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UniProtKB - Q687X5 (STEA4_HUMAN)

Entry version 134 (02 Dec 2020)
Sequence version 1 (11 Oct 2004)
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Protein

Metalloreductase STEAP4

Gene

STEAP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Integral membrane protein that functions as NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe3+ chelate that is bound on the other side of the membrane. Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe3+ chelate (PubMed:30337524). Can also reduce Cu2+ to Cu1+ (By similarity). Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin-resistance (PubMed:18430367, PubMed:18381574). Involved in inflammatory arthritis, through the regulation of inflammatory cytokines (PubMed:19660107). Inhibits anchorage-independent cell proliferation (PubMed:19787193).By similarity5 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=13.7 µM for Fe3+-NTA1 Publication
  2. KM=4.2 µM for NADPH1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei67NADPCombined sources1 Publication1
    Binding sitei106NADP; via amide nitrogenCombined sources1 Publication1
    Binding sitei139NADP; via amide nitrogenBy similarity1
    Binding sitei140FADCombined sources1 Publication1
    Binding sitei148FADCombined sources1 Publication1
    Binding sitei171NADPBy similarity1
    Binding sitei269FADCombined sources1 Publication1
    Binding sitei290FADCombined sources1 Publication1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi304Iron (heme axial ligand)Combined sources1 Publication1
    Binding sitei366FADCombined sources1 Publication1
    Binding sitei383FADCombined sources1 Publication1
    Metal bindingi397Iron (heme axial ligand)Combined sources1 Publication1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi27 – 30NADPCombined sources1 Publication4
    Nucleotide bindingi49 – 50NADPCombined sources1 Publication2
    Nucleotide bindingi81 – 85NADPCombined sources1 Publication5

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    GO - Biological processi

    Complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionOxidoreductase
    Biological processElectron transport, Ion transport, Iron transport, Transport
    LigandCopper, FAD, Flavoprotein, Heme, Iron, Metal-binding, NADP

    Enzyme and pathway databases

    Pathway Commons web resource for biological pathway data

    More...    PathwayCommonsi    		Q687X5

    Protein family/group databases

    Transport Classification Database

    More...    TCDBi    		5.B.6.1.3, the transmembrane epithelial antigen protein-3 ferric reductase (steap) family

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Metalloreductase STEAP4 (EC:1.16.1.91 Publication)
    Alternative name(s):
    Six-transmembrane epithelial antigen of prostate 4
    SixTransMembrane protein of prostate 2
    Tumor necrosis factor, alpha-induced protein 9
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:STEAP4
    Synonyms:STAMP21 Publication, TNFAIP9
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

    Organism-specific databases

    Eukaryotic Pathogen and Host Database Resources

    More...    EuPathDBi    		HostDB:ENSG00000127954.12

    Human Gene Nomenclature Database

    More...    HGNCi    		HGNC:21923, STEAP4

    Online Mendelian Inheritance in Man (OMIM)

    More...    MIMi    		611098, gene

    neXtProt; the human protein knowledge platform

    More...    neXtProti    		NX_Q687X5

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei202 – 224Helical1 PublicationAdd BLAST23
    Transmembranei236 – 256Helical1 PublicationAdd BLAST21
    Transmembranei293 – 313Helical1 PublicationAdd BLAST21
    Transmembranei342 – 362Helical1 PublicationAdd BLAST21
    Transmembranei381 – 401Helical1 PublicationAdd BLAST21
    Transmembranei419 – 439Helical1 PublicationAdd BLAST21

    Keywords - Cellular componenti

    Cell membrane, Endosome, Golgi apparatus, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi138S → Q: Strongly reduced enzyme activity. No effect on trimerization and on heme binding. 1 Publication1

    Organism-specific databases

    DisGeNET

    More...    DisGeNETi    		79689

    Open Targets

    More...    OpenTargetsi    		ENSG00000127954

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...    PharmGKBi    		PA134874572

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...    Pharosi    		Q687X5, Tbio

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...    BioMutai    		STEAP4

    Domain mapping of disease mutations (DMDM)

    More...    DMDMi    		74748242

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002851741 – 459Metalloreductase STEAP4Add BLAST459

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi323N-linked (GlcNAc...) asparagineCombined sources2 Publications1

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...    EPDi    		Q687X5

    jPOST - Japan Proteome Standard Repository/Database

    More...    jPOSTi    		Q687X5

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...    MassIVEi    		Q687X5

    MaxQB - The MaxQuant DataBase

    More...    MaxQBi    		Q687X5

    PaxDb, a database of protein abundance averages across all three domains of life

    More...    PaxDbi    		Q687X5

    PeptideAtlas

    More...    PeptideAtlasi    		Q687X5

    PRoteomics IDEntifications database

    More...    PRIDEi    		Q687X5

    ProteomicsDB: a multi-organism proteome resource

    More...    ProteomicsDBi    		65993 [Q687X5-1]
    65994 [Q687X5-2]

    PTM databases

    GlyGen: Computational and Informatics Resources for Glycoscience

    More...    GlyGeni    		Q687X5, 1 site

    iPTMnet integrated resource for PTMs in systems biology context

    More...    iPTMneti    		Q687X5

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...    PhosphoSitePlusi    		Q687X5

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Ubiquitous. Highly expressed in adipose tissue. Expressed in placenta, lung, heart and prostate. Detected at lower levels in liver, skeletal muscle, pancreas, testis and small intestine. Highly expressed in joints of patients with rheumatoid arthritis and localized with CD68 cells, a marker for macrophages.6 Publications

    <p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    By TNF and IL1B/interleukin-1 beta in adipose tissue. Up-regulated by androgens, including testosterone and dihydrotestosterone (DHT).3 Publications

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...    Bgeei    		ENSG00000127954, Expressed in pericardium and 197 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...    ExpressionAtlasi    		Q687X5, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...    Genevisiblei    		Q687X5, HS

    Organism-specific databases

    Human Protein Atlas

    More...    HPAi    		ENSG00000127954, Tissue enhanced (adipose)

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homotrimer (PubMed:30337524).

    Interacts with PTK2/FAK1; the interaction may regulate PTK2 phosphorylation.

    2 Publications

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...    BioGRIDi    		122810, 2 interactors

    Protein interaction database and analysis system

    More...    IntActi    		Q687X5, 2 interactors

    STRING: functional protein association networks

    More...    STRINGi    		9606.ENSP00000369419

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...    RNActi    		Q687X5, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1459
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...    SMRi    		Q687X5

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    Protein Data Bank in Europe - Knowledge Base

    More...    PDBe-KBi    		Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini247 – 395Ferric oxidoreductaseSequence analysisAdd BLAST149

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the STEAP family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		ENOG502R746, Eukaryota

    Ensembl GeneTree

    More...    GeneTreei    		ENSGT00390000008042

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...    HOGENOMi    		CLU_034618_1_1_1

    InParanoid: Eukaryotic Ortholog Groups

    More...    InParanoidi    		Q687X5

    Identification of Orthologs from Complete Genome Data

    More...    OMAi    		CTFHTYL

    Database of Orthologous Groups

    More...    OrthoDBi    		638341at2759

    Database for complete collections of gene phylogenies

    More...    PhylomeDBi    		Q687X5

    TreeFam database of animal gene trees

    More...    TreeFami    		TF332031

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR013130, Fe3_Rdtase_TM_dom
    IPR036291, NAD(P)-bd_dom_sf
    IPR028939, P5C_Rdtase_cat_N

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF03807, F420_oxidored, 1 hit
    PF01794, Ferric_reduct, 1 hit

    Superfamily database of structural and functional annotation

    More...    SUPFAMi    		SSF51735, SSF51735, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q687X5-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MEKTCIDALP LTMNSSEKQE TVCIFGTGDF GRSLGLKMLQ CGYSVVFGSR 
            60         70         80         90        100
    NPQKTTLLPS GAEVLSYSEA AKKSGIIIIA IHREHYDFLT ELTEVLNGKI 
           110        120        130        140        150
    LVDISNNLKI NQYPESNAEY LAHLVPGAHV VKAFNTISAW ALQSGALDAS 
           160        170        180        190        200
    RQVFVCGNDS KAKQRVMDIV RNLGLTPMDQ GSLMAAKEIE KYPLQLFPMW 
           210        220        230        240        250
    RFPFYLSAVL CVFLFFYCVI RDVIYPYVYE KKDNTFRMAI SIPNRIFPIT 
           260        270        280        290        300
    ALTLLALVYL PGVIAAILQL YRGTKYRRFP DWLDHWMLCR KQLGLVALGF 
           310        320        330        340        350
    AFLHVLYTLV IPIRYYVRWR LGNLTVTQAI LKKENPFSTS SAWLSDSYVA 
           360        370        380        390        400
    LGILGFFLFV LLGITSLPSV SNAVNWREFR FVQSKLGYLT LILCTAHTLV 
           410        420        430        440        450
    YGGKRFLSPS NLRWYLPAAY VLGLIIPCTV LVIKFVLIMP CVDNTLTRIR 

    QGWERNSKH
    Length:459
    Mass (Da):51,981
    Last modified:October 11, 2004 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFA3BF0F2B1001FE5
    GO
    Isoform 2 (identifier: Q687X5-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         153-328: Missing.

    Show »
    Length:283
    Mass (Da):31,310
    Checksum:i05110EAC5D032317
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    		Gene namesLengthAnnotation
    C9JS50C9JS50_HUMAN
    Metalloreductase STEAP4
    STEAP4
    		339Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAQ04064 differs from that shown. Reason: Frameshift.Curated
    The sequence BAB15559 differs from that shown. Reason: Frameshift.Curated
    The sequence CAH56271 differs from that shown. Reason: Erroneous initiation.Curated

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03197675G → D1 PublicationCorresponds to variant dbSNP:rs1981529Ensembl.1
    Natural variantiVAR_031977122A → T. Corresponds to variant dbSNP:rs34741656Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_024833153 – 328Missing in isoform 2. 1 PublicationAdd BLAST176

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		AF423422 mRNA Translation: AAQ04063.1
    AF423423 mRNA Translation: AAQ04064.1 Frameshift.
    AK026806 mRNA Translation: BAB15559.1 Frameshift.
    BC020600 mRNA Translation: AAH20600.1
    AL833044 mRNA Translation: CAH56271.1 Different initiation.

    The Consensus CDS (CCDS) project

    More...    CCDSi    		CCDS43611.1 [Q687X5-1]
    CCDS56494.1 [Q687X5-2]

    NCBI Reference Sequences

    More...    RefSeqi    		NP_001192244.1, NM_001205315.1 [Q687X5-1]
    NP_001192245.1, NM_001205316.1 [Q687X5-2]
    NP_078912.2, NM_024636.3 [Q687X5-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...    Ensembli    		ENST00000301959; ENSP00000305545; ENSG00000127954 [Q687X5-2]
    ENST00000380079; ENSP00000369419; ENSG00000127954 [Q687X5-1]

    Database of genes from NCBI RefSeq genomes

    More...    GeneIDi    		79689

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		hsa:79689

    UCSC genome browser

    More...    UCSCi    		uc003ujs.4, human [Q687X5-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		AF423422 mRNA Translation: AAQ04063.1
    AF423423 mRNA Translation: AAQ04064.1 Frameshift.
    AK026806 mRNA Translation: BAB15559.1 Frameshift.
    BC020600 mRNA Translation: AAH20600.1
    AL833044 mRNA Translation: CAH56271.1 Different initiation.
    CCDSiCCDS43611.1 [Q687X5-1]
    CCDS56494.1 [Q687X5-2]
    RefSeqiNP_001192244.1, NM_001205315.1 [Q687X5-1]
    NP_001192245.1, NM_001205316.1 [Q687X5-2]
    NP_078912.2, NM_024636.3 [Q687X5-1]

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...    PDBei

    Protein Data Bank RCSB

    More...    RCSB PDBi

    Protein Data Bank Japan

    More...    PDBji
    Links Updated
    		PDB entryMethodResolution (Å)ChainPositionsPDBsum
    6HCYelectron microscopy3.10A/B/C1-459[»]
    6HD1electron microscopy3.80A/B/C1-459[»]
    SMRiQ687X5
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGRIDi122810, 2 interactors
    IntActiQ687X5, 2 interactors
    STRINGi9606.ENSP00000369419

    Protein family/group databases

    TCDBi5.B.6.1.3, the transmembrane epithelial antigen protein-3 ferric reductase (steap) family

    PTM databases

    GlyGeniQ687X5, 1 site
    iPTMnetiQ687X5
    PhosphoSitePlusiQ687X5

    Polymorphism and mutation databases

    BioMutaiSTEAP4
    DMDMi74748242

    Proteomic databases

    EPDiQ687X5
    jPOSTiQ687X5
    MassIVEiQ687X5
    MaxQBiQ687X5
    PaxDbiQ687X5
    PeptideAtlasiQ687X5
    PRIDEiQ687X5
    ProteomicsDBi65993 [Q687X5-1]
    65994 [Q687X5-2]

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...    Antibodypediai    		29814, 281 antibodies

    Genome annotation databases

    EnsembliENST00000301959; ENSP00000305545; ENSG00000127954 [Q687X5-2]
    ENST00000380079; ENSP00000369419; ENSG00000127954 [Q687X5-1]
    GeneIDi79689
    KEGGihsa:79689
    UCSCiuc003ujs.4, human [Q687X5-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...    CTDi    		79689
    DisGeNETi79689
    EuPathDBiHostDB:ENSG00000127954.12

    GeneCards: human genes, protein and diseases

    More...    GeneCardsi    		STEAP4
    HGNCiHGNC:21923, STEAP4
    HPAiENSG00000127954, Tissue enhanced (adipose)
    MIMi611098, gene
    neXtProtiNX_Q687X5
    OpenTargetsiENSG00000127954
    PharmGKBiPA134874572

    GenAtlas: human gene database

    More...    GenAtlasi    		Search...

    Phylogenomic databases

    eggNOGiENOG502R746, Eukaryota
    GeneTreeiENSGT00390000008042
    HOGENOMiCLU_034618_1_1_1
    InParanoidiQ687X5
    OMAiCTFHTYL
    OrthoDBi638341at2759
    PhylomeDBiQ687X5
    TreeFamiTF332031

    Enzyme and pathway databases

    PathwayCommonsiQ687X5

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...    BioGRID-ORCSi    		79689, 4 hits in 840 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...    ChiTaRSi    		STEAP4, human

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...    GenomeRNAii    		79689
    PharosiQ687X5, Tbio

    Protein Ontology

    More...    PROi    		PR:Q687X5
    RNActiQ687X5, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...    SOURCEi    		Search...

    Gene expression databases

    BgeeiENSG00000127954, Expressed in pericardium and 197 other tissues
    ExpressionAtlasiQ687X5, baseline and differential
    GenevisibleiQ687X5, HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR013130, Fe3_Rdtase_TM_dom
    IPR036291, NAD(P)-bd_dom_sf
    IPR028939, P5C_Rdtase_cat_N
    PfamiView protein in Pfam
    PF03807, F420_oxidored, 1 hit
    PF01794, Ferric_reduct, 1 hit
    SUPFAMiSSF51735, SSF51735, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...    ProtoNeti    		Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTEA4_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q687X5
    Secondary accession number(s): Q658Q9
    , Q687X4, Q8WWB0, Q9H5R1
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: October 11, 2004
    Last modified: December 2, 2020
    This is version 134 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families
    6. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
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