UniProtKB - Q688C4 (ID3_XENTR)
Protein
DNA-binding protein inhibitor ID-3
Gene
id3
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Functioni
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Influences cell fate decisions in the embryo by sequestering and blocking the activity of the bHLH transcription factors that control these decisions. Inhibits the binding of myogenic bHLH-containing complexes to E-box DNA, thereby preventing activation of muscle-specific target genes. Also inhibits the activity of neurogenic factor neurod1/neuroD. Plays a role in cell cycle progression and survival of neural crest progenitors; binding to either hes4-B/hairy2b or stat3 blocks the formation of transcription factor complexes and the repressor function of hes4-B/hairy2B, to allow neural crest progenitors to differentiate. May play a role in the regulation of the circadian rhythm (By similarity).By similarity
GO - Molecular functioni
- bHLH transcription factor binding Source: UniProtKB
- protein dimerization activity Source: InterPro
GO - Biological processi
- cell differentiation Source: GO_Central
- circadian regulation of gene expression Source: GO_Central
- dopaminergic neuron differentiation Source: Ensembl
- negative regulation of DNA binding Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- neural crest formation Source: UniProtKB
- regulation of cell cycle Source: UniProtKB
Keywordsi
Molecular function | Developmental protein, Repressor |
Biological process | Biological rhythms, Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: DNA-binding protein inhibitor ID-3By similarityAlternative name(s): Inhibitor of DNA binding 3By similarity Inhibitor of differentiation 3 |
Gene namesi | Name:id3 ORF Names:TGas044c15.1 |
Organismi | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
Taxonomic identifieri | 8364 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana |
Proteomesi |
|
Organism-specific databases
Xenbasei | XB-GENE-495261, id3 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotationBy similarity
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000390726 | 1 – 118 | DNA-binding protein inhibitor ID-3Add BLAST | 118 |
Proteomic databases
PaxDbi | Q688C4 |
Expressioni
Gene expression databases
Bgeei | ENSXETG00000020653, Expressed in embryo and 21 other tissues |
Interactioni
Subunit structurei
Homodimer (By similarity). Heterodimer with other HLH proteins.
Interacts (via HLH domain) with the bHLH protein hes4/hairy2 (via Orange domain).
Interacts with stat3 (By similarity).
By similarityGO - Molecular functioni
- bHLH transcription factor binding Source: UniProtKB
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
STRINGi | 8364.ENSXETP00000044625 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 32 – 84 | bHLHPROSITE-ProRule annotationAdd BLAST | 53 |
Phylogenomic databases
eggNOGi | ENOG502S53I, Eukaryota |
GeneTreei | ENSGT00940000160504 |
HOGENOMi | CLU_116790_1_0_1 |
InParanoidi | Q688C4 |
OMAi | RNKHSCL |
OrthoDBi | 1624054at2759 |
TreeFami | TF326217 |
Family and domain databases
CDDi | cd00083, HLH, 1 hit |
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR026052, DNA-bd_prot-inh IPR036638, HLH_DNA-bd_sf |
PANTHERi | PTHR11723, PTHR11723, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
Q688C4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKAISPVRSM SSCYQAVCCL SEQSLSIARG SSHKGPGVDE PMGLLYDMNG
60 70 80 90 100
CYSKLKELVP GIPQGSKLSQ VEILQHVIDY IFDLQIVLGE DQQQNSILNL
110
QKSDFSELAT QGDASVCH
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF6VZR3 | F6VZR3_XENTR | Sodium channel protein | stk11ip id3 | 1,108 | Annotation score: | ||
A0A6I8QPR5 | A0A6I8QPR5_XENTR | Serine/threonine-protein kinase 11-... | stk11ip | 1,135 | Annotation score: | ||
A0A6I8QSR8 | A0A6I8QSR8_XENTR | Serine/threonine-protein kinase 11-... | stk11ip | 299 | Annotation score: | ||
A0A6I8RI91 | A0A6I8RI91_XENTR | Serine/threonine-protein kinase 11-... | stk11ip | 1,160 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC151468 Genomic DNA Translation: AAU12853.1 CR761665 mRNA Translation: CAJ83590.1 BC170654 mRNA Translation: AAI70654.1 BC170656 mRNA Translation: AAI70656.1 |
RefSeqi | NP_001016271.1, NM_001016271.2 |
Genome annotation databases
Ensembli | ENSXETT00000044625; ENSXETP00000044625; ENSXETG00000020653 |
GeneIDi | 549025 |
KEGGi | xtr:549025 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC151468 Genomic DNA Translation: AAU12853.1 CR761665 mRNA Translation: CAJ83590.1 BC170654 mRNA Translation: AAI70654.1 BC170656 mRNA Translation: AAI70656.1 |
RefSeqi | NP_001016271.1, NM_001016271.2 |
3D structure databases
SMRi | Q688C4 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 8364.ENSXETP00000044625 |
Proteomic databases
PaxDbi | Q688C4 |
Genome annotation databases
Ensembli | ENSXETT00000044625; ENSXETP00000044625; ENSXETG00000020653 |
GeneIDi | 549025 |
KEGGi | xtr:549025 |
Organism-specific databases
CTDi | 3399 |
Xenbasei | XB-GENE-495261, id3 |
Phylogenomic databases
eggNOGi | ENOG502S53I, Eukaryota |
GeneTreei | ENSGT00940000160504 |
HOGENOMi | CLU_116790_1_0_1 |
InParanoidi | Q688C4 |
OMAi | RNKHSCL |
OrthoDBi | 1624054at2759 |
TreeFami | TF326217 |
Gene expression databases
Bgeei | ENSXETG00000020653, Expressed in embryo and 21 other tissues |
Family and domain databases
CDDi | cd00083, HLH, 1 hit |
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR026052, DNA-bd_prot-inh IPR036638, HLH_DNA-bd_sf |
PANTHERi | PTHR11723, PTHR11723, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ID3_XENTR | |
Accessioni | Q688C4Primary (citable) accession number: Q688C4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 19, 2010 |
Last sequence update: | October 11, 2004 | |
Last modified: | December 2, 2020 | |
This is version 93 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |