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Protein

Alkaline nuclease

Gene

AE

Organism
Human herpesvirus 1 (HHV-1) (Human herpes simplex virus 1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays a role in processing non linear or branched viral DNA intermediates in order to promote the production of mature packaged unit-length linear progeny viral DNA molecules. Exhibits endonuclease and exonuclease activities and accepts both double-stranded and single-stranded DNA as substrate. Exonuclease digestion of DNA is in the 5'-> 3' direction and the products are 5'-monophosphate nucleosides. Additionally, forms a recombinase with the major DNA-binding protein, which displays strand exchange activity.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei280Required for functionUniRule annotation1
Sitei340Required for functionUniRule annotation1
Sitei364Required for functionUniRule annotation1
Sitei366Required for functionUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonucleaseUniRule annotation, ExonucleaseUniRule annotationImported, Hydrolase, Nuclease
Biological processHost-virus interactionUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Alkaline nucleaseUniRule annotation (EC:3.1.-.-UniRule annotation)
Gene namesi
Name:AEImported
Synonyms:UL12Imported
OrganismiHuman herpesvirus 1 (HHV-1) (Human herpes simplex virus 1)Imported
Taxonomic identifieri10298 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000110982 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasmUniRule annotation, Host nucleusUniRule annotation

Interactioni

Subunit structurei

Interacts with major DNA-binding protein; this interaction increases the nuclease processivity of the alkaline exonuclease.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae alkaline nuclease family.UniRule annotation

Family and domain databases

Gene3Di3.90.320.10, 1 hit
HAMAPiMF_04009 HSV_AN, 1 hit
InterProiView protein in InterPro
IPR011604 Exonuc_phg/RecB_C
IPR001616 Herpes_alk_exo
IPR011335 Restrct_endonuc-II-like
IPR034720 Viral_alk_exo
PfamiView protein in Pfam
PF01771 Herpes_alk_exo, 1 hit
PRINTSiPR00924 ALKEXNUCLASE
SUPFAMiSSF52980 SSF52980, 1 hit

Sequencei

Sequence statusi: Complete.

Q68978-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESTGGPACP PGRTVTKRSW ALAEDTPRGP DSPPKRPRPN SLPLTTTFRP
60 70 80 90 100
LPPPPQTTSA VDPSSHSPVN PPRDQHATDT ADEKPRAASP ALSDASGPPT
110 120 130 140 150
PDIPLSPGGT HARDPDADPD SPDLDSMWSA SVIPNALPSH ILAETFERHL
160 170 180 190 200
RGLLRGVRAP LAIGPLWARL DYLCSLAVVL EEAGMVDRGL GRHLWRLTRR
210 220 230 240 250
APPAAADAVA PRPLMGFYEA ATQNQADCQL WALLRRGLTT ASTLRWGPQG
260 270 280 290 300
PCFSPQWLKH NASLRPDVQS SAVMFGRVNE PTARSLLFRY CVGRADDGGE
310 320 330 340 350
AGADTRRFIF HEPSDLAEEN VHTCGVLMDG HTGMVGASLD ILVCPRDIHG
360 370 380 390 400
YLAPVPKTPL AFYEVKCRAK YAFDPMDPSD PTASAYEDLM AHRSPEAFRA
410 420 430 440 450
FIRSIPKPSV RYFAPGRVPG PEEALVTQDQ AWSEAHASGE KRRCSAADRA
460 470 480 490 500
LVELNSGVVS EVLLFGAPDL GRHTISPVSW SSGDLVRREP VFANPRHPNF
510 520 530 540 550
KQILVQGYVL DSHFPDCPPH PHLVTFIGRH RTSAEEGVTF RLEDGAGALG
560 570 580 590 600
AAGPSKASIL PNQAVPIALI ITPVRIDPEI YKAIQRSSRL AFDDTLAELW
610 620
ASRSPGPGPA AAETTSSSPT TGRSSR
Length:626
Mass (Da):67,470
Last modified:November 1, 1996 - v1
Checksum:iA651D03A29C70260
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02022 Genomic DNA Translation: AAA45771.1
DQ889502 Genomic DNA Translation: ABI63474.1
JN420339 Genomic DNA Translation: AER37806.1
KT425109 Genomic DNA Translation: ALM22728.1
KX946970 Genomic DNA Translation: AOY36630.1
MH160377 Genomic DNA Translation: AWO70821.1
MH160385 Genomic DNA Translation: AWO71570.1
MG999891 Genomic DNA Translation: AWW12638.1
LT594109 Genomic DNA Translation: SBS69299.1
LT594110 Genomic DNA Translation: SBS69350.1
LT594111 Genomic DNA Translation: SBS69367.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02022 Genomic DNA Translation: AAA45771.1
DQ889502 Genomic DNA Translation: ABI63474.1
JN420339 Genomic DNA Translation: AER37806.1
KT425109 Genomic DNA Translation: ALM22728.1
KX946970 Genomic DNA Translation: AOY36630.1
MH160377 Genomic DNA Translation: AWO70821.1
MH160385 Genomic DNA Translation: AWO71570.1
MG999891 Genomic DNA Translation: AWW12638.1
LT594109 Genomic DNA Translation: SBS69299.1
LT594110 Genomic DNA Translation: SBS69350.1
LT594111 Genomic DNA Translation: SBS69367.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.90.320.10, 1 hit
HAMAPiMF_04009 HSV_AN, 1 hit
InterProiView protein in InterPro
IPR011604 Exonuc_phg/RecB_C
IPR001616 Herpes_alk_exo
IPR011335 Restrct_endonuc-II-like
IPR034720 Viral_alk_exo
PfamiView protein in Pfam
PF01771 Herpes_alk_exo, 1 hit
PRINTSiPR00924 ALKEXNUCLASE
SUPFAMiSSF52980 SSF52980, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ68978_HHV1
AccessioniPrimary (citable) accession number: Q68978
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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