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UniProtKB - Q68CJ9 (CR3L3_HUMAN)

Entry version 156 (02 Dec 2020)
Sequence version 2 (29 May 2007)
Previous versions | rss
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Protein

Cyclic AMP-responsive element-binding protein 3-like protein 3

Gene

CREB3L3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE (By similarity). May function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression. Regulates FGF21 transcription (By similarity).By similarity3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation, Unfolded protein response

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q68CJ9

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-8874211, CREB3 factors activate genes
R-HSA-8963889, Assembly of active LPL and LIPC lipase complexes

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cyclic AMP-responsive element-binding protein 3-like protein 3
Short name:
cAMP-responsive element-binding protein 3-like protein 3
Alternative name(s):
Transcription factor CREB-H
Cleaved into the following chain:
Processed cyclic AMP-responsive element-binding protein 3-like protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CREB3L3
Synonyms:CREBH
ORF Names:HYST1481
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000060566.13

Human Gene Nomenclature Database

More...HGNCi		HGNC:18855, CREB3L3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		611998, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q68CJ9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 322CytoplasmicSequence analysisAdd BLAST322
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei323 – 343Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini344 – 461LumenalSequence analysisAdd BLAST118

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi294K → R: Loss of ubiquitination by SYNV1/HRD1. 1 Publication1
Mutagenesisi361R → A: Decreases proteolytic cleavage upon ER stress. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		84699

Open Targets

More...OpenTargetsi		ENSG00000060566

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134882161

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q68CJ9, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CREB3L3

Domain mapping of disease mutations (DMDM)

More...DMDMi		148886847

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002880741 – 461Cyclic AMP-responsive element-binding protein 3-like protein 3Add BLAST461
ChainiPRO_00002962161 – ?Processed cyclic AMP-responsive element-binding protein 3-like protein 3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei173PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki294Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi379O-linked (GalNAc...) serine1 Publication1
Glycosylationi410N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi413N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi420N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi427N-linked (GlcNAc...) asparagine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2).1 Publication
N- and O-glycosylated. N-glycosylation is required for optimal proteolytic activation. O-glycosylated with core 1 or possibly core 8 glycans.2 Publications
Ubiquitinated at Lys-294 by SYNV1/HRD1 via 'Lys-27'-linked ubiquitin.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei363 – 364Cleavage; by PS1By similarity2

Keywords - PTMi

Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q68CJ9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q68CJ9

PeptideAtlas

More...PeptideAtlasi		Q68CJ9

PRoteomics IDEntifications database

More...PRIDEi		Q68CJ9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		66003 [Q68CJ9-1]
66004 [Q68CJ9-2]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		804, 1 O-Linked glycan (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q68CJ9, 6 sites, 1 O-linked glycan (2 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q68CJ9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q68CJ9

UniCarbKB; an annotated and curated database of glycan structures

More...UniCarbKBi		Q68CJ9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Exclusively expressed in liver. Underexpressed in hepatocellular carcinoma tissues.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000060566, Expressed in right lobe of liver and 91 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q68CJ9, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000060566, Group enriched (intestine, liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds DNA as a dimer (By similarity). May form homodimers (PubMed:16469704).

Interacts with ATF6 (PubMed:16469704).

Interacts with SYNV1/HRD1; this interaction leads to CREB3L3 ubiquitination and proteasomal degradation (By similarity).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		124213, 34 interactors

Protein interaction database and analysis system

More...IntActi		Q68CJ9, 28 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000078445

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q68CJ9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q68CJ9

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini243 – 306bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni245 – 274Basic motifPROSITE-ProRule annotationAdd BLAST30
Regioni285 – 306Leucine-zipperPROSITE-ProRule annotationAdd BLAST22

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the bZIP family. ATF subfamily.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0709, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159261

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_047257_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q68CJ9

Identification of Orthologs from Complete Genome Data

More...OMAi		AIDLDMW

Database of Orthologous Groups

More...OrthoDBi		644485at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q68CJ9

TreeFam database of animal gene trees

More...TreeFami		TF316079

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004827, bZIP
IPR029806, CREBH

The PANTHER Classification System

More...PANTHERi		PTHR45996:SF1, PTHR45996:SF1, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00170, bZIP_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00338, BRLZ, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50217, BZIP, 1 hit
PS00036, BZIP_BASIC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q68CJ9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNTDLAAGKM ASAACSMDPI DSFELLDLLF DRQDGILRHV ELGEGWGHVK 
        60         70         80         90        100
DQQVLPNPDS DDFLSSILGS GDSLPSSPLW SPEGSDSGIS EDLPSDPQDT 
       110        120        130        140        150
PPRSGPATSP AGCHPAQPGK GPCLSYHPGN SCSTTTPGPV IQVPEASVTI 
       160        170        180        190        200
DLEMWSPGGR ICAEKPADPV DLSPRCNLTV KDLLLSGSSG DLQQHHLGAS 
       210        220        230        240        250
YLLRPGAGHC QELVLTEDEK KLLAKEGITL PTQLPLTKYE ERVLKKIRRK 
       260        270        280        290        300
IRNKQSAQES RKKKKEYIDG LETRMSACTA QNQELQRKVL HLEKQNLSLL 
       310        320        330        340        350
EQLKKLQAIV VQSTSKSAQT GTCVAVLLLS FALIILPSIS PFGPNKTESP 
       360        370        380        390        400
GDFAPVRVFS RTLHNDAASR VAADAVPGSE APGPRPEADT TREESPGSPG 
       410        420        430        440        450
ADWGFQDTAN LTNSTEELDN ATLVLRNATE GLGQVALLDW VAPGPSTGSG 
       460 
RAGLEAAGDE L
Length:461
Mass (Da):49,077
Last modified:May 29, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC40F5AA626661F80
GO
Isoform 2 (identifier: Q68CJ9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     53-53: Missing.

Show »
Length:460
Mass (Da):48,949
Checksum:i53E643AF4D09C329
GO
Isoform 3 (identifier: Q68CJ9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     193-194: Missing.

Show »
Length:459
Mass (Da):48,821
Checksum:iEBED4351D3DD72C3
GO
Isoform 4 (identifier: Q68CJ9-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     239-337: YEERVLKKIR...LLSFALIILP → DVSLHCSESG...AQRCCLPRGC
     338-461: Missing.

Show »
Length:337
Mass (Da):35,845
Checksum:i11A7E28F406DE1FC
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD18804 differs from that shown. Aberrant splicing.Curated
The sequence BAD18804 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti437L → P in BAD18804 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02563753Missing in isoform 2. 1 Publication1
Alternative sequenceiVSP_054876193 – 194Missing in isoform 3. 1 Publication2
Alternative sequenceiVSP_055635239 – 337YEERV…LIILP → DVSLHCSESGVTEESLASRE AKPVPLGATEETPGHCGAVH QQVSPDRHLCRSPVAVLCPH HPPLHQPFWPQQNREPWGLC ACTSVLQNFAQRCCLPRGC in isoform 4. 1 PublicationAdd BLAST99
Alternative sequenceiVSP_055636338 – 461Missing in isoform 4. 1 PublicationAdd BLAST124

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB050902 mRNA Translation: BAB47242.1
AB073612 mRNA Translation: BAD38649.1
AK172839 mRNA Translation: BAD18804.1 Sequence problems.
AK313099 mRNA Translation: BAG35923.1
AC016586 Genomic DNA No translation available.
CH471139 Genomic DNA Translation: EAW69260.1
BC101508 mRNA Translation: AAI01509.1
BC101504 mRNA Translation: AAI01505.1
BC143609 mRNA Translation: AAI43610.1
BC143610 mRNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12121.1 [Q68CJ9-1]
CCDS62498.1 [Q68CJ9-5]
CCDS62499.1 [Q68CJ9-4]
CCDS62500.1 [Q68CJ9-2]

NCBI Reference Sequences

More...RefSeqi		NP_001258924.1, NM_001271995.1 [Q68CJ9-2]
NP_001258925.1, NM_001271996.1 [Q68CJ9-4]
NP_001258926.1, NM_001271997.1 [Q68CJ9-5]
NP_115996.1, NM_032607.2 [Q68CJ9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000078445; ENSP00000078445; ENSG00000060566 [Q68CJ9-1]
ENST00000595923; ENSP00000469355; ENSG00000060566 [Q68CJ9-2]
ENST00000602147; ENSP00000470119; ENSG00000060566 [Q68CJ9-5]
ENST00000602257; ENSP00000472399; ENSG00000060566 [Q68CJ9-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		84699

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:84699

UCSC genome browser

More...UCSCi		uc002lzl.4, human [Q68CJ9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB050902 mRNA Translation: BAB47242.1
AB073612 mRNA Translation: BAD38649.1
AK172839 mRNA Translation: BAD18804.1 Sequence problems.
AK313099 mRNA Translation: BAG35923.1
AC016586 Genomic DNA No translation available.
CH471139 Genomic DNA Translation: EAW69260.1
BC101508 mRNA Translation: AAI01509.1
BC101504 mRNA Translation: AAI01505.1
BC143609 mRNA Translation: AAI43610.1
BC143610 mRNA No translation available.
CCDSiCCDS12121.1 [Q68CJ9-1]
CCDS62498.1 [Q68CJ9-5]
CCDS62499.1 [Q68CJ9-4]
CCDS62500.1 [Q68CJ9-2]
RefSeqiNP_001258924.1, NM_001271995.1 [Q68CJ9-2]
NP_001258925.1, NM_001271996.1 [Q68CJ9-4]
NP_001258926.1, NM_001271997.1 [Q68CJ9-5]
NP_115996.1, NM_032607.2 [Q68CJ9-1]

3D structure databases

SMRiQ68CJ9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi124213, 34 interactors
IntActiQ68CJ9, 28 interactors
STRINGi9606.ENSP00000078445

PTM databases

GlyConnecti804, 1 O-Linked glycan (1 site)
GlyGeniQ68CJ9, 6 sites, 1 O-linked glycan (2 sites)
iPTMnetiQ68CJ9
PhosphoSitePlusiQ68CJ9
UniCarbKBiQ68CJ9

Polymorphism and mutation databases

BioMutaiCREB3L3
DMDMi148886847

Proteomic databases

MassIVEiQ68CJ9
PaxDbiQ68CJ9
PeptideAtlasiQ68CJ9
PRIDEiQ68CJ9
ProteomicsDBi66003 [Q68CJ9-1]
66004 [Q68CJ9-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		42393, 57 antibodies

The DNASU plasmid repository

More...DNASUi		84699

Genome annotation databases

EnsembliENST00000078445; ENSP00000078445; ENSG00000060566 [Q68CJ9-1]
ENST00000595923; ENSP00000469355; ENSG00000060566 [Q68CJ9-2]
ENST00000602147; ENSP00000470119; ENSG00000060566 [Q68CJ9-5]
ENST00000602257; ENSP00000472399; ENSG00000060566 [Q68CJ9-4]
GeneIDi84699
KEGGihsa:84699
UCSCiuc002lzl.4, human [Q68CJ9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		84699
DisGeNETi84699
EuPathDBiHostDB:ENSG00000060566.13

GeneCards: human genes, protein and diseases

More...GeneCardsi		CREB3L3
HGNCiHGNC:18855, CREB3L3
HPAiENSG00000060566, Group enriched (intestine, liver)
MIMi611998, gene
neXtProtiNX_Q68CJ9
OpenTargetsiENSG00000060566
PharmGKBiPA134882161

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0709, Eukaryota
GeneTreeiENSGT00940000159261
HOGENOMiCLU_047257_1_0_1
InParanoidiQ68CJ9
OMAiAIDLDMW
OrthoDBi644485at2759
PhylomeDBiQ68CJ9
TreeFamiTF316079

Enzyme and pathway databases

PathwayCommonsiQ68CJ9
ReactomeiR-HSA-8874211, CREB3 factors activate genes
R-HSA-8963889, Assembly of active LPL and LIPC lipase complexes

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		84699, 5 hits in 865 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CREB3L3, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		84699
PharosiQ68CJ9, Tbio

Protein Ontology

More...PROi		PR:Q68CJ9
RNActiQ68CJ9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000060566, Expressed in right lobe of liver and 91 other tissues
GenevisibleiQ68CJ9, HS

Family and domain databases

InterProiView protein in InterPro
IPR004827, bZIP
IPR029806, CREBH
PANTHERiPTHR45996:SF1, PTHR45996:SF1, 1 hit
PfamiView protein in Pfam
PF00170, bZIP_1, 1 hit
SMARTiView protein in SMART
SM00338, BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217, BZIP, 1 hit
PS00036, BZIP_BASIC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCR3L3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q68CJ9
Secondary accession number(s): B2R7S6
, B7ZL69, M0QYW7, Q6ZMC5, Q96TB9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: December 2, 2020
This is version 156 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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