UniProtKB - Q687X5 (STEA4_HUMAN)

BLAST

>sp|Q687X5|STEA4_HUMAN Metalloreductase STEAP4 OS=Homo sapiens OX=9606 GN=STEAP4 PE=1 SV=1
MEKTCIDALPLTMNSSEKQETVCIFGTGDFGRSLGLKMLQCGYSVVFGSRNPQKTTLLPS
GAEVLSYSEAAKKSGIIIIAIHREHYDFLTELTEVLNGKILVDISNNLKINQYPESNAEY
LAHLVPGAHVVKAFNTISAWALQSGALDASRQVFVCGNDSKAKQRVMDIVRNLGLTPMDQ
GSLMAAKEIEKYPLQLFPMWRFPFYLSAVLCVFLFFYCVIRDVIYPYVYEKKDNTFRMAI
SIPNRIFPITALTLLALVYLPGVIAAILQLYRGTKYRRFPDWLDHWMLCRKQLGLVALGF
AFLHVLYTLVIPIRYYVRWRLGNLTVTQAILKKENPFSTSSAWLSDSYVALGILGFFLFV
LLGITSLPSVSNAVNWREFRFVQSKLGYLTLILCTAHTLVYGGKRFLSPSNLRWYLPAAY
VLGLIIPCTVLVIKFVLIMPCVDNTLTRIRQGWERNSKH

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History
Entry version 118 (07 Nov 2018)
Sequence version 1 (11 Oct 2004)
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Protein

Metalloreductase STEAP4

Gene

STEAP4

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Metalloreductase that has the ability to reduce both Fe³⁺ to Fe²⁺ and Cu²⁺ to Cu¹⁺ (By similarity). Uses NADP⁺ as acceptor (By similarity). Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin-resistance (PubMed:18430367, PubMed:18381574). Involved in inflammatory arthritis, through the regulation of inflammatory cytokines (PubMed:19660107). Inhibits anchorage-independent cell proliferation (PubMed:19787193).By similarity4 Publications

Cofactorⁱ

FADBy similarityNote: Can also utilize the flavins FMN and riboflavin.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	67	NADPBy similarity	1
Binding siteⁱ	106	NADP; via amide nitrogenBy similarity	1
Binding siteⁱ	139	NADP; via amide nitrogenBy similarity	1
Binding siteⁱ	171	NADPBy similarity	1
Metal bindingⁱ	304	Iron (heme axial ligand)By similarity	1
Metal bindingⁱ	397	Iron (heme axial ligand)By similarity	1

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	27 – 30	NADPBy similarity	4
Nucleotide bindingⁱ	49 – 50	NADPBy similarity	2
Nucleotide bindingⁱ	81 – 85	NADPBy similarity	5

GO - Molecular functionⁱ

cupric reductase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
ferric-chelate reductase (NADPH) activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

copper ion import
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
fat cell differentiation Source: UniProtKB
ferric iron import across cell outer membrane
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
iron ion homeostasis Source: UniProtKB-KW
oxidation-reduction process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Oxidoreductase
Biological process	Ion transport, Iron transport, Transport
Ligand	Copper, FAD, Flavoprotein, Heme, Iron, Metal-binding, NAD, NADP

Protein family/group databases

TCDBⁱ	5.B.6.1.3 the transmembrane epithelial antigen protein-3 ferric reductase (steap) family

TCDBⁱ

5.B.6.1.3 the transmembrane epithelial antigen protein-3 ferric reductase (steap) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Metalloreductase STEAP4 (EC:1.16.1.-) Alternative name(s): Six-transmembrane epithelial antigen of prostate 4 SixTransMembrane protein of prostate 2 Tumor necrosis factor, alpha-induced protein 9
Gene namesⁱ	Name:STEAP4 Synonyms:STAMP2, TNFAIP9
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000127954.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:21923 STEAP4
MIMⁱ	611098 gene
neXtProtⁱ	NX_Q687X5

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	196 – 216	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	246 – 266	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	293 – 313	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	348 – 368	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	381 – 401	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	419 – 439	HelicalSequence analysisAdd BLAST	21

Keywords - Cellular componentⁱ

Cell membrane, Endosome, Golgi apparatus, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	79689
Open Targets More...OpenTargetsⁱ	ENSG00000127954
PharmGKBⁱ	PA134874572

Polymorphism and mutation databases

BioMutaⁱ	STEAP4
DMDMⁱ	74748242

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000285174	1 – 459	Metalloreductase STEAP4Add BLAST		459

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	323	N-linked (GlcNAc...) asparagine1 Publication		1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

EPDⁱ	Q687X5
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q687X5
PaxDbⁱ	Q687X5
PeptideAtlas More...PeptideAtlasⁱ	Q687X5
PRIDEⁱ	Q687X5
ProteomicsDBⁱ	65993 65994 [Q687X5-2]

PTM databases

iPTMnetⁱ	Q687X5
PhosphoSitePlusⁱ	Q687X5

Expressionⁱ

Tissue specificityⁱ

Ubiquitous. Highly expressed in adipose tissue. Expressed in placenta, lung, heart and prostate. Detected at lower levels in liver, skeletal muscle, pancreas, testis and small intestine. Highly expressed in joints of patients with rheumatoid arthritis and localized with CD68 cells, a marker for macrophages.6 Publications

Inductionⁱ

By TNF and IL1B/interleukin-1 beta in adipose tissue. Up-regulated by androgens, including testosterone and dihydrotestosterone (DHT).3 Publications

Gene expression databases

Bgeeⁱ	ENSG00000127954 Expressed in 180 organ(s), highest expression level in pericardium
CleanExⁱ	HS_STEAP4
ExpressionAtlasⁱ	Q687X5 baseline and differential
Genevisibleⁱ	Q687X5 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA075871

HPAⁱ

HPA075871

Interactionⁱ

Subunit structureⁱ

Homodimer (By similarity). Interacts with PTK2/FAK1; the interaction may regulate PTK2 phosphorylation.By similarity1 Publication

Protein-protein interaction databases

BioGridⁱ	122810, 2 interactors
IntActⁱ	Q687X5, 1 interactor
STRINGⁱ	9606.ENSP00000369419

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q687X5
SMRⁱ	Q687X5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	247 – 395	Ferric oxidoreductaseSequence analysisAdd BLAST		149

Sequence similaritiesⁱ

Belongs to the STEAP family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IF4F Eukaryota COG2085 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000008042
HOGENOMⁱ	HOG000234491
HOVERGENⁱ	HBG054379
InParanoidⁱ	Q687X5
KEGG Orthology (KO) More...KOⁱ	K19876
OMAⁱ	YCVIREV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0F9X
PhylomeDBⁱ	Q687X5
TreeFamⁱ	TF332031

Family and domain databases

InterProⁱ	View protein in InterPro IPR013130 Fe3_Rdtase_TM_dom IPR036291 NAD(P)-bd_dom_sf IPR028939 P5C_Rdtase_cat_N
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03807 F420_oxidored, 1 hit PF01794 Ferric_reduct, 1 hit
SUPFAMⁱ	SSF51735 SSF51735, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q687X5-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEKTCIDALP LTMNSSEKQE TVCIFGTGDF GRSLGLKMLQ CGYSVVFGSR 
        60         70         80         90        100
NPQKTTLLPS GAEVLSYSEA AKKSGIIIIA IHREHYDFLT ELTEVLNGKI 
       110        120        130        140        150
LVDISNNLKI NQYPESNAEY LAHLVPGAHV VKAFNTISAW ALQSGALDAS 
       160        170        180        190        200
RQVFVCGNDS KAKQRVMDIV RNLGLTPMDQ GSLMAAKEIE KYPLQLFPMW 
       210        220        230        240        250
RFPFYLSAVL CVFLFFYCVI RDVIYPYVYE KKDNTFRMAI SIPNRIFPIT 
       260        270        280        290        300
ALTLLALVYL PGVIAAILQL YRGTKYRRFP DWLDHWMLCR KQLGLVALGF 
       310        320        330        340        350
AFLHVLYTLV IPIRYYVRWR LGNLTVTQAI LKKENPFSTS SAWLSDSYVA 
       360        370        380        390        400
LGILGFFLFV LLGITSLPSV SNAVNWREFR FVQSKLGYLT LILCTAHTLV 
       410        420        430        440        450
YGGKRFLSPS NLRWYLPAAY VLGLIIPCTV LVIKFVLIMP CVDNTLTRIR 

QGWERNSKH

Length:459

Mass (Da):51,981

Last modified:October 11, 2004 - v1

Checksum:ⁱFA3BF0F2B1001FE5

Isoform 2 (identifier: Q687X5-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
153-328: Missing.

« Hide

        10         20         30         40         50
MEKTCIDALP LTMNSSEKQE TVCIFGTGDF GRSLGLKMLQ CGYSVVFGSR 
        60         70         80         90        100
NPQKTTLLPS GAEVLSYSEA AKKSGIIIIA IHREHYDFLT ELTEVLNGKI 
       110        120        130        140        150
LVDISNNLKI NQYPESNAEY LAHLVPGAHV VKAFNTISAW ALQSGALDAS 
       160        170        180        190        200
RQAILKKENP FSTSSAWLSD SYVALGILGF FLFVLLGITS LPSVSNAVNW 
       210        220        230        240        250
REFRFVQSKL GYLTLILCTA HTLVYGGKRF LSPSNLRWYL PAAYVLGLII 
       260        270        280 
PCTVLVIKFV LIMPCVDNTL TRIRQGWERN SKH

Show »

Length:283

Mass (Da):31,310

Checksum:ⁱ05110EAC5D032317

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	C9JS50	C9JS50_HUMAN		Metalloreductase STEAP4 Metalloreductase STEAP4	STEAP4	339	Annotation score:

Sequence cautionⁱ

The sequence AAQ04064 differs from that shown. Reason: Frameshift at position 384.Curated

The sequence BAB15559 differs from that shown. Reason: Frameshift at positions 252 and 364.Curated

The sequence CAH56271 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_031976	75	G → D1 PublicationCorresponds to variant dbSNP:rs1981529Ensembl.		1
Natural variantⁱVAR_031977	122	A → T. Corresponds to variant dbSNP:rs34741656Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_024833	153 – 328	Missing in isoform 2. 1 PublicationAdd BLAST		176

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF423422 mRNA Translation: AAQ04063.1 AF423423 mRNA Translation: AAQ04064.1 Frameshift. AK026806 mRNA Translation: BAB15559.1 Frameshift. BC020600 mRNA Translation: AAH20600.1 AL833044 mRNA Translation: CAH56271.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS43611.1 [Q687X5-1] CCDS56494.1 [Q687X5-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001192244.1, NM_001205315.1 [Q687X5-1] NP_001192245.1, NM_001205316.1 [Q687X5-2] NP_078912.2, NM_024636.3 [Q687X5-1]
UniGeneⁱ	Hs.521008

Genome annotation databases

Ensemblⁱ	ENST00000301959; ENSP00000305545; ENSG00000127954 [Q687X5-2] ENST00000380079; ENSP00000369419; ENSG00000127954 [Q687X5-1]
GeneIDⁱ	79689
KEGGⁱ	hsa:79689
UCSC genome browser More...UCSCⁱ	uc003ujs.4 human [Q687X5-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q687X5	STEAP family member 4 (Fragment)		PIG		129	UniRef100_Q687X5

Protein	Similar proteins		Species	Score	Length	Source
Q687X5	STEAP family member 4 (Fragment)		PIG		129	UniRef90_Q687X5
Uncharacterized protein		MACMU		569
Uncharacterized protein		PAPAN		569
Uncharacterized protein		MACFA		569
Uncharacterized protein		MANLE		459
+23
Q687X5-2	STEAP4 isoform 2		PANTR		283	UniRef90_Q687X5-2
Uncharacterized protein		PANPA		283
STEAP4 metalloreductase		SAIBB		283
STEAP4 metalloreductase		CALJA		283
Uncharacterized protein		MACMU		283
+14

Protein	Similar proteins		Species	Score	Length	Source
Q687X5	STEAP family member 4 (Fragment)		PIG		129	UniRef50_Q687X5
Uncharacterized protein		MACMU		569
Uncharacterized protein		MACFA		569
Uncharacterized protein		MANLE		459
Uncharacterized protein		PAPAN		569
+171
Q687X5-2	Uncharacterized protein		NOMLE		283	UniRef50_Q687X5-2
STEAP4 metalloreductase		GORGO		283
STEAP4 metalloreductase		SAIBB		283
Uncharacterized protein		AOTNA		283
Uncharacterized protein		Cebus capucinus imitator		283
+25

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF423422 mRNA Translation: AAQ04063.1 AF423423 mRNA Translation: AAQ04064.1 Frameshift. AK026806 mRNA Translation: BAB15559.1 Frameshift. BC020600 mRNA Translation: AAH20600.1 AL833044 mRNA Translation: CAH56271.1 Different initiation.
CCDSⁱ	CCDS43611.1 [Q687X5-1] CCDS56494.1 [Q687X5-2]
RefSeqⁱ	NP_001192244.1, NM_001205315.1 [Q687X5-1] NP_001192245.1, NM_001205316.1 [Q687X5-2] NP_078912.2, NM_024636.3 [Q687X5-1]
UniGeneⁱ	Hs.521008

3D structure databases

ProteinModelPortalⁱ	Q687X5
SMRⁱ	Q687X5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	122810, 2 interactors
IntActⁱ	Q687X5, 1 interactor
STRINGⁱ	9606.ENSP00000369419

Protein family/group databases

TCDBⁱ	5.B.6.1.3 the transmembrane epithelial antigen protein-3 ferric reductase (steap) family

TCDBⁱ

5.B.6.1.3 the transmembrane epithelial antigen protein-3 ferric reductase (steap) family

PTM databases

iPTMnetⁱ	Q687X5
PhosphoSitePlusⁱ	Q687X5

Polymorphism and mutation databases

BioMutaⁱ	STEAP4
DMDMⁱ	74748242

Proteomic databases

EPDⁱ	Q687X5
MaxQBⁱ	Q687X5
PaxDbⁱ	Q687X5
PeptideAtlasⁱ	Q687X5
PRIDEⁱ	Q687X5
ProteomicsDBⁱ	65993 65994 [Q687X5-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000301959; ENSP00000305545; ENSG00000127954 [Q687X5-2] ENST00000380079; ENSP00000369419; ENSG00000127954 [Q687X5-1]
GeneIDⁱ	79689
KEGGⁱ	hsa:79689
UCSCⁱ	uc003ujs.4 human [Q687X5-1]

Organism-specific databases

CTDⁱ	79689
DisGeNETⁱ	79689
EuPathDBⁱ	HostDB:ENSG00000127954.12
GeneCardsⁱ	STEAP4
HGNCⁱ	HGNC:21923 STEAP4
HPAⁱ	HPA075871
MIMⁱ	611098 gene
neXtProtⁱ	NX_Q687X5
OpenTargetsⁱ	ENSG00000127954
PharmGKBⁱ	PA134874572
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IF4F Eukaryota COG2085 LUCA
GeneTreeⁱ	ENSGT00390000008042
HOGENOMⁱ	HOG000234491
HOVERGENⁱ	HBG054379
InParanoidⁱ	Q687X5
KOⁱ	K19876
OMAⁱ	YCVIREV
OrthoDBⁱ	EOG091G0F9X
PhylomeDBⁱ	Q687X5
TreeFamⁱ	TF332031

Miscellaneous databases

ChiTaRSⁱ	STEAP4 human
GenomeRNAiⁱ	79689
Protein Ontology More...PROⁱ	PR:Q687X5
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000127954 Expressed in 180 organ(s), highest expression level in pericardium
CleanExⁱ	HS_STEAP4
ExpressionAtlasⁱ	Q687X5 baseline and differential
Genevisibleⁱ	Q687X5 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR013130 Fe3_Rdtase_TM_dom IPR036291 NAD(P)-bd_dom_sf IPR028939 P5C_Rdtase_cat_N
Pfamⁱ	View protein in Pfam PF03807 F420_oxidored, 1 hit PF01794 Ferric_reduct, 1 hit
SUPFAMⁱ	SSF51735 SSF51735, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	STEA4_HUMAN
Accessionⁱ	Q687X5Primary (citable) accession number: Q687X5 Secondary accession number(s): Q658Q9 , Q687X4, Q8WWB0, Q9H5R1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 1, 2007
	Last sequence update:	October 11, 2004
	Last modified:	November 7, 2018
	This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM

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UniProtKB - Q687X5 (STEA4_HUMAN)

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Metalloreductase STEAP4

STEAP4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endosome

Plasma membrane

Golgi apparatus

Endosome

Extracellular region or secreted

Golgi apparatus

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ