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Protein

Regenerating islet-derived protein 4

Gene

Reg4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandLectin

Names & Taxonomyi

Protein namesi
Recommended name:
Regenerating islet-derived protein 4
Short name:
REG-4
Gene namesi
Name:Reg4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1303341 Reg4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
ChainiPRO_000001743923 – 157Regenerating islet-derived protein 4Add BLAST135

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 40PROSITE-ProRule annotation
Glycosylationi49N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi57 ↔ 153PROSITE-ProRule annotation
Glycosylationi62N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi101N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi128 ↔ 145PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ68AX7
PRIDEiQ68AX7

Expressioni

Gene expression databases

BgeeiENSRNOG00000019046 Expressed in 4 organ(s), highest expression level in colon

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025821

Structurei

3D structure databases

ProteinModelPortaliQ68AX7
SMRiQ68AX7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 154C-type lectinPROSITE-ProRule annotationAdd BLAST119

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni97 – 101Carbohydrate-bindingBy similarity5
Regioni134 – 136Carbohydrate-bindingBy similarity3

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00700000104249
HOGENOMiHOG000010281
HOVERGENiHBG004151
InParanoidiQ68AX7
KOiK22244
OMAiHFICKFT
OrthoDBiEOG091G0PSR
PhylomeDBiQ68AX7

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q68AX7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASKCVRLLL LLSWVAGPEV LSDILRPSCA SGWFNYRSHC YGYFRKLRNW
60 70 80 90 100
SHAELECQSY GNGSHLASVL NPKEASVISK YITGYQRSLP VWIGLHDPQK
110 120 130 140 150
NASWQWIDGS TNQYRPWSPR TKSEARHCTE MNPKDKFLTW NKNGCTKRQH

FLCKYRP
Length:157
Mass (Da):18,269
Last modified:October 11, 2004 - v1
Checksum:i55B129FB10BA4D1D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB164049 mRNA Translation: BAD38673.1
RefSeqiNP_001004096.1, NM_001004096.1
XP_006233071.1, XM_006233009.3
XP_008759543.1, XM_008761321.2
XP_017446498.1, XM_017591009.1
UniGeneiRn.83573

Genome annotation databases

EnsembliENSRNOT00000025821; ENSRNOP00000025821; ENSRNOG00000019046
GeneIDi445583
KEGGirno:445583
UCSCiRGD:1303341 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB164049 mRNA Translation: BAD38673.1
RefSeqiNP_001004096.1, NM_001004096.1
XP_006233071.1, XM_006233009.3
XP_008759543.1, XM_008761321.2
XP_017446498.1, XM_017591009.1
UniGeneiRn.83573

3D structure databases

ProteinModelPortaliQ68AX7
SMRiQ68AX7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025821

Proteomic databases

PaxDbiQ68AX7
PRIDEiQ68AX7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000025821; ENSRNOP00000025821; ENSRNOG00000019046
GeneIDi445583
KEGGirno:445583
UCSCiRGD:1303341 rat

Organism-specific databases

CTDi83998
RGDi1303341 Reg4

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00700000104249
HOGENOMiHOG000010281
HOVERGENiHBG004151
InParanoidiQ68AX7
KOiK22244
OMAiHFICKFT
OrthoDBiEOG091G0PSR
PhylomeDBiQ68AX7

Miscellaneous databases

PROiPR:Q68AX7

Gene expression databases

BgeeiENSRNOG00000019046 Expressed in 4 organ(s), highest expression level in colon

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiREG4_RAT
AccessioniPrimary (citable) accession number: Q68AX7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: October 11, 2004
Last modified: October 10, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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