UniProtKB - Q68AZ0 (CCL4_CANLF)
Protein
C-C motif chemokine 4
Gene
CCL4
Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Functioni
Monokine with inflammatory and chemokinetic properties.By similarity
GO - Molecular functioni
- CCR chemokine receptor binding Source: GO_Central
- chemokine activity Source: GO_Central
GO - Biological processi
- cellular response to interferon-gamma Source: GO_Central
- cellular response to interleukin-1 Source: GO_Central
- cellular response to tumor necrosis factor Source: GO_Central
- chemokine-mediated signaling pathway Source: GO_Central
- eosinophil chemotaxis Source: GO_Central
- G protein-coupled receptor signaling pathway Source: GO_Central
- inflammatory response Source: GO_Central
- lymphocyte chemotaxis Source: GO_Central
- monocyte chemotaxis Source: GO_Central
- neutrophil chemotaxis Source: GO_Central
- positive regulation of ERK1 and ERK2 cascade Source: GO_Central
- positive regulation of GTPase activity Source: GO_Central
Keywordsi
Molecular function | Cytokine |
Biological process | Chemotaxis, Inflammatory response |
Enzyme and pathway databases
Reactomei | R-CFA-418594, G alpha (i) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: C-C motif chemokine 4Alternative name(s): Small-inducible cytokine A4 |
Gene namesi | Name:CCL4 Synonyms:SCYA4 |
Organismi | Canis lupus familiaris (Dog) (Canis familiaris) |
Taxonomic identifieri | 9615 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis › |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular space Source: GO_Central
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | By similarityAdd BLAST | 23 | |
ChainiPRO_0000326236 | 24 – 92 | C-C motif chemokine 4Add BLAST | 69 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 34 ↔ 58 | By similarity | ||
Disulfide bondi | 35 ↔ 74 | By similarity |
Keywords - PTMi
Disulfide bondProteomic databases
PaxDbi | Q68AZ0 |
Expressioni
Gene expression databases
Bgeei | ENSCAFG00000018164, Expressed in stomach and 49 other tissues |
Interactioni
Subunit structurei
Homodimer.
Interacts with CCR5 (By similarity).
By similarityGO - Molecular functioni
- CCR chemokine receptor binding Source: GO_Central
- chemokine activity Source: GO_Central
Protein-protein interaction databases
STRINGi | 9612.ENSCAFP00000026825 |
Family & Domainsi
Sequence similaritiesi
Belongs to the intercrine beta (chemokine CC) family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S8M4, Eukaryota |
GeneTreei | ENSGT00940000165089 |
HOGENOMi | CLU_141716_4_0_1 |
InParanoidi | Q68AZ0 |
OMAi | VMDYYET |
OrthoDBi | 1575018at2759 |
TreeFami | TF334888 |
Family and domain databases
InterProi | View protein in InterPro IPR039809, Chemokine_b/g/d IPR000827, Chemokine_CC_CS IPR001811, Chemokine_IL8-like_dom IPR036048, Interleukin_8-like_sf |
PANTHERi | PTHR12015, PTHR12015, 1 hit |
Pfami | View protein in Pfam PF00048, IL8, 1 hit |
SMARTi | View protein in SMART SM00199, SCY, 1 hit |
SUPFAMi | SSF54117, SSF54117, 1 hit |
PROSITEi | View protein in PROSITE PS00472, SMALL_CYTOKINES_CC, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
Q68AZ0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKLCVTVLSL LVLVAAFCSP ALSAPMGSDP PTACCFSYTL RKIPRNFVAD
60 70 80 90
YFETSSLCSQ PAVVFQTRRG RQVCANPSEP WVQEYMDDLE LN
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE2RA85 | E2RA85_CANLF | C-C motif chemokine | LOC480600 | 93 | Annotation score: | ||
A0A5F4C268 | A0A5F4C268_CANLF | C-C motif chemokine | LOC480600 | 93 | Annotation score: | ||
A0A5F4BY13 | A0A5F4BY13_CANLF | SCY domain-containing protein | LOC480600 | 97 | Annotation score: | ||
A0A5F4DC55 | A0A5F4DC55_CANLF | SCY domain-containing protein | LOC480600 | 80 | Annotation score: | ||
A0A5F4BTV1 | A0A5F4BTV1_CANLF | SCY domain-containing protein | LOC480600 | 64 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB163435 mRNA Translation: BAD37148.1 AB183194 mRNA Translation: BAD83842.1 |
RefSeqi | NP_001005250.1, NM_001005250.1 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB163435 mRNA Translation: BAD37148.1 AB183194 mRNA Translation: BAD83842.1 |
RefSeqi | NP_001005250.1, NM_001005250.1 |
3D structure databases
SMRi | Q68AZ0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9612.ENSCAFP00000026825 |
Proteomic databases
PaxDbi | Q68AZ0 |
Genome annotation databases
Organism-specific databases
CTDi | 6351 |
Phylogenomic databases
eggNOGi | ENOG502S8M4, Eukaryota |
GeneTreei | ENSGT00940000165089 |
HOGENOMi | CLU_141716_4_0_1 |
InParanoidi | Q68AZ0 |
OMAi | VMDYYET |
OrthoDBi | 1575018at2759 |
TreeFami | TF334888 |
Enzyme and pathway databases
Reactomei | R-CFA-418594, G alpha (i) signalling events |
Gene expression databases
Bgeei | ENSCAFG00000018164, Expressed in stomach and 49 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR039809, Chemokine_b/g/d IPR000827, Chemokine_CC_CS IPR001811, Chemokine_IL8-like_dom IPR036048, Interleukin_8-like_sf |
PANTHERi | PTHR12015, PTHR12015, 1 hit |
Pfami | View protein in Pfam PF00048, IL8, 1 hit |
SMARTi | View protein in SMART SM00199, SCY, 1 hit |
SUPFAMi | SSF54117, SSF54117, 1 hit |
PROSITEi | View protein in PROSITE PS00472, SMALL_CYTOKINES_CC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CCL4_CANLF | |
Accessioni | Q68AZ0Primary (citable) accession number: Q68AZ0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 18, 2008 |
Last sequence update: | October 11, 2004 | |
Last modified: | December 2, 2020 | |
This is version 101 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families