi | hsa:25941 |
UCSCi | uc002kzw.3, human [Q68CL5-2] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK295817 mRNA Translation: BAG58634.1 AB073382 mRNA Translation: BAD38633.1 AC009854 Genomic DNA No translation available. AC090333 Genomic DNA No translation available. BC015178 mRNA Translation: AAH15178.2 BC022199 mRNA Translation: AAH22199.2 Different initiation. BC087845 mRNA Translation: AAH87845.1 AL050225 mRNA Translation: CAB43322.2 Different initiation. AY598336 mRNA Translation: AAT06747.1 |
CCDSi | CCDS32817.1 [Q68CL5-2] CCDS62421.1 [Q68CL5-1] CCDS62422.1 [Q68CL5-4] CCDS62423.1 [Q68CL5-3] CCDS62424.1 [Q68CL5-5] |
PIRi | T08811 |
RefSeqi | NP_001258878.1, NM_001271949.1 [Q68CL5-4] NP_001258879.1, NM_001271950.1 [Q68CL5-1] NP_001258880.1, NM_001271951.1 [Q68CL5-5] NP_001258881.1, NM_001271952.1 NP_001258883.1, NM_001271954.1 [Q68CL5-3] NP_056291.2, NM_015476.3 [Q68CL5-2] |
3D structure databases
SMRi | Q68CL5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 117438, 15 interactors |
IntActi | Q68CL5, 11 interactors |
STRINGi | 9606.ENSP00000464780 |
PTM databases
iPTMneti | Q68CL5 |
PhosphoSitePlusi | Q68CL5 |
Polymorphism and mutation databases
BioMutai | TPGS2 |
DMDMi | 114152891 |
Proteomic databases
jPOSTi | Q68CL5 |
MassIVEi | Q68CL5 |
PaxDbi | Q68CL5 |
PeptideAtlasi | Q68CL5 |
PRIDEi | Q68CL5 |
ProteomicsDBi | 66006 [Q68CL5-2] 66007 [Q68CL5-1] 66008 [Q68CL5-3] |
Protocols and materials databases
Antibodypediai | 22336, 114 antibodies |
DNASUi | 25941 |
Genome annotation databases
Ensembli | ENST00000334295; ENSP00000335144; ENSG00000134779 [Q68CL5-2] ENST00000383056; ENSP00000372530; ENSG00000134779 [Q68CL5-1] ENST00000589049; ENSP00000466973; ENSG00000134779 [Q68CL5-3] ENST00000590842; ENSP00000464780; ENSG00000134779 [Q68CL5-5] ENST00000593035; ENSP00000467392; ENSG00000134779 [Q68CL5-4] |
GeneIDi | 25941 |
KEGGi | hsa:25941 |
UCSCi | uc002kzw.3, human [Q68CL5-2] |
Organism-specific databases
CTDi | 25941 |
DisGeNETi | 25941 |
EuPathDBi | HostDB:ENSG00000134779.14 |
GeneCardsi | TPGS2 |
HGNCi | HGNC:24561, TPGS2 |
HPAi | ENSG00000134779, Low tissue specificity |
neXtProti | NX_Q68CL5 |
OpenTargetsi | ENSG00000134779 |
PharmGKBi | PA128394637 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502R21Z, Eukaryota |
GeneTreei | ENSGT00390000018344 |
HOGENOMi | CLU_079178_0_0_1 |
InParanoidi | Q68CL5 |
OrthoDBi | 1286883at2759 |
PhylomeDBi | Q68CL5 |
TreeFami | TF325540 |
Enzyme and pathway databases
PathwayCommonsi | Q68CL5 |
Reactomei | R-HSA-8955332, Carboxyterminal post-translational modifications of tubulin |
Miscellaneous databases
BioGRID-ORCSi | 25941, 2 hits in 842 CRISPR screens |
ChiTaRSi | TPGS2, human |
GenomeRNAii | 25941 |
Pharosi | Q68CL5, Tdark |
PROi | PR:Q68CL5 |
RNActi | Q68CL5, protein |
Gene expression databases
Bgeei | ENSG00000134779, Expressed in testis and 238 other tissues |
ExpressionAtlasi | Q68CL5, baseline and differential |
Genevisiblei | Q68CL5, HS |
Family and domain databases
InterProi | View protein in InterPro IPR018958, Knr4/Smi1-like_dom IPR039231, TPGS2 |
PANTHERi | PTHR31854, PTHR31854, 1 hit |
SMARTi | View protein in SMART SM00860, SMI1_KNR4, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TPGS2_HUMAN | |
Accessioni | Q68CL5Primary (citable) accession number: Q68CL5 Secondary accession number(s): B4DIX2 Q9Y435 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2005 |
Last sequence update: | September 5, 2006 | |
Last modified: | December 2, 2020 | |
This is version 127 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations