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Protein

Olfactomedin-like protein 2B

Gene

OLFML2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactomedin-like protein 2B
Alternative name(s):
Photomedin-2
Gene namesi
Name:OLFML2B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162745.10
HGNCiHGNC:24558 OLFML2B
neXtProtiNX_Q68BL8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi25903
OpenTargetsiENSG00000162745
PharmGKBiPA134990758

Polymorphism and mutation databases

BioMutaiOLFML2B
DMDMi160418997

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
ChainiPRO_000031142623 – 750Olfactomedin-like protein 2BAdd BLAST728

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi187N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi213N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi494 ↔ 680PROSITE-ProRule annotation
Glycosylationi695N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

O-glycosylated and N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ68BL8
PaxDbiQ68BL8
PeptideAtlasiQ68BL8
PRIDEiQ68BL8
ProteomicsDBi65999
66000 [Q68BL8-2]
TopDownProteomicsiQ68BL8-1 [Q68BL8-1]

PTM databases

iPTMnetiQ68BL8
PhosphoSitePlusiQ68BL8

Expressioni

Gene expression databases

BgeeiENSG00000162745
CleanExiHS_OLFML2B
ExpressionAtlasiQ68BL8 baseline and differential
GenevisibleiQ68BL8 HS

Organism-specific databases

HPAiHPA054136
HPA062739

Interactioni

Subunit structurei

Homodimer. Binds to heparin and chondroitin sulfate E (By similarity).By similarity

Protein-protein interaction databases

BioGridi117410, 5 interactors
STRINGi9606.ENSP00000294794

Structurei

3D structure databases

ProteinModelPortaliQ68BL8
SMRiQ68BL8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini493 – 750Olfactomedin-likePROSITE-ProRule annotationAdd BLAST258

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili40 – 68Sequence analysisAdd BLAST29
Coiled coili179 – 213Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi233 – 238Poly-Ala6

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiKOG3545 Eukaryota
ENOG410ZJ72 LUCA
GeneTreeiENSGT00760000119005
HOGENOMiHOG000043072
HOVERGENiHBG108214
InParanoidiQ68BL8
PhylomeDBiQ68BL8
TreeFamiTF351220

Family and domain databases

InterProiView protein in InterPro
IPR003112 Olfac-like_dom
IPR031233 OLFML2B
PANTHERiPTHR23192:SF37 PTHR23192:SF37, 1 hit
PfamiView protein in Pfam
PF02191 OLF, 1 hit
SMARTiView protein in SMART
SM00284 OLF, 1 hit
PROSITEiView protein in PROSITE
PS51132 OLF, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q68BL8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKPRLLVLY FALIVVPAWV SSIVLTGTSE PPDAQTVAPA EDETLQNEAD
60 70 80 90 100
NQENVLSQLL GDYDKVKAMS EGSDCQCKCV VRPLGRDACQ RINAGASRKE
110 120 130 140 150
DFYTVETITS GSSCKCACVA PPSALNPCEG DFRLQKLREA DSQDLKLSTI
160 170 180 190 200
IDMLEGAFYG LDLLKLHSVT TKLVGRVDKL EEEVSKNLTK ENEQIKEDME
210 220 230 240 250
EIRTEMNKRG KENCSENILD SMPDIRSALQ RDAAAAYAHP EYEERFLQEE
260 270 280 290 300
TVSQQINSIE LLQTRPLALP EVVKSQRPLQ RQVHLRGRPA SQPTVIRGIT
310 320 330 340 350
YYKAKVSEEE NDIEEQQDEF FSGDNGVDLL IEDQLLRHNG LMTSVTRRPA
360 370 380 390 400
ATRQGHSTAV TSDLNARTAP WSSALPQPST SDPSIANHAS VGPTLQTTSV
410 420 430 440 450
SPDPTRESVL QPSPQVPATT VAHTATQQPA APAPPAVSPR EALMEAMHTV
460 470 480 490 500
PVPPTTVRTD SLGKDAPAGW GTTPASPTLS PEEEDDIRNV IGRCKDTLST
510 520 530 540 550
ITGPTTQNTY GRNEGAWMKD PLAKDERIYV TNYYYGNTLV EFRNLENFKQ
560 570 580 590 600
GRWSNSYKLP YSWIGTGHVV YNGAFYYNRA FTRNIIKYDL KQRYVAAWAM
610 620 630 640 650
LHDVAYEEAT PWRWQGHSDV DFAVDENGLW LIYPALDDEG FSQEVIVLSK
660 670 680 690 700
LNAADLSTQK ETTWRTGLRR NFYGNCFVIC GVLYAVDSYN QRNANISYAF
710 720 730 740 750
DTHTNTQIVP RLLFENEYSY TTQIDYNPKD RLLYAWDNGH QVTYHVIFAY
Length:750
Mass (Da):83,999
Last modified:November 13, 2007 - v2
Checksum:i85014757EDC8C3D0
GO
Isoform 2 (identifier: Q68BL8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-517: Missing.

Show »
Length:233
Mass (Da):27,554
Checksum:i5044803E2AA2FECC
GO

Sequence cautioni

The sequence CAH71496 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03724810Y → C. Corresponds to variant dbSNP:rs12130792Ensembl.1
Natural variantiVAR_037249470W → R2 PublicationsCorresponds to variant dbSNP:rs2499836Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0295641 – 517Missing in isoform 2. 1 PublicationAdd BLAST517

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB119054 mRNA Translation: BAD38863.1
AK316154 mRNA Translation: BAH14525.1
BX648975 mRNA Translation: CAI45982.1
AL050137 mRNA Translation: CAB43286.1
AL590408, AL391825 Genomic DNA Translation: CAH71496.1 Sequence problems.
AL391825, AL590408 Genomic DNA Translation: CAH73984.1
AL391825 Genomic DNA Translation: CAH73987.1
BC047472 mRNA Translation: AAH47472.1
BC067274 mRNA Translation: AAH67274.1
CCDSiCCDS1236.1 [Q68BL8-1]
PIRiT08771
RefSeqiNP_001284642.1, NM_001297713.1
NP_001334629.1, NM_001347700.1
NP_056256.1, NM_015441.2 [Q68BL8-1]
UniGeneiHs.507515

Genome annotation databases

EnsembliENST00000294794; ENSP00000294794; ENSG00000162745 [Q68BL8-1]
ENST00000367938; ENSP00000356915; ENSG00000162745 [Q68BL8-2]
GeneIDi25903
KEGGihsa:25903
UCSCiuc001gbt.4 human [Q68BL8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOLM2B_HUMAN
AccessioniPrimary (citable) accession number: Q68BL8
Secondary accession number(s): B7ZA39
, Q5VU96, Q6NX46, Q86X11, Q9Y3X6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: June 20, 2018
This is version 100 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

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